The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae
Open accessAbstract
Lysine acetylation is a frequently occurring posttranslational modification; however, little is known about the origin and regulation of most sites. Here we used quantitative mass spectrometry to analyze acetylation dynamics and stoichiometry in S accharomyces cerevisiae . We found that acetylation accumulated in growth‐arrested cells in a manner that depended on acetyl‐ C o A generation in distinct subcellular compartments. Mitochondrial acetylation levels correlated with acetyl‐ C o A concentration in vivo and acetyl‐ C o A acetylated lysine residues nonenzymatically in vitro . We developed a method to estimate acetylation stoichiometry and found that the vast majority of mitochondrial and cytoplasmic acetylation had a very low stoichiometry. However, mitochondrial acetylation occurred at a significantly higher basal level than cytoplasmic acetylation, consistent with the distinct acetylation dynamics and higher acetyl‐ C o A concentration in mitochondria. High stoichiometry acetylation occurred mostly on histones, proteins present in histone acetyltransferase and deacetylase complexes, and on transcription factors. These data show that a majority of acetylation occurs at very low levels in exponentially growing yeast and is uniformly affected by exposure to acetyl‐ C o A .
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Lysine acetylation targets protein complexes and co-regulates major cellular functions
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Self-citationRegulation of cellular metabolism by protein lysine acetylation
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Self-citationFunctions and mechanisms of non-histone protein acetylation
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Self-citationModulation of cellular processes by histone and non-histone protein acetylation
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Metadata
- Authors
- Weinert, B. T., Iesmantavicius, V., Moustafa, T., Schölz, C., Wagner, S. A., Magnes, C., Zechner, R., & Choudhary, C.
- Venue
- Molecular Systems Biology
- Published
- 2014-01
- Volume
- 10
- Issue
- 1
- Pages
- 716-716
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2121532196
- Cited by
- 275
- References
- 14
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- gold
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- Weinert, B. T., Iesmantavicius, V., Moustafa, T., Schölz, C., Wagner, S. A., Magnes, C., Zechner, R., & Choudhary, C. (2014). Acetylation dynamics and stoichiometry in Saccharomyces cerevisiae. Molecular Systems Biology. https://doi.org/10.1002/msb.134766
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