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Changing synaptic specificities in the nervous system of Caenorhabditis elegans: Differentiation of the DD motoneurons
Abstract
During postembryonic development, the DD motoneurons in the nematode Caenorhabditis elegans completely reorganize their pattern of synapses. Ablation of a pair of embryonic precursors results in the absence of this entire class of motoneurons. In their absence animals exhibit two developmentally distinct locomotory defects. The transition period from one defect to the other is correlated with the synaptic reorganization of the DD mns. Mutations in a gene (unc-123) have been isolated that exhibit locomotory defects similar to those of the ablated adult animals. Genetic and cellular analyses of one of these alleles suggest that the unc-123 gene product may be involved in the reestablishment of functional synapses in these neurons.
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“In contrast, forward locomotion in these mutants or D-ablated worms is described either as wild type (Walthall et al., 1993; Yanik et al., 2004), or nearly wild type with a reduction in amplitude (McIntire et al., 1993b).”
From Gait Modulation in C. elegans: An Integrated Neuromechanical Model (2012) · cites this paper as Walthall et al., 1993
In the citing paper
“The function of D-class neurons can be knocked out through mutation of genes required in the GABA pathway (McIntire et al., 1993b), by targeted killing of D-class neurons (Walthall et al., 1993) and by laser axotomy (Yanik et al., 2004), yielding essentially the same so-called shrinker phenotype (Hodgkin, 1983) in all cases: When touched on the head, wild type worms will back up, whereas worms who”
From Gait Modulation in C. elegans: An Integrated Neuromechanical Model (2012) · cites this paper as Walthall et al., 1993
In the citing paper
“In fact, in every case where forward locomotion of GABA pathway defective worms was reported (McIntire et al., 1993b; Walthall et al., 1993; Yanik et al., 2004), the assay was performed on agar.”
From Gait Modulation in C. elegans: An Integrated Neuromechanical Model (2012) · cites this paper as Walthall et al., 1993
Citations
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Cited by
Sorted by citations
Gait Modulation in C. elegans: An Integrated Neuromechanical Model
Boyle, J. H., Berri, S., & Cohen, N. (2012) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2012.00010 · Cited by 148
“In the model, the ventral cord circuit (White et al., 1976, 1986; Chen et al., 2006) is simplified to a single AVB command neuron that drives a series of N = 12 repeating units, each containing one motor neuron of each class DBn,VBn, DDn, and VDn, with n = 1, . . ., N (see Figure 1C).”
Guest, M., Bull, K., Walker, R. J., Amliwala, K., O’Connor, V., Harder, A., Holden-Dye, L., & Hopper, N. A. (2007) · International Journal for Parasitology · doi:10.1016/j.ijpara.2007.05.006 · Cited by 118
“For example, laser ablation of the inhibitory DD motorneurones also results in coiling (Walthall et al., 1993) as does reduction-of-function mutations in unc-17 which is required for excitatory cholingergic signalling (Alfonso et al., 1993).”
Sleep and Development in Genetically Tractable Model Organisms
Kayser, M. S., & Biron, D. (2016) · Genetics · doi:10.1534/genetics.116.189589 · Cited by 78
Axon guidance mechanisms in Caenorhabditis elegans.
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Ge, S., Kim, K., Li, C., & Walthall, W. W. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.032 · Cited by 47
“This is based upon the observation that mutations that affect the D mns and ablations of the DD mns (Walthall et al., 1993), and DD and VD mns (McIntire et al.”
BackgroundSelf-citation
Metadata
- Authors
- Walthall, W. W., Li, L., Plunkett, J. A., & Hsu, C.
- Affiliations
- Georgia State University (US)
- Corresponding author
- Walthall, W. W.
- ORCID
- Hsu, Chia‐Yu
- Venue
- Journal of Neurobiology
- Publisher
- Wiley
- Published
- 1993-12
- Volume
- 24
- Issue
- 12
- Pages
- 1589-1599
- ISSN
- 0022-3034 (ISSN-L)
- 1097-4695
- OpenAlex
- W2004905041
- Cited by
- 18
- References
- 0
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- synaptic remodeling, synaptic specificity, locomotion defects, neuronal differentiation, postembryonic development, Caenorhabditis elegans
- MeSH terms
- Animals, Cell Differentiation, Motor Activity, Motor Neurons, Mutation, Nervous System, Synapses, Gene Expression, Caenorhabditis elegans
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