First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system

Cowans, Nicholas J.; Spencer, Kevin

doi:10.1002/pd.1665

Cited by 160Pregnancy and preeclampsia studiesPrenatal Screening and DiagnosticsBirth, Development, and Health

First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system

Cowans, Nicholas J., Spencer, Kevin·2007·Prenatal Diagnosis

DOI 10.1002/pd.1665

Open this paper in CoChat — free account

Abstract

BACKGROUND: PAPP-A is a marker used as part of the most effective method of screening for chromosomal anomalies in the first trimester. ADAM12 is a recently discovered pregnancy associated member of the ADAM (a multidomain glycoprotein metalloprotease) family. Recently, ADAM12 has been shown as a potential marker for early screening for chromosomal anomalies. Both PAPP-A and ADAM12 have been identified as proteases to insulin-like growth factor binding proteins. In this role, they may have a regulatory function in controlling the amount of free bioactive insulin-like growth factor (IGF). We therefore wish to examine if the levels of either of these proteases are related to various growth related adverse pregnancy outcomes. MATERIALS AND METHODS: PAPP-A and ADAM12 were measured in a subset of samples collected at 11 to 14 weeks as part of an OSCAR clinic screening for chromosomal anomalies. Follow-up of pregnancies screened between September 1999 and August 2003 identified 1705 pregnancies with an outcome of intrauterine fetal demise on or after 24 weeks, preterm delivery at 24-34 weeks or 35-36 weeks, very low birthweight (<1.5 kg), low birthweight (<2.5 kg), large birthweight (>4.5 kg), and birth weight below the 3rd or 5th or 10th centile for gestation. A series of 414 normal outcome pregnancies constituted the control group. Marker levels were adjusted for gestation and maternal weight and the log MoM of the markers were compared using t-test of unequal variance between the control group and the various adverse outcome groups. RESULTS: ADAM12 and PAPP-A concentrations were reduced in low for gestational age birth weights and in all births with weights below 2.5 kg. There was a linear relationship between the severity of the IUGR and the decrease in PAPP-A and ADAM12. In the larger babies, only ADAM12 was found to be significantly increased in babies above the 90th centile of weight for gestation. CONCLUSIONS: The results of our study are compatible with the proposed role of ADAM12 and PAPP-A in promoting growth and development by breaking down IGF binding proteins and causing the release of free IGF for uptake into cells to promote growth. In those cases that eventually result in poor fetal growth, levels of PAPP-A and ADAM12 at 11-14 weeks are significantly lower than normal-in this instance, lowered PAPP-A and ADAM12 would result in less free IGF being available for cell uptake and growth stimulation. Further studies may elucidate if screening using such modalities can lead to new potential treatments for poorly growing fetuses.

Integrity signals

Registry

Crossref · 10.1002/pd.1665

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Low PAPP-A at 11-14 weeks is associated with an increased risk of SGA.
“If serum pregnancy-associated plasma protein-A (PAPP-A) has been measured as part of the trisomy screening protocol then this may be taken into account too as low PAPP-A at 11–14 weeks is associated with an increased risk of SGA [11].”
From Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta (2019) · cites this paper as [11]

