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Cited by 26Cutaneous Melanoma Detection and ManagementGlycosylation and Glycoproteins ResearchMelanoma and MAPK Pathways

Classification of CEA‐related positivity in primary and metastatic malignant melanoma

Sanders, D. S. A., Evans, A. T., Allen, C. A., Bryant, F. J., Johnson, G. D., Hopkins, J., Stocks, S. C., Marsden, J. R. +1 more·1994·The Journal of Pathology
DOI 10.1002/path.1711720409
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Abstract

Using a panel of antibodies to carcinoembryonic antigen (CEA), in paraffin‐processed biopsy material patchy, predominantly membranous positivity was seen on tumour cells in 70 per cent of cases of superficial spreading melanoma, 60 per cent of nodular melanomas, and 75 per cent of secondary deposits studied with unabsorbed polyclonal anti‐CEA only. No staining was seen using monoclonal anti‐CEAs. Localization of CEA to the cell membrane was confirmed with confocal microscopy. Immunoblotting of fresh frozen material detected CEA of around 180 kD in both primary and metastatic melanomas migrating with an apparent molecular weight of between 150 and 200 kD, indicating variable glycosylation of the protein. Recognition of an adhesive role for CEA with roles in immunolocalization and immunotherapy emphasizes the importance of more precise classification of CEA‐related positivity in human tumours.

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Crossref · 10.1002/path.1711720409

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  • MT111/MEDI-565 targets CEA, a widely expressed tumor antigen highly expressed in colorectal cancer and also in a substantial proportion of carcinomas of the lung, pancreas, stomach, ovary, uterus, breast and a subset of melanomas.

    “MT111/MEDI-565 targets the carcinoembryonic antigen (CEA, also called CEACAM5), a widely expressed tumor antigen highly expressed in colorectal cancer, and also in a substantial proportion of carcinomas of the lung, pancreas, stomach, ovary, uterus, breast and a subset of melanomas. 58”

    From Bispecific antibodies for cancer therapy: The light at the end of the tunnel? (2009) · cites this paper as [58]

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Authors
Sanders, D. S. A., Evans, A. T., Allen, C. A., Bryant, F. J., Johnson, G. D., Hopkins, J., Stocks, S. C., Marsden, J. R., & Kerr, M. A.
Affiliations
  • University of Birmingham (GB)
  • Ninewells Hospital (GB)
  • Queen Elizabeth Hospital Birmingham (GB)
  • Birmingham General Hospital (GB)
Corresponding author
Sanders, D. S. A.
ORCID
Kerr, M. A.
Venue
The Journal of Pathology
Publisher
Wiley
Published
1994-04
Volume
172
Issue
4
Pages
343-348
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.1711720409
OpenAlex
W2165395787
Cited by
26
References
17
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2016: 1 · 2015: 2 · 2012: 1
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4093 d)
Locations
  • The Journal of Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords
carcinoembryonic antigen, melanoma, metastatic melanoma, superficial spreading melanoma, nodular melanoma
MeSH terms
Carcinoembryonic Antigen, Humans, Immunoenzyme Techniques, Melanoma, Skin Neoplasms, Immunoblotting, Cryopreservation, Paraffin Embedding

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