The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
The Role of Vitamin A in Wound Healing
Abstract
Vitamin A is an essential micronutrient that comes in multiple forms, including retinols, retinals, and retinoic acids. Dietary vitamin A is absorbed as retinol from preformed retinoids or as pro–vitamin A carotenoids that are converted into retinol in the enterocyte. These are then delivered to the liver for storage via chylomicrons and later released into the circulation and to its biologically active tissues bound to retinol‐binding protein. Vitamin A is a crucial component of many important and diverse biological functions, including reproduction, embryological development, cellular differentiation, growth, immunity, and vision. Vitamin A functions mostly through nuclear retinoic acid receptors, retinoid X receptors, and peroxisome proliferator‐activated receptors. Retinoids regulate the growth and differentiation of many cell types within skin, and its deficiency leads to abnormal epithelial keratinization. In wounded tissue, vitamin A stimulates epidermal turnover, increases the rate of re‐epithelialization, and restores epithelial structure. Retinoids have the unique ability to reverse the inhibitory effects of anti‐inflammatory steroids on wound healing. In addition to its role in the inflammatory phase of wound healing, retinoic acid has been demonstrated to enhance production of extracellular matrix components such as collagen type I and fibronectin, increase proliferation of keratinocytes and fibroblasts, and decrease levels of degrading matrix metalloproteinases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Retinoids also affect the thickness and color of the skin, regulate the function of the sebaceous glands, and limit sebum production, as well as being responsible for hair and nail growth, and also influencing the distribution of melanin in the skin [27,30,35].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [30]
In the citing paper
“Topically applied retinoids penetrate the keratinized epidermis and, to a lesser extent, the dermis and subcutaneous tissue [27,30,35].”
From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [30]
Citations
Cites
Trumbo (2001) · doi:10.1016/s0002-8223(01)00078-5 · Cited by 4,852
TISSUE CHANGES FOLLOWING DEPRIVATION OF FAT-SOLUBLE A VITAMIN
Wolbach, S., & Howe, P. R. (1925) · Journal of Experimental Medicine · doi:10.1084/jem.42.6.753 · Cited by 1,674
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410
Gene expression regulation by retinoic acid
Balmer, J. E., & Blomhoff, R. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r100015-jlr200 · Cited by 1,039
Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).
Sporn, M. B., Dunlop, N. M., Newton, D. L., & Smith, J. M. (1976) · PubMed · Cited by 992
A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A
Kawaguchi, R., Yu, J., Honda, J., Hu, J., Whitelegge, J., Ping, P., Wiita, P., Bok, D., & Sun, H. (2007) · Science · doi:10.1126/science.1136244 · Cited by 836
Teratogenicity of high vitamin A intake
Rothman, K. J., Moore, L. L., Singer, M. R., Nguyen, U.-S. D. T., Mannino, S., & Milunsky, A. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332101 · Cited by 754
Schug, T. T., Berry, D. C., Shaw, N. S., Travis, S. N., & Noy, N. (2007) · Cell · doi:10.1016/j.cell.2007.02.050 · Cited by 680
Varani, J., Warner, R. L., Gharaee-Kermani, M., Phan, S. H., Kang, S., Chung, J., Wang, Z., Datta, S. C., Fisher, G. J., & Voorhees, J. J. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00902.x · Cited by 643
The acute and chronic toxic effects of vitamin A
Penniston, K. L., & Tanumihardjo, S. A. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.191 · Cited by 576
Topical Tretinoin Improves Photoaged Skin