Fetal nutrition and cardiovascular disease in adult life
Barker, D. J. P., Godfrey, K. M., Gluckman, P. D., Harding, J. E., Owens, J. A., & Robinson, J. S. (1993) · The Lancet · doi:10.1016/0140-6736(93)91224-a · Cited by 2,753 · see citing works
Parental imprinting of the mouse insulin-like growth factor II gene
DeChiara, T. M., Robertson, E. J., & Efstratiadis, A. (1991) · Cell · doi:10.1016/0092-8674(91)90513-x · Cited by 1,795 · see citing works
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
DeChiara, T. M., Efstratiadis, A., & Robertsen, E. J. (1990) · Nature · doi:10.1038/345078a0 · Cited by 1,663 · see citing works
IGF-I is required for normal embryonic growth in mice.Preprint
Powell-Braxton, L., Hollingshead, P. G., Warburton, C., Dowd, M., Pitts-Meek, S., Dalton, D. K., Gillett, N. A., & Stewart, T. A. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2609 · Cited by 795 · see citing works
The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A
Lawrence, J. B., Oxvig, C., Overgaard, M. T., Sottrup-Jensen, L., Gleich, G. J., Hays, L. G., Yates, J. R., & Conover, C. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3149 · Cited by 706 · see citing works
An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.
ELGIN, R. G., Busby, W. H., & Clemmons, D. R. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.10.3254 · Cited by 680 · see citing works
First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: A population-based screening study (The FASTER Trial)
Dugoff, L., Hobbins, J. C., Malone, F. D., Porter, T. F., Luthy, D. A., Comstock, C. H., Hankins, G., Berkowitz, R. L., Merkatz, I. R., Craigo, S., et al. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.06.052 · Cited by 625 · see citing works
A screening program for trisomy 21 at 10–14 weeks using fetal nuchal translucency, maternal serum free β‐human chorionic gonadotropin and pregnancy‐associated plasma protein‐A
Spencer, K., Souter, V. L., Tul, N., Snijders, R. J. M., & Nicolaides, K. H. (1999) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.1469-0705.1999.13040231.x · Cited by 564 · see citing works
Birthweight and the Risk for Type 2 Diabetes Mellitus in Adult Women
Rich-Edwards, J. W., Colditz, G. A., Stampfer, M. J., Willett, W. C., Gillman, M. W., Hennekens, C. H., Speizer, F. E., & Manson, J. E. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-4_part_1-199902160-00005 · Cited by 544 · see citing works
Early Pregnancy Levels of Pregnancy-Associated Plasma Protein A and the Risk of Intrauterine Growth Restriction, Premature Birth, Preeclampsia, and Stillbirth
Smith, G. C. S., Stenhouse, E., Crossley, J. A., Aitken, D. A., Cameron, A. D., & Connor, J. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8430 · Cited by 478 · see citing works
New birthweight and head circumference centiles for gestational ages 24 to 42 weeks
Yudkin, P. L., Aboualfa, M., Eyre, J. A., Redman, C. W. G., & Wilkinson, A. R. (1987) · Early Human Development · doi:10.1016/0378-3782(87)90099-5 · Cited by 441 · see citing works
First trimester maternal serum free β human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications
Ong, C. Y. T., Liao, A. W., Spencer, K., Munim, S., & Nicolaides, K. H. (2000) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2000.tb11618.x · Cited by 347 · see citing works
A Novel, Secreted Form of Human ADAM 12 (Meltrin α) Provokes Myogenesis in Vivo
Gilpin, B., Loechel, F., Mattéi, M., Engvall, E., Albrechtsen, R., & Wewer, U. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.157 · Cited by 315 · see citing works
ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3
Loechel, F., Fox, J. W., Murphy, G., Albrechtsen, R., & Wewer, U. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3835 · Cited by 314 · see citing works
Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.
Oh, Y., Muller, H. L., Pham, H. M., & Rosenfeld, R. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74273-2 · Cited by 312 · see citing works
Structure of the Mr 140,000 growth hormone-dependent insulin-like growth factor binding protein complex: determination by reconstitution and affinity-labeling.
Baxter, R. C., & Martin, J. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.6898 · Cited by 311 · see citing works
Association of extreme first-trimester free human chorionic gonadotropin-β, pregnancy-associated plasma protein A, and nuchal translucency with intrauterine growth restriction and other adverse pregnancy outcomes
Krantz, D., Goetzl, L. M., Simpson, J. L., Thom, E. A., Zachary, J. M., Hallahan, T., Silver, R. K., Pergament, E., Platt, L. D., Filkins, K. A., et al. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.068 · Cited by 290 · see citing works
Maternal smoking and its association with birth weight
Bernstein, I. M., Mongeon, J. A., Badger, G. J., Solomon, L., Heil, S. H., & Higgins, S. T. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000182580.78402.d2 · Cited by 246 · see citing works
Decreased first trimester PAPP‐A is a predictor of adverse pregnancy outcome
Yaron, Y., Heifetz, S., Ochshorn, Y., Lehavi, O., & Orr‐Urtreger, A. (2002) · Prenatal Diagnosis · doi:10.1002/pd.407 · Cited by 189 · see citing works
In vivo proteolysis of serum insulin-like growth factor (IGF) binding protein-3 results in increased availability of IGF to target cells.
Blat, C., Villaudy, J., & Binoux, M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117229 · Cited by 186 · see citing works
Is Older Maternal Age a Risk Factor for Preterm Birth and Fetal Growth Restriction? A SystematicReview
Newburn‐Cook, C. V., & Onyskiw, J. E. (2005) · Health Care For Women International · doi:10.1080/07399330500230912 · Cited by 144 · see citing works
REFINEMENTS IN MANAGING MATERNAL WEIGHT ADJUSTMENT FOR INTERPRETING PRENATAL SCREENING RESULTS
Neveux, L. M., PALOMAKI, G. E., LARRIVEE, D. A., Knight, G. J., & Haddow, J. E. (1996) · Prenatal Diagnosis · doi:10.1002/(sici)1097-0223(199612)16:12 · Cited by 132 · see citing works
Reduction of the Disintegrin and Metalloprotease ADAM12 in Preeclampsia
Laigaard, J., Sørensen, T. L., Placing, S., Holck, P., Fröhlich, C., Wøjdemann, K. R., Sundberg, K., Shalmi, A. C., Tabor, A., Nørgaard‐Pedersen, B., et al. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000165829.65319.65 · Cited by 127 · see citing works
Predicting complications of pregnancy with first‐trimester maternal serum free‐βhCG, PAPP‐A and inhibin‐A
Tul, N., Pušenjak, S., Osredkar, J., Spencer, K., & Novak‐Antolič, Ž. (2003) · Prenatal Diagnosis · doi:10.1002/pd.735 · Cited by 126 · see citing works
Heparin Modulates the Binding of Insulin-like Growth Factor (IGF) Binding Protein-5 to a Membrane Protein in Osteoblastic Cells
Andress, D. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.47.28289 · Cited by 118 · see citing works
First‐trimester ultrasound and biochemical markers of aneuploidy and the prediction of impending fetal death
Spencer, K., Cowans, N. J., Avgidou, K., & Nicolaides, K. H. (2006) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.3809 · Cited by 115 · see citing works
Maternal weight correction of maternal serum PAPP‐A and free β‐hCG MoM when screening for trisomy 21 in the first trimester of pregnancy
Spencer, K., Bindra, R., & Nicolaides, K. H. (2003) · Prenatal Diagnosis · doi:10.1002/pd.708 · Cited by 114 · see citing works
Maternal Smoking and Down Syndrome: The Confounding Effect of Maternal Age
Chen, C.-L., Gilbert, T. J., & Daling, J. R. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009831 · Cited by 112 · see citing works
ADAM12: a novel first‐trimester maternal serum marker for Down syndrome
Laigaard, J., Sørensen, T. L., Fröhlich, C., Pedersen, B. N., Christiansen, M., Schiøtt, K. M., Uldbjerg, N., Albrechtsen, R., Clausen, H. V., Ottesen, B., et al. (2003) · Prenatal Diagnosis · doi:10.1002/pd.762 · Cited by 107 · see citing works
The clinical utility of maternal body mass index in pregnancy
Wolfe, H. M., Zador, I. E., Gross, T. L., Martier, S. S., & Sokol, R. J. (1991) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(91)90705-v · Cited by 95 · see citing works
The impact of correcting for smoking status when screening for chromosomal anomalies using maternal serum biochemistry and fetal nuchal translucency thickness in the first trimester of pregnancy
Spencer, K., Bindra, R., Cacho, A. M., & Nicolaides, K. H. (2004) · Prenatal Diagnosis · doi:10.1002/pd.819 · Cited by 87 · see citing works
ADAM 12 as a second‐trimester maternal serum marker in screening for Down syndrome
Christiansen, M., Spencer, K., Laigaard, J., Cowans, N. J., Larsen, S. O., & Wewer, U. M. (2007) · Prenatal Diagnosis · doi:10.1002/pd.1750 · Cited by 70 · see citing works
The impact of maternal smoking on fetal and infant growth
Vielwerth, S., Jensen, R. B., Larsen, T., & Greisen, G. O. (2006) · Early Human Development · doi:10.1016/j.earlhumdev.2006.09.010 · Cited by 65 · see citing works
ADAM 12 as a first‐trimester maternal serum marker in screening for Down syndrome
Laigaard, J., Spencer, K., Christiansen, M., Cowans, N. J., Larsen, S. O., Pedersen, B. N., & Wewer, U. M. (2006) · Prenatal Diagnosis · doi:10.1002/pd.1540 · Cited by 64 · see citing works
Glycosaminoglycans inhibit formation of the 140 kDa insulin-like growth factor-binding protein complex
Baxter, R. C. (1990) · Biochemical Journal · doi:10.1042/bj2710773 · Cited by 58 · see citing works
The level of ADAM12-S in maternal serum is an early first-trimester marker of fetal trisomy 18
Laigaard, J., Christiansen, M., Fröhlich, C., Pedersen, B. N., Ottesen, B., & Wewer, U. M. (2005) · Prenatal Diagnosis · doi:10.1002/pd.1029 · Cited by 55 · see citing works
Maternal serum ADAM12 levels in Down and Edwards' syndrome pregnancies at 9–12 weeks' gestation
Laigaard, J., Cuckle, H., Wewer, U. M., & Christiansen, M. (2006) · Prenatal Diagnosis · doi:10.1002/pd.1480 · Cited by 54 · see citing works
Expression of Pregnancy-associated Plasma Protein-A (PAPP-A) During Human Villous Trophoblast Differentiation In Vitro
Guibourdenche, J., Frendo, J., Pidoux, G., Bertin, G. I., Luton, D., MULLER, F. M., Porquet, D., & Evain‐Brion, D. (2003) · Placenta · doi:10.1053/plac.2002.0944 · Cited by 54 · see citing works
Exclusion of uniparental inheritance of chromosome 15 in a fetus with a familial dicentric (Y;15) translocation
White, L. M., Treat, K. M., Leff, A., Styers, D., Mitchell, M., & Knoll, J. H. M. (1998) · Prenatal Diagnosis · doi:10.1002/(sici)1097-0223(199802)18:2 · Cited by 47 · see citing works
An IGF binding protein is an inhibitor of fgf stimulation
Villaudy, J., Delbé, J., Blat, C., Desauty, G., Golde, A., & HAREL, L. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041490319 · Cited by 45 · see citing works
Fetal demise with Smith-Lemli-Opitz syndrome confirmed by tissue sterol analysis and the absence of measurable 7-dehydrocholesterol ?7-reductase activity in chorionic villi
Linck, L. M., Hayflick, S. J., Lin, D. S., Battaile, K. P., Ginat, S., Burlingame, T. G., Gibson, K. M., Honda, M., Honda, A., Salen, G., et al. (2000) · Prenatal Diagnosis · doi:10.1002/(sici)1097-0223(200003)20:3 · Cited by 32 · see citing works
First-trimester maternal serum levels of placental hormones are independent predictors of second-trimester fetal growth parameters
Leung, T. Y., Chan, L. W., Leung, T. N., Fung, T. Y., Sahota, D. S., & Lau, T. K. (2006) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.2656 · Cited by 31 · see citing works
The influence of smoking on the pregnancy-associated plasma protein A, free β human chorionic gonadotrophin and nuchal translucency
Niemimaa, M., Heinonen, S. T., Seppälä, M., & Ryynänen, M. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1046/j.1471-0528.2003.02364.x · Cited by 31 · see citing works
Metabolic clearance of insulin-like growth factor-II in sheep
Hodgkinson, S. C., Davis, S. R., Moore, L. G., Henderson, H. V., & Gluckman, P. D. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1230461 · Cited by 29 · see citing works
Comparison of nuchal translucency measurement and mid‐gestation serum screening in assisted reproduction versus naturally conceived singleton pregnancies
Maymon, R., Dreazen, E., Rozinsky, S., Bukovsky, I., Weinraub, Z., & Herman, A. (1999) · Prenatal Diagnosis · doi:10.1002/(sici)1097-0223(199911)19:11 · Cited by 25 · see citing works
Effect of smoking on pregnancy-associated plasma protein A, free β-human chorionic gonadotropin, and nuchal translucency in the first trimester of pregnancy
Yiğiter, A. B., Kavak, Z. N., Bakırcı, N., & Gökaslan, H. (2006) · Advances in Therapy · doi:10.1007/bf02850353 · Cited by 19 · see citing works

