Lipofuscin Accumulation in the Vastus Lateralis Muscle in Patients with Chronic Obstructive Pulmonary Disease
Abstract
Exercise-induced oxidative stress has been reported in patients with chronic obstructive pulmonary disease (COPD) and may play a role in muscle fatigue. It is speculated that oxidative stress during exercise originates from the contracting muscles but this has not been documented. The accumulation of lipofuscin, a marker of cellular oxidative damage, was evaluated in the vastus lateralis muscle in 17 patients with COPD and 10 healthy subjects of similar age. Each subject performed a stepwise exercise test up to maximal capacity during which oxygen uptake (VO(2)) was measured. Resting and peak exercise blood gases were also obtained. Two indices of lipofuscin accumulation were used: lipofuscin inclusions/fiber ratio (LI/F) and lipofuscin inclusions/fiber cross-sectional area ratio (LI/CSA). These ratios were also determined for each specific fiber-type. LI/F (P 0.05). Increased lipofuscin accumulation, a marker of oxidative damage, was found in the vastus lateralis muscle in patients with COPD compared to healthy subjects. Oxidative damage of muscle tissue may thus be involved in skeletal muscle dysfunction and wasting in COPD.
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Several studies have found increased lipofuscin accumulation in COPD quadriceps and higher levels of 4-HNE in quadriceps tissue, as well as in cultured myotubes from COPD patients.
“For example, several studies have found an increased lipofuscin accumulation in COPD quadriceps [126] and higher levels of hydroxy-2-nonenal (4-HNE) in quadriceps tissue [87,127], as well as in cultured myotubes from COPD patients [128].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [126]
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Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease
Hussain, S., Cheol, K., & Mofarrahi, M. (2008) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s4480 · Cited by 224 · see citing works
Muscle Wasting and Changes in Muscle Protein Metabolism in Chronic Obstructive Pulmonary Disease
Jagoe, R. T., & Engelen, M. P. K. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004608 · Cited by 134 · see citing works
The Mitochondrial Phenotype of Peripheral Muscle in Chronic Obstructive Pulmonary Disease
Picard, M., Godin, R., Sinnreich, M., Baril, J., Bourbeau, J., Perrault, H., Taivassalo, T., & Burelle, Y. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1005oc · Cited by 95 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
“For example, several studies have found an increased lipofuscin accumulation in COPD quadriceps [126] and higher levels of hydroxy-2-nonenal (4-HNE) in quadriceps”
Background
- Authors
- Allaire, J., Maltais, F., LeBlanc, P., Simard, P., Whittom, F., Doyon, J., Simard, C., & Jobin, J.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
- Corresponding author
- Jobin, Jean
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2002-02-19
- Volume
- 25
- Issue
- 3
- Pages
- 383-389
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2117685789
- Cited by
- 85
- References
- 0
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 9 · 2013: 4
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- lipofuscin accumulation, chronic obstructive pulmonary disease, vastus lateralis, oxidative stress, exercise-induced oxidative damage, skeletal muscle dysfunction, muscle atrophy, muscle fiber type, type I muscle fibers, fast-twitch muscle, exercise oxygen consumption, muscle fatigue
- MeSH terms
- Aged, Inclusion Bodies, Physical Exertion, Female, Humans, Lipofuscin, Male, Middle Aged, Oxidative Stress, Muscle, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Muscle Fatigue, Pulmonary Disease, Chronic Obstructive
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