The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Drug‐screening platform based on the contractility of tissue‐engineered muscle
Open accessAbstract
A tissue‐based approach to in vitro drug screening allows for determination of the cumulative positive and negative effects of a drug at the tissue rather than the cellular or subcellular level. Skeletal muscle myoblasts were tissue‐engineered into three‐dimensional muscle with parallel myofibers generating directed forces. When grown attached to two flexible microposts (μposts) acting as artificial tendons in a 96‐well plate format, the miniature bioartificial muscles (mBAMs) generated tetanic (active) forces upon electrical stimulation measured with a novel image‐based motion detection system. mBAM myofiber hypertrophy and active force increased in response to insulin‐like growth factor 1. In contrast, mBAM deterioration and weakness was observed with a cholesterol‐lowering statin. The results described in this study demonstrate the integration of tissue engineering and biomechanical testing into a single platform for the screening of compounds affecting muscle strength. Muscle Nerve, 2007
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Cites
Identification of ubiquitin ligases required for skeletal muscle atrophy.
Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061894 · Cited by 2,887
Musarò, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E. R., L Sweeney, H., & Rosenthal, N. (2001) · Nature Genetics · doi:10.1038/84839 · Cited by 1,137
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
Glass, D. J. (2003) · Nature Cell Biology · doi:10.1038/ncb0203-87 · Cited by 694
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Engineered In Vitro Disease Models
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K.-J., Karalis, K., Kim, H. J., MacQueen, L., Mahmoodian, R., et al. (2015) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040418 · Cited by 554
Development of a drug screening platform based on engineered heart tissue
Hansen, A., Eder, A., Bönstrup, M., Flato, M., Mewe, M., Schaaf, S., Aksehirlioglu, B., Schwörer, A., Uebeler, J., & Eschenhagen, T. (2010) · Circulation Research · doi:10.1161/circresaha.109.211458 · Cited by 510
Measuring cell-generated forces: a guide to the available tools
Polacheck, W. J., & Chen, C. S. (2016) · Nature Methods · doi:10.1038/nmeth.3834 · Cited by 489
Sala, L., van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312067 · Cited by 416
Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology
Schaaf, S., Shibamiya, A., Mewe, M., Eder, A., Stöhr, A., Hirt, M. N., Rau, T., Zimmermann, W.-H., Conradi, L., Eschenhagen, T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026397 · Cited by 365
Metadata
- Authors
- Vandenburgh, H., Shansky, J., Benesch‐Lee, F., Barbata, V., Reid, J., Thorrez, L., Valentini, R., & Crawford, G.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2008-03-19
- Volume
- 37
- Issue
- 4
- Pages
- 438-447
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W1976896311
- Cited by
- 316
- References
- 4
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Vandenburgh, H., Shansky, J., Benesch‐Lee, F., Barbata, V., Reid, J., Thorrez, L., Valentini, R., & Crawford, G. (2008). Drug‐screening platform based on the contractility of tissue‐engineered muscle. Muscle & Nerve. https://doi.org/10.1002/mus.20931
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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