Flagged first, then by citations

Sorted by citations

Potential markers of preeclampsia – a review
Grill, S., Rusterholz, C., Zanetti‐Dällenbach, R., Tercanli, S., Holzgreve, W., Hahn, S., & Lapaire, O. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-70 · Cited by 294 · see citing works
Low levels of maternal serum PAPP‐A in the first trimester and the risk of pre‐eclampsia
Spencer, K., Cowans, N. J., & Nicolaides, K. H. (2007) · Prenatal Diagnosis · doi:10.1002/pd.1890 · Cited by 208 · see citing works
Prediction of small-for-gestation neonates from biophysical and biochemical markers at 11-13 weeks
Karagiannis, G., Akolekar, R., Sarquis, R., Wright, D., & Nicolaides, K. H. (2011) · Fetal Diagnosis and Therapy · doi:10.1159/000321694 · Cited by 195 · see citing works
Diagnosis and management of fetal growth restriction
Bamfo, J. E. A. K., & Odibo, A. O. (2011) · Journal of Pregnancy · doi:10.1155/2011/640715 · Cited by 178 · see citing works
Novel biomarkers for the prediction of the spontaneous preterm birth phenotype: a systematic review and meta-analysis
Conde‐Agudelo, A., Papageorghiou, A. T., Kennedy, S. H., & Villar, J. (2011) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2011.02923.x · Cited by 163 · see citing works
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers
Gaccioli, F., Aye, I. L. M. H., Sovio, U., Jones, D. S., & Smith, G. C. S. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.002 · Cited by 159 · see citing works
First‐trimester biochemical markers of aneuploidy and the prediction of small‐for‐gestational age fetuses
Spencer, K., Cowans, N. J., Avgidou, K., Molina, F. S., & Nicolaides, K. H. (2007) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5165 · Cited by 155 · see citing works
Prediction of spontaneous preterm delivery from maternal factors, obstetric history and placental perfusion and function at 11–13 weeks
Beta, J., Akolekar, R., Ventura, W., Syngelaki, A., & Nicolaides, K. H. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2662 · Cited by 152 · see citing works
Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta‐analysis
Conde‐Agudelo, A., Papageorghiou, A. T., Kennedy, S. H., & Villar, J. (2013) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12172 · Cited by 148 · see citing works
Predictive factors for intrauterine growth restriction.
Albu, A. R., ANCA, A. F., Horhoianu, V., & Horhoianu, I. A. (2014) · Europe PMC (PubMed Central) · Cited by 142 · see citing works
Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction
Colson, A., Sonveaux, P., Debiève, F., & Sferruzzi-Perri, A. N. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa053 · Cited by 145 · see citing works
First‐trimester assessment of placenta function and the prediction of preeclampsia and intrauterine growth restriction
Zhong, Y., Tuuli, M. G., & Odibo, A. O. (2010) · Prenatal Diagnosis · doi:10.1002/pd.2475 · Cited by 139 · see citing works
First‐trimester ultrasound and biochemical markers of aneuploidy and the prediction of preterm or early preterm delivery
Spencer, K., Cowans, N. J., Molina, F. S., Kagan, K. O., & Nicolaides, K. H. (2007) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5163 · Cited by 124 · see citing works
Genetic Architecture of Feeding Behavior and Feed Efficiency in a Duroc Pig Population
Ding, R., Yang, M. J., Wang, X., Quan, J., Zhuang, Z., Zhou, S., Li, S., Xu, Z., Zheng, E., Cai, G., et al. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00220 · Cited by 118 · see citing works
Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy
Li, Q., Sharkey, A., Sheridan, M. A., Magistrati, E., Arutyunyan, A., Huhn, O., Sancho‐Serra, C., Anderson, H. E., McGovern, N. N., Esposito, L., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.013 · Cited by 120 · see citing works
Serum screening in first trimester to predict pre-eclampsia, small for gestational age and preterm delivery: systematic review and meta-analysis
Zhong, Y., Zhu, F., & Ding, Y. (2015) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-015-0608-y · Cited by 112 · see citing works
Predicting the risk of pre‐eclampsia between 11 and 13 weeks' gestation by combining maternal characteristics and serum analytes, PAPP‐A and free β‐hCG
Goetzinger, K. R., Singla, A., Gerkowicz, S. A., Dicke, J. M., Gray, D. L., & Odibo, A. O. (2010) · Prenatal Diagnosis · doi:10.1002/pd.2627 · Cited by 85 · see citing works
ADAM12s in maternal serum as a potential marker of pre‐eclampsia
Spencer, K., Cowans, N. J., & Stamatopoulou, A. (2008) · Prenatal Diagnosis · doi:10.1002/pd.1957 · Cited by 77 · see citing works
Clinical Presentation of Preeclampsia and the Diagnostic Value of Proteins and Their Methylation Products as Biomarkers in Pregnant Women with Preeclampsia and Their Newborns
Portelli, M., & Baron, B. (2018) · Journal of Pregnancy · doi:10.1155/2018/2632637 · Cited by 77 · see citing works
Screening for Pre-eclampsia–Lessons from Aneuploidy Screening
Cuckle, H. (2011) · Placenta · doi:10.1016/j.placenta.2010.07.015 · Cited by 72 · see citing works
First-Trimester Maternal Serum a Disintegrin and Metalloprotease 12 (ADAM12) and Adverse Pregnancy Outcome
Poon, L. C., Chelemen, T., Granvillano, O., Pandeva, I., & Nicolaides, K. H. (2008) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e318188d6f9 · Cited by 71 · see citing works
A disintegrin and metalloproteinase-12 (ADAM12): Function, roles in disease progression, and clinical implications
Nyren‐Erickson, E. K., Jones, J. M., Srivastava, D. K., & Mallik, S. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.011 · Cited by 70 · see citing works
First-trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction
Odibo, A. O., Zhong, Y., Longtine, M. S., Tuuli, M. G., Odibo, L., Cahill, A. G., Macones, G. A., & Nelson, D. M. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.016 · Cited by 66 · see citing works
Association between first‐trimester maternal serum pregnancy‐associated plasma protein‐A and obstetric complications
D’Antonio, F., Rijo, C., Thilaganathan, B., Akolekar, R., Khalil, A. A., Papageourgiou, A., & Bhide, A. (2013) · Prenatal Diagnosis · doi:10.1002/pd.4141 · Cited by 64 · see citing works
Review: The ADAM metalloproteinases – Novel regulators of trophoblast invasion?
Pollheimer, J., Fock, V., & Knöfler, M. (2013) · Placenta · doi:10.1016/j.placenta.2013.10.012 · Cited by 63 · see citing works
Which ultrasound or biochemical markers are independent predictors of small‐for‐gestational age?
Law, L. W., Leung, T. Y., Sahota, D. S., Chan, L. W., Fung, T. Y., & Lau, T. K. (2009) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.6455 · Cited by 59 · see citing works
Low levels of maternal serum PAPP‐A in early pregnancy and the risk of adverse outcomes