Weiss, J. (1988) · JAMA · doi:10.1001/jama.1988.03720040019020 · Cited by 490
Effects of Cortisone and Vitamin A on Wound Healing
Ehrlich, H. P., & Hunt, T. K. (1968) · Annals of Surgery · doi:10.1097/00000658-196803000-00004 · Cited by 457
Hepatic stellate cell lipid droplets: A specialized lipid droplet for retinoid storage
Blaner, W. S., O'Byrne, S. M., Wongsiriroj, N., Kluwe, J., D'Ambrosio, D. M., Jiang, H., Schwabe, R. F., Hillman, E. M. C., Piantedosi, R., & Libien, J. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2008.11.001 · Cited by 444
Vitamin A and retinoid signaling: genomic and nongenomic effects
Al Tanoury, Z., Piskunov, A., & Rochette-Egly, C. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r030833 · Cited by 408
Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids
Harrison, E. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.002 · Cited by 365
Effects of Steroids and Retinoids on Wound Healing
Wicke, C. (2000) · Archives of Surgery · doi:10.1001/archsurg.135.11.1265 · Cited by 358
Tissue distribution and metabolism of newly absorbed vitamin A in the rat
Goodman, D. S., Huang, H. S., & Shiratori, T. (1965) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39309-3 · Cited by 292
Class B Scavenger Receptor-Mediated Intestinal Absorption of Dietary β-Carotene and Cholesterol
van Bennekum, A., Werder, M., Thuahnai, S. T., Han, C.-H., Duong, P., Williams, D. L., Wettstein, P., Schulthess, G., Phillips, M. C., & Hauser, H. (2005) · Biochemistry · doi:10.1021/bi0484320 · Cited by 290
Biochemical Indicators of Vitamin A Deficiency: Serum Retinol and Serum Retinol Binding Protein
de Pee, S., & Dary, O. (2002) · Journal of Nutrition · doi:10.1093/jn/132.9.2895s · Cited by 277
Effects of Vitamin A and Glucocorticoids upon Inflammation and Collagen Synthesis
Ehrlich, H. P., Tarver, H., & Hunt, T. K. (1973) · Annals of Surgery · doi:10.1097/00000658-197302000-00017 · Cited by 252
Colors with Functions: Elucidating the Biochemical and Molecular Basis of Carotenoid Metabolism
Lintig, J. V. (2010) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141027 · Cited by 239
Modulation of T Cell and Innate Immune Responses by Retinoic Acid
Raverdeau, M., & Mills, K. H. G. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303245 · Cited by 222
Effects of chronic corticosteroids and vitamin a on the healing of intestinal anastomoses
Phillips, J. D., Kim, C. S., Fonkalsrud, E. W., Zeng, H., & Dindar, H. (1992) · The American Journal of Surgery · doi:10.1016/0002-9610(92)90255-p · Cited by 206
Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites
Russell, R. M., Boyer, J. L., Bagheri, S. A., & Hruban, Z. (1974) · New England Journal of Medicine · doi:10.1056/nejm197408292910903 · Cited by 205
Stephensen, C. B., & Gildengorin, G. L. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1170 · Cited by 195
Hunt, T. K., Ehrlich, H. P., García, J. A., & Dunphy, J. E. (1969) · Annals of Surgery · doi:10.1097/00000658-196910000-00014 · Cited by 182
Epidemiology of vitamin A deficiency and xerophthalmia in at-risk populations
Sherwin, J. C., Reacher, M. H., Dean, W. H., & Ngondi, J. (2012) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/j.trstmh.2012.01.004 · Cited by 161
Vitamin A Absorption, Storage and Mobilization
Blaner, W. S., Li, Y., Brun, P.-J., Yuen, J. J., Lee, S.-A., & Clugston, R. D. (2016) · Subcellular Biochemistry · doi:10.1007/978-94-024-0945-1_4 · Cited by 161
Hunt, T. K. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70238-7 · Cited by 160
Topical Retinoids in Acne Vulgaris
Thielitz, A., & Gollnick, H. P. M. (2008) · American Journal of Clinical Dermatology · doi:10.2165/0128071-200809060-00003 · Cited by 145
Meeting the Vitamin A Requirement: The Efficacy and Importance ofβ-Carotene in Animal Species
