The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human tuberculous granulomas induce peripheral lymphoid follicle‐like structures to orchestrate local host defence in the lung
Abstract
The human tuberculous granuloma provides the morphological basis for local immune processes central to the outcome of tuberculosis. Because of the scarcity of information in human patients, the aim of the present study was to gain insights into the functional and structural properties of infiltrated tissue. To this end, the mycobacterial load in lesions and dissemination to different tissue locations were investigated, as well as distribution, biological functions, and interactions of host immune cells. Analysis of early granuloma formation in formerly healthy lung tissue revealed a spatio‐temporal sequence of cellular infiltration to sites of mycobacterial infection. A general structure of the developing granuloma was identified, comprising an inner cell layer with few CD8+ cells surrounding the necrotic centre and an outer area of lymphocyte infiltration harbouring mycobacteria‐containing antigen‐presenting cells as well as CD4+, CD8+, and B cells in active follicle‐like centres resembling secondary lymphoid organs. It is concluded that the follicular structures in the peripheral rim of granulomas serve as a morphological substrate for the orchestration of the enduring host response in pulmonary tuberculosis. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Citations
Cites
Cell‐Wall Alterations as an Attribute of Mycobacterium tuberculosis in Latent Infection
Seiler, P., Ulrichs, T., Bandermann, S., Pradl, L., Jörg, S., Krenn, V., Morawietz, L., Kaufmann, S. H. E., & Aichele, P. (2003) · The Journal of Infectious Diseases · doi:10.1086/378563 · Cited by 157 · cited 1×
“The distribution of mycobacteria or intracellular mycobacterial material can be visualized by immunohistological staining using pAbBCG [21].”
MethodSelf-citation
Cited by
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
Pitzalis, C., Jones, G. W., Bombardieri, M., & Jones, S. A. (2014) · Nature Reviews Immunology · doi:10.1038/nri3700 · Cited by 698
The development of inducible bronchus-associated lymphoid tissue depends on IL-17
Rangel-Moreno, J., Carragher, D. M., de la Luz Garcia-Hernandez, M., Hwang, J. Y., Kusser, K., Hartson, L., Kolls, J. K., Khader, S. A., & Randall, T. D. (2011) · Nature Immunology · doi:10.1038/ni.2053 · Cited by 441
Tsai, M. C., Chakravarty, S., Zhu, G., Xu, J., Tanaka, K., Koch, C., Tufariello, J., Flynn, J., & Chan, J. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00612.x · Cited by 414
Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 312
Inflammatory signaling in human tuberculosis granulomas is spatially organized
Marakalala, M. J., Raju, R. M., Sharma, K., Zhang, Y. J., Eugenin, E. A., Prideaux, B., Daudelin, I. B., Chen, P.-Y., Booty, M. G., Kim, J. H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4073 · Cited by 308
Metadata
- Authors
- Ulrichs, T., Kosmiadi, G. A., Trusov, V., Jörg, S., Pradl, L., Titukhina, M., Mishenko, V., Gushina, N., & Kaufmann, S. H.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2004-09-16
- Volume
- 204
- Issue
- 2
- Pages
- 217-228
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2025755851
- Cited by
- 331
- References
- 1
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- closed
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