Spencer, C., Allen, V. M., Flowerdew, G. J., Dooley, K., & Dodds, L. A. (2008) · Prenatal Diagnosis · doi:10.1002/pd.2116 · Cited by 59 · see citing works
Maternal‐placental insulin‐like growth factor (IGF) signaling and its importance to normal embryo‐fetal development
Bowman, C., Streck, R. D., & Chapin, R. E. (2010) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20249 · Cited by 57 · see citing works
First trimester maternal serum PAPP‐A, β‐hCG and ADAM12 in prediction of small‐for‐gestational‐age fetuses
Pihl, K., Larsen, T., Krebs, L., & Christiansen, M. (2008) · Prenatal Diagnosis · doi:10.1002/pd.2141 · Cited by 55 · see citing works
First trimester serum PAPP‐A and NGAL in the prediction of late‐onset pre‐eclampsia
D’Anna, R., Baviera, G., Giordano, P., Russo, S., Dugo, N., Santamaria, A., & Corrado, F. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2339 · Cited by 54 · see citing works
Regulation of pregnancy-associated plasma protein A2 (PAPPA2) in a human placental trophoblast cell line (BeWo)
Wagner, P. K., Otomo, A., & Christians, J. K. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-48 · Cited by 52 · see citing works
Prediction of macrosomia at birth in type-1 and 2 diabetic pregnancies with biomarkers of early placentation
Kuć, S., Wortelboer, E. J., Koster, M. P. H., de Valk, H. W., Schielen, P. C. J. I., & Visser, G. H. A. (2011) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2011.02904.x · Cited by 52 · see citing works
Variation of Papp-A Level in the First Trimester of Pregnancy and Its Clinical Outcome
Patil, M., Panchanadikar, T. M., & Wagh, G. N. (2013) · The Journal of Obstetrics and Gynecology of India · doi:10.1007/s13224-013-0481-4 · Cited by 51 · see citing works
A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development
Aghababaei, M., Perdu, S., Irvine, K., & Beristain, A. G. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat084 · Cited by 49 · see citing works
First‐trimester combined screening for Down syndrome: prediction of low birth weight, small for gestational age and pre‐term delivery in a cohort of non‐selected women
Pihl, K., Sørensen, T. L., Nørgaard‐Pedersen, B., Larsen, S. O., Nguyen, T. H., Krebs, L., Larsen, T., & Christiansen, M. (2008) · Prenatal Diagnosis · doi:10.1002/pd.1946 · Cited by 49 · see citing works
Extravillous Trophoblast-Associated ADAM12 Exerts Pro-Invasive Properties, Including Induction of Integrin Beta 1-Mediated Cellular Spreading1
Biadasiewicz, K., Fock, V., Dekan, S., Proestling, K., Velicky, P., Haider, S., Knöfler, M., Fröhlich, C., & Pollheimer, J. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.115279 · Cited by 45 · see citing works
First‐trimester maternal placental protein 13 levels in pregnancies resulting in adverse outcomes
Cowans, N. J., Spencer, K., & Meiri, H. (2008) · Prenatal Diagnosis · doi:10.1002/pd.1921 · Cited by 45 · see citing works
ADAM12 is an effective marker in the second trimester of pregnancy for prenatal screening of Down syndrome
Wang, M., Lü, S., Zhu, Y., & Li, H. (2010) · Prenatal Diagnosis · doi:10.1002/pd.2523 · Cited by 45 · see citing works
First-, Second-, and Third-Trimester Screening for Preeclampsia and Intrauterine Growth Restriction
Rodriguez, A. R., Tuuli, M. G., & Odibo, A. O. (2016) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2016.01.007 · Cited by 44 · see citing works
Longitudinal trends in fetoplacental biochemical markers, uterine artery pulsatility index and maternal blood pressure during the first trimester of pregnancy
Wortelboer, E. J., Koster, M. P. H., Kuć, S., Eijkemans, M. J. C., Bilardo, C. M., Schielen, P. C. J. I., & Visser, G. H. A. (2011) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.9029 · Cited by 41 · see citing works
Multi‐Marker Maternal Serum Screening for Chromosomal Abnormalities
Cuckle, H., & BENN, P. A. (2009) · doi:10.1002/9781444314342.ch24 · Cited by 39 · see citing works
First trimester screening for intra‐uterine growth restriction and early‐onset pre‐eclampsia
Vandenberghe, G., Mensink, I., Twisk, J. W. R., Blankenstein, M. A., Heijboer, A. C., & van Vugt, J. M. G. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2807 · Cited by 36 · see citing works
ADAM12 is expressed by astrocytes during experimental demyelination
Baertling, F., Kokozidou, M., Pufe, T., Clarner, T., Windoffer, R., Wruck, C. J., Brandenburg, L., Beyer, C., & Kipp, M. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.049 · Cited by 36 · see citing works
A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy
Rausch, M., Beer, L. A., Sammel, M. D., Takács, P., Chung, K., Shaunik, A., Speicher, D. W., & Barnhart, K. T. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.12.040 · Cited by 36 · see citing works
First trimester predictors of adverse pregnancy outcomes
Brameld, K., Dickinson, J. E., O'Leary, P. C., Bower, C. I., Goldblatt, J., Hewitt, B. G., Murch, A. R., & Stock, R. (2008) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2008.00912.x · Cited by 35 · see citing works
Circulating biomarkers associated with placental dysfunction and their utility for predicting fetal growth restriction
Hong, J. G. S., & Kumar, S. (2023) · Clinical Science · doi:10.1042/cs20220300 · Cited by 36 · see citing works
First-Trimester Levels of Pregnancy-Associated Plasma Protein A2 (PAPP-A2) in the Maternal Circulation Are Elevated in Pregnancies That Subsequently Develop Preeclampsia
Crosley, E., Durland, U., Seethram, K., MacRae, S., Gruslin, A., & Christians, J. K. (2013) · Reproductive Sciences · doi:10.1177/1933719113512532 · Cited by 32 · see citing works
Altered levels of insulin‐like growth factor binding protein proteases in preeclampsia and intrauterine growth restriction
Christians, J. K., & Gruslin, A. (2010) · Prenatal Diagnosis · doi:10.1002/pd.2583 · Cited by 32 · see citing works
The secretion of PAPP-A, ADAM12, and PP13 correlates with the size of the placenta for the first month of pregnancy
Sahraravand, M., Järvelä, I. Y., Laitinen, P. H., Tekay, A., & Ryynänen, M. (2011) · Placenta · doi:10.1016/j.placenta.2011.10.005 · Cited by 32 · see citing works
ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy
Spencer, K., & Cowans, N. J. (2007) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701483389 · Cited by 32 · see citing works
First trimester serum analytes, maternal characteristics and ultrasound markers to predict pregnancies at risk for preterm birth
Stout, M. J., Goetzinger, K. R., Tuuli, M. G., Cahill, A. G., Macones, G., & Odibo, A. O. (2012) · Placenta · doi:10.1016/j.placenta.2012.10.013 · Cited by 31 · see citing works
Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta
Mathewlynn, S., & Collins, S. L. (2019) · Placenta · doi:10.1016/j.placenta.2019.06.379 · Cited by 30 · see citing works
Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes
Nieves-Colón, M. A., Rivera, K. M. B., Sandoval, K., Dávalos, V. V., Lencinas, L. E. E., Mendoza‐Revilla, J., Adhikari, K., González-Buenfil, R., Chen, J. W., Zhang, E., et al. (2022) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2022.04.014 · Cited by 29 · see citing works
The Role of Serum Markers and Uterine Artery Doppler in Identifying At-Risk Pregnancies
Tuuli, M. G., & Odibo, A. O. (2011) · Clinics in Perinatology · doi:10.1016/j.clp.2010.12.007 · Cited by 30 · see citing works
ISGylation: A Conserved Pathway in Mammalian Pregnancy
Hansen, T. R., & Pru, J. K. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0817-2_2 · Cited by 30 · see citing works
Deletion of the Isg15 Gene Results in Up-Regulation of Decidual Cell Survival Genes and Down-Regulation of Adhesion Genes: Implication for Regulation by IL-1β
Ashley, R. L., Henkes, L. E., Bouma, G. J., Pru, J. K., & Hansen, T. R. (2010) · Endocrinology · doi:10.1210/en.2010-0166 · Cited by 29 · see citing works
First Trimester Placental Biomarkers for Pregnancy Outcomes
Cristodoro, M., Messa, M., Tossetta, G., Marzioni, D., Dell’avanzo, M., Inversetti, A., & Simone, N. D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116136 · Cited by 28 · see citing works
Placental Protein-13 and Pregnancy-Associated Plasma Protein-A as First Trimester Screening Markers for Hypertensive Disorders and Small for Gestational Age Outcomes
Stamatopoulou, A., Cowans, N. J., Matwejew, E., von Kaisenberg, C., & Spencer, K. (2010) · Hypertension in Pregnancy · doi:10.3109/10641955.2010.484081 · Cited by 28 · see citing works
The Impact of First-Trimester Serum Free β-Human Chorionic Gonadotropin and Pregnancy-Associated Plasma Protein A on the Diagnosis of Fetal Growth Restriction and Small for Gestational Age Infant
Montanari, L., Alfei, A., Albonico, G., Moratti, R., Arossa, A., Beneventi, F., & Spinillo, A. (2009) · Fetal Diagnosis and Therapy · doi:10.1159/000207554 · Cited by 27 · see citing works
First‐trimester prediction of preterm birth using ADAM12, PAPP‐A, uterine artery Doppler, and maternal characteristics
Goetzinger, K. R., Cahill, A. G., Kemna, J., Odibo, L., Macones, G. A., & Odibo, A. O. (2012) · Prenatal Diagnosis · doi:10.1002/pd.3949 · Cited by 25 · see citing works
Prenatal diagnosis--principles of diagnostic procedures and genetic counseling.
Stembalska, A., Ślężak, R., Pesz, K. A., Gil, J., & Sasiadek, M. M. (2007) · PubMed · doi:10.5603/4493 · Cited by 25 · see citing works
Placental volume and vascularization flow indices by 3D power Doppler US using VOCAL technique and correlation with IGF-1, free beta-hCG, PAPP-A, and uterine artery Doppler at 11–14 weeks of pregnancy
Yiğiter, A. B., Kavak, Z. N., Durukan, B., İşçi, H., Uzuner, A., Uyar, E., & Gökaslan, H. (2011) · Journal of Perinatal Medicine · doi:10.1515/jpm.2010.136 · Cited by 25 · see citing works
Blood‐based biomarkers in the maternal circulation associated with fetal growth restriction
Tong, S. Y. C., Kaitu’u‐Lino, T. J., Walker, S. P., & MacDonald, T. M. (2019) · Prenatal Diagnosis · doi:10.1002/pd.5525 · Cited by 24 · see citing works
Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia
Qu, H., & Khalil, R. A. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115266 · Cited by 24 · see citing works
First‐trimester ADAM12s as early markers of trisomy 21: a promise still unfulfilled?
Spencer, K., Cowans, N. J., Uldbjerg, N., & Tørring, N. (2008) · Prenatal Diagnosis · doi:10.1002/pd.1978 · Cited by 23 · see citing works
First-trimester maternal serum screening and the risk for fetal distress during labor
Uccella, S., Colombo, G., Bulgheroni, C., Serati, M., Bogani, G., Salvatore, S., Ghezzi, F., & Bolis, P. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.05.009 · Cited by 22 · see citing works
Metalloprotease (ADAM12-S) as a Predictor of Preeclampsia: Correlation with Severity, Maternal Complications, Fetal Outcome, and Doppler Parameters
El-Sherbiny, W. S., Nasr, A. S., & Soliman, A. (2012) · Hypertension in Pregnancy · doi:10.3109/10641955.2012.690059 · Cited by 22 · see citing works
Embryo‐fetal developmental toxicity of figitumumab, an anti‐insulin‐like growth factor‐1 receptor (IGF‐1R) monoclonal antibody, in cynomolgus monkeys
Bowman, C., Chmielewski, G., Oneda, S., Finco, D., Boucher, M., & Todd, M. D. (2010) · Birth Defects Research Part B Developmental and Reproductive Toxicology · doi:10.1002/bdrb.20248 · Cited by 21 · see citing works
The risk of adverse pregnancy outcome among pregnancies with extremely low maternal PAPP-A
Kaijomaa, M., Ulander, V., Hämäläinen, E. K., Alfthan, H. V., Markkanen, H. M., Heinonen, S. T., & Stefanović, V. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4946 · Cited by 21 · see citing works
Mid-Trimester Maternal ADAM12 Levels Differ According to Fetal Gender in Pregnancies Complicated by Preeclampsia
Myers, J., Thomas, G. R., Tuytten, R., Herrewege, Y. V., Djiokep, R. O., Roberts, C. T., Kenny, L. C., Simpson, N., North, R. A., & Baker, P. N. (2014) · Reproductive Sciences · doi:10.1177/1933719114537713 · Cited by 20 · see citing works
Maternal serum ADAM12s in the late first trimester of pregnancies with Trisomy 21
Spencer, K., Cowans, N. J., & Stamatopoulou, A. (2008) · Prenatal Diagnosis · doi:10.1002/pd.1994 · Cited by 20 · see citing works
ADAM12s as a first‐trimester screening marker of trisomy
Wortelboer, E. J., Linskens, I. H., Koster, M. P. H., Stoutenbeek, P., Cuckle, H., Blankenstein, M. A., Visser, G. H. A., van Vugt, J. M. G., & Schielen, P. C. J. I. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2300 · Cited by 20 · see citing works
Maternal serum ADAM12s as a marker of rare aneuploidies in the first or second trimester of pregnancy
Spencer, K., Cowans, N. J., & Stamatopoulou, A. (2007) · Prenatal Diagnosis · doi:10.1002/pd.1885 · Cited by 19 · see citing works
First- and Second-Trimester Screening for Preeclampsia and Intrauterine Growth Restriction
Tuuli, M. G., & Odibo, A. O. (2010) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2010.05.002 · Cited by 16 · see citing works
Monochorionic twins with selective fetal growth restriction: insight from placental whole-transcriptome analysis
Li, W., Chung, C., Wang, C. C., Chan, T., Leung, B. W., Chan, O. K., Wu, L., Appiah, K., Chaemsaithong, P., Cheng, Y. K. Y., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.05.008 · Cited by 16 · see citing works
Maternal serum insulin-like growth factor (IGF-I) and binding proteins IGFBP-1 and IGFBP-3 at 11–13 weeks’ gestation in pregnancies delivering small for gestational age neonates
Sifakis, S., Akolekar, R., Kappou, D., Mantas, N., & Nicolaides, K. H. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2011.12.022 · Cited by 16 · see citing works
