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Cited by 70Nerve injury and regenerationMuscle Physiology and DisordersNeurogenetic and Muscular Disorders Research

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Neuromuscular activity impairs axonal sprouting in partially denervated muscles by inhibiting bridge formation of perisynaptic Schwann cells

Tam, S. L., Gordon, T.·2003·Journal of Neurobiology
DOI 10.1002/neu.10276
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Abstract

Following partial denervation of rat hindlimb muscle, terminal Schwann cells extend processes from denervated endplates to induce and guide sprouting from the remaining intact axons. Increased neuromuscular activity significantly reduces motor unit enlargement and sprouting during the acute phase of sprouting. These findings led to the hypothesis that increased neuromuscular activity perturbs formation of Schwann cell bridges and thereby reduces sprouting. Adult rat tibialis anterior (TA) muscles were extensively denervated by avulsion of L4 spinal root and were immediately subjected to normal caged activity or running exercise (8 h daily) for 3, 7, 14, 21, and 28 days. Combined silver/cholinesterase histochemical staining revealed that the progressive reinnervation of denervated endplates by sprouts over a 1 month period in the extensively partially denervated TA muscles was completely abolished by increased neuromuscular activity. Immunohistochemical staining and triple immunofluorescence revealed that the increased neuromuscular activity did not perturb the production of Schwann cell processes, but prevented bridging between Schwann cell processes at innervated and denervated endplates. Our findings suggest that failure of Schwann cell processes to bridge between endplates accounts, at least in part, for the inhibitory effect of increased neuromuscular activity on sprouting. © 2003 Wiley Periodicals, Inc. J Neurobiol 57: 221–234, 2003

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Crossref · 10.1002/neu.10276

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Research works printed but not linked: 2

  1. Rabben I, 1997, Distribution of extrajunctional acetylcholine receptors in rat skeletal muscle after inactivation by botulinum toxin, Soc Neurosci Abstr, 23, 154
  2. Tam SL, 1998, Detrimental effect of neuromuscular activity on the ability of terminal Schwann cells to induce sprouting in extensively denervated tibialis anterior muscle, Soc Neurosci Abstr, 24, 413.16

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Metadata

Authors
Tam, S. L., & Gordon, T.
Affiliations
University of Alberta (CA)
Corresponding author
Gordon, T.
ORCID
Gordon, T.
Venue
Journal of Neurobiology
Publisher
Wiley
Published
2003-10-06
Volume
57
Issue
2
Pages
221-234
ISSN
  • 0022-3034 (ISSN-L)
  • 1097-4695
DOI
10.1002/neu.10276
OpenAlex
W2076384214
Cited by
70
References
47
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 10 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 1
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Keywords
axonal sprouting, partial denervation, neuromuscular activity, Schwann cells, perisynaptic Schwann cells, tibialis anterior, running, reinnervation
MeSH terms
Animals, Female, Hindlimb, Immunohistochemistry, Motor Activity, Motor Endplate, Muscle Denervation, Nerve Regeneration, Schwann Cells, Time Factors, Rats, Sprague-Dawley, Muscle, Skeletal, Rats

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