H. Pylori as a predictor of marginal ulceration: A nationwide analysis
Abstract
Objective: Helicobacter pylori has been implicated as a risk factor for development of marginal ulceration following gastric bypass, although studies have been small and yielded conflicting results. This study sought to determine the relationship between H. pylori infection and development of marginal ulceration following bariatric surgery in a nationwide analysis. Methods: This was a retrospective cohort study using the 2012 Nationwide Inpatient Sample (NIS) database. Discharges with ICD‐9‐CM code indicating marginal ulceration and a secondary ICD‐9‐CM code for bariatric surgery were included. Primary outcome was incidence of marginal ulceration. A stepwise forward selection model was used to build the multivariate logistic regression model based on known risk factors. A P value of 0.05 was considered significant. Results: There were 253,765 patients who met inclusion criteria. Prevalence of marginal ulceration was 3.90%. Of those patients found to have marginal ulceration, 31.20% of patients were H. pylori ‐positive. Final multivariate regression analysis revealed that H. pylori was the strongest independent predictor of marginal ulceration. Conclusions: H. pylori is an independent predictor of marginal ulceration using a large national database. Preoperative testing for and eradication of H. pylori prior to bariatric surgery may be an important preventive measure to reduce the incidence of ulcer development.
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Multivariable analysis of a registry cohort found H. pylori status to be the most important independent predictor of marginal ulceration in patients undergoing RYGB.
“Multivariable analysis of a registry cohort found H. pylori status to be the most important independent predictor of marginal ulceration in patients undergoing RYGB, but it had little impact on the outcome of other bariatric operations [39].”
H. pylori status had little impact on the outcome of other bariatric operations.
“Multivariable analysis of a registry cohort found H. pylori status to be the most important independent predictor of marginal ulceration in patients undergoing RYGB, but it had little impact on the outcome of other bariatric operations [39].”
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- Authors
- Schulman, A. R., Abougergi, M. S., & Thompson, C. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Catalyst Medical Consulting, LLC Baltimore Maryland USA
- Corresponding author
- Thompson, Christopher C.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2017-02-23
- Volume
- 25
- Issue
- 3
- Pages
- 522-526
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2589222724
- Cited by
- 52
- References
- 28
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 9 · 2018: 2 · 2017: 7
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007533)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Keywords
- Helicobacter pylori, marginal ulceration, gastric bypass, bariatric surgery, postoperative complications, risk factors, Helicobacter pylori eradication
- MeSH terms
- Female, Humans, Male, Middle Aged, Peptic Ulcer, Postoperative Complications, Retrospective Studies, Risk Factors, Gastric Bypass, Incidence, Prevalence, Helicobacter pylori, Helicobacter Infections, International Classification of Diseases
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