Green, A. S., & Fascetti, A. J. (2016) · The Scientific World JOURNAL · doi:10.1155/2016/7393620 · Cited by 144
During, A., & Harrison, E. H. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m700263-jlr200 · Cited by 137
Oral Retinoids in the Treatment of Seborrhoea and Acne
Orfanos, C. E., & Zouboulis, C. C. (1998) · Dermatology · doi:10.1159/000017848 · Cited by 130
The multifaceted nature of retinoid transport and metabolism
(2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.05.04 · Cited by 125
Hypervitaminosis A syndrome: A paradigm of retinoid side effects
Silverman, A. K., Ellis, C. N., & Voorhees, J. J. (1987) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(87)70133-9 · Cited by 121
Moriwaki, H., Blaner, W. S., Piantedosi, R., & Goodman, D. S. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38430-3 · Cited by 105
Patients with Chronic Leg Ulcers Show Diminished Levels of Vitamins A and E, Carotenes, and Zinc
Rojas, A. I., & Phillips, T. J. (1999) · Dermatologic Surgery · doi:10.1046/j.1524-4725.1999.99074.x · Cited by 99
Reboul, E., Berton, A., Moussa, M., Kreuzer, C., Crenon, I., & Borel, P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.12.013 · Cited by 90
Benign Intracranial Hypertension Associated With Hypervitaminosis A
Feldman, M. H., & Schlezinger, N. S. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480190005001 · Cited by 85
Daly, T. J., & Weston, W. L. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70248-x · Cited by 76
Molecular Mechanisms of Intrinsic Skin Aging and Retinoid-Induced Repair and Reversal
Varani, J., Fisher, G. J., Kang, S., & Voorhees, J. J. (1998) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.1998.14 · Cited by 74
The noninvasive mouse ear swelling assay *1I. Refinements for detecting weak contact sensitizers
Thorne, P. S. (1991) · Fundamental and Applied Toxicology · doi:10.1016/0272-0590(91)90186-8 · Cited by 67
Inflammation and biomarkers of micronutrient status
Thurnham, D. I., & Northrop‐Clewes, C. A. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000323 · Cited by 66
Influence of Vitamin A on Wound Healing in Rats with Femoral Fracture
Seifter, E., CROWLEY, L. V., Rettura, G., NAKAOS, K., GRUBER, C., Kan, D., & Levenson, S. Μ. (1975) · Annals of Surgery · doi:10.1097/00000658-197506000-00013 · Cited by 59
Retinyl ester hydrolytic activity associated with human intestinal brush border membranes
Rigtrup, K. M., McEwen, L., Said, H., & Ong, D. E. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.1.111 · Cited by 56
Safety Evaluation of Synthetic β-Carotene
Woutersen, R. A., Wolterbeek, A. P. M., Appel, M. J., van den Berg, H., Goldbohm, R. A., & Feron, V. J. (1999) · Critical Reviews in Toxicology · doi:10.1080/10408449991349267 · Cited by 56
Vitamin A Esterification in Human Epidermis: A Relation to Keratinocyte Differentiation
Törmä, H., & Vahlquist, A. (1990) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12873990 · Cited by 54
Studies on the in vivo transfer to retinoids from parenchymal to stellate cells in rat liver
Blaner, W. S., Dixon, J. L., Moriwaki, H., MARTINO, R. A., Stein, O., Stein, Y., & Goodman, D. S. (1987) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1987.tb11058.x · Cited by 49
Acitretin revisited in the era of biologics
Booij, M. T., & van de Kerkhof, P. C. M. (2010) · Journal of Dermatological Treatment · doi:10.3109/09546630903578582 · Cited by 44
Moody, B. J. (1982) · Clinica Chimica Acta · doi:10.1016/0009-8981(82)90229-7 · Cited by 43
Glucocorticoid and retinoid regulation of alpha‐2 type I procollagen promoter activity
Perez, J. R., Shull, S., Cutroneo, K. R., Gendimenico, G. J., Capetola, R. J., & Mezick, J. A. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240500107 · Cited by 43
Reversal of postoperative immunosuppression in man by vitamin A.