First trimester screening for trisomy 21 in gestational week 8-10 by ADAM12-S as a maternal serum marker
Tørring, N., Ball, S., Wright, D., Sarkissian, G., Guitton, M., & Darbouret, B. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-129 · Cited by 16 · see citing works
Altered placental expression of PAPPA2 does not affect birth weight in mice
Wagner, P. K., & Christians, J. K. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-90 · Cited by 16 · see citing works
Evaluation of biochemical markers combined with uterine artery Doppler parameters in fetuses with growth restriction: a case–control study
Zamarian, A. C. P., Júnior, E. A., Daher, S., Rôlo, L. C., Moron, A. F., & Nardozza, L. M. M. (2016) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-016-4024-y · Cited by 16 · see citing works
Maternal serum ADAM12s as a potential marker of trisomy 21 prior to 10 weeks of gestation
Spencer, K., Vereecken, A. J., & Cowans, N. J. (2008) · Prenatal Diagnosis · doi:10.1002/pd.1939 · Cited by 16 · see citing works
Complex patterns of ADAM12 mRNA and protein splice variants in the human placenta
Kokozidou, M., Drewlo, S., Bartz, C., Raven, G., Brandenburg, L., Wruck, C. J., & Pufe, T. (2011) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2010.12.002 · Cited by 15 · see citing works
Maternal Serum ADAM-12 as a Potential Marker for Different Adverse Pregnancy Outcomes
Matwejew, E., Cowans, N. J., Stamatopoulou, A., Spencer, K., & von Kaisenberg, C. S. (2010) · Fetal Diagnosis and Therapy · doi:10.1159/000275669 · Cited by 15 · see citing works
Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death
Gallo, D. M., Fitzgerald, W., Romero, R. J., Gomez‐Lopez, N., Gudicha, D. W., Than, N. G., Bosco, M., Chaiworapongsa, T., Jung, E., Meyyazhagan, A., et al. (2023) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2023.2177529 · Cited by 14 · see citing works
Maternal Serum Disintegrin and Metalloprotease Protein-12 in Early Pregnancy as a Potential Marker of Adverse Pregnancy Outcomes
Yang, J., Wu, J. T., Guo, F., Wang, D., Chen, K., Li, J., Du, L. L., & Yin, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097284 · Cited by 14 · see citing works
Biochemical markers for prediction of preclampsia: review of the literature.
Monte, S. (2011) · PubMed Central · Cited by 14 · see citing works
The proform of eosinophil major basic protein: a new maternal serum marker for adverse pregnancy outcome
Pihl, K., Larsen, T., Rasmussen, S. M., Krebs, L., & Christiansen, M. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2331 · Cited by 14 · see citing works
The Elsevier Trophoblast Research Award Lecture: Importance of metzincin proteases in trophoblast biology and placental development: A focus on ADAM12
Aghababaei, M., & Beristain, A. G. (2014) · Placenta · doi:10.1016/j.placenta.2014.12.016 · Cited by 13 · see citing works
Maternal Serum ADAM12 Levels Correlate with PAPP-A Levels during the First Trimester
Valinen, Y., Peuhkurinen, S., Järvelä, I. Y., Laitinen, P. H., & Ryynänen, M. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000289178 · Cited by 13 · see citing works
ADAM 12 may be used to reduce the false positive rate of first trimester combined screening for Down syndrome
Christiansen, M., Pihl, K., Hedley, P. L., Gjerris, A. C., Lind, P. Ø., Larsen, S. O., Krebs, L., & Larsen, T. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2405 · Cited by 13 · see citing works
ADAM12 in first trimester maternal serum from pregnancies conceived by assisted reproduction techniques (ART)
Laigaard, J., Pedersen, N. G., Larsen, S. O., Hedley, P. L., Wøjdemann, K. R., Gjerris, A. C., Shalmi, A. C., Sundberg, K., Tabor, A., & Christiansen, M. (2009) · Prenatal Diagnosis · doi:10.1002/pd.2180 · Cited by 13 · see citing works
The role of placental hormones and metabolites in modulating uterine circulation in physiological and pathological pregnancies
Esposito, M., Paulesu, L. R., & Mandalà, M. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1637570 · Cited by 14 · see citing works
Screening for abnormal placentation and adverse pregnancy outcomes with maternal serum biomarkers in the second trimester
Goetzinger, K. R., & Odibo, A. O. (2014) · Prenatal Diagnosis · doi:10.1002/pd.4370 · Cited by 12 · see citing works
The role of maternal serumbeta-HCG and PAPP-A levels at gestational weeks 10 to 14 in the prediction of pre-eclampsia
Özdamar, Ö., Gün, İ., Keskin, U., Koçak, N. A., & Müngen, E. (2014) · Pakistan Journal of Medical Sciences · doi:10.12669/pjms.303.4554 · Cited by 12 · see citing works
A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks’ gestation in pregnancies destined to deliver small for gestational age infants
Andres, F., Wong, G. P., Walker, S. P., MacDonald, T. M., Keenan, E., Cannon, P., Nguyen, T. V., Hannan, N. J., Tong, S. Y. C., & Kaitu’u‐Lino, T. J. (2021) · Placenta · doi:10.1016/j.placenta.2021.11.001 · Cited by 11 · see citing works
Association between PAPP-A and placental thickness
Mesdaghinia, E., Behrashi, M., Saeidi, A., & Kalahroodi, M. A. (2016) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.29252/ijrm.14.6.421 · Cited by 11 · see citing works
Serum pregnancy-associated plasma protein A levels in the first, second and third trimester of pregnancy: relation to newborn anthropometric parameters and maternal tobacco smoking
Chełchowska, M., Gajewska, J., Mazur, J., Ambroszkiewicz, J., Maciejewski, T., & Leibschang, J. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.62908 · Cited by 11 · see citing works
Second trimester maternal serum ADAM12 levels in Down's syndrome pregnancies
Donalson, K., Turner, S., Wastell, H., & Cuckle, H. (2008) · Prenatal Diagnosis · doi:10.1002/pd.2043 · Cited by 11 · see citing works
Correlation of neonatal weight with maternal serum levels of pregnancy-associated plasma protein-A during the first trimester of pregnancy: a retrospective study
Giudice, I., Benintende, G., Nicolò, A. M. D., Mangiameli, D., Carrara, G., Randazzo, C., Sapuppo, I. M., & Gulisano, A. (2014) · Journal of Perinatal Medicine · doi:10.1515/jpm-2013-0249 · Cited by 10 · see citing works
Effect of a new marker, ADAM12, on Down risk figures in first trimester screening
Valinen, Y., Laitinen, P. H., Ranta, J. K., Ignatius, J., Järvelä, I. Y., & Ryynänen, M. (2009) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050902755478 · Cited by 10 · see citing works
ADAM12s and PP13 as first trimester screening markers for adverse pregnancy outcome
Deurloo, K. L., Linskens, I. H., Heymans, M. W., Heijboer, A. C., Blankenstein, M. A., & van Vugt, J. M. G. (2012) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0566 · Cited by 10 · see citing works

