Muscle Wasting and Changes in Muscle Protein Metabolism in Chronic Obstructive Pulmonary Disease
Open accessAbstract
Loss of skeletal muscle mass is now recognised as an important feature of chronic obstructive pulmonary disease (COPD) which contributes to symptoms and influences prognosis. The changes in skeletal muscle remain poorly understood, largely because only a few studies have been performed to define the adaptations in whole body and muscle protein metabolism in COPD. The first sections of this review summarise background information about skeletal muscle wasting in COPD, and focuses on the studies concerned with amino acid profiles and protein synthesis and degradation rates. To aid interpretation some discussion of the techniques commonly used is included. A variety of different catabolic factors may determine whether chronic obstructive pulmonary disease patients become cachectic. The precise role for each one of these factors as well as the intracellular pathways activated in muscle as a result of chronic obstructive pulmonary disease are unknown and remain to be defined. Details of the actions of a range of different catabolic factors and potential mechanisms will be discussed.
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Alterations in amino acid profiles in COPD include decreased glutamate and glutathione levels in COPD quadriceps.
“Alterations in amino acid (AA) profiles have been reviewed by Jagoe and Engelen [136] and include decreased glutamate and glutathione levels in COPD quadriceps [137].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [136]
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Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752 · see citing works
Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Lin, J., Wu, H., Tarr, P. T., Zhang, C.-Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., et al. (2002) · Nature · doi:10.1038/nature00904 · Cited by 2,546 · see citing works
Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583 · see citing works
Weight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease
Schols, A. M. W. J., Slangen, J. J. M., Volovics, L., & Wouters, E. F. �. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.9705017 · Cited by 1,084 · see citing works
Peripheral Muscle Weakness Contributes to Exercise Limitation in COPD
Gosselink, R., Troosters, T., & Decramer, M. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630582 · Cited by 1,024 · see citing works
NF-κB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia
D, D. C. G., Mayo, M. W., Madrid, L. V., Wang, C., & Baldwin, A. S. (2000) · Science · doi:10.1126/science.289.5488.2363 · Cited by 922 · see citing works
Marquis, K., Debigaré, R., Lacasse, Y., Leblanc, P., Jobin, J., Carrier, G., & Maltais, F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2107031 · Cited by 840 · see citing works
Peripheral Muscle Weakness in Patients with Chronic Obstructive Pulmonary Disease
BERNARD, S., LeBLANC, P., WHITTOM, F., CARRIER, G., JOBIN, J., BELLEAU, R., & MALTAIS, F. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.2.9711023 · Cited by 817 · see citing works
Anthony, J. C., Yoshizawa, F., Anthony, T. G., Vary, T. C., Jefferson, L. S., & Kimball, S. R. (2000) · Journal of Nutrition · doi:10.1093/jn/130.10.2413 · Cited by 804 · see citing works
Schols, A. M. W. J., Soeters, P. B., Dingemans, A. C., Mostert, R., Frantzen, P. J., & Wouters, E. F. �. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.5.1151 · Cited by 723 · see citing works
Reversal of Catabolism by Beta-Blockade after Severe Burns
Herndon, D. N., Hart, D. W., Wolf, S. E., Chinkes, D. L., & Wolfe, R. R. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010342 · Cited by 638 · see citing works
Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis
Urban, R. J., Bodenburg, Y. H., Gilkison, C., Foxworth, J., Coggan, A. R., Wolfe, R. R., & Ferrando, A. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.5.e820 · Cited by 608 · see citing works
Schols, A. M. W. J., Buurman, W. A., den Brekel, A. J. S.-V., Dentener, M. A., & Wouters, E. F. �. (1996) · Thorax · doi:10.1136/thx.51.8.819 · Cited by 520 · see citing works
Li, Y., Schwartz, R. J., Waddell, I. D., Holloway, B. R., & Reid, M. B. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.871 · Cited by 502 · see citing works
Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
Ferrando, A. A., Lane, H. W., Stuart, C. A., Davis-Street, J. E., & Wolfe, R. R. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e627 · Cited by 498 · see citing works
Corticosteroids Contribute to Muscle Weakness in Chronic Airflow Obstruction
Decramer, M., Lacquet, L. M., Fagard, R., & Rogiers, P. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.1.8025735 · Cited by 481 · see citing works
Schols, A. M. W. J., Soeters, P. B., Mostert, R., Pluymers, R. J., & Wouters, E. F. �. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.4.7551381 · Cited by 461 · see citing works
Bailey, J. L., Wang, X., England, B. K., Price, S. R., Ding, X., & Mitch, W. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118566 · Cited by 455 · see citing works
WHITTOM, F., JOBIN, J., SIMARD, P.-M., LEBLANC, P., SIMARD, C., BERNARD, S., BELLEAU, R., & MALTAIS, F. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199810000-00001 · Cited by 447 · see citing works
Biolo, G., Declan Fleming, R. Y., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117731 · Cited by 442 · see citing works
Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor‐κΒ
LANGEN, R. C. J., Schols, A. M. W. J., KELDERS, M. C. J. M., Wouters, E. F. �., & Janssen-Heininger, Y. M. W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0463 · Cited by 423 · see citing works
Cellular Adaptations in the Diaphragm in Chronic Obstructive Pulmonary Disease
Levine, S., Kaiser, L., Leferovich, J., & Tikunov, B. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712183372503 · Cited by 404 · see citing works
What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?
