Supercritical carbon dioxide extraction of colchicine and related alkaloids from seeds of Colchicum autumnale L.
Abstract
A method for the extraction of the alkaloids colchicine, 3-demethylcolchicine and colchicoside from seeds of Colchicum autumnale by supercritical carbon dioxide has been established. Several parameters such as pressure, temperature, percentage of modifier and extraction time have been examined. Two extraction steps with constant carbon dioxide density (0.90 g/mL) and flux (1.5 mL/min) were required to extract the alkaloids in 110 min using 3% methanol as modifier. The quantitative determination of the alkaloids was performed by HPLC; the percentages of recovery were higher than 98% for the three alkaloids. This extraction procedure was compared with a conventional method involving maceration and sonication, and the same levels of alkaloids were obtained in each case. The supercritical carbon dioxide method is, however, very efficient, more rapid and more environmentally friendly than conventional methods.
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SFE can be used to extract alkaloids, such as Pyrrolidine, caffeine, Olchicine, and Vinblastine, essential oils, terpenes, flavonoids, and phenolic compounds.
“SFE can be used to extract alkaloids, such as Pyrrolidine [92], caffeine [93], Olchicine [94], and Vinblastine [95], essential oils [96], terpenes [97], flavonoids [98], and phenolic compounds [99].”
From Valorization of Fruit Waste for Bioactive Compounds and Their Applications in the Food Industry (2023) · cites this paper as [94]
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Recent advances in extraction of nutraceuticals from plants
Wang, L., & Weller, C. L. (2006) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2005.12.004 · Cited by 2,046 · see citing works
Uwineza, P. A., & Waśkiewicz, A. (2020) · Molecules · doi:10.3390/molecules25173847 · Cited by 638 · see citing works
Valorization of Fruit Waste for Bioactive Compounds and Their Applications in the Food Industry
Nirmal, N., Khanashyam, A., Mundanat, A., Shah, K., Babu, K., Thorakkattu, P., Al-Asmari, F., & Pandiselvam, R. (2023) · Foods · doi:10.3390/foods12030556 · Cited by 305 · see citing works
“SFE can be used to extract alkaloids, such as Pyrrolidine [92], caffeine [93], Olchicine [94], and Vinblastine [95], essential oils [96], terpenes [97], flavonoids [98], and phenolic compounds [99].”
Supercritical Fluid Extraction of Pyrrolidine Alkaloid from Leaves of <i>Piper amalago</i> L.
Carrara, V. S., Filho, L. C., Garcia, V. A. S., Faiões, V. S., Cunha-Júnior, E. F., Torres-Santos, E. C., & Cortez, D. A. G. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/7401748 · Cited by 25 · see citing works
- Authors
- Ellington, E., Bastida, J., Viladomat, F., & Codina, C.
- Affiliations
- Universitat de Barcelona (ES)
- Corresponding author
- Codina, Carles
- ORCID
- Bastida, Jaume
- Venue
- Phytochemical Analysis
- Publisher
- Wiley
- Published
- 2003-04-30
- Volume
- 14
- Issue
- 3
- Pages
- 164-169
- ISSN
- 0958-0344 (ISSN-L)
- 1099-1565
- OpenAlex
- W2086299654
- Cited by
- 47
- References
- 0
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 2
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemical Analysis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Physical Sciences › Chemistry › Organic Chemistry › Chemical synthesis and alkaloids
- Keywords
- supercritical CO2 extraction, colchicine, colchicoside, Colchicum autumnale, alkaloids, seeds, extraction conditions, methanol modifier, green extraction
- MeSH terms
- Methanol, Alkaloids, Carbon Dioxide, Colchicine, Colchicum, Seeds, Temperature, Time Factors, Molecular Structure, Chromatography, Supercritical Fluid
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