Cited by 205Wound Healing and TreatmentsRetinoids in leukemia and cellular processesBurn Injury Management and Outcomes

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The Role of Vitamin A in Wound Healing

Polcz, Monica E., Barbul, Adrian·2019·Nutrition in Clinical Practice

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Abstract

Vitamin A is an essential micronutrient that comes in multiple forms, including retinols, retinals, and retinoic acids. Dietary vitamin A is absorbed as retinol from preformed retinoids or as pro–vitamin A carotenoids that are converted into retinol in the enterocyte. These are then delivered to the liver for storage via chylomicrons and later released into the circulation and to its biologically active tissues bound to retinol‐binding protein. Vitamin A is a crucial component of many important and diverse biological functions, including reproduction, embryological development, cellular differentiation, growth, immunity, and vision. Vitamin A functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator‐activated receptors. Retinoids regulate the growth and differentiation of many cell types within skin, and its deficiency leads to abnormal epithelial keratinization. In wounded tissue, vitamin A stimulates epidermal turnover, increases the rate of re‐epithelialization, and restores epithelial structure. Retinoids have the unique ability to reverse the inhibitory effects of anti‐inflammatory steroids on wound healing. In addition to its role in the inflammatory phase of wound healing, retinoic acid has been demonstrated to enhance production of extracellular matrix components such as collagen type I and fibronectin, increase proliferation of keratinocytes and fibroblasts, and decrease levels of degrading matrix metalloproteinases.

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Authors: Polcz, M. E., & Barbul, A.
Affiliations: Vanderbilt University Medical Center (US)
VA Tennessee Valley Healthcare System (US)
Corresponding author: Polcz, Monica E.
ORCID: Polcz, Monica E.
Barbul, Adrian
Venue: Nutrition in Clinical Practice
Publisher: Wiley
Published: 2019-08-07
Volume: 34
Issue: 5
Pages: 695-700
ISSN: 0884-5336 (ISSN-L)
1941-2452
DOI: 10.1002/ncp.10376
OpenAlex: W2965905064
Cited by: 205
References: 74
Citations by year: 2026: 20 · 2025: 40 · 2024: 45 · 2023: 32 · 2022: 30 · 2021: 20 · 2020: 16 · 2019: 2
FWCI: 2.38
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Nutrition in Clinical Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
Keywords: vitamin A, wound healing, retinoids, retinoic acid, retinol, carotenoids, retinol-binding protein, retinoic acid receptor, keratinization, re-epithelialization, extracellular matrix, type I collagen, fibronectin, matrix metalloproteinases, keratinocyte proliferation, fibroblast proliferation, anti-inflammatory steroids, epithelial cell turnover
MeSH terms: Humans, Retinoids, Retinol-Binding Proteins, Vitamin A, Wound Healing, Receptors, Retinoic Acid

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The Role of Vitamin A in Wound Healing

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