Role of disease severity, illness perceptions, and mood on quality of life in muscle disease
Abstract
Introduction The aim of this study was to describe the effect of muscle disease upon QoL and to explore the influence of disease severity, mood, and illness perception on the QoL of these patients. Methods Validated questionnaires assessing QoL (Individualized Neuromuscular QoL and SF-36), disease severity (Health Assessment Questionnaire), mood (Hospital Anxiety and Depression Scale) and illness perception (Illness Perception Questionnaire) were sent to adults with muscle disease. Results We received 302 responses (return rate 75%). QoL was reduced, particularly for "physical" domains, but "psychological" domains were also affected. Disease severity was the main determinant for the "physical" domains of QoL, but mood and illness perception played a part. Conversely, mood and illness perception were the main determinants for the "psychological" domains of QoL. Conclusions Because mood and illness perception explain significant variance in QoL in muscle disease, there is scope for devising psychosocial interventions that may improve QoL for those with muscle disease.
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- Authors
- Rose, M. R., Sadjadi, R., Weinman, J., Akhtar, T., Pandya, S., Kissel, J. T., Jackson, C. E., & the Muscle Study Group
- Affiliations
- King's College London (GB)
- King's College Hospital (GB)
- University of Rochester Medicine (US)
- The Ohio State University (US)
- The University of Texas at San Antonio Health Science Center (US)
- Corresponding author
- Rose, Michael R.
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 2012-08-20
- Volume
- 46
- Issue
- 3
- Pages
- 351-359
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2008214468
- Cited by
- 73
- References
- 3
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 5 · 2020: 1 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 5 · 2015: 2 · 2014: 7 · 2013: 5 · 2012: 2
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Muscular Dystrophy Association of USA
- Topics
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- myopathy, quality of life, disease severity, illness perception, mood, anxiety, depression, neuromuscular disorders, psychosocial interventions
- MeSH terms
- Adult, Affect, Aged, Attitude to Health, Female, Humans, Male, Middle Aged, Muscular Diseases, Perception, Quality of Life, Surveys and Questionnaires, Severity of Illness Index
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