Jagoe, R. T., & Goldberg, A. L. (2001) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/00075197-200105000-00003 · Cited by 399 · see citing works
Self-citationNutritional Status and Mortality in Chronic Obstructive Pulmonary Disease
Gray‐Donald, K., Gibbons, L. A., Shapiro, S. H., Macklem, P. T., & Martin, J. G. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630580 · Cited by 397 · see citing works
Mechanism of Amino Acid-Induced Skeletal Muscle Insulin Resistance in Humans
Krebs, M., Krssak, M., Bernroider, E., Anderwald, C., Brehm, A., Meyerspeer, M., Nowotny, P., Roth, E., Waldhäusl, W., & Roden, M. (2002) · Diabetes · doi:10.2337/diabetes.51.3.599 · Cited by 392 · see citing works
ENGELEN, M. P. K. J., Schols, A. M. W. J., Baken, W., Wesseling, G., & Wouters, E. F. �. (1994) · European Respiratory Journal · doi:10.1183/09031936.94.07101793 · Cited by 368 · see citing works
Self-citationInsulin action and insulin resistance in human skeletal muscle
Zierath, J. R., Krook, A., & Wallberg-Henriksson, H. (2000) · Diabetologia · doi:10.1007/s001250051457 · Cited by 367 · see citing works
Muscular Atrophy Following Immobilisation
Appell, H.-J. (1990) · Sports Medicine · doi:10.2165/00007256-199010010-00005 · Cited by 358 · see citing works
Wing, S. S., & Goldberg, A. L. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.4.e668 · Cited by 345 · see citing works
Patterns of gene expression in atrophying skeletal muscles: response to food deprivation
Jagoe, R. T., Lecker, S. H., Gomes, M., & Goldberg, A. L. (2002) · The FASEB Journal · doi:10.1096/fj.02-0312com · Cited by 344 · see citing works
Self-citationSkeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease
Agustí, A. G. N., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., & Busquets, X. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2108013 · Cited by 343 · see citing works
Mostert, R., Goris, A. H. C., Weling-Scheepers, C. A., Wouters, E. F. �., & Schols, A. M. W. J. (2000) · Respiratory Medicine · doi:10.1053/rmed.2000.0829 · Cited by 329 · see citing works
Gosker, H. R., van Mameren, H., van Dijk, P., ENGELEN, M. P. K. J., Vusse, G. J., Wouters, E. F. �., & Schols, A. M. W. J. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00762001 · Cited by 299 · see citing works
Self-citationProof of the effect of testosterone on skeletal muscle
Bhasin, S., Woodhouse, L. J., & Storer, T. W. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700027 · Cited by 294 · see citing works
Maltais, F. (2000) · Thorax · doi:10.1136/thorax.55.10.848 · Cited by 284 · see citing works
McKoy, G., Ashley, W. W., Mander, J., Yang, S. Y., Williams, N., Russell, B., & Goldspink, G. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0583v.x · Cited by 280 · see citing works
Taillandier, D., AUROUSSEAU, E., Meynial‐Denis, D., Béchet, D., Ferrara, M., Cottin, P., Ducastaing, A., Bigard, X. A., Guezennec, C. Y., Schmid, H.-P., et al. (1996) · Biochemical Journal · doi:10.1042/bj3160065 · Cited by 272 · see citing works
Diaphragm Strength in Chronic Obstructive Pulmonary Disease
Polkey, M. I., Kyroussis, D., Hamnegärd, C. H., MILLS, G. H., Green, M., & Moxham, J. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.5.8912741 · Cited by 267 · see citing works
Bed-rest-induced insulin resistance occurs primarily in muscle
Stuart, C. A., Shangraw, R. E., Prince, M. J., Peters, E. J., & Wolfe, R. R. (1988) · Metabolism · doi:10.1016/0026-0495(88)90018-2 · Cited by 258 · see citing works
Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.
Tiao, G. M., Fagan, J. M., Roegner, V., Lieberman, M. A., Wang, J. J., Fischer, J. E., & Hasselgren, P. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118421 · Cited by 248 · see citing works
Ferreira, I. M., VERRESCHI, I. T. D. N., Nery, L. E., Goldstein, R. S., Zamel, N., Brooks, D., & Jardim, J. R. (1998) · CHEST Journal · doi:10.1378/chest.114.1.19 · Cited by 241 · see citing works
Baarends, E. M., Schols, A. M. W. J., Mostert, R., & Wouters, E. F. �. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10122807 · Cited by 241 · see citing works
Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting
Mitch, W. E., Bailey, J. L., Wang, X., Jurkovitz, C. T., Newby, D. E., & Price, S. R. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.5.c1132 · Cited by 237 · see citing works
Peripheral Muscle Wasting in Chronic Obstructive Pulmonary Disease
Debigaré, R., Côt́e, C. H., & Maltais, F. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.9.2104035 · Cited by 230 · see citing works
ENGELEN, M. P. K. J., Schols, A. M. W. J., Does, J. D., & Wouters, E. F. �. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.3.733 · Cited by 229 · see citing works
Self-citationDecrease in human quadriceps muscle protein turnover consequent upon leg immobilization
Gibson, J. N. A., Halliday, D., Morrison, W. L., Stoward, P. J., Hornsby, G. A., Watt, P., Murdoch, G., & Rennie, M. J. (1987) · Clinical Science · doi:10.1042/cs0720503 · Cited by 226 · see citing works
Administration of Growth Hormone to Underweight Patients with Chronic Obstructive Pulmonary Disease
Burdet, L., de Muralt, B., Schütz, Y., Pichard, C., & Fitting, J.-W. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.6.9704142 · Cited by 224 · see citing works
Chronic Obstructive Pulmonary Disease: Capillarity and Fiber-Type Characteristics of Skeletal Muscle
Jobin, J., Maltais, F., Doyon, J.-F., LeBlanc, P., Simard, P.-M., Simard, A.-A., & Simard, C. (1998) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199811000-00005 · Cited by 224 · see citing works
Mansoor, O., Beaufrère, B., Boirie, Y., Rallière, C., Taillandier, D., AUROUSSEAU, E., Schoeffler, P., Arnal, M., & Attaix, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.2714 · Cited by 221 · see citing works
Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation
Reaich, D., Channon, S. M., Scrimgeour, C. M., Daley, S. E., Wilkinson, R., & Goodship, T. H. J. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.2.e230 · Cited by 209 · see citing works
Mordier, S. B., Deval, C., Béchet, D., Tassa, A., & Ferrara, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003633200 · Cited by 208 · see citing works
Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture
Vandenburgh, H. H., Karlisch, P., Shansky, J., & Feldstein, R. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.260.3.c475 · Cited by 204 · see citing works
Gosker, H. R., Engelen, M. P., van Mameren, H., van Dijk, P. J., van der Vusse, G. J., Wouters, E. F., & Schols, A. M. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.113 · Cited by 200 · see citing works
Self-citationWilliams, A. B., Sun, X., Fischer, J. E., & Hasselgren, P. (1999) · Surgery · doi:10.1016/s0039-6060(99)70131-5 · Cited by 196 · see citing works
Kamischke, A., Kemper, D., Castel, M., Luthke, M., Rolf, C., Behre, H. M., MAGNUSSEN, H., & Nieschlag, E. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.11010041 · Cited by 195 · see citing works
Nutrition in CAPD: Serum bicarbonate and the ubiquitin-proteasome system in muscle
Pickering, W. P., Price, S. R., Bircher, G., Marinovic, A. C., Mitch, W. E., & Walls, J. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00276.x · Cited by 190 · see citing works
Creutzberg, E. C., Schols, A. M. W. J., Weling-Scheepers, C. A., Buurman, W. A., & Wouters, E. F. �. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.3.9808075 · Cited by 186 · see citing works
Baracos, V. E., & Goldberg, A. L. (1986) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1986.251.4.c588 · Cited by 185 · see citing works
Effects of an acute exacerbation on nutritional and metabolic profile of patients with COPD
Vermeeren, M., Schols, A. M., & Wouters, E. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10102264 · Cited by 183 · see citing works
TNF-α-Induced Insulin Resistance In Vivo and Its Prevention by Troglitazone
Miles, P. D. G., Romeo, O. M., Higo, K., Cohen, A., Rafaat, K., & Olefsky, J. M. (1997) · Diabetes · doi:10.2337/diab.46.11.1678 · Cited by 182 · see citing works
Fryburg, D. A. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.2.e331 · Cited by 180 · see citing works
Energy Balance in Chronic Obstructive Pulmonary Disease
Schols, A. M. W. J., Soeters, P. B., Mostert, R., Saris, W. H. M., & Wouters, E. F. �. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.6.1248 · Cited by 173 · see citing works
Total Free Living Energy Expenditure in Patients With Severe Chronic Obstructive Pulmonary Disease
Baarends, E. M., Schols, A. M. W. J., Pannemans, D. L. E., Westerterp, K. R., & Wouters, E. F. �. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032193 · Cited by 166 · see citing works
Dentener, M. A., Creutzberg, E. C., Schols, A. M. W. J., Mantovani, A., Veer, C. V., Buurman, W. A., & Wouters, E. F. M. (2001) · Thorax · doi:10.1136/thorax.56.9.721 · Cited by 165 · see citing works
Increased muscle ubiquitin mRNA levels in gastric cancer patients.
