Recent advances in supercritical fluid extraction of natural bioactive compounds from natural plant materials
Open accessAbstract
In this review, recent advances in greener technology for extracting natural bioactive components from plant origin sources are discussed. Bioactive compounds of plant origin have been defined as natural chemical compounds present in small amounts in plants. Researchers have shown interest in extracting bioactive compounds because of their human health benefits and characteristics of being eco-friendly and generally recognized as safe. Various new extraction methods and conventional extraction methods have been developed, however, until now, no unique approach has been presented as a benchmark for extracting natural bioactive compounds from plants. The selectivity and productivity of traditional and modern extraction techniques generally depend on selecting the critical input parameters, knowing the nature of plant-based samples, the structure of bioactive compounds, and good scientific skills. This work aims to discuss the recent advances in supercritical fluid extraction techniques, especially supercritical carbon dioxide, along with the fundamental principles for extracting bioactive compounds from natural plant materials such as herbs, spices, aromatic and medicinal plants.
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CO2 is non-toxic, non-flammable, cost-effective, possesses a low critical temperature, can be efficiently recycled, easily removed, and exhibits high solubility for non-polar molecules, making it an ideal solvent in SFE.
“CO2 is non-toxic, non-flammable, cost-effective, and possesses a low critical temperature. It can be efficiently recycled during the extraction process and easily removed afterward. Additionally, CO2 exhibits high solubility for non-polar molecules, making it an ideal solvent in SFE [128].”
From A comprehensive review of ultrasonic assisted extraction (UAE) for bioactive components: Principles, advantages, equipment, and combined technologies (2023) · cites this paper as [128]
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“Additionally, CO 2 exhibits high solubility for non-polar molecules, making it an ideal solvent in SFE [128].”
BackgroundConventional versus green extraction techniques — a comparative perspective
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Valorization of Food Processing Waste to Produce Valuable Polyphenolics
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Olea europea and By-Products: Extraction Methods and Cosmetic Applications
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- Authors
- Uwineza, P. A., & Waśkiewicz, A.
- Affiliations
- Poznań University of Life Sciences (PL)
- Corresponding author
- Uwineza, Pascaline Aimee
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2020-08-24
- Volume
- 25
- Issue
- 17
- Pages
- 3847
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC7504334
- OpenAlex
- W3080724744
- Cited by
- 638
- References
- 128
- Citations by year
- 2026: 127 · 2025: 182 · 2024: 128 · 2023: 104 · 2022: 67 · 2021: 27 · 2020: 2
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Narodowe Centrum Nauki (2018/31/B/NZ9/03485)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Phase Equilibria and Thermodynamics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Keywords
- supercritical fluid extraction, supercritical carbon dioxide, bioactive compounds, plant extracts, green extraction technologies, medicinal plants, herbs and spices, extraction conditions, extraction selectivity
- MeSH terms
- Plant Extracts, Plants, Medicinal, Chromatography, Supercritical Fluid, Phytochemicals
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