The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
Abstract
The aim of this study was to investigate the occurrence of (pre)neoplastic lesions in overtly normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The presence of (pre)neoplastic lesions was scored in histological specimens from 12 women with a genetically determined predisposition for ovarian cancer, of whom seven tested positive for a germline BRCA1 mutation. A control group included 13 women. Immunohistochemistry was used to determine the expression of p21, p27, p53, cyclin A, cyclin D1, bcl‐2, Ki67, HER‐2/neu, and the oestrogen and progesterone receptors. Loss of heterozygosity (LOH) analysis on the BRCA1 locus was also assessed on dysplastic tissue by PCR studies. Of the 12 women with a predisposition for ovarian cancer, six showed dysplasia, including one case of severe dysplasia. Five harboured hyperplastic lesions and in one woman no histological aberrations were found in the Fallopian tube. No hyperplastic, dysplastic or neoplastic lesions were detected in the Fallopian tubes of control subjects. In the cases studied, morphologically normal tubal epithelium contained a higher proportion of Ki67‐expressing cells (p=0.005) and lower fractions of cells expressing p21 (p<0.0001) and p27 (p=0.006) than in the control group. Even higher fractions of proliferating cells were found in dysplastic areas (p=0.07) and accumulation of p53 was observed in the severely dysplastic lesion. Expression patterns of other proteins studied, including the hormone receptors, were similar in cases and controls. One subject, a germline BRCA1 mutation carrier, showed loss of the wild‐type BRCA1 allele in the severely dysplastic lesion. In conclusion, the Fallopian tubes of women predisposed to developing ovarian cancer frequently harbour dysplastic changes, accompanied by changes in cell‐cycle and apoptosis‐related proteins, indicating an increased risk of developing tubal cancer. Copyright © 2001 John Wiley & Sons, Ltd.
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Laser capture microdissection in pathology: Figure 1
Fend, F., & Raffeld, M. (2000) · Journal of Clinical Pathology · doi:10.1136/jcp.53.9.666 · Cited by 275
Primary carcinoma of the Fallopian tube
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Self-citationMolecular Evidence Linking Primary Cancer of the Fallopian Tube to BRCA1 Germline Mutations
Zweemer, R. P., van Diest, P. J., Verheijen, R. H. M., Ryan, A., Gille, J. J. P., Sijmons, R. H., Jacobs, I. J., Menko, F. H., & Kenemans, P. (2000) · Gynecologic Oncology · doi:10.1006/gyno.1999.5623 · Cited by 191
Self-citationBcl-2 and p53 Protein Expression, Apoptosis, and p53 Mutation in Human Epithelial Ovarian Cancers
Chan, W.-Y., Cheung, K.-K., Schorge, J. O., Huang, L.-W., Welch, W. R., Bell, D. A., Berkowitz, R. S., & Mok, S. C. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64744-x · Cited by 171
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Obstetrical and Gynaecological Pathology
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Emerging roles of BRCA1 in transcriptional regulation and DNA repair
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Cited by
Colombo, N., Sessa, C., du Bois, A., Ledermann, J., McCluggage, W. G., McNeish, I., Morice, P., Pignata, S., Ray-Coquard, I., Vergote, I., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz062 · Cited by 1,197
Medeiros, F., Muto, M. G., Lee, Y., Elvin, J. A., Callahan, M. J., Feltmate, C., Garber, J. E., Cramer, D. W., & Crum, C. P. (2006) · American Journal of Surgical Pathology · doi:10.1097/01.pas.0000180854.28831.77 · Cited by 916
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Kopper, O., de Witte, C. J., Lõhmussaar, K., Valle-Inclan, J. E., Hami, N., Kester, L., Balgobind, A. V., Korving, J., Proost, N., Begthel, H., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0422-6 · Cited by 834
Self-citationNew Insights Into the Pathogenesis of Serous Ovarian Cancer and Its Clinical Impact
Levanon, K., Crum, C., & Drapkin, R. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.1107 · Cited by 412
Soong, T. R., Howitt, B. E., Horowitz, N., Nucci, M. R., & Crum, C. P. (2019) · Gynecologic Oncology · doi:10.1016/j.ygyno.2018.11.033 · Cited by 110
Metadata
- Authors
- Piek, J. M. J., van Diest, P. J., Zweemer, R. P., Jansen, J. W., Poort‐Keesom, R. J. J., Menko, F. H., Gille, J. J. P., Jongsma, A. P. M., Pals, G., Kenemans, P., & Verheijen, R. H. M.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2001-10-19
- Volume
- 195
- Issue
- 4
- Pages
- 451-456
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2041634324
- Cited by
- 787
- References
- 15
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Piek, J. M. J., van Diest, P. J., Zweemer, R. P., Jansen, J. W., Poort‐Keesom, R. J. J., Menko, F. H., Gille, J. J. P., Jongsma, A. P. M., Pals, G., Kenemans, P., & Verheijen, R. H. M. (2001). Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer. The Journal of Pathology. https://doi.org/10.1002/path.1000
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