Overactive bladder and autonomic dysfunction: lower urinary tract symptoms in females with postural tachycardia syndrome
Open accessAbstract
Aims: Postural Tachycardia Syndrome (POTS) represents an autonomic disorder predominantly affecting females between 15 and 50 years of age. POTS is a chronic disorder (>6 months) characterized by an excessive heart rate increment on standing (>30 beats/min) in the presence of characteristic symptoms of cerebral hypoperfusion or sympathetic activation. Patients have clinically been noted to describe lower urinary tract symptoms (LUTS), although urologic symptoms have not been methodically assessed in the POTS population. Herein, we present data from a pilot study designed to identify and quantitate overactive bladder (OAB) in patients diagnosed with POTS. Methods: Patients admitted to the Vanderbilt Autonomic Dysfunction Center between June 2009 and October 2010 for evaluation for the potential diagnosis of POTS completed a validated, standardized questionnaire for OAB (OAB‐q) at presentation. Symptom score and subscale analyses were conducted. Subscale health related quality of life (HRQL) scores were transformed into a 0–100 scale, with higher scores reflecting superior HRQL. Data are presented as mean ± SD. Results: Thirty‐two females presented for evaluation of symptoms consistent with POTS. Twenty‐nine women were subsequently diagnosed with POTS with 19 of these patients completing the OAB‐q questionnaire (65.5% response rate). Average age was 33.5 ± 8.3 years. Symptom severity transformed score was 26.0 ± 16.4, with 13 of 19 patients (68.4%) meeting clinical criteria for diagnosis of probable clinically significant OAB. Nocturia was the most bothersome symptom, followed by increased daytime frequency and urgency. Conclusions: This pilot study describes bothersome lower urinary tract dysfunction in patients presenting with POTS as assessed by patient‐reported questionnaire data. Nocturia demonstrated the greatest negative impact on health‐related quality of life (HRQL), while social interaction was the least affected HRQL domain. In patients with dysautonomia, this data provides a critical baseline for mechanistic insight into both disease‐specific and global pathophysiology of nocturia and OAB. Neurourol. Urodynam. 36:610–613, 2017 . © 2016 Wiley Periodicals, Inc.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lower urinary tract symptoms, including increased daytime frequency, urgency, and nocturia have been reported at higher frequencies in POTS.
“Lower urinary tract symptoms, including increased daytime frequency, urgency, and nocturia have been reported at higher frequencies in POTS (90).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [90]
The Results report that 13 of 19 women with POTS met criteria for probable overactive bladder and identify nocturia, frequency, and urgency as bothersome symptoms. The paper does not establish that each symptom occurs more frequently in POTS than in a comparison group, or separately quantify increased daytime frequency. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Abrams, P., Cardozo, L., Fall, M., GRIFFITHS, D. J., Rosier, P. F. W. M., Ulmsten, U., Kerrebroeck, P. V., Victor, A., & Wein, A. (2002) · Neurourology and Urodynamics · doi:10.1002/nau.10052 · Cited by 8,301 · see citing works
editor-in-chief, A. J. W. (2012) · Elsevier eBooks · Cited by 2,713 · see citing works
Shumaker, S. A., Wyman, J. F., Uebersax, J. S., McClish, D. K., & Fantl, J. A. (1994) · Quality of Life Research · doi:10.1007/bf00451721 · Cited by 1,098 · see citing works
Abrams, P., Cardozo, L., Fall, M., GRIFFITHS, D. J., Rosier, P. F. W. M., Ulmsten, U., Kerrebroeck, P. V., Victor, A., & Wein, A. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.125704 · Cited by 1,041 · see citing works
Diagnosis and Treatment of Overactive Bladder (Non-Neurogenic) in Adults: AUA/SUFU Guideline
Gormley, E. A., Lightner, D. J., Burgio, K. L., Chai, T. C., Clemens, J. Q., Culkin, D. J., Das, A. K., Foster, H. E., Scarpero, H. M., Tessier, C., et al. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.09.079 · Cited by 710 · see citing works
Coyne, K. S., Revicki, D. A., Hunt, T., Corey, R., Stewart, W. F., Bentkover, J. D., Kurth, H., & Abrams, P. (2002) · Quality of Life Research · doi:10.1023/a:1016370925601 · Cited by 609 · see citing works
Postural tachycardia syndrome: a heterogeneous and multifactorial disorder
Benarroch, E. E. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.08.013 · Cited by 370 · see citing works
Postural Tachycardia Syndrome (POTS)
Raj, S. R. (2013) · Circulation · doi:10.1161/circulationaha.112.144501 · Cited by 320 · see citing works
Self-citationOveractive bladder symptoms: Do we need urodynamics?