(www.interscience.wiley.com) DOI: 10.1002/pd.1665
Diagn, P., & Cowans, N. J. (2015)
ADAM12: a novel first‐trimester maternal serum marker for Down syndrome
Laigaard, J., Sørensen, T. L., Fröhlich, C., Pedersen, B. N., Christiansen, M., Schiøtt, K. M., Uldbjerg, N., Albrechtsen, R., Clausen, H. V., Ottesen, B., et al. (2003) · Prenatal Diagnosis · doi:10.1002/pd.762 · Cited by 107 · see citing works
Predictive value of biochemical marker ADAM-12 at first trimester of pregnancy for hypertension and intrauterine growth restriction
Kasimis, C., Evangelinakis, N. E., Rotas, M., Georgitsi, M., Pelekanos, N., & Kassanos, D. (2016) · Clinical and Experimental Obstetrics & Gynecology · doi:10.12891/ceog2000.2016 · Cited by 7 · see citing works
Maternal Serum ADAM12 Levels Correlate with PAPP-A Levels during the First Trimester
Valinen, Y., Peuhkurinen, S., Järvelä, I. Y., Laitinen, P. H., & Ryynänen, M. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000289178 · Cited by 13 · see citing works
血清妊娠相关蛋白-A与解整合素-金属蛋白酶12在早孕期产前筛查中运用的初步探讨
林晓娟, 孙庆梅, 刘婷婷, 吕玲, 郝胜菊, 吴菊, Li, J., 宋筱玉, 代维斯, & 赵媛 (2014) · Chin J Obstet Gynecol · doi:10.3877/cma.j.issn.1673-5250.2014.04.015

