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Cited by 481

The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Tubular kidney injury molecule‐1 (KIM‐1) in human renal disease

Open access
van Timmeren, MM, van den Heuvel, MC, Bailly, V, Bakker, SJL, van Goor, H, Stegeman, CA·2007·The Journal of Pathology
DOI 10.1002/path.2175
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Abstract

KIM‐1, a transmembrane tubular protein with unknown function, is undetectable in normal kidneys, but is markedly induced in experimental renal injury. The KIM‐1 ectodomain is cleaved, detectable in urine, and reflects renal damage. KIM‐1 expression in human renal biopsies and its correlation with urinary KIM‐1 (uKIM‐1) is unknown. In biopsies from various renal diseases ( n = 102) and controls ( n = 7), the fraction of KIM‐1 positive tubules and different renal damage parameters were scored. Double labelling was performed for KIM‐1 with macrophages (M Ø ), α‐smooth muscle actin (α‐SMA), proximal (aquaporin‐1) and distal (E‐cadherin) tubular markers and a dedifferentiation marker (vimentin). uKIM‐1 at the time of biopsy ( n = 53) was measured by ELISA. Renal KIM‐1 was significantly increased in all diseases versus controls ( p < 0.05), except minimal change. KIM‐1 was primarily expressed at the luminal side of dedifferentiated proximal tubules, in areas with fibrosis (α‐SMA) and inflammation (M Ø ). Independent of the disease, renal KIM‐1 correlated positively with renal damage, negatively with renal function, but not with proteinuria. uKIM‐1 was increased in renal patients versus controls ( p < 0.001), including minimal change, and correlated positively with tissue KIM‐1 and M Ø , negatively with renal function, but not with proteinuria. In conclusion, KIM‐1 is upregulated in renal disease and is associated with renal fibrosis and inflammation. uKIM‐1 is also associated with inflammation and renal function, and reflects tissue KIM‐1, indicating that it can be used as a non‐invasive biomarker in renal disease. Copyright © 2007 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Metadata

Authors
van Timmeren, M., van den Heuvel, M., Bailly, V, Bakker, S., van Goor, H., & Stegeman, C.
Venue
The Journal of Pathology
Publisher
Wiley
Published
2007-05-11
Volume
212
Issue
2
Pages
209-217
ISSN
  • 0022-3417 (ISSN-L)
  • 1096-9896
DOI
10.1002/path.2175
OpenAlex
W2039499065
Cited by
481
References
23
FWCI
12.13
Type
journal article
Language
en
Open access
bronze

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