Digesu, G. A., Khullar, V., Cardozo, L., & Salvatore, S. (2003) · Neurourology and Urodynamics · doi:10.1002/nau.10099 · Cited by 245 · see citing works
Validation of an overactive bladder awareness tool for use in primary care settings
Coyne, K. S., Zyczynski, T. M., Margolis, M. K., Elinoff, V., & Roberts, R. G. (2005) · Advances in Therapy · doi:10.1007/bf02850085 · Cited by 201 · see citing works
(2006) · PubMed · Cited by 190 · see citing works
Self-citationDrake, M. J., Mills, I., & Gillespie, J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05549-0 · Cited by 165 · see citing works
The hemodynamic and neurohumoral phenotype of postural tachycardia syndrome
Garland, E. M., Raj, S. R., Black, B. K., Harris, P. A., & Robertson, D. (2007) · Neurology · doi:10.1212/01.wnl.0000267663.05398.40 · Cited by 159 · see citing works
Self-citationThe responsiveness of the Overactive Bladder Questionnaire (OAB-q)
Coyne, K. S., Matza, L. S., & Thompson, C. L. (2005) · Quality of Life Research · doi:10.1007/s11136-004-0706-1 · Cited by 136 · see citing works
Sleep Disturbances and Diminished Quality of Life in Postural Tachycardia Syndrome
Bagai, K., Song, Y., Ling, J. F., Malow, B., Black, B. K., Biaggioni, I., Robertson, D., & Raj, S. R. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.28110 · Cited by 134 · see citing works
Self-citationGuiming, L., & Daneshgari, F. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20132407 · Cited by 99 · see citing works
Hashim, H., & Abrams, P. (2007) · Current Opinion in Urology · doi:10.1097/mou.0b013e32819ed7f9 · Cited by 97 · see citing works
Loavenbruck, A., Iturrino, J., Singer, W., Sletten, D. M., Low, P. A., Zinsmeister, A. R., & Bharucha, A. E. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12480 · Cited by 63 · see citing works
Hubeaux, K., Deffieux, X., Raibaut, P., Breton, F. L., Jousse, M., & Amarenco, G. (2011) · Neurourology and Urodynamics · doi:10.1002/nau.21154 · Cited by 51 · see citing works
Autonomic nervous control of the urinary bladder
Ochodnický, P., Uvelius, B., Andersson, K., & Michel, M. C. (2012) · Acta Physiologica · doi:10.1111/apha.12010 · Cited by 46 · see citing works
Validation of a bladder symptom screening tool in women with incontinence due to overactive bladder
Cardozo, L., Staskin, D. R., Currie, B. M., Wiklund, I. E., GLOBE, D. R., Signori, M., Dmochowski, R. R., MacDiarmid, S., Νitti, V. W., & Noblett, K. L. (2014) · International Urogynecology Journal · doi:10.1007/s00192-014-2417-7 · Cited by 31 · see citing works
Self-citationHsiao, S., Su, T., Chen, C., Chang, T., & Lin, H. (2014) · Maturitas · doi:10.1016/j.maturitas.2014.06.001 · Cited by 26 · see citing works
Ateş, E., İpekçi, T., Akın, Y., Kızılay, F., Kukul, E., & Günteki̇n, E. (2014) · Neurourology and Urodynamics · doi:10.1002/nau.22652 · Cited by 20 · see citing works
Comorbid health conditions in women with syncope
Ulaş, Ü. H., Chelimsky, T. C., Chelimsky, G. G., Mandawat, A., McNeeley, K., & Alshekhlee, A. (2010) · Clinical Autonomic Research · doi:10.1007/s10286-010-0070-x · Cited by 18 · see citing works
Blanc, F., Pichot, V., Roche, F., Jc, B., & Tostain, J.-B. (2001) · PubMed · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [21]Wein AJaRRD Neuromuscular dysfunction of the lower urinary tract - Chapter 65 Campbell-Walsh Urology 10th K LR Wein AJ Novick AC Partin AW Peters CA 2013 Elsevier Philadelphia
Cited by
Sorted by citations
Postural Orthostatic Tachycardia Syndrome
Bryarly, M., Phillips, L. T., Fu, Q., Vernino, S., & Levine, B. D. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.059 · Cited by 245 · see citing works
Pathophysiology of refractory overactive bladder
