The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Weight‐loss interventions for adolescents with Down syndrome: a systematic review
Abstract
Objective: Youth with Down syndrome (DS) experience high rates of overweight and obesity; therefore, weight‐loss interventions are warranted. We aimed to systematically review weight‐loss interventions for adolescents with DS to better understand the most effective strategies and identify the current gaps in the literature. Methods: This systematic review followed Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines (International Prospective Register of Systematic Reviews [PROSPERO] #CRD42022303781). Databases were searched through July 28, 2023, and screening, evaluation, and data extraction were performed by two independent reviewers. Change scores for weight or BMI were presented by study design and intervention components. Results: The 26 included papers describing 24 unique studies included a total of n = 1171 participants, of whom n = 393 were participants with DS. Eleven studies focused on physical activity, one on diet, and two on physical activity and diet; seven studies used multicomponent interventions; and three studies investigated laparoscopic sleeve gastrectomy. Thirteen studies using either a multicomponent intervention, a physical activity intervention, or surgery resulted in weight loss or a decrease in BMI in adolescents with DS. Conclusions: Weight‐loss interventions can be effective for adolescents with DS and could benefit from increasing duration/intensity to meet the existing weight‐loss intervention recommendations. More research on surgery and weight‐loss medications is needed.
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Evidence-based weight loss interventions tailored to young adults with ID remain limited.
“Despite this vulnerability, evidence-based weight loss interventions tailored to young adults with ID remain limited13,14.”
From A cooking skills intervention for long-term weight loss in young adults with intellectual disabilities: Rationale and design for a randomized trial (2026) · cites this paper as [14]
The Discussion says the literature is too scarce to inform clinical practice and identifies the review’s population as adolescents aged 13–22, which includes some young adults. The claim extends that finding to young adults with intellectual disability generally, a population the review does not assess as a whole. (LLM, conf=0.84)
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Page, M. J., Moher, D., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · BMJ · doi:10.1136/bmj.n160 · Cited by 13,262 · cited 1×
“This study was conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) [23] and was registered with International Prospective Register of Systematic Reviews (PROSPERO; #CRD42022303781).”
Garvey, W. T., Mechanick, J. I., Brett, E. M., Garber, A. J., Hurley, D. L., Jastreboff, A. M., Nadolsky, K., Pessah-Pollack, R., & Plodkowski, R. (2016) · Endocrine Practice · doi:10.4158/ep161365.gl · Cited by 1,914
Hampl, S. E., Hassink, S. G., Skinner, A. C., Armstrong, S. C., Barlow, S. E., Bolling, C. F., Avila Edwards, K. C., Eneli, I., Hamre, R., Joseph, M. M., et al. (2023) · Pediatrics · doi:10.1542/peds.2022-060640 · Cited by 1,389 · cited 1×
“…least 150 min of moderate-intensity physical activity per week and adhering to a diet with a calorie deficit of 500 kcal to achieve that weight loss over 6 months, whereas the AAP guidelines for children and adolescents require at least 60 min per day, with no guidance for a calorie deficit [62].”
Eisenberg, D., Shikora, S. A., Aarts, E., Aminian, A., Angrisani, L., Cohen, R. V., De Luca, M., Faria, S. L., Goodpaster, K. P. S., Haddad, A., et al. (2022) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2022.08.013 · Cited by 985
A review of current guidelines for the treatment of obesity
(2022) · The American Journal of Managed Care · doi:10.37765/ajmc.2022.89292 · Cited by 207
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Cited by
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Ptomey, L. T., Danon, J. C., Catley, D., Washburn, R. A., Bodde, A., Diaz, F. J., Helsel, B. C., Rice, A. M., Sherman, J. R., Koester, M., et al. (2026) · Contemporary Clinical Trials · doi:10.1016/j.cct.2026.108380
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Metadata
- Authors
- Hilgenkamp, T. I. M., Davidson, E., Diaz, K. M., Fleming, R., Foster Kirk, R., Hastert, M., Kim, J., Mann, S., Usseglio, J., Videlefsky, A., & Ptomey, L.
- Affiliations
- Department of Physical Therapy University of Nevada Las Vegas Las Vegas, Nevada USA
- Department of Pediatrics Boston Children's Hospital Boston Massachusetts USA
- Department of Medicine Columbia University Medical Center New York New York USA
- Department of Exercise and Health Sciences University of Massachusetts Boston Boston Massachusetts USA
- Hinge Health San Francisco California USA
- Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA
- People's Community Clinic Austin Texas USA
- Mann Method Physical Therapy and Fitness Arvada Colorado USA
- Augustus C. Long Health Sciences Library Columbia University Medical Center New York New York USA
- Adult Disability Medical Healthcare Clinic Atlanta Georgia USA
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2025-03-10
- Volume
- 33
- Issue
- 4
- Pages
- 632-658
- ISSN
- 1930-7381
- 1930-739X
- PMC
- PMC11937868
- Cited by
- 7
- References
- 5
- Language
- en
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