The Mitochondrial Phenotype of Peripheral Muscle in Chronic Obstructive Pulmonary Disease
Abstract
Rationale Peripheral muscle alterations have been recognized to contribute to disability in chronic obstructive pulmonary disease (COPD). Objectives To describe the mitochondrial phenotype in a moderate to severe COPD population and age-matched controls. Methods Three primary aspects of mitochondrial function were assessed in permeabilized locomotor muscle fibers. Measurements and main results Respiration rates per milligram of fiber weight were significantly lower in COPD muscle compared with healthy age-matched control muscle under various respiratory states. However, when variations in mitochondrial volume were taken into account by normalizing respiration per unit of citrate synthase activity, differences between the two groups were abolished, suggesting the absence of specific mitochondrial respiratory impairment in COPD. H(2)O(2) production per mitochondrion was higher both under basal and ADP-stimulated states, suggesting that mitochondria from COPD muscle have properties that potentiate H(2)O(2) release. Direct assessment of mitochondrial sensitivity to Ca(2+)-induced opening of the permeability transition pore (PTP) indicated that mitochondria from patients with COPD were more resistant to PTP opening than their counterparts in control subjects. Conclusions Comparison of these results with those of studies comparing healthy glycolytic with oxidative muscle suggests that these differences may be attributable to greater type II fiber expression in COPD muscle, as mitoc…
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Some authors have found increased COX activity in COPD patients with resting hypoxemia and with exercise hypoxemia, while others have not found any significant increase.
“While some authors have found an increased COX activity in COPD patients with resting hypoxemia [96] and with exercise hypoxemia [97], others have not found any significant increase [98].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [98]
Picard and colleagues observed decreased state 2 and state 3 respiration in COPD fibers compared to healthy controls; normalization with respect to citrate synthase activity abolished these differences.
“First, Picard and colleagues observed a decreased state 2 and state 3 respiration in COPD fibers compared to healthy controls. However, a normalization with respect to the citrate synthase activity abolished these differences [98].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [98]
Permeabilized muscle fibers from COPD patients show more resistance to Ca2+-induced mPTP opening than those from healthy controls, attributed to an increased proportion of type II fibers, which are intrinsically more resistant.
“Picard and colleagues reported that there was more resistance to Ca2+-induced mPTP opening in permeabilized muscle fibers from COPD patients than in those from healthy control subjects, attributed to the increased proportion of type II fibers, which are intrinsically more resistant to Ca2+-induced mPTP opening [98].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [98]
In permeabilized fibers normalized per unit of citrate synthase activity, H2O2 release is significantly higher in COPD patients compared to control subjects during state 2 and state 3:CII.
“Picard and colleagues also showed in permeabilized fibers normalized per unit of citrate synthase activity that H2O2 release was significantly higher in COPD patients compared to control subjects during state 2 and state 3:CII [98].”
From Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting (2023) · cites this paper as [98]
Cites
Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,295 · see citing works
The Pathophysiology of Mitochondrial Cell Death
Green, D. R., & Kroemer, G. (2004) · Science · doi:10.1126/science.1099320 · Cited by 3,416 · see citing works
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432 · see citing works
The mitochondrial permeability transition
Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,395 · see citing works
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works
Superoxide production by the mitochondrial respiratory chain
Turrens, J. F. (1997) · Bioscience Reports · doi:10.1023/a:1027374931887 · Cited by 903 · see citing works
Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033506 · Cited by 881 · see citing works
Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells
Kuznetsov, A. V., Veksler, V., Gellerich, F. N., Saks, V. A., Margreiter, R., & Kunz, W. S. (2008) · Nature Protocols · doi:10.1038/nprot.2008.61 · Cited by 805 · see citing works
The Ca2+-induced membrane transition in mitochondria
Haworth, R. A., & Hunter, D. R. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90372-2 · Cited by 793 · see citing works
Mitochondrial permeability transition: a common pathway to necrosis and apoptosis
Js, K., He, L., & Lemasters, J. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00618-1 · Cited by 756 · see citing works
Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y
Schutz, Y., Kyle, U. G., & Pichard, C. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802037 · Cited by 668 · see citing works
Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency
Irwin, W., Bergamin, N., Sabatelli, P., Reggiani, C., Megighian, A., Merlini, L., Braghetta, P., Columbaro, M., Volpin, D., Bressan, G. M., et al. (2003) · Nature Genetics · doi:10.1038/ng1270 · Cited by 509 · see citing works
Mitochondrial H + Leak and ROS Generation: An Odd Couple
Brookes, P. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.016 · Cited by 447 · see citing works
WHITTOM, F., JOBIN, J., SIMARD, P.-M., LEBLANC, P., SIMARD, C., BERNARD, S., BELLEAU, R., & MALTAIS, F. (1998) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199810000-00001 · Cited by 447 · see citing works
Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo
Saks, V. A., Veksler, V., Kuznetsov, A. V., Kay, L., Sikk, P., Tiivel, T., Tranqui, L., Olivares, J., Winkler, K., Wiedemann, F. R., et al. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5653-4_7 · Cited by 361 · see citing works
Millay, D. P., Sargent, M. A., Osińska, H. E., Baines, C. P., Barton, E. R., Vuagniaux, G., Sweeney, H. L., Robbins, J. M., & Molkentin, J. D. (2008) · Nature Medicine · doi:10.1038/nm1736 · Cited by 357 · see citing works
Skeletal Muscle Apoptosis and Weight Loss in Chronic Obstructive Pulmonary Disease
Agustí, A. G. N., Sauleda, J., Miralles, C., Gomez, C., Togores, B., Sala, E., Batle, S., & Busquets, X. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2108013 · Cited by 343 · see citing works
Type II skeletal myofibers possess unique properties that potentiate mitochondrial H2O2 generation
Anderson, E. J., & Neufer, P. D. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00402.2005 · Cited by 329 · see citing works
Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vitro
Veksler, V., Kuznetsov, A. V., Kay, L., Sikk, P., Tiivel, T., Tranqui, L., Olivares, J., Winkler, K., Wiedemann, F. R., & Kunz, W. S. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006834912257 · Cited by 308 · see citing works
Gosker, H. R., van Mameren, H., van Dijk, P., ENGELEN, M. P. K. J., Vusse, G. J., Wouters, E. F. �., & Schols, A. M. W. J. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00762001 · Cited by 299 · see citing works
The Role of Apoptosis in the Normal Aging Brain, Skeletal Muscle, and Heart
POLLACK, M., Phaneuf, S., Dirks, A. J., & Leeuwenburgh, C. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02086.x · Cited by 285 · see citing works
Maltais, F. (2000) · Thorax · doi:10.1136/thorax.55.10.848 · Cited by 284 · see citing works
Decramer, M. L. A., de Bock, V., & Dom, R. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.6.8665061 · Cited by 283 · see citing works
Schwerzmann, K., Hoppeler, H. H., Kayar, S. R., & Weibel, E. R. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1583 · Cited by 272 · see citing works
Oxidative Stress and Respiratory Muscle Dysfunction in Severe Chronic Obstructive Pulmonary Disease
Barreiro, E., de la Puente, B., Minguella, J., Corominas, J. M., Serrano, S., Hussain, S. N. A., & Gea, J. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-887oc · Cited by 244 · see citing works
Muscle Atrophy and Hypertrophy Signaling in Patients with Chronic Obstructive Pulmonary Disease
Doucet, M., Russell, A. P., Léger, B., Debigaré, R., Joanisse, D. R., Caron, M.-A., LeBlanc, P., & Maltais, F. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200605-704oc · Cited by 243 · see citing works
Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation
Levraut, J., Iwase, H., Shao, Z. H., Hoek, T. L. V., & Schumacker, P. T. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00708.2002 · Cited by 226 · see citing works
Chronic Obstructive Pulmonary Disease: Capillarity and Fiber-Type Characteristics of Skeletal Muscle
Jobin, J., Maltais, F., Doyon, J.-F., LeBlanc, P., Simard, P.-M., Simard, A.-A., & Simard, C. (1998) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199811000-00005 · Cited by 224 · see citing works
Taivassalo, T., Gardner, J. L., Taylor, R. W., Schaefer, A. M., Newman, J., Barron, M. J., Haller, R. G., & Turnbull, D. M. (2006) · Brain · doi:10.1093/brain/awl282 · Cited by 220 · see citing works
Self-citationMerlini, L., Angelin, A., Tiepolo, T., Braghetta, P., Sabatelli, P., Zamparelli, A., Ferlini, A., Maraldi, N. M., Bonaldo, P., & Bernardi, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800962105 · Cited by 207 · see citing works
Mitochondrial permeability transitions: how many doors to the house?
