The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Calcium regulation of gene expression in neuronal cells
Abstract
Long‐term adaptive changes in neurons following brief periods of neuronal activity are likely to involve changes in gene expression. The mechanisms of activity‐dependent gene expression have been explored in central neurons and the neuronal cell line PC12. Calcium influx through either NMDA receptors or voltage‐sensitive calcium channels leads to the rapid induction of a number of immediate‐early genes including c‐fos. Promoter analysis indicates that Ca 2+ influx through different calcium channels activates distinct signaling pathways that either target the serum response element (SRE) or the calcium response element (CaRE) within the c‐fos promoter. Transcription through the CaRE requires the induced phosphorylation of the cAMP response element binding protein (CREB) at Ser133. This site on CREB is also phosphorylated in the suprachiasmatic nucleus in in vivo upon light stimulation. These observations suggest Ca 2+ can regulate gene expression by multiple signaling pathways including one that involves the Ca 2+‐dependent phosphorylation of the transcription factor CREB. 1994 John Wiley & Sons, Inc.
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Citations
Cites
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
Bading, H., Ginty, D. D., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.8097060 · Cited by 1,157
Self-citationIntracellular injections of EGTA block induction of hippocampal long-term potentiation
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G., & Schottler, F. (1983) · Nature · doi:10.1038/305719a0 · Cited by 1,116
Cited by
Lev, S., Moreno, H., Martinez, R., Canoll, P., Peles, E., Musacchio, J. M., Plowman, G. D., Rudy, B., & Schlessinger, J. (1995) · Nature · doi:10.1038/376737a0 · Cited by 1,381
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232
Self-citationAbsence Epilepsy in Tottering Mutant Mice Is Associated with Calcium Channel Defects
Fletcher, C. F., Lutz, C. M., O'Sullivan, T. N., Shaughnessy, J. D., Hawkes, R., Frankel, W. N., Copeland, N. G., & Jenkins, N. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81381-1 · Cited by 772
Invited review c-Fos as a transcription factor: a stressful (re)view from a functional map
Kovács, K. J. (1998) · Neurochemistry International · doi:10.1016/s0197-0186(98)00023-0 · Cited by 740
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Metadata
- Authors
- Ghosh, A., Ginty, D. D., Bading, H., & Greenberg, M. E.
- Venue
- Journal of Neurobiology
- Publisher
- Wiley
- Published
- 1994-03
- Volume
- 25
- Issue
- 3
- Pages
- 294-303
- ISSN
- 0022-3034 (ISSN-L)
- 1097-4695
- OpenAlex
- W2041497541
- Cited by
- 327
- References
- 2
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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