Be, C., Gill, G., Pr, C., & Morris, P. J. (1979) · PubMed · Cited by 43
White Cell Involvement in the Inflammatory, Wound Healing, and Immune Actions of Vitamin A
Barbul, A., Thysen, B., Rettura, G., Levenson, S. Μ., & SEIFTER, E. J. (1978) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860717800200208 · Cited by 40
Self-citationRetinol (vitamin A) is a cofactor in CD3‐induced human T‐lymphocyte activation
Allende, L. M., Corell, A., Madroño, A., Góngora, R., Rodríguez‐Gallego, C., López-Goyanes, A., Rosal, M. C., & Arnaiz‐Villena, A. (1997) · Immunology · doi:10.1111/j.1365-2567.1997.00388.x · Cited by 39
VITAMIN A ASSAY IN BURNED PATIENTS
Rai, K., & Courtemanche, A. D. (1975) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-197505000-00008 · Cited by 39
Modulation of B-Cell Immunoglobulin Synthesis by Retinoic Acid
Ballow, M. C., Wang, W., & Xiang, S. (1996) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1996.0144 · Cited by 38
Carotenoids and Retinoids: Nomenclature, Chemistry, and Analysis
Harrison, E. H., & Curley, R. W. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-024-0945-1_1 · Cited by 38
The Visual Function of the Vitamins A
Wald, G. (1961) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60872-9 · Cited by 37
Zone II flexor tendon repair: Effects of vitamins A, E, β-carotene
Greenwald, D. P., Sharzer, L. A., Padawer, J., Levenson, S. Μ., & Seifter, E. (1990) · Journal of Surgical Research · doi:10.1016/0022-4804(90)90117-k · Cited by 36
Retinol-Binding Protein Mediates Uptake of Retinol to Cultured Human Keratinocytes
Båvik, C., Peterson, P. A., & Eriksson, U. (1995) · Experimental Cell Research · doi:10.1006/excr.1995.1045 · Cited by 34
Busch, C., Siegenthaler, G., Vahlquist, A., Nordlinder, H., Sundelin, J., Saksena, P., & Eriksson, U. J. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12614757 · Cited by 33
Physiological Role of Retinyl Palmitate in the Skin
Fu, P. P., Xia, Q., Boudreau, M. D., Howard, P. C., Tolleson, W. H., & Wamer, W. G. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)75009-9 · Cited by 32
Sorg, O., Iran, C., Carraux, P., Grand, D., Hügin, A. W., Didierjean, L., & Saurat, J. ‐. (2005) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2005.tb01450.x · Cited by 28
Molecular Mechanisms of Intrinsic Skin Aging and Retinoid-Induced Repair and Reversal
Varani, J., Fisher, G. J., Kang, S., & Voorhees, J. J. (1998) · Journal of Investigative Dermatology · doi:10.1038/jidsp.1998.14 · Cited by 28
Isotretinoin Therapy for Progressive Systemic Sclerosis
Bahmer, F. A. (1985) · Archives of Dermatology · doi:10.1001/archderm.1985.01660030028010 · Cited by 24
Effect of vitamin A and citral on peritoneal adhesion formation
Demetriou, A. A., Seifter, E., & Levenson, S. Μ. (1974) · Journal of Surgical Research · doi:10.1016/0022-4804(74)90138-3 · Cited by 20
Effects of Vitamin A and Beta Carotene on Intra-abdominal Sepsis
Demetriou, A. A. (1984) · Archives of Surgery · doi:10.1001/archsurg.1984.01390140027005 · Cited by 20
Transcriptional regulation by retinoic acid of interleukin-2 alpha receptors in human B cells.
