Evidence‐Based Medicine and Primary Care: Keeping Up Is Hard to Do
Abstract
Primary‐care physicians feel pressure to be knowledgeable, efficient, comprehensive, and compassionate while delivering evidence‐based medical care. Incorporating evidence‐based medicine into practice requires training in the skills of finding and applying good evidence to patients, and, increasingly, infrastructure that supports the incorporation of evidence into electronic health records. Physicians cite many barriers to the use of evidence‐based medicine in practice. In this review, we examine evidence of the value of evidence‐based medicine in clinical practice, discuss the interface of evidence and shared decision‐making, suggest tools and approaches for incorporating evidence‐based medicine into practice, and discuss the impact of recent health insurance reform on expectations and incentives for physicians with respect to evidence‐based practice. Mt Sinai J Med 79:545–554, 2012. © 2012 Mount Sinai School of Medicine
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Even when studies exist, they can have conflicting findings arising from heterogeneous patient populations, study designs of variable quality, or nonstandard endpoints.
“Second, even when studies exist, they can have conflicting findings arising from heterogeneous patient populations, study designs of variable quality, or nonstandard endpoints.”
From Answering real-world clinical questions using large language model, retrieval-augmented generation, and agentic systems (2025) · cites this paper as [9]
Cites
Evidence based medicine: what it is and what it isn't
Sackett, D. L., Rosenberg, W. M. C., Gray, J. A. M., Haynes, R. B., & Richardson, W. S. (1996) · BMJ · doi:10.1136/bmj.312.7023.71 · Cited by 15,769 · see citing works
Why Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020124 · Cited by 10,505 · see citing works
Evidence-Based Medicine: How to Practice and Teach EBM
Sackett, D. L. (2000) · Cited by 5,950 · see citing works
Why Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · CHANCE · doi:10.1080/09332480.2005.10722754 · Cited by 4,702 · see citing works
Contradicted and Initially Stronger Effects in Highly Cited Clinical Research
Ioannidis, J. P. A. (2005) · JAMA · doi:10.1001/jama.294.2.218 · Cited by 1,465 · see citing works
Evidence-based medicine : how to practice and teach EBM
Straus, S. E. (2005) · Cited by 1,378 · see citing works
General practitioners' perceptions of the route to evidence based medicine: a questionnaire survey
McColl, A., Smith, H. E., White, P., & Field, J. R. (1998) · BMJ · doi:10.1136/bmj.316.7128.361 · Cited by 887 · see citing works
Imaging strategies for low-back pain: systematic review and meta-analysis
Chou, R., Fu, R. F., Carrino, J. A., & Deyo, R. A. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60172-0 · Cited by 612 · see citing works
Roy-Byrne, P., Craske, M. G., Sullivan, G., Rose, R. D., Edlund, M. J., Lang, A. J., Bystritsky, A., Welch, S. S., Chavira, D. A., Golinelli, D., et al. (2010) · JAMA · doi:10.1001/jama.2010.608 · Cited by 452 · see citing works
Why general practitioners do not implement evidence: qualitative study
Freeman, A., & Sweeney, K. (2001) · BMJ · doi:10.1136/bmj.323.7321.1100 · Cited by 398 · see citing works
Self-reported Hypertension Treatment Practices Among Primary Care Physicians
Hyman, D. J., & Pavlik, V. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.15.2281 · Cited by 357 · see citing works
