The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent
Abstract
In order to expand our understanding of the molecular changes underlying the complex pathology of pancreatic malignancy, global gene expression profiling of pancreatic adenocarcinoma compared with normal pancreatic tissue was performed. Human cDNA arrays comprising 9932 elements were interrogated with fluorescence‐labelled normal and adenocarcinoma samples (nine tumours, three normal pancreata, and three cell lines). The data were analysed for differential gene expression, which was confirmed by serial analysis of gene expression (SAGE), digital differential display (DDD) analysis, and immunohistochemistry for selected cases. The array data were filtered to produce lists of a total of 75 genes significantly up‐regulated or down‐regulated in pancreatic adenocarcinoma. Two of those showing the highest differential were members of the S100 family of Ca‐binding proteins, namely S100P and S100A6, and therefore the S100 genes were studied in more detail. By immunohistochemical analysis of custom‐built, pancreas‐specific tissue arrays and commercially available, normal/cancer tissue arrays that included a wide variety of different tumour types, differential expression of S100P protein was found to be almost exclusive to pancreatic cancer. S100P could therefore represent a useful biomarker for pancreatic adenocarcinomas. Copyright © 2003 John Wiley & Sons, Ltd.
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Donato, R. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00046-2 · Cited by 1,580
Cited by
Regularized gene selection in cancer microarray meta-analysis
Ma, S., & Huang, J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-1 · Cited by 831
Maitra, A., & Hruban, R. H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.154305 · Cited by 707
Cross, S. S., Hamdy, F. C., Deloulme, J. C., & Rehman, I. (2005) · Histopathology · doi:10.1111/j.1365-2559.2005.02097.x · Cited by 259
Arumugam, T., Ramachandran, V., & Logsdon, C. D. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj498 · Cited by 159
S100P: a novel therapeutic target for cancer
Arumugam, T., & Logsdon, C. D. (2011) · Amino Acids · doi:10.1007/s00726-010-0496-4 · Cited by 125
Metadata
- Authors
- Crnogorac‐Jurcevic, T., Missiaglia, E., Blaveri, E., Gangeswaran, R., Jones, M., Terris, B., Costello, E., Neoptolemos, J. P., & Lemoine, N. R.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2003-07-07
- Volume
- 201
- Issue
- 1
- Pages
- 63-74
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2120014725
- Cited by
- 180
- References
- 1
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
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