CoChat
Sign Up
Cited by 77Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlLong-Term Effects of COVID-19

Evaluation of postural tachycardia syndrome (POTS)

Goodman, Brent P.·2018·Autonomic Neuroscience
DOI 10.1016/j.autneu.2018.04.004
Open this paper in CoChat — free account

Abstract

The diagnostic evaluation of a patient with suspected postural tachycardia syndrome (POTS) requires a thoughtful diagnostic approach utilizing a careful clinical history and examination, laboratory, and autonomic testing. This article outlines the importance of a thorough history in identifying mechanism of symptom onset, clinical features, associated clinical conditions or disorders, and factors that may result in symptom exacerbation. The clinical examination involves an assessment of pupillary responses, an evaluation for sudomotor and vasomotor signs, and an assessment for joint hypermobility. Laboratory testing helps to exclude mimics of autonomic dysfunction, recognize conditions that may exacerbate symptoms, and to identify conditions that may cause or be associated with autonomic nervous system disease. The purpose of autonomic testing is to confirm a POTS diagnosis, exclude other causes of orthostatic intolerance, and may provide for characterization of POTS into neuropathic and hyperadrenergic subtypes. Other diagnostic studies, such as epidermal skin punch biopsy, exercise testing, radiographic studies, sleep studies, gastrointestinal motility studies, and urodynamic studies should be considered when clinically appropriate.

Integrity signals

Registry

Crossref · 10.1016/j.autneu.2018.04.004

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Tests that measure the integrity of the cardiovagal and peripheral vasomotor adrenergic responses will be normal in most, but not all, POTS patients.

    “Tests that measure the integrity of the cardiovagal and peripheral vasomotor adrenergic responses will be normal in most, but not all, POTS patients (Goodman, 2018).”

    From Postural orthostatic tachycardia syndrome (POTS): State of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1 (2021) · cites this paper as Goodman, 2018

  • Cardiovascular POTS symptoms relate to inadequate and exaggerated standing heart rate increase, global postural haemodynamic instability with hypertensive or hypotensive tendency, cerebral hypoperfusion, venous pooling, and vascular tone dysregulation in specific areas.

    “This group of symptoms is related to an inadequate and exaggerated heart rate increase on standing, global postural haemodynamic instability, either hypertensive or hypotensive tendency, cerebral hypoperfusion, venous pooling, and disorders of vascular tone regulation in specific areas such as head, coronary arteries, skin, extremities [20,32,34,35] (Table 2).”

    From Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management (2019) · cites this paper as [34]

Cites

Flagged first, then by citations

1 of the 60 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Goodman, B. P.
Affiliations
Mayo Clinic in Arizona (US)
Corresponding author
Goodman, Brent P.
Venue
Autonomic Neuroscience
Publisher
Elsevier BV
Published
2018-12
Volume
215
Pages
12-19
ISSN
1566-0702 (ISSN-L)
DOI
10.1016/j.autneu.2018.04.004
OpenAlex
W2802784698
Cited by
77
References
60
Citations by year
2026: 4 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 9 · 2018: 6
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Autonomic Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
Keywords
postural orthostatic tachycardia syndrome, autonomic dysfunction, orthostatic intolerance, diagnostic assessment, medical history, autonomic function testing, sudomotor function, vasomotor function, joint hypermobility, exercise testing, polysomnography, gastrointestinal motility, urodynamic study
MeSH terms
Humans, Postural Orthostatic Tachycardia Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review