Electronic Health Records and Quality of Diabetes Care
Cebul, R. D., Love, T. E., Jain, A., & Hebert, C. J. (2011) · New England Journal of Medicine · doi:10.1056/nejmsa1102519 · Cited by 332 · see citing works
Wegwarth, O., Schwartz, L. M., Woloshin, S., Gaissmaier, W., & Gigerenzer, G. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-156-5-201203060-00005 · Cited by 304 · see citing works
Using alternative statistical formats for presenting risks and risk reductions
Akl, E. A., Oxman, A. D., Herrin, J. S., Vist, G. E., Terrenato, I., Sperati, F., Costiniuk, C. T., Blank, D., & Schünemann, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006776.pub2 · Cited by 253 · see citing works
Users' Guides to the Medical Literature: Essentials of Evidence-Based Clinical Practice
Guyatt, G. H. (2001) · Cited by 243 · see citing works
Barratt, A. L. (2008) · Patient Education and Counseling · doi:10.1016/j.pec.2008.07.054 · Cited by 234 · see citing works
Effects of computerized guidelines for managing heart disease in primary care
Tierney, W. M., Overhage, J. M., Murray, M. D., Harris, L. E., Zhou, X., Eckert, G. J., Smith, F. E., Nienaber, N. A., McDonald, C. J., & Wolinsky, F. D. (2003) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2003.30635.x · Cited by 199 · see citing works
A Controlled Trial of Web-Based Diabetes Disease Management
Meigs, J. B., Cagliero, E., Dubey, A. K., Murphy-Sheehy, P., Gildesgame, C., Chueh, H. C., Barry, M. J., Singer, D. E., & Nathan, D. M. (2003) · Diabetes Care · doi:10.2337/diacare.26.3.750 · Cited by 197 · see citing works
Ahmed, H., Naik, G., Willoughby, H., & Edwards, A. (2012) · BMJ · doi:10.1136/bmj.e3996 · Cited by 167 · see citing works
Boyd, C. M., Reider, L., Frey, K., Scharfstein, D., Leff, B., Wolff, J., Groves, C., Karm, L., Wegener, S., Marsteller, J., et al. (2010) · Journal of General Internal Medicine · doi:10.1007/s11606-009-1192-5 · Cited by 159 · see citing works
Tierney, W. M., Overhage, J. M., Murray, M. D., Harris, L. E., Zhou, X., Eckert, G. J., Smith, F. E., Nienaber, N. A., McDonald, C. J., & Wolinsky, F. D. (2005) · Health Services Research · doi:10.1111/j.1475-6773.2005.0t369.x · Cited by 137 · see citing works
Murray, M. D., Harris, L. E., Overhage, J. M., Zhou, X., Eckert, G. J., Smith, F. E., Buchanan, N. N., Wolinsky, F. D., McDonald, C. J., & Tierney, W. M. (2004) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.24.4.324.33173 · Cited by 133 · see citing works
Tierney, W. M., Overhage, J. M., Murray, M. D., et al. (2005) · PubMed · doi:10.1111/j.1475-6773.2005.00368.x · Cited by 124 · see citing works
Christakis, D., Zimmerman, F. J., Wright, J. A., Garrison, M. M., Rivara, F. P., & Davis, R. L. (2001) · PEDIATRICS · doi:10.1542/peds.107.2.e15 · Cited by 118 · see citing works
Stewart, W. F., Shah, N. R., Selna, M. J., Paulus, R. A., & Walker, J. M. (2007) · Health Affairs · doi:10.1377/hlthaff.26.2.w181 · Cited by 111 · see citing works
Evidence, Preferences, Recommendations — Finding the Right Balance in Patient Care
Quill, T. E., & Holloway, R. G. (2012) · New England Journal of Medicine · doi:10.1056/nejmp1201535 · Cited by 107 · see citing works
Evidence-based medicine in primary care: qualitative study of family physicians
Tracy, C. S., Dantas, G. C., & Upshur, R. E. G. (2003) · BMC Family Practice · doi:10.1186/1471-2296-4-6 · Cited by 107 · see citing works
Guided care and the cost of complex healthcare: a preliminary report.
