Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease
Abstract
Guidelines for the diagnosis and treatment of gastroesophageal reflux disease (GERD) were published in 1995 and updated in 1999. These and other guidelines undergo periodic review. Advances continue to be made in the area of GERD, leading us to review and revise previous guideline statements. GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. These guidelines were developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee, and approved by the Board of Trustees. Diagnostic guidelines address empiric therapy and the use of endoscopy, ambulatory reflux monitoring, and esophageal manometry in GERD. Treatment guidelines address the role of lifestyle changes, patient directed (OTC) therapy, acid suppression, promotility therapy, maintenance therapy, antireflux surgery, and endoscopic therapy in GERD. Finally, there is a discussion of the rare patient with refractory GERD and a list of areas in need of additional study.
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PPIs are the first-choice treatment for acid-related disorders such as bleeding, peptic ulcers, gastroesophageal reflux, erosive esophagitis (ERD) and certain dyspepsia subtypes.
“PPIs are the first-choice treatment for acid-related disorders such as bleeding, peptic ulcers, gastroesophageal reflux, erosive esophagitis (ERD) and certain dyspepsia subtypes[2-5].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [3]
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- Authors
- DeVault, K. R., & Castell, D. O.
- Affiliations
- Mayo Clinic in Florida (US)
- Medical University of South Carolina (US)
- ORCID
- DeVault, Kenneth R.
- Venue
- The American Journal of Gastroenterology
- Published
- 2005-01
- Volume
- 100
- Issue
- 1
- Pages
- 190-200
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2105606912
- Cited by
- 1,130
- References
- 192
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 16 · 2023: 13 · 2022: 15 · 2021: 25 · 2020: 23 · 2019: 21 · 2018: 37 · 2017: 29 · 2016: 42 · 2015: 44 · 2014: 44 · 2013: 50 · 2012: 65
- FWCI
- 75.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Keywords
- gastroesophageal reflux disease, diagnosis, treatment, empirical treatment, endoscopy, esophageal manometry, lifestyle modification, acid suppression, maintenance therapy, antireflux surgery, endoscopic treatment, refractory GERD
- MeSH terms
- Anti-Ulcer Agents, Endoscopy, Esophagus, Gastroesophageal Reflux, Humans, Life Style, Manometry, Self Care, Monitoring, Ambulatory
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