Chen, L., & Kuo, H. (2019) · LUTS Lower Urinary Tract Symptoms · doi:10.1111/luts.12262 · Cited by 78 · see citing works
Evaluation of postural tachycardia syndrome (POTS)
Goodman, B. P. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.004 · Cited by 77 · see citing works
The Central Autonomic Network and Regulation of Bladder Function
Roy, H., & Green, A. L. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00535 · Cited by 76 · see citing works
Pediatric joint hypermobility: a diagnostic framework and narrative review
Tofts, L. J., Simmonds, J., Schwartz, S. B., Richheimer, R. M., O’Connor, C., Elias, E., Engelbert, R., Cleary, K., Tinkle, B. T., Kline, A. D., et al. (2023) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-023-02717-2 · Cited by 74 · see citing works
“Primary dysautonomia [34] Joint pain > 40%, muscle pain > 30% > 90% Nausea, early satiety > 60%, abdominal pain > 50%, constipation diarrhea and vomiting all > 20% 68% (note adults only) [35]”
BackgroundCOVID-19 Induced Postural Orthostatic Tachycardia Syndrome (POTS): A Review
Mallick, D. C., Goyal, L., Chourasia, P. K., Zapata, M. R., Yashi, K., & Surani, S. (2023) · Cureus · doi:10.7759/cureus.36955 · Cited by 58 · see citing works
Quantitative assessment of autonomic symptom burden in Postural tachycardia syndrome (POTS)
Rea, N. A., Campbell, C. L., & Cortez, M. M. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.03.032 · Cited by 52 · see citing works
Management of headache and chronic pain in POTS
Cook, G. A., & Sandroni, P. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.06.004 · Cited by 28 · see citing works
Smith, S. J., Sichlau, M. J., Sewall, L. E., Smith, B. H., Chen, B., Khurana, N., & Rowe, P. C. (2022) · Phlebology The Journal of Venous Disease · doi:10.1177/02683555221112567 · Cited by 20 · see citing works
Smith, S. J., Sichlau, M. J., Smith, B. H., Knight, D. R. T., Chen, B., & Rowe, P. C. (2023) · Phlebology The Journal of Venous Disease · doi:10.1177/02683555231219737 · Cited by 16 · see citing works
Postural orthostatic tachycardia syndrome: pathophysiology, management, and experimental therapies
Narasimhan, B., Aggarwal, D., Satish, P., Kantharia, B. K., & Aronow, W. S. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2121697 · Cited by 12 · see citing works
Synergistic but separable sensory changes in postural tachycardia syndrome and chronic migraine
Cortez, M. M., Millsap, L., & Brennan, K. C. (2021) · Clinical Autonomic Research · doi:10.1007/s10286-020-00740-y · Cited by 11 · see citing works
The Postural Tachycardia Syndrome (PoTS) Bladder—Urodynamic Findings
Walker, N. F., Gall, R., Gall, N. P., Feuer, J., Harvey, H., & Taylor, C. (2021) · Urology · doi:10.1016/j.urology.2021.02.028 · Cited by 9 · see citing works
Postural Orthostatic Tachycardia Syndrome Associated with COVID-19: A Narrative Review
Park, J.-H., Park, S., Kim, N.-H., Lee, Y., Chang, Y., & Song, T.-J. (2024) · Medicina · doi:10.3390/medicina60081325 · Cited by 9 · see citing works
Current optimal pharmacologic therapies for overactive bladder
Jiang, Y., & Kuo, H. (2023) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2023.2264183 · Cited by 8 · see citing works
Lower urinary tract dysfunction reported in autonomic disorders
Vichayanrat, E., Koay, S., Hentzen, C., Wright, S. L., Batla, A., Simeoni, S., Iodice, V., & Panicker, J. N. (2025) · Autonomic Neuroscience · doi:10.1016/j.autneu.2025.103341 · Cited by 7 · see citing works
Impact of Autonomic Dysfunction on Lower Urinary Tract Symptoms
Kowalik, C. G., Cohn, J. A., Kaufman, M. R., Reynolds, W. M., Dmochowski, R. R., & Milam, D. F. (2017) · Current Bladder Dysfunction Reports · doi:10.1007/s11884-017-0426-3 · Cited by 6 · see citing works