Leff, B. A., Reider, L. M., Frick, K. D., Scharfstein, D. O., Boyd, C. M., Frey, K. P., Karm, L., & Boult, C. (2009) · PubMed · Cited by 99 · see citing works
Shuval, K., Berkovits, E., Netzer, D., Hekselman, I., Linn, S., Brezis, M., & Reis, S. P. (2007) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2007.00859.x · Cited by 98 · see citing works
Dubey, V., Mathew, R., Iglar, K., Moineddin, R., & Glazier, R. H. (2006) · BMC Family Practice · doi:10.1186/1471-2296-7-44 · Cited by 96 · see citing works
USERS’ GUIDES TO THE MEDICAL LITERATURE. ESSENTIALS OF EVIDENCE-BASED CLINICAL PRACTICE
Fineout‐Overholt, E. (2002) · CIN Computers Informatics Nursing · doi:10.1097/00024665-200209000-00006 · Cited by 89 · see citing works
Chaney, E. F., Rubenstein, L. V., Liu, C., Yano, E. M., Bolkan, C. R., Lee, M., Simon, B. F., Lanto, A. B., Felker, B. L., & Uman, J. E. (2011) · Implementation Science · doi:10.1186/1748-5908-6-121 · Cited by 88 · see citing works
Herbert, C. P. (2004) · Family Practice · doi:10.1093/fampra/cmh515 · Cited by 83 · see citing works
the Competence Network Heart Failure, Peters-Klimm, F., Campbell, S., Hermann, K., Kunz, C. U., Müller‐Tasch, T., & Szécsényi, J. (2010) · Trials · doi:10.1186/1745-6215-11-56 · Cited by 83 · see citing works
Bower, P., Kennedy, A. P., Reeves, D., Rogers, A. E., Blakeman, T., Chew-Graham, C. A., Bowen, R., Eden, M., Gardner, C., Hann, M., et al. (2012) · Implementation Science · doi:10.1186/1748-5908-7-7 · Cited by 65 · see citing works
Typical Electronic Health Record Use in Primary Care Practices and the Quality of Diabetes Care
Crosson, J. C., Ohman‐Strickland, P., Cohen, D. J., Clark, E. C., & Crabtree, B. F. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1370 · Cited by 62 · see citing works
USERS’ GUIDES TO THE MEDICAL LITERATURE. A MANUAL FOR EVIDENCE-BASED CLINICAL PRACTICE
Fineout‐Overholt, E. (2002) · CIN Computers Informatics Nursing · doi:10.1097/00024665-200209000-00005 · Cited by 61 · see citing works
Neuner‐Jehle, S., Senn, O., Wegwarth, O., Rosemann, T. J., & Steurer, J. (2011) · BMC Family Practice · doi:10.1186/1471-2296-12-15 · Cited by 58 · see citing works
Critical appraisal skills of family physicians in Ontario, Canada
Godwin, M. S., & Seguin, R. (2003) · BMC Medical Education · doi:10.1186/1472-6920-3-10 · Cited by 55 · see citing works
de Belvis, A. G., Pelone, F., Biasco, A., Ricciardi, W., & Volpe, M. (2009) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.05.007 · Cited by 50 · see citing works
Evidence-based medicine knowledge, attitudes, and skills of community faculty
Beasley, B. W., & Woolley, D. C. (2002) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2002.11110.x · Cited by 46 · see citing works
Evidence-Based Medicine In The United States—De Rigueur Or Dream Deferred?
Mendelson, D., & Carino, T. V. (2005) · Health Affairs · doi:10.1377/hlthaff.24.1.133 · Cited by 46 · see citing works
The Evolving Primary Care Physician
Okie, S. (2012) · New England Journal of Medicine · doi:10.1056/nejmp1201526 · Cited by 40 · see citing works
Kiessling, A., LEWITT, M. S., & Henriksson, P. (2011) · The Annals of Family Medicine · doi:10.1370/afm.1248 · Cited by 38 · see citing works
Improved health or improved decision making? The ethical goals of EBM
Gupta, M. (2011) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2011.01743.x · Cited by 37 · see citing works
Electronic health records: is the evidence base any use?