Zoratti, M., Szabó, I., & Marchi, U. D. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.10.006 · Cited by 205 · see citing works
From muscle disuse to myopathy in COPD: potential contribution of oxidative stress
Couillard, A., & Prefaut, C. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00139904 · Cited by 187 · see citing works
Mitochondrial function as a determinant of recovery or death in cell response to injury
Lisa, F. D., & Bernardi, P. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5653-4_25 · Cited by 184 · see citing works
Richardson, R. S., Leek, B. T., Gavin, T. P., Haseler, L. J., Mudaliar, S. R. D., Henry, R. R., Mathieu-Costello, O. A., & Wagner, P. D. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200305-627oc · Cited by 175 · see citing works
Cytokine Profile in Quadriceps Muscles of Patients with Severe COPD
Barreiro, E., Schols, A. M. W. J., Polkey, M. I., Galdiz, J. B., Gosker, H. R., Swallow, E. B., Coronell, C., Gea, J., & on behalf of the ENIGMA in COPD project (2007) · Thorax · doi:10.1136/thx.2007.078030 · Cited by 175 · see citing works
Bupivacaine Myotoxicity Is Mediated by Mitochondria
Irwin, W., Fontaine, E. M., Agnolucci, L., Penzo, D., Betto, R., Bortolotto, S. K., Reggiani, C., Salviati, G., & Bernardi, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108938200 · Cited by 175 · see citing works
Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD
Gosker, H. R., Hesselink, M. K. C., Duimel, H., Ward, K., & Schols, A. M. W. J. (2007) · European Respiratory Journal · doi:10.1183/09031936.00146906 · Cited by 172 · see citing works
Peroxisome Proliferator-Activated Receptor Expression Is Reduced in Skeletal Muscle in COPD
Remels, A. H., Schrauwen, P., Broekhuizen, R., Willems, J., Kersten, S., Gosker, H. R., & Schols, A. M. (2007) · European Respiratory Journal · doi:10.1183/09031936.00144106 · Cited by 168 · see citing works
Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease
Gosker, H. R., Kubat, B., Schaart, G., Vusse, G. J., Wouters, E. F. �., & Schols, A. M. W. J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00012803 · Cited by 168 · see citing works
Ichas, F., Jouaville, L. S., Sidash, S. S., Mazat, J., & Holmuhamedov, E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00615-6 · Cited by 159 · see citing works
Barreiro, E., Gea, J., Corominas, J. M., & Hussain, S. N. A. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0138oc · Cited by 156 · see citing works
SAULEDA, J., GARCÍA-PALMER, F., WIESNER, R. J., TARRAGA, S., HARTING, I., TOMÁS, P., GÓMEZ, C., SAUS, C., PALOU, A., & AGUSTÍ, A. G. N. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.5.9710039 · Cited by 154 · see citing works
Mitochondrial function as a determinant of recovery or death in cell response to injury
Lisa, F. D., & Bernardi, P. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006810523586 · Cited by 150 · see citing works
Mitochondrial Dysfunction in COPD Patients with Low Body Mass Index
Rabinovich, R. A., Bastos, R., Ardite, E., Llinàs, L., Orozco-Levi, M., Gea, J., Vilaró, J., Barberà, J. A., Rodríguez-Roisin, R., Fernández-Checa, J. C., et al. (2007) · European Respiratory Journal · doi:10.1183/09031936.00086306 · Cited by 144 · see citing works
HIF-1–Dependent Respiratory, Cardiovascular, and Redox Responses to Chronic Intermittent Hypoxia
Semenza, G. L., & Prabhakar, N. R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1691 · Cited by 129 · see citing works
A novel technique for nonvolitional assessment of quadriceps muscle endurance in humans
Swallow, E. B., Gosker, H. R., Ward, K., Moore, A., Dayer, M., Hopkinson, N. S., Schols, A. M. W. J., Moxham, J., & Polkey, M. I. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00025.2007 · Cited by 121 · see citing works
Skeletal muscles in chronic obstructive pulmonary disease: Deconditioning, or myopathy?
Wagner, P. D. (2006) · Respirology · doi:10.1111/j.1440-1843.2006.00939.x · Cited by 100 · see citing works
Update in Chronic Obstructive Pulmonary Disease 2006
Rabe, K. F., Beghé, B., Luppi, F., & Fabbri, L. M. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200704-586up · Cited by 98 · see citing works
Skeletal Muscle Function in COPD
Casaburi, R. H. (2000) · CHEST Journal · doi:10.1378/chest.117.5_suppl_1.267s-a · Cited by 98 · see citing works
Peripheral Muscle Dysfunction in Chronic Obstructive Pulmonary Disease
Maltais, F., Leblanc, P., Jobin, J., & Casaburi, R. H. (2000) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70176-3 · Cited by 92 · see citing works
Picard, M. A., Csukly, K., Robillard, M.-È., Godin, R., Ascah, A., Bourcier‐Lucas, C., & Burelle, Y. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90357.2008 · Cited by 90 · see citing works
Self-citationNutritional Abnormalities and Supplementation in Chronic Obstructive Pulmonary Disease
Schols, A. M. W. J., & Wouters, E. F. �. (2000) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70182-9 · Cited by 89 · see citing works
Barreiro, E., Gea, J., Matar, G., & Hussain, S. N. A. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0114oc · Cited by 89 · see citing works
Allaire, J., Maltais, F., LeBlanc, P., Simard, P., Whittom, F., Doyon, J., Simard, C., & Jobin, J. (2002) · Muscle & Nerve · doi:10.1002/mus.10039 · Cited by 85 · see citing works