Bossola, M., Muscaritoli, M., Costelli, P., Bellantone, R., Pacelli, F., Busquets, S., Argilès, J., López-Soriano, F., Civello, I. M., Baccino, F., et al. (2001) · American Journal of Physiology. Regulatory Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.5.r1518 · Cited by 164 · see citing works
MacDOUGALL, J. D., Green, H. J., Sutton, J. R., Coates, G., Cymerman, A., Young, P. M. M., & Houston, C. S. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09176.x · Cited by 159 · see citing works
Testosterone administration in severe burns ameliorates muscle catabolism
Ferrando, A. A., Sheffield‐Moore, M., Wolf, S. E., Herndon, D. N., & Wolfe, R. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200110000-00015 · Cited by 158 · see citing works
Satta, A., Migliori, G. B., Spanevello, A., Neri, M., Bottinelli, R., Canepari, M., Pellegrino, M. A., & Reggiani, C. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10122853 · Cited by 155 · see citing works
Gea, J., Pastó, M., Carmona, M. A., Orozco‐Levi, M., Palomeque, J., & Broquetas, J. M. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.17509390 · Cited by 147 · see citing works
Growth hormone acutely stimulates skeletal muscle but not whole-body protein synthesis in humans
Fryburg, D. A., & Barrett, E. J. (1993) · Metabolism · doi:10.1016/0026-0495(93)90285-v · Cited by 145 · see citing works
Weinstein, S. P., Paquin, T., Pritsker, A., & Haber, R. S. (1995) · Diabetes · doi:10.2337/diab.44.4.441 · Cited by 145 · see citing works
Inhaled Nitric Oxide. A Bronchodilator in Mild Asthmatics With Methacholine-Induced Bronchospasm
Kacmarek, R. M., Ripple, R. E., Cockrill, B. A., Bloch, K. J., Zapol, W. M., & Johnson, D. C. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.1.8542105 · Cited by 143 · see citing works
Relationship Between Respiratory Muscle Strength and Lean Body Mass in Men With COPD
Nishimura, Y., Tsutsumi, M., Nakata, H., Tsunenari, T., Maeda, H., & Yokoyama, M. (1995) · CHEST Journal · doi:10.1378/chest.107.5.1232 · Cited by 141 · see citing works
Wuyam, B., Payen, J. F., Levy, P. A., Bensaidane, H., Reutenauer, H., Bas, J. L., & Benabid, A. (1992) · European Respiratory Journal · doi:10.1183/09031936.93.05020157 · Cited by 139 · see citing works
Oxygen saturation during daily activities in chronic obstructive pulmonary disease
Schenkel, N. S., Burdet, L., de Muralt, B., & Fitting, J. W. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09122584 · Cited by 139 · see citing works
Tissue-specific regulation of mitochondrial and cytoplasmic protein synthesis rates by insulin
Boirie, Y., Short, K. R., Ahlman, B., Charlton, M., & Nair, K. S. (2001) · Diabetes · doi:10.2337/diabetes.50.12.2652 · Cited by 137 · see citing works
Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis
Kayali, A. G., Young, V. R., & Goodman, M. N. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.5.e621 · Cited by 136 · see citing works
Weight Loss is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease
Schols, A. M. W. J., Slangen, J. J. M., Volovics, L., & Wouters, E. F. �. (1999) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199907000-00014 · Cited by 132 · see citing works
Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD
Levine, S., Gregory, C. M., Nguyen, T., Shrager, J. B., Kaiser, L. R., Rubinstein, N. A., & Dudley, G. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00116.2001 · Cited by 131 · see citing works
Atrophy and growth failure of rat hindlimb muscles in tail-cast suspension
Jaspers, S. R., & Tischler, M. E. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.57.5.1472 · Cited by 131 · see citing works
Reversal of COPD-Associated Weight Loss Using the Anabolic Agent Oxandrolone
Yeh, S., DeGuzman, B., & Kramer, T. (2002) · CHEST Journal · doi:10.1378/chest.122.2.421 · Cited by 131 · see citing works
Regulation of skeletal-muscle–protein turnover in cancer-associated cachexia
Baracos, V. E. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00407-x · Cited by 124 · see citing works
Morrison, W. L., Gibson, J. N. A., Scrimgeour, C. M., & Rennie, M. J. (1988) · Clinical Science · doi:10.1042/cs0750415 · Cited by 123 · see citing works
Medina, R., Wing, S. S., Haas, A., & Goldberg, A. L. (1991) · PubMed · Cited by 119 · see citing works
Engelen, M. P., Wouters, E. F., Deutz, N. E., Menheere, P. P., & Schols, A. M. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.6.1480 · Cited by 116 · see citing works
Self-citationENGELEN, M. P. K. J., Deutz, N. E. P., Wouters, E. F. �., & Schols, A. M. W. J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.2002045 · Cited by 115 · see citing works
Self-citationDenne, S. C., Liechty, E. A., Liu, Y. M., Brechtel, G., & Baron, A. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.6.e809 · Cited by 115 · see citing works
POUW, E. M., SCHOLS, A. M. W. J., DEUTZ, N. E. P., & WOUTERS, E. F. M. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.3.9708097 · Cited by 114 · see citing works
Sites of protein conservation and loss during starvation: influence of adiposity
Goodman, M. N., Lowell, B., Belur, E., & Ruderman, N. B. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.246.5.e383 · Cited by 110 · see citing works
Mitch, W. E. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.3.359 · Cited by 108 · see citing works
Clenbuterol, a beta 2-agonist, retards atrophy in denervated muscles
Zeman, R. J., Ludemann, R., & Etlinger, J. D. (1987) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1987.252.1.e152 · Cited by 107 · see citing works
Jagoe, R. T., Redfern, C. P. F., Roberts, R. G., Gibson, G. J., & Goodship, T. H. J. (2002) · Clinical Science · doi:10.1042/cs1020353 · Cited by 102 · see citing works
Self-citationRegulation of IGF‐I, IGFBP‐4 and IGFBP‐5 gene expression by loading in mouse skeletal muscle
Awede, B. L., Thissen, J., Gailly, P. L., & Lebacq, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01469-6 · Cited by 96 · see citing works
Effect of short-term unweighting on human skeletal muscle strength and size.