Clamp, S., & Keen, J. (2007) · Medical Informatics and the Internet in Medicine · doi:10.1080/14639230601097903 · Cited by 37 · see citing works
Evaluating primary care doctors’ evidence‐based medicine skills in a busy clinical setting
Shuval, K., Shachak, A., Linn, S., Brezis, M., & Reis, S. P. (2007) · Journal of Evaluation in Clinical Practice · doi:10.1111/j.1365-2753.2007.00805.x · Cited by 34 · see citing works
Faculty training in evidence-based medicine: Improving evidence acquisition and critical appraisal
Nicholson, L. J., Warde, C., & Boker, J. R. (2007) · Journal of Continuing Education in the Health Professions · doi:10.1002/chp.90 · Cited by 34 · see citing works
Electronic health records, clinical decision support, and blood pressure control.
Samal, L., Linder, J. A., Lipsitz, S. R., & Hicks, L. S. (2011) · PubMed · Cited by 33 · see citing works
Gulliford, M. C., van Staa, T. P., McDermott, L. M., Dregan, A., McCann, G., Ashworth, M. J., Charlton, J., Grieve, A. P., Little, P. S., Moore, M. V., et al. (2011) · Trials · doi:10.1186/1745-6215-12-115 · Cited by 32 · see citing works
Communicating benefits and risks of screening for prostate, colon, and breast cancer.
Barrett, B. P., & McKenna, P. (2011) · PubMed · Cited by 30 · see citing works
Panella, M., Marchisio, S., Barbieri, A., & Stanislao, F. D. (2008) · BMC Health Services Research · doi:10.1186/1472-6963-8-223 · Cited by 29 · see citing works
Kunz, R., Wegscheider, K., Guyatt, G. H., Zielinski, W., Rakowsky, N. A., Donner‐Banzhoff, N., & Müller-Lissner, S. A. (2007) · BMJ Quality & Safety · doi:10.1136/qshc.2006.020305 · Cited by 26 · see citing works
The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Bundrick, J. B. (2009) · Mayo Clinic Proceedings · doi:10.4065/84.11.1045-h · Cited by 22 · see citing works
Association between primary care physicians' evidence-based medicine knowledge and quality of care
Shuval, K., Linn, S., Brezis, M., Shadmi, E., Green, M. L., & Reis, S. P. (2009) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzp054 · Cited by 21 · see citing works
Zwar, N. A., Hermiz, O. S., Hasan, I., Comino, E. J., Middleton, S., Vagholkar, S., & Marks, G. B. (2008) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-8-8 · Cited by 17 · see citing works
Schoenthaler, A., Luerassi, L., Teresi, J. A., Silver, S. A., Kong, J., Odedosu, T., Trilling, S., Errico, A., Uvwo, O., Sebek, K., et al. (2011) · Trials · doi:10.1186/1745-6215-12-265 · Cited by 13 · see citing works
Improving information management in primary care: the proof is in the pudding
Reed, V. A., Schifferdecker, K. E., & Homa, K. A. (2008) · Journal of Innovation in Health Informatics · doi:10.14236/jhi.v16i3.696 · Cited by 7 · see citing works
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Lukacs, B., Cornu, J., Aout, M., Tessier, N., Hodée, C., Haab, F., Cussenot, O., Merlière, Y., Moysan, V., & Vicaut, É. (2013) · European Urology · doi:10.1016/j.eururo.2013.02.026 · Cited by 96 · see citing works
Low, Y. S., Jackson, M. L., Hyde, R. J., Brown, R. E., Sanghavi, N. M., Baldwin, J. D., Pike, C. W., Muralidharan, J., Hui, G., Alexander, N., et al. (2025) · DIGITAL HEALTH · doi:10.1177/20552076251348850 · Cited by 51 · see citing works
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Campbell, J. M., Umapathysivam, K., Xue, Y., & Lockwood, C. S. (2015) · Worldviews on Evidence-Based Nursing · doi:10.1111/wvn.12114 · Cited by 46 · see citing works
