The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
The Role of Vitamin A in Wound Healing
Abstract
Vitamin A is an essential micronutrient that comes in multiple forms, including retinols, retinals, and retinoic acids. Dietary vitamin A is absorbed as retinol from preformed retinoids or as pro–vitamin A carotenoids that are converted into retinol in the enterocyte. These are then delivered to the liver for storage via chylomicrons and later released into the circulation and to its biologically active tissues bound to retinol‐binding protein. Vitamin A is a crucial component of many important and diverse biological functions, including reproduction, embryological development, cellular differentiation, growth, immunity, and vision. Vitamin A functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator‐activated receptors. Retinoids regulate the growth and differentiation of many cell types within skin, and its deficiency leads to abnormal epithelial keratinization. In wounded tissue, vitamin A stimulates epidermal turnover, increases the rate of re‐epithelialization, and restores epithelial structure. Retinoids have the unique ability to reverse the inhibitory effects of anti‐inflammatory steroids on wound healing. In addition to its role in the inflammatory phase of wound healing, retinoic acid has been demonstrated to enhance production of extracellular matrix components such as collagen type I and fibronectin, increase proliferation of keratinocytes and fibroblasts, and decrease levels of degrading matrix metalloproteinases.
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“Retinoids also affect the thickness and color of the skin, regulate the function of the sebaceous glands, and limit sebum production, as well as being responsible for hair and nail growth, and also influencing the distribution of melanin in the skin [27,30,35].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [30]
In the citing paper
“Topically applied retinoids penetrate the keratinized epidermis and, to a lesser extent, the dermis and subcutaneous tissue [27,30,35].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [30]
Citations
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Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345
“Topically applied retinoids penetrate the keratinized epidermis and, to a lesser extent, the dermis and subcutaneous tissue [27,30,35].”
BackgroundWound Healing: A Comprehensive Review
Almadani, Y. H., Vorstenbosch, J., Davison, P. G., & Murphy, A. M. (2021) · Seminars in Plastic Surgery · doi:10.1055/s-0041-1731791 · Cited by 369
Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing
Jiang, Z., Zheng, Z., Yu, S., Gao, Y., Ma, J., Huang, L., & Yang, L. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071829 · Cited by 186
Monkeypox: A Comprehensive Review
Harapan, H., Ophinni, Y., Megawati, D., Frediansyah, A., Mamada, S. S., Salampe, M., Emran, T. B., Winardi, W., Fathima, R., Sirinam, S., et al. (2022) · Viruses · doi:10.3390/v14102155 · Cited by 171
Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
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Metadata
- Authors
- Polcz, M. E., & Barbul, A.
- Affiliations
- Vanderbilt University Medical Center (US)
- VA Tennessee Valley Healthcare System (US)
- Corresponding author
- Polcz, Monica E.
- Venue
- Nutrition in Clinical Practice
- Publisher
- Wiley
- Published
- 2019-08-07
- Volume
- 34
- Issue
- 5
- Pages
- 695-700
- ISSN
- 0884-5336 (ISSN-L)
- 1941-2452
- OpenAlex
- W2965905064
- Cited by
- 205
- References
- 74
- Citations by year
- 2026: 20 · 2025: 40 · 2024: 45 · 2023: 32 · 2022: 30 · 2021: 20 · 2020: 16 · 2019: 2
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
- Keywords
- vitamin A, wound healing, retinoids, retinoic acid, retinol, carotenoids, retinol-binding protein, retinoic acid receptor, keratinization, re-epithelialization, extracellular matrix, type I collagen, fibronectin, matrix metalloproteinases, keratinocyte proliferation, fibroblast proliferation, anti-inflammatory steroids, epithelial cell turnover
- MeSH terms
- Humans, Retinoids, Retinol-Binding Proteins, Vitamin A, Wound Healing, Receptors, Retinoic Acid
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