Adams, G. R., Hather, B. M., & Dudley, G. A. (1994) · PubMed · Cited by 94 · see citing works
Doumit, M. E., & Koohmaraie, M. (1999) · Journal of Animal Science · doi:10.2527/1999.7761467x · Cited by 94 · see citing works
Baarends, E. M., Schols, A. M. W. J., Westerterp, K. R., & Wouters, E. F. �. (1997) · Thorax · doi:10.1136/thx.52.9.780 · Cited by 92 · see citing works
Friedman, J. E., Dohm, G. L., Elton, C. W., Rovira, A., Chen, J. J., Leggett-Frazier, N., Atkinson, S., Thomas, F., Long, S. D., & Caro, J. F. (1991) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1991.261.1.e87 · Cited by 88 · see citing works
Skeletal Muscle Denervation Increases Satellite Cell Susceptibility to Apoptosis
Jejurikar, S. S., Marcelo, C. L., & Kuzon, W. M. (2002) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200207000-00027 · Cited by 86 · see citing works
Skeletal muscle is a primary site of insulin resistance in essential hypertension
Capaldo, B., Lembo, G., Napoli, R., Rendina, V., ALBANO, G., Saccà, L., & Trimarco, B. (1991) · Metabolism · doi:10.1016/0026-0495(91)90036-v · Cited by 86 · see citing works
The effects of 6 hours of hypoxia on protein synthesis in rat tissues in vivo and in vitro
Preedy, V. R., Smith, D. M., & Sugden, P. H. (1985) · Biochemical Journal · doi:10.1042/bj2280179 · Cited by 86 · see citing works
Allaire, J., Maltais, F., LeBlanc, P., Simard, P., Whittom, F., Doyon, J., Simard, C., & Jobin, J. (2002) · Muscle & Nerve · doi:10.1002/mus.10039 · Cited by 85 · see citing works
Hofford, J. M., Milakofsky, L., Vogel, W. H., Sacher, R. S., Savage, G. J., & Pell, S. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.4_pt_1.902 · Cited by 83 · see citing works
Yoneda, T., Yoshikawa, M., Fu, A., Tsukaguchi, K., Okamoto, Y., & Takenaka, H. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00509-8 · Cited by 83 · see citing works
The Daily Energy Expenditure in Stable Chronic Obstructive Pulmonary Disease
Hügli, O., Schutz, Y., & Fitting, J. W. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.1.8542132 · Cited by 83 · see citing works
Muscle Fiber Type Changes in Human Skeletal Muscle After Injuries and Immobilization
Häggmark, T., Eriksson, E., & Jansson, E. (1986) · Orthopedics · doi:10.3928/0147-7447-19860201-08 · Cited by 80 · see citing works
TNF-α is involved in activating DNA fragmentation in skeletal muscle
Carbó, N., Busquets, S., van Royen, M. E., Alvarez, B., López-Soriano, F. J., & Argilés, J. M. A. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600167 · Cited by 75 · see citing works
Impaired glucose tolerance in patients with chronic hypoxic pulmonary disease.
Hjalmarsen, A., Aasebø, U., Birkeland, K., Sager, G., & Jorde, R. (1996) · PubMed · Cited by 72 · see citing works
Effects of Exercise on Amino Acid Metabolism in Patients with Chronic Obstructive Pulmonary Disease
ENGELEN, M. P. K. J., Wouters, E. F. �., Deutz, N. E. P., Does, J. D., & Schols, A. M. W. J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.4.2006137 · Cited by 71 · see citing works
Self-citationNavegantes, L. C. C., Resano, N. M. Z., Migliorini, R. H., & Kettelhut, Í. D. C. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.3.e449 · Cited by 69 · see citing works
Ubiquitin and proteasome gene expression is increased in skeletal muscle of slim AIDS patients.
Llovera, M., García-Martínez, C., Agell, N., López-Soriano, F., Authier, F., Ghérardi, R., & Argilés, J. (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2.1.69 · Cited by 68 · see citing works
Suppression of muscle protein turnover and amino acid degradation by dietary protein deficiency
Tawa, N. E., & Goldberg, A. L. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.263.2.e317 · Cited by 59 · see citing works
Effect of Insulin on Amino Acid Uptake and Protein Turnover in Skeletal Muscle From Septic Rats
Hasselgren, P.-O. (1987) · Archives of Surgery · doi:10.1001/archsurg.1987.01400140110015 · Cited by 57 · see citing works
Fang, C., Li, B. G., Wang, J. J., Fischer, J. E., & Hasselgren, P.-O. J. (1997) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607197021005245 · Cited by 54 · see citing works
Sepsis in mice stimulates muscle proteolysis in the absence of IL-6
Williams, A., Wang, J. J., Wang, L., Sun, X., Fischer, J. E., & Hasselgren, P.-O. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.275.6.r1983 · Cited by 44 · see citing works
Kobayashi, A., Yoneda, T., Yoshikawa, M., Ikuno, M., Takenaka, H., Fukuoka, A., Narita, N., & Nezu, K. (2000) · Lung · doi:10.1007/s004080000014 · Cited by 43 · see citing works
Biolo, G., Bosutti, A., Iscra, F., Toigo, G., Gullo, A., & Guarnieri, G. (2000) · Metabolism · doi:10.1053/meta.2000.6236 · Cited by 42 · see citing works
Skeletal muscle insulin resistance after trauma: insulin signaling and glucose transport
Strömmer, L., Permert, J., Arnelo, U., Koehler, C., Isaksson, B., Larsson, J., Lundkvist, I., Björnholm, M., Kawano, Y., Wallberg‐Henriksson, H., et al. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e351 · Cited by 41 · see citing works
Effect of clenbuterol on growth, carcase and skeletal muscle characteristics in broiler chickens
Rehfeldt, C., Schadereit, R., Weikard, R., & Reichel, K. (1997) · British Poultry Science · doi:10.1080/00071669708418004 · Cited by 39 · see citing works
Navegantes, L. C. C., Resano, N. M. Z., Migliorini, R. H., & Kettelhut, Í. D. C. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.5.e883 · Cited by 37 · see citing works
Alvarez, B., Quinn, L. S., Busquets, S., López-Soriano, F. J., & Argilés, J. M. A. (2001) · PubMed · Cited by 36 · see citing works
Distribution of Muscle Mass and Maximal Exercise Performance in Patients With COPD
Yoshikawa, M., Yoneda, T., Takenaka, H., Fukuoka, A., Okamoto, Y., Narita, N., & Nezu, K. (2001) · CHEST Journal · doi:10.1378/chest.119.1.93 · Cited by 33 · see citing works
IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats
Hobler, S. C., Williams, A. B., Fischer, J. E., & Hasselgren, P.-O. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.2.r571 · Cited by 32 · see citing works
Rallière, C., Tauveron, I., Taillandier, D., Guy, L., Boiteux, J., Giraud, B., Attaix, D., & Thiéblot, P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4221 · Cited by 30 · see citing works
Bhasin, S., & Javanbakht, M. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300605 · Cited by 28 · see citing works
Plasma amino acid levels in patients with chronic obstructive pulmonary disease.
Schols, A. M. W. J., Deutz, N. E. P., Mostert, R., & Wouters, E. F. �. (1993) · PubMed · Cited by 26 · see citing works
van der Heijden, E. H. F. M., Dekhuijzen, P. N. R., Folgering, H. T. M., Ginsel, L. A., & van Herwaarden, C. L. A. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.215 · Cited by 25 · see citing works
Thermogenic effect of bronchodilators in patients with chronic obstructive pulmonary disease
Burdet, L., de Muralt, B., Schutz, Y., & Fitting, J. W. (1997) · Thorax · doi:10.1136/thx.52.2.130 · Cited by 25 · see citing works
Aguilaniu, B., Shapses, S. A., Pajon, A., Levy, P. A., Sarrot, F., Leverve, X. M., Pagé, É., & ASKANAZI, J. (1992) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607192016003248 · Cited by 24 · see citing works
Piitulainen, E., Areberg, J., ́n, M. L., Eriksson, S., Mattsson, S., & Wollmer, P. (2002) · CHEST Journal · doi:10.1378/chest.122.4.1240 · Cited by 23 · see citing works
Insulin resistance is not exhibited by advanced chronic obstructive pulmonary disease patients
Jakobsson, P., Jorfeldt, L., & von Schenck, H. (1995) · Clinical Physiology · doi:10.1111/j.1475-097x.1995.tb00543.x · Cited by 21 · see citing works
Protein metabolism during treatment of chest infection in patients with cystic fibrosis
Morton, R. E., HUTCHINGS, J. J., Halliday, D., Rennie, M. J., & Wolman, S. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.2.214 · Cited by 13 · see citing works
Skeletal muscle insulin resistance during Escherichia coli bacteremic shock in the dog.
Rm, R., Jm, H., & Emerson, T. E. (1981) · PubMed · Cited by 12 · see citing works
Førli, L., Pedersen, J. I., Bjørtuft, Ø., Vatn, M., Kofstad, J., & Boe, J. (2000) · Respiratory Medicine · doi:10.1053/rmed.2000.0830 · Cited by 10 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Skeletal muscle dysfunction in chronic obstructive pulmo- nary disease. A statement of the American Thoracic Society and European Respiratory Society. Am J Respir Crit Care Med 1999; 159: S1-S40.
- Schols AMWJ, Soeters PB, Mostert R, Pluymers RJ, Wouters EFM. Physiological effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995; 152: 1268-1274.
- Mitch WE. Mechanisms causing loss of lean body mass in kidney disease. Am J Clin Nutr 1998; 67: 359-366.
Cited by
Sorted by citations
Chronic obstructive pulmonary disease
Rabe, K. F., & Watz, H. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31222-9 · Cited by 968 · see citing works
O'Donnell, D., Aaron, S., Bourbeau, J., Hernandez, P., Marciniuk, D., Balter, M., Ford, G., Gervais, A., Goldstein, R., Hodder, R., et al. (2007) · Canadian Respiratory Journal · doi:10.1155/2007/830570 · Cited by 688 · see citing works
Vestbo, J., Prescott, E., Almdal, T., Dahl, M., Nordestgaard, B. G., Andersen, T., Sørensen, T. I. A., & Lange, P. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-969oc · Cited by 642 · see citing works
Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410 · see citing works
Pathophysiology of muscle dysfunction in COPD.
Gea, J., Agustí, A., & Roca, J. (2013) · Journal of applied physiology · doi:10.1152/japplphysiol.00981.2012 · Cited by 227 · see citing works
Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle
Edstrom, E., Altun, M., Hagglund, M., & Ulfhake, B. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.7.663 · Cited by 196 · see citing works
From muscle disuse to myopathy in COPD: potential contribution of oxidative stress
Couillard, A., & Prefaut, C. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00139904 · Cited by 187 · see citing works
PPARγ inhibits NF-κB-dependent transcriptional activation in skeletal muscle
Remels, A. H. V., LANGEN, R. C. J., Gosker, H. R., Russell, A. P., Spaapen, F., Voncken, J. W., Schrauwen, P., & Schols, A. M. W. J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90632.2008 · Cited by 189 · see citing works
The response of human skeletal muscle tissue to hypoxia
Lundby, C., Calbet, J. A. L., & Robach, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0146-8 · Cited by 183 · see citing works
Factors contributing to muscle wasting and dysfunction in COPD patients.
Wüst, R. C. I., & Degens, H. (2007) · PubMed Central · Cited by 179 · see citing works
Gea, J., Pascual-Guàrdia, S., Casadevall, C., Orozco‐Levi, M., & Barreiro, E. (2015) · PubMed Central · doi:10.3978/j.issn.2072-1439.2015.08.04 · Cited by 177 · see citing works
Manifestações sistêmicas na doença pulmonar obstrutiva crônica
Dourado, V. Z., Tanni, S. É., do Vale, S. A., Faganello, M. M., Sanchez, F. F., & Godoy, I. (2006) · Jornal Brasileiro de Pneumologia · doi:10.1590/s1806-37132006000200012 · Cited by 144 · see citing works
Phenotypes of Chronic Obstructive Pulmonary Disease
Friedlander, A. L., Lynch, D. A., Dyar, L. A., & Bowler, R. P. (2007) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550701629663 · Cited by 138 · see citing works
The Role of Autophagy in Skeletal Muscle Diseases
Xia, Q., Huang, X., Huang, J., Zheng, Y., March, M., Li, J., & Wei, Y. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.638983 · Cited by 130 · see citing works
Ubhi, B. K., Cheng, K. K., Dong, J., Janowitz, T., Jodrell, D. I., Tal‐Singer, R., MacNee, W., Lomas, D. A., Riley, J. H., Griffin, J. L., et al. (2012) · Molecular BioSystems · doi:10.1039/c2mb25194a · Cited by 119 · see citing works
Sepsis Is Associated with a Preferential Diaphragmatic Atrophy
Jung, B., Nougaret, S., Conseil, M., Coisel, Y., Futier, E., Chanques, G., Molinari, N., Lacampagne, A., Matecki, S., & Jaber, S. (2014) · Anesthesiology · doi:10.1097/aln.0000000000000201 · Cited by 113 · see citing works
Sergi, G., Coin, A., Marín, S., Vianello, A., Manzan, A., Peruzza, S., Inelmen, E. M., Busetto, L., Mulone, S., & Enzi, G. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.03.008 · Cited by 110 · see citing works
Biochemical changes in response to intensive resistance exercise training in the elderly
Bautmans, I., Njemini, R., Vasseur, S., Chabert, H., Moens, L., Demanet, C., & Mets, T. (2005) · Gerontology · doi:10.1159/000085122 · Cited by 98 · see citing works
Abdulai, R. M., Jensen, T. J., Patel, N. R., Polkey, M. I., Jansson, P., Celli, B. R., & Rennard, S. I. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0615ci · Cited by 91 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
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Network medicine, multimorbidity and the lung in the elderly
Faner, R., Cruz, T., López-Giraldo, A., & Agustí, A. G. N. (2014) · European Respiratory Journal · doi:10.1183/09031936.00078714 · Cited by 73 · see citing works
Mechanisms of striated muscle dysfunction during acute exacerbations of COPD
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Wandrag, L., Brett, S. J., Frost, G. S., & Hickson, M. (2014) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12238 · Cited by 68 · see citing works
Cigarette Smoking and Brain Regulation of Energy Homeostasis
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Stege, G., Vos, P. J. E., van den Elshout, F. J. J., Dekhuijzen, P. N. R., van de Ven, M. J. T., & Heijdra, Y. F. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2007.12.026 · Cited by 63 · see citing works
Electrical stimulation and peripheral muscle function in COPD: A systematic review
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Piehl‐Aulin, K., Jones, I. R., Lindvall, B., Magnuson, A., & Abdel‐Halim, S. M. (2009) · Respiration · doi:10.1159/000207793 · Cited by 64 · see citing works
Effect of Systemic Inflammation on Inspiratory and Limb Muscle Strength and Bulk in Cystic Fibrosis
Dufresne, V., Knoop, C., Muylem, A. V., Malfroot, A., Lamotte, M., Opdekamp, C., Deboeck, G., Cassart, M., Stallenberg, B., Casimir, G. J. A., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200802-232oc · Cited by 62 · see citing works
Prokopidis, K., & Witard, O. C. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000135 · Cited by 64 · see citing works
Jutley, G. S., Sahota, K., Sahbudin, I., Filer, A. D., Arayssi, T., Young, S. P., & Raza, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676105 · Cited by 62 · see citing works
Remels, A. H. V., Gosker, H. R., van der Velden, J. L. J., LANGEN, R. C. J., & Schols, A. M. W. J. (2007) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2007.06.003 · Cited by 62 · see citing works
Chen, H., Hansen, M. J., Jones, J. E. C., Vlahos, R., Anderson, G. P., & Morris, M. J. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00442.2007 · Cited by 58 · see citing works
Chronic obstructive pulmonary disease: effects beyond the lungs
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Eliason, G., Abdel-Halim, S. M., Piehl-Aulin, K., & Kadi, F. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-97 · Cited by 57 · see citing works
Time course of cigarette smoke-induced changes of systemic inflammation and muscle structure
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Weight Gain in Cachectic COPD Patients Receiving Noninvasive Positive-Pressure Ventilation
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Long-term cigarette smoke exposure increases uncoupling protein expression but reduces energy intake
Chen, H., Hansen, M. J., Jones, J. E. C., Vlahos, R., Anderson, G. P., & Morris, M. J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.067 · Cited by 55 · see citing works
Body composition and sarcopenia in patients with chronic obstructive pulmonary disease
Costa, T. M. D. R. L., Costa, F. M., Jonasson, T. H., Moreira, C. A., Boguszewski, C. L., & Borba, V. Z. C. (2018) · Endocrine · doi:10.1007/s12020-018-1533-4 · Cited by 55 · see citing works
Radom‐Aizik, S., Kaminski, N., Hayek, S., Halkin, H., Cooper, D. M., & Ben-Dov, I. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00577.2006 · Cited by 54 · see citing works
Altered mitochondrial regulation in quadriceps muscles of patients with COPD
Naimi, A. I., Bourbeau, J., Perrault, H., Baril, J., Wright‐Paradis, C., Rossi, A. M., Taivassalo, T., Sheel, A. W., Rabøl, R., Dela, F., et al. (2010) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2010.00988.x · Cited by 51 · see citing works
Physical performance and muscular characteristics in different stages of COPD
Eliason, G., Abdel‐Halim, S. M., Arvidsson, B., Kadi, F., & Piehl‐Aulin, K. (2009) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2008.00858.x · Cited by 50 · see citing works
Systemic Inflammation in COPD: Is Genetic Susceptibility a Key Factor?
Yanbaeva, D. G., Dentener, M. A., Creutzberg, E. C., & Wouters, E. F. �. (2006) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1080/15412550500493436 · Cited by 50 · see citing works
de Theije, C. C., LANGEN, R. C. J., Lamers, W. H., Schols, A. M. W. J., & Köhler, E. S. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00354.2012 · Cited by 48 · see citing works
Dunstan, R. H., Sparkes, D. L., Macdonald, M. M., de Jonge, X. J., Dascombe, B. J., Gottfries, J., Gottfries, C. G., & Roberts, T. K. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0240-y · Cited by 48 · see citing works
Nutritional State and COPD: Effects on Dyspnoea and Exercise Tolerance
Tramontano, A., & Palange, P. (2023) · Nutrients · doi:10.3390/nu15071786 · Cited by 47 · see citing works
Chen, H., Iglesias, M. A., Caruso, V., & Morris, M. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027260 · Cited by 47 · see citing works
Calvani, R., Rodríguez‐Mañas, L., Picca, A., Marini, F., Biancolillo, A., Laosa, O., Pedraza, L., Gervasoni, J., Primiano, A., Conta, G., et al. (2020) · Nutrients · doi:10.3390/nu12010199 · Cited by 44 · see citing works
Chronic Obstructive Pulmonary Disease: Linking Outcomes and Pathobiology of Disease Modification
Rennard, S. I. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200512-129sf · Cited by 42 · see citing works
Exercise capacity and quadriceps muscle metabolism following training in subjects with COPD
McKeough, Z. J., Alison, J. A., Bye, P. T. P., Trenell, M. I., Sachinwalla, T., Thompson, C. H., & Kemp, G. J. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.01.017 · Cited by 41 · see citing works
Petersen, A. M. W., Mittendorfer, B., Magkos, F., Iversen, M., & Pedersen, B. K. (2008) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2007.00727.x · Cited by 40 · see citing works
de Theije, C. C., Schols, A. M. W. J., Lamers, W. H., Ceelen, J., van Gorp, R. H., Hermans, J. J. R., Köhler, E. S., & LANGEN, R. C. J. (2017) · Endocrinology · doi:10.1210/en.2017-00603 · Cited by 33 · see citing works
Lung function and six-minute walk test performance in individuals with sickle cell disease
Ohara, D. G., Ruas, G., de Walsh, I. A. P., Castro, S. S., & Jamami, M. (2014) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552012005000139 · Cited by 32 · see citing works
Skeletal muscle response to inflammation—Lessons for chronic obstructive pulmonary disease
Reid, W. D., Rurak, J., & Harris, R. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181b6ea1d · Cited by 30 · see citing works
Persistent Uncontrolled Asthma: Long-Term Impact on Physical Activity and Body Composition
Abdo, M., Waschki, B., Kirsten, A., Trinkmann, F., Biller, H., Herzmann, C., von Mutius, E., Kopp, M., Hansen, G., Rabe, K. F., et al. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s299756 · Cited by 28 · see citing works
Overcoming Gaps in the Management of Chronic Obstructive Pulmonary Disease in Older Patients
Gelberg, J., & McIvor, A. (2010) · Drugs & Aging · doi:10.2165/11535220-000000000-00000 · Cited by 27 · see citing works
Acute vs chronic hypoxia: what are the consequences for skeletal muscle mass?
Deldicque, L., & Francaux, M. (2013) · Cellular and Molecular Exercise Physiology · doi:10.7457/cmep.v2i1.e5 · Cited by 27 · see citing works
Coin, A., Sergi, G., Marín, S., Vianello, A., Perissinotto, E., Sarti, S., Rinaldi, G., Mosele, M., Inelmen, E. M., Enzi, G., et al. (2010) · The Aging Male · doi:10.3109/13685531003657784 · Cited by 25 · see citing works
Enzyme Catalytic Activities in Chronic Obstructive Pulmonary Disease
Čepelak, I., Dodig, S., Romić, D., Ruljančić, N., Popović‐Grle, S., & Malić, A. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.01.004 · Cited by 25 · see citing works
Mônico‐Neto, M., Giampá, S. Q. D. C., Lee, K. S., de Melo, C. M., Souza, H. D. S., Dattilo, M., Minali, P. A., Prado, P. H. S., Tufik, S., de Mello, M. T., et al. (2015) · International Journal of Endocrinology · doi:10.1155/2015/908159 · Cited by 25 · see citing works
Peñailillo, L., Valladares-Ide, D., Jannas-Vela, S., Flores‐Opazo, M., Jalón, M., I, L. M., Nuñez, I., & Orlando Díaz, P. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02061-4 · Cited by 27 · see citing works
Larson, K. R., Jayakrishnan, D., Sauza, K. A. S., Goodson, M. L., CHAFFIN, A. T. B., Davidyan, A., Pathak, S. J., Fang, Y., Magaña, D. G., Miller, B. F., et al. (2024) · Endocrinology · doi:10.1210/endocr/bqae004 · Cited by 24 · see citing works
Yazdanpanah, L., Shidfar, F., Moosavi, A. J., Heidarnazhad, H., & Haghani, H. (2010) · PubMed · Cited by 24 · see citing works
Role of nutrition in patients with coexisting chronic obstructive pulmonary disease and sarcopenia
Nan, Y., Zhou, Y., Dai, Z., Yan, T., Zhong, P., Zhang, F., Chen, Q., & Peng, L. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1214684 · Cited by 23 · see citing works
Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies
Wang, L., van Iersel, L. E. J., Pelgrim, C. E., Lu, J., van Ark, I., Leusink-Muis, T., Gosker, H. R., LANGEN, R. C. J., Schols, A. M. W. J., Argilés, J. M. A., et al. (2022) · Cells · doi:10.3390/cells11182893 · Cited by 23 · see citing works
Avaliação muscular isocinética do quadríceps em indivíduos com doença pulmonar obstrutiva crónica
Vieira, L., Bottaro, M., Celes, R. S., Viegas, C. A. D. A., & Silva, C. A. M. E. (2010) · Revista Portuguesa de Pneumologia · doi:10.1016/s0873-2159(15)30068-4 · Cited by 23 · see citing works
Ismail, D. K., Eltagui, M. H., Hussein, Z. A., Eid, M. A., & Aly, S. M. (2018) · Egyptian Journal of Medical Human Genetics · doi:10.1016/j.ejmhg.2018.04.005 · Cited by 20 · see citing works
Calvani, R., Picca, A., Rodríguez‐Mañas, L., Tosato, M., Coelho‐Júnior, H. J., Biancolillo, A., Laosa, O., Gervasoni, J., Primiano, A., Santucci, L., et al. (2023) · Metabolites · doi:10.3390/metabo13040542 · Cited by 19 · see citing works
Acute vs. chronic hypoxia: What are the consequences for skeletal muscle mass?
Deldicque, L., & Francaux, M. (2013) · doi:10.7457/cmep.v2i1 · Cited by 19 · see citing works
Thibault, R., Gallic, E. L., Picard-Kossovsky, M., Darmaun, D., & Chambellan, A. (2010) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2010.06.013 · Cited by 17 · see citing works
Can muscle protein metabolism be specifically targeted by exercise training in COPD?
