The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
VHL and HIF signalling in renal cell carcinogenesis
Abstract
Hypoxia‐inducible factor (HIF) plays an important role in renal tumourigenesis. In the majority of clear cell RCC (ccRCC), the most frequent and highly vascularized RCC subtype, HIF is constitutively activated by inactivation of the von Hippel–Lindau gene. Of the HIF subunits, HIF‐2α appears to be more oncogenic than HIF‐1α, in that HIF‐2α activates pro‐tumourigenic target genes. In addition, recent studies indicate that HIF‐1α, more than HIF‐2α, can undergo proteasomal degradation in VHL − /− RCC cells. A more detailed understanding of the molecular basis of hypoxia and angiogenesis in renal carcinogenesis has set the stage for the development of targeted therapies, inhibiting multiple HIF‐related pathways, such as the phosphatidylinositol 3‐kinase–AKT–mTOR, RAS/RAF/MAP, and VEGF signalling routes. However, despite the positive results of these targeting agents in progression‐free survival, clinical resistance remains an issue. Recent pre‐clinical studies have suggested new targeting approaches such as inhibition of HIF‐driven key metabolic enzymes and have introduced new HIF targeting agents, such as histone deacetylase inhibitors, with successful anti‐neoplastic effects. In this review, we discuss existing and novel findings about RCC carcinogenesis, with subsequent clinical implications. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Cites
The biology of VEGF and its receptors
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BackgroundThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180
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Cited by
Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
Masiero, M., Simões, F. C., Han, H. D., Snell, C., Peterkin, T., Bridges, E., Mangala, L. S., Wu, S. Y.-Y., Pradeep, S., Li, D., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.004 · Cited by 313
Casillas, A. L., Chauhan, S. S., Toth, R. K., Sainz, A. G., Clements, A. N., Jensen, C. C., Langlais, P. R., Miranti, C. K., Cress, A. E., & Warfel, N. A. (2021) · Oncogene · doi:10.1038/s41388-021-01915-1 · Cited by 44
Shang, D., Xu, X., Wang, D., Li, Y., & Liu, Y. (2013) · World Journal of Urology · doi:10.1007/s00345-013-1077-4 · Cited by 12
Metadata
- Authors
- Baldewijns, M. M., van Vlodrop, I. J., Vermeulen, P. B., Soetekouw, P. M., van Engeland, M., & de Bruïne, A. P.
- Venue
- The Journal of Pathology
- Publisher
- Wiley
- Published
- 2010-05-04
- Volume
- 221
- Issue
- 2
- Pages
- 125-138
- ISSN
- 0022-3417 (ISSN-L)
- 1096-9896
- OpenAlex
- W2143013757
- Cited by
- 316
- References
- 143
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
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