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Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks

Nanda, Surabhi, Savvidou, Mina, Syngelaki, Argyro, Akolekar, Ranjit, Nicolaides, Kypros H.·2011·Prenatal Diagnosis

Abstract

Objective: To develop a model for the prediction of gestational diabetes mellitus (GDM) from maternal characteristics and biochemical markers at 11 to 13 weeks' gestation. Methods: A prospective screening study on early prediction of pregnancy complications (n = 11, 464), including 297 (2.6%) cases of GDM was used to create the predictive model of GDM based on maternal characteristics. Maternal serum concentrations of adiponectin, follistatin‐like‐3 (FSTL3) and sex hormone‐binding globulin (SHBG) were measured in a case‐control study of 80 women who developed GDM and 300 controls. Results: In the screening study, maternal age, body mass index, racial origin, previous history of GDM and macrosomic neonate were significant independent predictors of future GDM. In the GDM group, compared to controls, the median multiple of the normal median adiponectin (0.66; IQR: 0.5–0.9 vs 1.02; IQR: 0.7–1.29) and SHBG (0.81; IQR: 0.6–1.04 vs 1.02; IQR: 0.8–1.2) was lower (p < 0.05), but FSTL3 was not significantly different. In screening for GDM by maternal characteristics, the detection rate was 61.6% at a false‐positive rate of 20% and the detection increased to 74.1% by the addition of adiponectin and SHBG. Conclusion: First‐trimester screening for GDM can be provided by a combination of maternal characteristics and biomarkers. Copyright © 2010 John Wiley & Sons, Ltd.

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Metadata

Authors
Nanda, S., Savvidou, M., Syngelaki, A., Akolekar, R., & Nicolaides, K. H.
Venue
Prenatal Diagnosis
Publisher
Wiley
Published
2010-12-28
Volume
31
Issue
2
Pages
135-141
ISSN
  • 0197-3851 (ISSN-L)
  • 1097-0223
OpenAlex
W2061142933
Cited by
254
References
11
FWCI
13.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks. https://app.cochat.ai/papers/10.1002/pd.2636
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Nanda, S., Savvidou, M., Syngelaki, A., Akolekar, R., & Nicolaides, K. H. (2011). Prediction of gestational diabetes mellitus by maternal factors and biomarkers at 11 to 13 weeks. Prenatal Diagnosis. https://doi.org/10.1002/pd.2636

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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