Csukly, K., Ascah, A., Matas, J., Gardiner, P. F., Fontaine, E. M., & Burelle, Y. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109702 · Cited by 68 · see citing works
Self-citationRemels, A. H. V., Gosker, H. R., van der Velden, J. L. J., LANGEN, R. C. J., & Schols, A. M. W. J. (2007) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2007.06.003 · Cited by 62 · see citing works
Rabinovich, R., Ardite, E., Mayer, A. F., Polo, M. F., Vilaró, J., Argilés, J. M. A., & Roca, J. (2006) · Respiration · doi:10.1159/000094395 · Cited by 58 · see citing works
Peripheral muscle composition and health status in patients with COPD
de, M. M., Torres, S. H., Gonzalez, Y., Romero, E., Hernández, N., Mata, A., & Tálamo, C. (2006) · Respiratory Medicine · doi:10.1016/j.rmed.2006.01.020 · Cited by 54 · see citing works
Martin, C., Dubouchaud, H., Mosoni, L., Chardigny, J., Oudot, A., Fontaine, E. M., Vergely, C., Kériel, C., Rochette, L., Leverve, X. M., et al. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00271.x · Cited by 49 · see citing works
Pereira, M. C., Isayama, R. N., Seabra, J. C. T., Campos, G. E. R., & Paschoal, I. A. (2004) · Muscle & Nerve · doi:10.1002/mus.20126 · Cited by 14 · see citing works
Response of Human Airway Epithelium In Vitro to Inflammatory Mediators
Martin, L. D., Norford, D. C., Voynow, J. A., & Adler, K. B. (2000) · CHEST Journal · doi:10.1378/chest.117.5_suppl_1.267s · Cited by 5 · see citing works
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Sorted by citations
Maltais, F., Decramer, M., Casaburi, R. H., Barreiro, E., Burelle, Y., Debigaré, R., Dekhuijzen, P. N. R., Franssen, F. M. E., Gayan‐Ramirez, G., Gea, J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201402-0373st · Cited by 1,113 · see citing works
Self-citationERS statement on respiratory muscle testing at rest and during exercise
Laveneziana, P., Albuquerque, A., Aliverti, A., Babb, T., Barreiro, E., Dres, M., Dubé, B., Fauroux, B., Gea, J., Guenette, J., et al. (2019) · European Respiratory Journal · doi:10.1183/13993003.01214-2018 · Cited by 743 · see citing works
The rise of mitochondria in medicine
Picard, M. A., Wallace, D. C., & Burelle, Y. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.07.003 · Cited by 454 · see citing works
Self-citationMuscle fiber type diversification during exercise and regeneration
Qaisar, R., Bhaskaran, S., & Van Remmen, H. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.025 · Cited by 283 · see citing works
Mitochondrial dysfunction in heart failure
Rosca, M. G., & Hoppel, C. L. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9340-0 · Cited by 250 · see citing works
Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence
Hara, H., Araya, J., Ito, S., Kobayashi, K., Takasaka, N., Yoshii, Y., Wakui, H., Kojima, J., Shimizu, K., Numata, T., et al. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00146.2013 · Cited by 219 · see citing works
Picard, M., Hepple, R. T., & Burelle, Y. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00368.2011 · Cited by 214 · see citing works
Self-citationMultisystem physiological perspective of human frailty and its modulation by physical activity
Taylor, J. A., Greenhaff, P. L., Bartlett, D. B., Jackson, T., Duggal, N. A., & Lord, J. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00037.2021 · Cited by 209 · see citing works
The mechanisms of cachexia underlying muscle dysfunction in COPD
Remels, A. H. V., Gosker, H. R., LANGEN, R. C. J., & Schols, A. M. W. J. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00790.2012 · Cited by 181 · see citing works
van den Borst, B., Slot, I. G. M., Hellwig, V. A. C. V., Vosse, B. A. H., KELDERS, M. C. J. M., Barreiro, E., Schols, A. M. W. J., & Gosker, H. R. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00508.2012 · Cited by 120 · see citing works
Iron deficiency as energetic insult to skeletal muscle in chronic diseases
Dzięgała, M., Josiak, K., Kasztura, M., Kobak, K. A., von Haehling, S., Banasiak, W., Anker, S. D., Ponikowski, P. P., & Jankowska, E. A. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12314 · Cited by 111 · see citing works
Bouitbir, J., Singh, F., Charles, A., Schlagowski, A.-I., Bonifacio, A., Echaniz‐Laguna, A., Gény, B., Krähenbühl, S., & Zoll, J. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6190 · Cited by 95 · see citing works
Rabinovich, R., & Vilaró, J. (2010) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328336438d · Cited by 91 · see citing works
Mitochondrial Dysfunction in Skeletal Muscle Pathologies
Abrigo, J., Simon, F., Cabrera, D., Vilos, C., & Cabello-Verrugio, C. (2019) · Current Protein & Peptide Science · doi:10.2174/1389203720666190402100902 · Cited by 88 · see citing works
Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting
Henrot, P., Dupin, I., Schilfarth, P., Esteves, P., Blervaque, L., Zysman, M., Gouzi, F., Hayot, M., Pomiès, P., & Berger, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076454 · Cited by 85 · see citing works
“While some authors have found an increased COX activity in COPD patients with resting hypoxemia [96] and with exercise hypoxemia [97], others have not found any significant increase [98].”
BackgroundResultInfluentialGodin, R., Daussin, F., Matecki, S., Li, T., Petrof, B. J., & Burelle, Y. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.240390 · Cited by 85 · see citing works
Self-citationNutritional status in chronic obstructive pulmonary disease: Role of hypoxia
Raguso, C. A., & Luthy, C. (2010) · Nutrition · doi:10.1016/j.nut.2010.07.009 · Cited by 83 · see citing works
Meyer, A., Zoll, J., Charles, A. L., Charloux, A., de Blay, F., Diemunsch, P., Sibilia, J., Piquard, F., & Geny, B. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2012.069468 · Cited by 90 · see citing works
Gene Expression Profiling in Vastus Lateralis Muscle During an Acute Exacerbation of COPD
Crul, T., Testelmans, D., Spruit, M., Troosters, T., Gosselink, R., Geeraerts, I., Decramer, M., & Gayan-Ramirez, G. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000303054 · Cited by 79 · see citing works
Vignaud, J., Loiseau, C., Hérault, J., Mayer, C., Côme, M., Martin, I., & Ulmann, L. (2023) · Antioxidants · doi:10.3390/antiox12051050 · Cited by 72 · see citing works
MacMillan, N. J., Kapchinsky, S., Goddard, Y., Gouspillou, G., Sena, R. D. S., Jagoe, R. T., Baril, J., Carver, T. E., Andersen, R. E., Richard, R., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00114 · Cited by 70 · see citing works
Self-citationComparative assessment of the quadriceps and the diaphragm in patients with COPD
Caron, M., Debigaré, R., Dekhuijzen, P. N. R., & Maltais, F. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00194.2009 · Cited by 68 · see citing works
High-intensity knee extensor training restores skeletal muscle function in COPD patients
Brønstad, E., Rognmo, Ø., Tjønna, A. E., Dedichen, H., Kirkeby‐Garstad, I., Haberg, A. K., Ingul, C. B., Wisløff, U., & Steinshamn, S. (2012) · European Respiratory Journal · doi:10.1183/09031936.00193411 · Cited by 66 · see citing works
Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD
Adami, A., Cao, R., Pórszász, J., Casaburi, R. H., & Rossiter, H. B. (2016) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2016.09.008 · Cited by 61 · see citing works
Physical activity, nutritional status and systemic inflammation in COPD
Laveneziana, P., & Palange, P. (2012) · European Respiratory Journal · doi:10.1183/09031936.00041212 · Cited by 62 · see citing works
Contribution of the Mitochondria to Locomotor Muscle Dysfunction in Patients with COPD
Taivassalo, T., & Hussain, S. N. A. (2016) · Chest · doi:10.1016/j.chest.2015.11.021 · Cited by 59 · see citing works
Self-citationHaji, G., Wiegman, C. H., Michaeloudes, C., Patel, M. S., Curtis, K., Bhavsar, P., Polkey, M. I., Adcock, I. M., Chung, K. F., & on behalf of the COPDMAP consortium (2020) · Respiratory Research · doi:10.1186/s12931-020-01527-5 · Cited by 58 · see citing works
Eliason, G., Abdel-Halim, S. M., Piehl-Aulin, K., & Kadi, F. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-97 · Cited by 57 · see citing works
Layec, G., Haseler, L. J., Hoff, J., & Richardson, R. S. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00835.2010 · Cited by 55 · see citing works
Altered mitochondrial regulation in quadriceps muscles of patients with COPD
Naimi, A. I., Bourbeau, J., Perrault, H., Baril, J., Wright‐Paradis, C., Rossi, A. M., Taivassalo, T., Sheel, A. W., Rabøl, R., Dela, F., et al. (2010) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2010.00988.x · Cited by 51 · see citing works
Self-citationMitochondria in Chronic Obstructive Pulmonary Disease and Lung Cancer: Where are We Now?
Nam, H.-S., Izumchenko, E., Dasgupta, S., & Hoque, M. O. (2017) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0373 · Cited by 51 · see citing works
Walking abnormalities are associated with COPD: An investigation of the NHANES III dataset
Yentes, J. M., Sayles, H. R., Meza, J. L., Mannino, D. M., Rennard, S. I., & Stergiou, N. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.06.007 · Cited by 47 · see citing works
Mitochondria of trained skeletal muscle are protected from deleterious effects of statins
Bouitbir, J., Daussin, F., Charles, A., Rasseneur, L., Dufour, S. P., Richard, R., Piquard, F., Gény, B., & Zoll, J. (2012) · Muscle & Nerve · doi:10.1002/mus.23309 · Cited by 46 · see citing works
Konokhova, Y., Spendiff, S., Jagoe, R. T., Aare, S., Kapchinsky, S., MacMillan, N. J., Rozakis, P., Picard, M., Aubertin-Leheudre, M., Pion, C. H., et al. (2016) · Skeletal Muscle · doi:10.1186/s13395-016-0083-9 · Cited by 46 · see citing works
Self-citationLocomotor Muscles in COPD: The Rationale for Rehabilitative Exercise Training
Marillier, M., Bernard, A., Vergès, S., & Neder, J. A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01590 · Cited by 46 · see citing works
Filho, D. M. R., Chicaybam, G., de‐Souza‐Ferreira, E., Martinez, C. G., Kurtenbach, E., Casimiro-Lopes, G., & Galina, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131766 · Cited by 46 · see citing works
Altered skeletal muscle mitochondrial phenotype in COPD: disease vs. disuse
Gifford, J. R., Trinity, J. D., Kwon, O.-S., Layec, G., Garten, R. S., Park, S., Nelson, A. D., & Richardson, R. S. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00788.2017 · Cited by 45 · see citing works
Gifford, J. R., Trinity, J. D., Layec, G., Garten, R. S., Park, S.-Y., Rossman, M. J., Larsen, S., Dela, F., & Richardson, R. S. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00460.2015 · Cited by 40 · see citing works
Wang, Y., Li, P., Cao, Y., Liu, C., Wang, J., & Wu, W. (2022) · Aging and Disease · doi:10.14336/ad.2022.0603 · Cited by 39 · see citing works
Metabolic derangements in COPD muscle dysfunction
Puente‐Maestu, L., Lázaro, A., & Humanes, B. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00815.2012 · Cited by 40 · see citing works
The pathophysiology of cachexia in chronic obstructive pulmonary disease
Schols, A. M. W. J., & Gosker, H. R. (2009) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328331e91c · Cited by 38 · see citing works
Muscle Oxidative Capacity Is Reduced in Both Upper and Lower Limbs in COPD
Adami, A., Corvino, R. B., Calmelat, R., Pórszász, J., Casaburi, R. H., & Rossiter, H. B. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002364 · Cited by 33 · see citing works
The Relevance of Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease
Bui, K.-L., Nyberg, A., Rabinovich, R., Saey, D., & Maltais, F. (2019) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2019.02.013 · Cited by 32 · see citing works
Chronic aryl hydrocarbon receptor activity phenocopies smoking‐induced skeletal muscle impairment
Thome, T., Míguez, K., Willms, A. J., Burke, S., Chandran, V., de Souza, A. R., Fitzgerald, L. F., Baglole, C. J., Anagnostou, M., Bourbeau, J., et al. (2021) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12826 · Cited by 32 · see citing works
Self-citationOxidative Stress Causes Muscle Structural Alterations via P38 MAPK Signaling in COPD Mouse Model
Mano, Y., Tsukamoto, M., Wang, K.-Y., Nabeshima, T., Kosugi, K., Tajima, T., Yamanaka, Y., Suzuki, H., Kawasaki, M., Nakamura, E., et al. (2022) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-022-01371-1 · Cited by 29 · see citing works
Update in Chronic Obstructive Pulmonary Disease 2008
Maclay, J. D., Rabinovich, R., & MacNee, W. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200901-0134up · Cited by 26 · see citing works
Mao, J., Li, Y., Feng, S., Liu, X., Tian, Y., Bian, Q., Li, J., Hu, Y., Zhang, L., Ji, H., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.587176 · Cited by 24 · see citing works
Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure
Decker, S. T., Kwon, O., Zhao, J., Hoidal, J. R., Heuckstadt, T., Richardson, R. S., Sanders, K. A., & Layec, G. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00544.2020 · Cited by 24 · see citing works
Mao, J., Li, Y., Li, S., Li, J., Tian, Y., Feng, S., Liu, X., Bian, Q., Li, J., Hu, Y., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/1216305 · Cited by 24 · see citing works
Immunologic Impact of Nutrient Depletion in Chronic Obstructive Pulmonary Disease
Herzog, R., & Cunningham-Rundles, S. (2011) · Current Drug Targets · doi:10.2174/138945011794751500 · Cited by 23 · see citing works
Marinari, S., Manigrasso, M. R., & Benedetto, F. D. (2013) · Multidisciplinary Respiratory Medicine · doi:10.1186/2049-6958-8-40 · Cited by 23 · see citing works
Neuromuscular weakness in chronic obstructive pulmonary disease
Alter, A., Aboussouan, L. S., & Mireles‐Cabodevila, E. (2017) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000360 · Cited by 21 · see citing works
Kwon, O. S., Decker, S. T., Zhao, J., Hoidal, J. R., Heuckstadt, T., Sanders, K. A., Richardson, R. S., & Layec, G. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.089 · Cited by 20 · see citing works
Layec, G., Haseler, L. J., & Richardson, R. S. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00986.2011 · Cited by 20 · see citing works
Balnis, J., Drake, L. A., Vincent, C. E., Korponay, T. C., Singer, D. V., Lacomis, D., Lee, C. G., Elias, J. A., Jourd’heuil, D., Singer, H. A., et al. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0551oc · Cited by 19 · see citing works
Fitzgerald, L. F., Lackey, J. B., Moussa, A., Shah, S., Castellanos, A. M., Khan, S., Schonk, M. M., Thome, T., Salyers, Z. R., Jakkidi, N. R., et al. (2024) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13439 · Cited by 18 · see citing works
Louvaris, Z., Habazettl, H., Asimakos, A., Wagner, H. E., Zakynthinos, S. G., Wagner, P. D., & Vogiatzis, I. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2016.12.013 · Cited by 18 · see citing works
Integrating Mechanisms of Exacerbated Atrophy and Other Adverse Skeletal Muscle Impact in COPD
Taivassalo, T., & Hepple, R. T. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.861617 · Cited by 16 · see citing works
Self-citationShould all patients with COPD be exercise trained?
Ribeiro, F. A., Thériault, M., Debigaré, R., & Maltais, F. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01124.2012 · Cited by 15 · see citing works
Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD
Latimer, L. E., Constantin-Teodosiu, D., Popat, B., Constantin, D., Houchen-Wolloff, L., Bolton, C. E., Steiner, M. C., & Greenhaff, P. L. (2022) · European Respiratory Journal · doi:10.1183/13993003.01507-2021 · Cited by 14 · see citing works
Jaitovich, A. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00292.2022 · Cited by 14 · see citing works
Khattri, R. B., Thome, T., Fitzgerald, L. F., Wohlgemuth, S. E., Hepple, R. T., & RYAN, T. E. (2022) · Toxics · doi:10.3390/toxics10030140 · Cited by 14 · see citing works
Abdellaoui, A., Gouzi, F., Notarnicola, C., Bourret, A., Suc, A., Laoudj‐Chenivesse, D., Héraud, N., Mercier, J. G., PREFAUT, C. G., Hayot, M., et al. (2025) · Acta Physiologica · doi:10.1111/apha.70079 · Cited by 12 · see citing works
Slot, I. G. M., van den Borst, B., Hellwig, V. A. C. V., Barreiro, E., Schols, A. M. W. J., & Gosker, H. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090150 · Cited by 12 · see citing works
Caron, M., Debigaré, R., Dekhuijzen, P. N. R., & Maltais, F. (2011) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2011.04.015 · Cited by 12 · see citing works
Balnis, J., Tufts, A., Jackson, E. L., Drake, L. A., Singer, D. V., Lacomis, D., Lee, C. G., Elias, J. A., Doles, J. D., Maher, L. J., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado8549 · Cited by 13 · see citing works
Perez, T., Mal, H., Aguilaniu, B., Brillet, P., Chaouat, A., Louis, R. E., Muir, J. F., Similowski, T., Berger, P., Burgel, P., et al. (2011) · Revue des Maladies Respiratoires · doi:10.1016/j.rmr.2010.08.011 · Cited by 11 · see citing works
Trivedi, A., Bade, G., Madan, K., Bhat, M., Guleria, R., & Talwar, A. (2022) · International Journal of COPD · doi:10.2147/copd.s337635 · Cited by 9 · see citing works
Trivedi, A., Bade, G., Madan, K., Bhat, M., Guleria, R., & Talwar, A. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 9 · see citing works
Alekseev, A. E., Guzun, R., Reyes, S., Pison, C. M., Schlattner, U., Selivanov, V. A., & Cascante, M. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.04.018 · Cited by 9 · see citing works
Zhang, J., Long, X.-Y., Xie, Y., Zhao, Z., Fang, L., Liu, L., Fu, W., Shu, J.-K., Wu, J., & Dai, L.-M. (2017) · Bioengineered · doi:10.1080/21655979.2017.1346757 · Cited by 9 · see citing works
Lazaar, A. L., & Greenhaff, P. L. (2012) · European Respiratory Journal · doi:10.1183/09031936.00051012 · Cited by 8 · see citing works
Giuriato, G., Paneroni, M., Venturelli, M., & Layec, G. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.08.004 · Cited by 6 · see citing works
Cyclophilin‐D is dispensable for atrophy and mitochondrial apoptotic signalling in denervated muscle
Daussin, F., Godin, R., Ascah, A., Deschênes, S., & Burelle, Y. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.202036 · Cited by 6 · see citing works
Self-citationAguilaniu, B., Plaindoux, A., Brosson, C., Jeanmart, M., Maitre, J., & Diab, S. (2009) · La Presse Médicale · doi:10.1016/j.lpm.2008.12.002 · Cited by 6 · see citing works
Mitotyping – An integrative framework to quantify mitochondrial specialization and plasticityPreprint
Monzel, A. S., Devine, J., Kapri, D., Sturm, G., Trumpff, C., Menon, V., Jager, P. L. D., Enriquez, J. A., & Picard, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.03.635951 · Cited by 6 · see citing works
Self-citationCaron, M., Thériault, M., Debigaré, R., & Maltais, F. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-673-3_9 · Cited by 5 · see citing works
Adami, A., Duan, F., Calmelat, R., Chen, Z., Casaburi, R. H., & Rossiter, H. B. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70178 · Cited by 3 · see citing works
Upper Limb Extremity Muscle-Dysfunction in Chronic Obstructive Pulmonary Disease: A Narrative Review
Suhas, K. M., Alaparthi, G. K., Krishnan, S. K., & Bairapareddy, K. C. (2020) · Current Respiratory Medicine Reviews · doi:10.2174/1573398x16999200621201220 · Cited by 3 · see citing works
Impact of obstructive sleep apnea on functional performance and muscle quality of patients with COPD
Camargo, P. F., Back, G. D., de Carvalho, L. C. S., Goulart, C. D. L., Lourencetti, L. R., Anjolim, L. F., & Borghi‐Silva, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-32126-3 · Cited by 2 · see citing works
Respiratory and Non-respiratory Muscle Dysfunction in COPD
Saey, D., Caron, M., Debigaré, R., & Maltais, F. (2014) · Springer eBooks · doi:10.1007/978-88-470-5647-3_21 · Cited by 1 · see citing works
Oberholzer, L., Mølmen, K. S., Hammarström, D., Slettaløkken, G., Lundby, A. M., Rønnestad, B. R., Ellefsen, S., & Lundby, C. (2022) · JCSM Rapid Communications · doi:10.1002/rco2.58 · Cited by 1 · see citing works
Villiot-Danger, E., Dupuis, J., & Girard, F. R. (2013) · Réanimation · doi:10.1007/s13546-012-0644-9 · Cited by 1 · see citing works
Silvera, S., Wilkinson, J. A., & LeBlanc, P. J. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.06.002 · Cited by 1 · see citing works
Mitochondrial Function in Lung Health and Disease
Puente‐Maestu, L., & Chancafe-Morgan, J. (2014) · Respiratory medicine · doi:10.1007/978-1-4939-0829-5_8
Effect of pulmonary rehabilitation on oxidative stress in patients with pulmonary diseases
Itoh, M., Nemoto, K., Tsuji, T., Nakamura, H., & Aoshiba, K. (2012) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2012.327125
Body Composition Abnormalities
van den Borst, B., & Schols, A. M. W. J. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-673-3_11
Kangxia, L. I., Yingqi, W. A. N. G., Caitao, C. H. E. N., Yanxia, S. O. N. G., Wu, W., & Li, J. (2024) · Rehabilitation Medicine · doi:10.3724/sp.j.1329.2024.04014
Adami, A., Duan, F., Calmelat, R., Chen, Z., Casaburi, R. H., & Rossiter, H. B. (2025) · medRxiv · doi:10.1101/2025.01.28.25321301
Lower-Limb Muscle Impairments in Patients with COPD: An Overview of the Past Decade
Brauwers, B., Spruit, M. A., Franssen, F. M. E., Vaes, A. W., & Machado, F. V. C. (2026) · Cells · doi:10.3390/cells15030220
Clinical study of bronchial wall area proportion in children and adolescents based on CT images
Wen, L., Shen, C., Han, Y., & Wang, X. M. (2026) · BMC Pulmonary Medicine · doi:10.1186/s12890-026-04436-3
Li, J., Li, P., Zhao, X., Jiang, L., Li, H., Chen, F., Chen, C.-T., Wu, W., & Liu, X. (2026) · Biomedicines · doi:10.3390/biomedicines14102240
- Authors
- Picard, M., Godin, R., Sinnreich, M., Baril, J., Bourbeau, J., Perrault, H., Taivassalo, T., & Burelle, Y.
- Affiliations
- Montreal Chest Institute (CA)
- Montreal Neurological Institute and Hospital (CA)
- Université de Montréal (CA)
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-11
- Volume
- 178
- Issue
- 10
- Pages
- 1040-1047
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1969203076
- Cited by
- 95
- References
- 61
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 11 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 9
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- chronic obstructive pulmonary disease, mitochondrial function, skeletal muscle, oxidative phosphorylation, hydrogen peroxide production, mitochondrial permeability transition pore, fast-twitch muscle, citrate synthase, exercise intolerance
- MeSH terms
- Aged, Forced Expiratory Volume, Humans, Male, Mitochondria, Phenotype, Case-Control Studies, Reactive Oxygen Species, Muscle, Skeletal, Pulmonary Disease, Chronic Obstructive, Voltage-Dependent Anion Channels
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