The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Evolution and functional cross‐talk of protein post‐translational modifications
Open accessAbstract
Protein post‐translational modifications ( PTM s) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states. Advances in mass spectrometry now enable proteome wide characterization of PTM s and have revealed a broad functional role for a range of different types of modifications. Here we review advances in the study of the evolution and function of PTM s that were spurred by these technological improvements. We provide an overview of studies focusing on the origin and evolution of regulatory enzymes as well as the evolutionary dynamics of modification sites. Finally, we discuss different mechanisms of altering protein activity via post‐translational regulation and progress made in the large‐scale functional characterization of PTM function.
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Metadata
- Authors
- Beltrao, P., Bork, P., Krogan, N. J., & van Noort, V.
- Venue
- Molecular Systems Biology
- Published
- 2013-01
- Volume
- 9
- Issue
- 1
- Pages
- 714-714
- ISSN
- 1744-4292 (ISSN-L)
- OpenAlex
- W2005893121
- Cited by
- 380
- References
- 14
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- gold
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