Bougioukas, K. I., Bouras, E., Avgerinos, K. I., Dardavessis, T., & Haidich, A. (2020) · Health Information & Libraries Journal · doi:10.1111/hir.12318 · Cited by 44 · see citing works
Rosis, S. D., & Seghieri, C. (2015) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-015-0185-z · Cited by 39 · see citing works
Rader, T., Pardo, J. P., Stacey, D., Ghogomu, E. A. T., Maxwell, L. J., Welch, V. A., Singh, J. A., Buchbinder, R., Légaré, F., Santesso, N. A., et al. (2013) · The Journal of Rheumatology · doi:10.3899/jrheum.121307 · Cited by 20 · see citing works
Vrdoljak, D., Petrić, D., Diminić-Lisica, I., Kranjčević, K., Janković, S. D., Delija, I., & Puljak, L. (2015) · European Journal of General Practice · doi:10.3109/13814788.2015.1046124 · Cited by 6 · see citing works
Pintado-Outumuro, E., Fraile, V. M., Salvador-González, B., Benito‐Aracil, L., Ibáñez, M. J., Sancho-Campos, M.-P., Alves-Tafur, C., & Lumillo‐Gutiérrez, I. (2024) · BMC Family Practice · doi:10.1186/s12875-024-02418-0 · Cited by 6 · see citing works
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Basu, A. (2019) · doi:10.1002/9781118907283.ch68 · Cited by 2 · see citing works
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Rodríguez‐Saldaña, J. (2019) · Springer eBooks · doi:10.1007/978-3-030-11815-0_21 · Cited by 1 · see citing works
Introduction to Meta AnalysisPreprint
Basu, A. (2014) · doi:10.7287/peerj.preprints.665v1
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Campbell, J. M. (2016) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2016-003062
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Cheng, Y., Zou, C., Liu, C., Jia, Y., Yang, R. H., Zhang, Y., Han, J., Lei, Y., & Liao, X. (2025) · BMC Family Practice · doi:10.1186/s12875-025-02838-6 · Cited by 2 · see citing works
Pintado-Outumuro, E., Fraile, V. M., Salvador-González, B., (15108986), L. B., Ibáñez, M. J., Sancho-Campos, M.-P., Alves-Tafur, C., & Lumillo‐Gutiérrez, I. (2024) · Figshare · doi:10.6084/m9.figshare.26723490
Assaoui, S., Billot, M., Rigoard, P., Ojardias, É., Bessaguet, H., Compagnat, M., Viseux, F., Heslot, C., & David, R. (2026) · doi:10.2196/preprints.92262
Ortiz, J. D., Hadvani, T., Zafar, S., Lipstein, E. A., Volk, R. J., Nicome, R., Ban, K., Arthur, C., Singh, A., Neubauer, H. C., et al. (2026) · Academic Pediatrics · doi:10.1016/j.acap.2026.103274
- Authors
- Zipkin, D. A., Greenblatt, L., & Kushinka, J. T.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Virginia Commonwealth University (US)
- Corresponding author
- Zipkin, Daniella A.
- Venue
- Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine
- Publisher
- Wiley
- Published
- 2012-09
- Volume
- 79
- Issue
- 5
- Pages
- 545-554
- ISSN
- 0027-2507 (ISSN-L)
- 1931-7581
- OpenAlex
- W2061396319
- Cited by
- 16
- References
- 59
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2020: 1 · 2019: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Sciences Research and Education
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
- Health Sciences › Health Professions › Health Information Management › Electronic Health Records Systems
- Keywords
- evidence-based medicine, primary care, barriers to evidence-based practice, shared decision-making, electronic health records, health insurance reform, physician incentives, clinical practice integration
- MeSH terms
- Humans, Patient Participation, Practice Patterns, Physicians', Primary Health Care, Information Storage and Retrieval, Evidence-Based Medicine, Libraries, Digital, Electronic Health Records
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