Simoes, D. C. M., & Vogiatzis, I. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.02.67 · Cited by 17 · see citing works
Assessment of Nutritional Status in Chronic Obstructive Pulmonary Disease Patients
Yazdanpanah, L., Shidfar, F., Moosavi, J., Heidarnazhad, H., & Haghani, H. (2009) · Cited by 16 · see citing works
Fogarty, A., Lewis, S., McKeever, T. M., & Britton, J. R. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.07.024 · Cited by 16 · see citing works
Lakhdar, R., & Rabinovich, R. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.05.81 · Cited by 15 · see citing works
Isokinetic muscle evaluation of quadriceps in patients with chronic obstructive pulmonary disease
Vieira, L., Bottaro, M., Celes, R. S., Viegas, C. A. D. A., & Melo‐Silva, C. A. (2010) · Revista Portuguesa de Pneumologia · doi:10.1016/s2173-5115(10)70074-9 · Cited by 14 · see citing works
Schüetz, P., Briel, M., Duerring, U., Müller, B., Schindler, C., & Viatte, S. (2010) · Swiss Medical Weekly · doi:10.4414/smw.2010.13109 · Cited by 12 · see citing works
Remigio‐Baker, R. A., Allison, M., Schreiner, P. J., Carnethon, M. R., Nettleton, J. A., Mujahid, M. S., Szklo, M., Crum, R. M., Leoutsakos, J., Franco, M., et al. (2015) · BMC Psychiatry · doi:10.1186/s12888-015-0604-9 · Cited by 12 · see citing works
Wang, C., Li, J.-X., Tang, D., Zhang, J., Fang, L., Fu, W., Liu, L., & Dai, L.-M. (2017) · International Journal of COPD · doi:10.2147/copd.s152134 · Cited by 12 · see citing works
Avdeev, S. N. (2007) · PULMONOLOGIYA · doi:10.18093/0869-0189-2007-0-2-104-116 · Cited by 10 · see citing works
Sarcopaenia in chronic obstructive pulmonary disease
STEINER, M. C. (2007) · Thorax · doi:10.1136/thx.2006.067009 · Cited by 10 · see citing works
Tomoda, K., Kubo, K., Hino, K., Kondoh, Y., Nishii, Y., Koyama, N., Yamamoto, Y., Yoshikawa, M., & Kimura, H. (2014) · Journal of Toxicological Sciences · doi:10.2131/jts.39.331 · Cited by 9 · see citing works
Alekseev, A. E., Guzun, R., Reyes, S., Pison, C. M., Schlattner, U., Selivanov, V. A., & Cascante, M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.04.018 · Cited by 9 · see citing works
Ma, Z., & Zhang, W. (2016) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2016.07.003 · Cited by 9 · see citing works
The Challenges of Chronic Obstructive Pulmonary Diseases (COPD)—A Perspective
Vandivier, R. W., & Voelkel, N. F. (2005) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200050676 · Cited by 9 · see citing works
Chronic lung diseases and kidney disease: pathophysiology and management
Rosa, S. D., Lassola, S., Taccone, F. S., & Battaglini, D. (2025) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaf077 · Cited by 8 · see citing works
Dunstan, R. H., Sparkes, D. L., Dascombe, B. J., Evans, C. A., Macdonald, M. M., Crompton, M. J., Franks, J., Murphy, G. R., Gottfries, J., Carlton, B. R., et al. (2015) · Comparative Exercise Physiology · doi:10.3920/cep150027 · Cited by 7 · see citing works
Muscle Dysfunction in Smokers and Patients With Mild COPD
Fonseca, J., Nellessen, A. G., & Pitta, F. D. O. (2019) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000400 · Cited by 7 · see citing works
Park, J. H., Nam, H. S., Park, M., & Kim, Y. H. (2024) · European Review of Aging and Physical Activity · doi:10.1186/s11556-024-00340-z · Cited by 6 · see citing works
Smoking, alcohol and risk of sarcopenia: a Mendelian randomisation study
Sha, T., Zhang, Y., Joshi, A. D., Lane, N. E., Wei, J., Li, W., Xie, H., Li, J., Li, C., Zeng, C., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-091656 · Cited by 6 · see citing works
Prévention des exacerbations de BPCO : un enjeu fondamental
Roche, N., Aguilaniu, B., Burgel, P., Durand‐Zaleski, I., Dusser, D. J., Escamilla, R., Perez, T., Rahérison, C., & Similowski, T. (2012) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2012.04.006 · Cited by 6 · see citing works
Biochemical Changes in Response to Intensive Resistance Exercise Training in the Elderly
Bautmans, I., Njemini, R., & Mets, T. F. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_21 · Cited by 6 · see citing works
Peripheral muscle dysfunction and chronic obstructive pulmonary disease
Breunung, L., & Roberts, C. M. (2011) · British Journal of Hospital Medicine · doi:10.12968/hmed.2011.72.1.17 · Cited by 5 · see citing works
Respiratory and skeletal muscles in chronic obstructive pulmonary disease
Gayan‐Ramirez, G., Koulouris, N. G., Roca, J., & Decramer, M. (2006) · European Respiratory Society eBooks · doi:10.1183/1025448x.00038011 · Cited by 5 · see citing works
Mattioli, R., Risola, D. D., Chiaradia, C., Dimauro, I., Mosca, L., Duranti, G., & Ceci, R. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70476 · Cited by 4 · see citing works
Zamani, Z., Ghanei, M., Panahi, Y., Arjmand, M., Sadeghi, S., Mirkhani, F., Parvin, S., Salehi, M., Sahebkar, A., & Vahabi, F. (2015) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12441 · Cited by 4 · see citing works
Huang, T., Yang, M., Zeng, Y., Huang, X., Wang, N., Chen, Y., Li, P., Yuan, J., Chen, C., Oliver, B. G. G., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.638576 · Cited by 4 · see citing works
TSUKANO, K., Suzuki, K., Shimamori, T., Sato, A., Kudo, K., Asano, R., AJITO, T., & Lakritz, J. (2014) · Journal of Veterinary Medical Science · doi:10.1292/jvms.14-0355 · Cited by 3 · see citing works
Effects of Pulmonary Rehabilitation on Lung Functions in Patients with COPD
Ahmed, M. N. U., Begum, S., Sultana, S., & Ali, T. (2014) · Journal of Bangladesh Society of Physiologist · doi:10.3329/jbsp.v8i2.18657 · Cited by 3 · see citing works
Unveiling the Knowledge Frontier: A Scientometric Analysis of COPD with Sarcopenia
Zou, J., & Peng, W. (2024) · International Journal of COPD · doi:10.2147/copd.s448494 · Cited by 3 · see citing works
Évaluation de l'état nutritionnel du patient BPCO
Thibault, R., Veale, D., Chailleux, E., Darmaun, D., & Chambellan, A. (2006) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2006.10.180 · Cited by 3 · see citing works
Lu, H., Zhang, Q., & Jiao, L. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1399038 · Cited by 2 · see citing works
- Authors
- Jagoe, R. T., & Engelen, M. P. K. J.
- Affiliations
- Aintree University Hospital (GB)
- Maastricht University Medical Centre (NL)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2003-11-02
- Volume
- 22
- Issue
- 46 suppl
- Pages
- 52s-63s
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2141973926
- Cited by
- 134
- References
- 134
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- chronic obstructive pulmonary disease, muscle atrophy, skeletal muscle atrophy, muscle protein metabolism, protein synthesis, protein degradation, amino acid composition, cachexia, muscle catabolism
- MeSH terms
- Amino Acids, Animals, Humans, Muscle Proteins, Muscular Atrophy, Body Mass Index, Muscle, Skeletal, Inflammation Mediators, Pulmonary Disease, Chronic Obstructive
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