High prevalence of obstructive sleep-disordered breathing in pediatric patients with Turner syndrome
Abstract
OBJECTIVE: Girls with Turner syndrome (TS) often have features that have been associated with obstructive sleep-disordered breathing (oSDB). However, little is known about oSDB in TS. Herein, we aimed to characterize oSDB in young patients with TS and identify associated risk factors. STUDY DESIGN: Retrospective cross-sectional study. SETTING: Tertiary care pediatric hospital. METHODS: We reviewed medical records for patients diagnosed with TS seen at our institution between October 1, 2007 and December 31, 2019 with the first outpatient visit before age 6 years. The prevalence of oSDB was compared to the general pediatric population with 1-sample binomial proportion tests. Clinical characteristics were compared between those diagnosed with oSDB and those without oSDB, and risk factors for oSDB were identified. RESULTS: Of 151 patients with TS, 73 (48%) were diagnosed with oSDB which is 4-fold higher than the general pediatric population (12%, P < 0.0001). In the multivariable model, adenoid, tonsillar, and inferior turbinate hypertrophy, birthweight, failure to thrive, and older age at the last clinic visit were all associated with increased odds for oSDB. CONCLUSION: Young children with TS have a high prevalence of oSDB and thus should be screened for oSDB. Polysomnography should be performed in those with associated risk factors and symptoms oSDB. Treatment of oSDB is imperative as individuals with TS are already at increased risk of behavioral problems, neurocognitive deficits, and growth impairment that may be worsened with oSDB.
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Observational studies suggest higher rates of sleep disorders in TS even in very young children.
“Observational studies suggest higher rates of sleep disorders in TS even in very young children.414,647,670”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [670]
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- Authors
- Pham, T. T., Davis, S. M., Tong, S., Campa, K. A., Friedman, N. R., & Gitomer, S. A.
- Affiliations
- University of Colorado Anschutz (US)
- Children's Hospital Colorado (US)
- Colorado School of Public Health (US)
- Corresponding author
- Gitomer, Sarah A.
- ORCID
- Venue
- Otolaryngology–Head and Neck Surgery
- Publisher
- Wiley
- Published
- 2023-11-08
- Volume
- 170
- Issue
- 3
- Pages
- 905-912
- ISSN
- 0161-6439 (ISSN-L)
- 0194-5998
- 1097-6817
- OpenAlex
- W4388492013
- Cited by
- 7
- References
- 49
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2
- FWCI
- 0.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Otolaryngology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Keywords
- Turner syndrome, obstructive sleep-disordered breathing, sleep apnea, pediatric patients, prevalence, risk factors, adenoid hypertrophy, tonsillar hypertrophy, inferior turbinate hypertrophy, birth weight, failure to thrive, polysomnography screening
- MeSH terms
- Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Retrospective Studies, Turner Syndrome, Prevalence, Sleep Apnea, Obstructive
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