Self-citationDysautonomia in systemic lupus erythematosus: when to suspect and how to investigate
Frazatto, C. F. C., Martinez, A. R. M., & Appenzeller, S. (2025) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2025.2511265 · Cited by 5 · see citing works
Postural Orthostatic Tachycardia Syndrome: Diagnosis and Management Guide for Nurses
Seeley, M., Lau, D. H., & Gallagher, C. (2023) · Nursing Research and Reviews · doi:10.2147/nrr.s394822 · Cited by 3 · see citing works
Herrera, A., & Behm, J. (2021) · Occupational Therapy In Health Care · doi:10.1080/07380577.2021.1967548 · Cited by 3 · see citing works
Bourne, K. M., Gamboa, A., Black, B., Hall, J., Biaggioni, I., Shibao, C. A., Diedrich, A., Peltier, A., Jacob, G., Okamoto, L. E., et al. (2026) · Journal of Internal Medicine · doi:10.1111/joim.70104 · Cited by 2 · see citing works
Self-citationMinnerath, E., Khazen, O., Panicker, J. N., Drake, M. J., & De, E. (2026) · Current Urology Reports · doi:10.1007/s11934-026-01343-2 · Cited by 2 · see citing works
Urological Considerations in PoTS
Tailor, V. K., & Khullar, V. (2020) · Springer eBooks · doi:10.1007/978-3-030-54165-1_17 · Cited by 2 · see citing works
Dizziness, Syncope, and Autonomic Dysfunction in Children
Kakavand, B. (2022) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2022.101512 · Cited by 2 · see citing works
Beyond Joint Hypermobility: Investigating Bladder Dysfunction in Hypermobile Ehlers‐Danlos Syndrome
Ansari, M., Pine, M., Sapkalova, V., Brodowsky, E. C., Powell, C. R., & Burns, R. T. (2026) · Neurourology and Urodynamics · doi:10.1002/nau.70351 · Cited by 1 · see citing works
Factores que dificultan el diagnóstico del síndrome de taquicardia ortostática postural
Méndez, A. M. V., Córdova, A., Cáceres, C., Perdomo, A., & Rodríguez, N. (2022) · ALERTA Revista Científica del Instituto Nacional de Salud · doi:10.5377/alerta.v5i2.13369
Aus dem Leben gerissen – Postakute Infektionssyndrome nach Covid-19
Hackl, V., & Hoffmann, K. (2024) · physiopraxis · doi:10.1055/a-2346-6668
Smith, S. J., Sichlau, M. J., Rowe, P. C., Knight, D. R. T., Chen, B., Smith, B. H., & Sichlau, I. C. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1574432
Tamilson, B., Fenske, O., Morrin, H., Coebergh, J., Agrawal, N., Owens, A., Lim, P., & Poole, N. (2026) · Swiss Archives of Neurology, Psychiatry and Psychotherapy · doi:10.3390/sanpp176020010
- Authors
- Kaufman, M. R., Chang‐Kit, L., Raj, S. R., Black, B. K., Milam, D. F., Reynolds, W. S., Biaggioni, I., Robertson, D., & Dmochowski, R. R.
- Affiliations
- Vanderbilt University (US)
- Division of Urology Albany Medical College Albany New York
- Department of Urologic Surgery Vanderbilt University Nashville Tennessee
- Corresponding author
- Kaufman, Melissa R.
- Venue
- Neurourology and Urodynamics
- Publisher
- Wiley
- Published
- 2016-02-09
- Volume
- 36
- Issue
- 3
- Pages
- 610-613
- ISSN
- 0733-2467 (ISSN-L)
- 1520-6777
- PMC
- PMC4980267
- OpenAlex
- W2275052573
- Cited by
- 29
- References
- 25
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurourology and Urodynamics (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P01 HL56694)
- Topics
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Keywords
- postural orthostatic tachycardia syndrome, overactive bladder, lower urinary tract symptoms, autonomic dysfunction, nocturia, health-related quality of life, women, urinary frequency
- MeSH terms
- Adult, Female, Humans, Pilot Projects, Quality of Life, Surveys and Questionnaires, Urinary Bladder, Overactive, Postural Orthostatic Tachycardia Syndrome, Lower Urinary Tract Symptoms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