Bhatti, L., & Sidell, N. (1994) · PubMed · Cited by 15
Sorg, O., Tran, C., Carraux, P., Grand, D., Hügin, A. W., Didierjean, L., & Saurat, J. ‐. (2005) · Photochemistry and Photobiology · doi:10.1562/2004-10-01-ra-333r1.1 · Cited by 15
Sailstad, D. M., Boykin, E. H., Slade, R., Doerfler, D. L., & Selgrade, M. K. (2000) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2000)0720766teoava2.0.co2 · Cited by 12
Effect of Corticosterone on the Plasma and Tissue Concentrations of Vitamin A in Rats
Atukorala, S., Basu, T. K., & Dickerson, J. W. T. (1981) · Annals of Nutrition and Metabolism · doi:10.1159/000176500 · Cited by 10
Effect of dietary supplementation with vitamin A on arterial healing in rats
Niu, X. T., Cushin, B. J., Reisner, A., Levenson, S. Μ., & Demetriou, A. A. (1987) · Journal of Surgical Research · doi:10.1016/0022-4804(87)90066-7 · Cited by 9
The Noninvasive Mouse Ear Swelling Assay
Thorne, P. S., Hawk, C., KALISZEWSKI, S. D., & Guiney, P. D. (1991) · Toxicological Sciences · doi:10.1093/toxsci/17.4.807 · Cited by 7
Research works printed but not linked: 1
- WHO, 2011, Guideline: Vitamin A Supplementation in Infants and Children 6–59 Months of Age
Cited by
Sorted by citations
Bioactive Compounds for Skin Health: A Review
Michalak, M., Pierzak, M., Kręcisz, B., & Suliga, E. (2021) · Nutrients · doi:10.3390/nu13010203 · Cited by 345
“Topically applied retinoids penetrate the keratinized epidermis and, to a lesser extent, the dermis and subcutaneous tissue [27,30,35].”
BackgroundWound Healing: A Comprehensive Review
Almadani, Y. H., Vorstenbosch, J., Davison, P. G., & Murphy, A. M. (2021) · Seminars in Plastic Surgery · doi:10.1055/s-0041-1731791 · Cited by 369
Nanofiber Scaffolds as Drug Delivery Systems Promoting Wound Healing
Jiang, Z., Zheng, Z., Yu, S., Gao, Y., Ma, J., Huang, L., & Yang, L. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071829 · Cited by 186
Monkeypox: A Comprehensive Review
Harapan, H., Ophinni, Y., Megawati, D., Frediansyah, A., Mamada, S. S., Salampe, M., Emran, T. B., Winardi, W., Fathima, R., Sirinam, S., et al. (2022) · Viruses · doi:10.3390/v14102155 · Cited by 171
Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back
Koklesová, L., Líšková, A., Samec, M., Buhrmann, C., Samuel, S. M., Varghese, E., Ashrafizadeh, M., Najafi, M., Shakibaei, M., Büsselberg, D., et al. (2020) · Cancers · doi:10.3390/cancers12092425 · Cited by 128
Metadata
- Authors
- Polcz, M. E., & Barbul, A.
- Affiliations
- Vanderbilt University Medical Center (US)
- VA Tennessee Valley Healthcare System (US)
- Corresponding author
- Polcz, Monica E.
- Venue
- Nutrition in Clinical Practice
- Publisher
- Wiley
- Published
- 2019-08-07
- Volume
- 34
- Issue
- 5
- Pages
- 695-700
- ISSN
- 0884-5336 (ISSN-L)
- 1941-2452
- OpenAlex
- W2965905064
- Cited by
- 205
- References
- 74
- Citations by year
- 2026: 20 · 2025: 40 · 2024: 45 · 2023: 32 · 2022: 30 · 2021: 20 · 2020: 16 · 2019: 2
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
- Keywords
- vitamin A, wound healing, retinoids, retinoic acid, retinol, carotenoids, retinol-binding protein, retinoic acid receptor, keratinization, re-epithelialization, extracellular matrix, type I collagen, fibronectin, matrix metalloproteinases, keratinocyte proliferation, fibroblast proliferation, anti-inflammatory steroids, epithelial cell turnover
- MeSH terms
- Humans, Retinoids, Retinol-Binding Proteins, Vitamin A, Wound Healing, Receptors, Retinoic Acid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