Authors: Cowans, N. J., & Spencer, K.
Affiliations: Harold Wood Hospital (GB)
Corresponding author: Spencer, Kevin
ORCID: Cowans, Nicholas J.
Spencer, Kevin
Venue: Prenatal Diagnosis
Publisher: Wiley
Published: 2007-02-05
Volume: 27
Issue: 3
Pages: 264-271
ISSN: 0197-3851 (ISSN-L)
1097-0223
DOI: 10.1002/pd.1665
OpenAlex: W2097737765
Cited by: 160
References: 46
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 7 · 2015: 6 · 2014: 11 · 2013: 12 · 2012: 13
FWCI: 21.06
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Prenatal Diagnosis (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: ADAM12, PAPP-A, insulin-like growth factor system, IGF binding proteins, fetal growth restriction, macrosomia, low birth weight, preterm birth, intrauterine fetal death, first-trimester biomarkers, adverse pregnancy outcomes, birthweight centiles
MeSH terms: ADAM12 Protein, Body Weight, Female, Fetal Growth Retardation, Gestational Age, Humans, Maternal Age, Membrane Proteins, Pregnancy, Pregnancy Outcome, Pregnancy Trimester, First, Pregnancy-Associated Plasma Protein-A, Smoking, Biomarkers, ADAM Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks