Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial.
Open accessAbstract
Objective:Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms. Design and Methods:In a prospective cohort study at a tertiary referral center, overweight/obese subjects (BMI 25‐39.9 kg/m2) were enrolled in a structured weight loss program. Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire. Results: A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (±18) kg, 35 (±5) kg/m2 and 103 (±13) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 ± 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05). Conclusions: In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects.
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Sustained weight loss of a similar magnitude to that observed in this trial has been linked to improvements in obesity-related complications, such as type 2 diabetes, with treatment guidelines recommending sustained weight loss of 5% to 15%.
“Sustained weight loss of a similar magnitude to that observed in this trial has been linked to improvements in obesityrelated complications, [25][26][27] such as type 2 diabetes, 28 with treatment guidelines recommending sustained weight loss of 5% to 15% for people with these conditions.5,6”
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- Authors
- Singh, M., Lee, J., Gupta, N., Gaddam, S., Smith, B. K., Wani, S. B., Sullivan, D. K., Rastogi, A., Bansal, A., Donnelly, J. E., & Sharma, P.
- Affiliations
- Veterans Health Administration (US)
- University of Kansas (US)
- University of Kansas Medical Center (US)
- Corresponding author
- Sharma, Prateek
- ORCID
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2013-02
- Volume
- 21
- Issue
- 2
- Pages
- 284-290
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC3853378
- OpenAlex
- W1991913146
- Cited by
- 195
- References
- 41
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 19 · 2023: 25 · 2022: 20 · 2021: 28 · 2020: 11 · 2019: 10 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 18 · 2014: 7 · 2013: 5 · 2012: 2
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- KU ScholarWorks (University of Kansas) (submittedVersion, other-oa)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076063, DK076063)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- gastroesophageal reflux disease, weight loss, overweight, slimming program, dietary change, physical activity, behavioral interventions, body mass index, waist circumference
- MeSH terms
- Adolescent, Adult, Aged, Female, Follow-Up Studies, Gastroesophageal Reflux, Humans, Life Style, Male, Middle Aged, Motor Activity, Obesity, Prospective Studies, Surveys and Questionnaires, Risk Factors, Weight Loss, Body Mass Index, Prevalence, Overweight, Young Adult
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