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ProFit: two‐dimensional prior‐knowledge fitting of J‐resolved spectra
Abstract
A two‐dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J‐resolved magnetic resonance spectroscopic data. The fitting procedure uses a linear combination of 2D model spectra. For reducing the degrees of freedom and increasing robustness, it is divided into a non‐linear outer loop and an inner linear least‐squares fit for the concentrations. In vitro and in vivo experiments on a whole‐body 3 T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N‐acetylaspartate, N‐acetylaspartylglutamate, choline‐containing compounds, glutamate, myo‐inositol, glutathione, scyllo‐inositol, γ‐aminobutyric acid, alanine and ascorbic acid. Copyright © 2006 John Wiley & Sons, Ltd.
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Cited by
In vivo magnetic resonance spectroscopy of GABA: A methodological review
Puts, N. A. J., & Edden, R. A. E. (2012) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2011.06.001 · Cited by 393
Wilson, M., Reynolds, G., Kauppinen, R. A., Arvanitis, T. N., & Peet, A. C. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22579 · Cited by 332
Walter, M., Henning, A., Grimm, S., Schulte, R. F., Beck, J., Dydak, U., Schnepf, B., Boeker, H., Boesiger, P., & Northoff, G. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.39 · Cited by 306
Self-citationGlutamate and glutamine: a review of in vivo MRS in the human brain
Ramadan, S., Lin, A., & Stanwell, P. (2013) · NMR in Biomedicine · doi:10.1002/nbm.3045 · Cited by 282
Abnormal Glutamatergic Neurotransmission and Neuronal-Glial Interactions in Acute Mania
Öngür, D., Jensen, J. E., Prescot, A. P., Stork, C., Lundy, M., Cohen, B. M., & Renshaw, P. F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.014 · Cited by 270
Metadata
- Authors
- Schulte, R. F., & Boesiger, P.
- Venue
- NMR in Biomedicine
- Publisher
- Wiley
- Published
- 2006-03-16
- Volume
- 19
- Issue
- 2
- Pages
- 255-263
- ISSN
- 0952-3480 (ISSN-L)
- 1099-1492
- OpenAlex
- W2003392039
- Cited by
- 175
- References
- 0
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schulte, R. F., & Boesiger, P. (2006). ProFit: two‐dimensional prior‐knowledge fitting of J‐resolved spectra. NMR in Biomedicine. https://doi.org/10.1002/nbm.1026
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