The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Gestational age and maternal weight effects on fetal cell‐free DNA in maternal plasma
Open accessAbstract
Objective: To determine the effects of gestational age and maternal weight on percent fetal cell‐free DNA (cfDNA) in maternal plasma and the change in fetal cfDNA amounts within the same patient over time. Methods: The cfDNA was extracted from maternal plasma from 22 384 singleton pregnancies of at least 10 weeks gestation undergoing the Harmony TM Prenatal Test. The Harmony Prenatal Test determined fetal percentage via directed analysis of cfDNA. Results: At 10 weeks 0 days to 10 weeks 6 days gestation, the median percent fetal cfDNA was 10.2%. Between 10 and 21 weeks gestation, percent fetal increased 0.1% per week (p < 0.0001), and 2% of pregnancies were below 4% fetal cfDNA. Beyond 21 weeks gestation, fetal cfDNA increased 1% per week (p < 0.0001). Fetal cfDNA percentage was proportional to gestational age and inversely proportional to maternal weight (p = 0.0016). Of 135 samples that were redrawn because of insufficient fetal cfDNA of the initial sample, 76 (56%) had greater than 4% fetal cfDNA in the sample from the second draw. Conclusion: Fetal cfDNA increases with gestation, decreases with increasing maternal weight, and generally improves upon a blood redraw when the first attempt has insufficient fetal cfDNA. © 2013 John Wiley & Sons, Ltd.
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Cites
Gynecologists (2009) · Cited by 1,035
Genome-Wide Fetal Aneuploidy Detection by Maternal Plasma DNA Sequencing
Bianchi, D. W., Platt, L. D., Goldberg, J. D., Abuhamad, A. Z., Sehnert, A. J., & Rava, R. P. (2012) · Obstetrics & Gynecology · doi:10.1097/aog.0b013e31824fb482 · Cited by 644
Screening for fetal aneuploidies at 11 to 13 weeks
Nicolaides, K. H. (2011) · Prenatal Diagnosis · doi:10.1002/pd.2637 · Cited by 642
Noninvasive prenatal testing for fetal trisomies in a routinely screened first-trimester population
Nicolaides, K. H., Syngelaki, A., Ashoor, G., Birdir, C., & Touzet, G. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.08.033 · Cited by 624
Norton, M. E., Brar, H., Weiss, J., Karimi, A., Laurent, L. C., Caughey, A. B., Rodriguez, M. H., Williams, J., Mitchell, M. E., Adair, C. D., et al. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.05.021 · Cited by 596
Self-citationACOG Practice Bulletin No. 77: Screening for Fetal Chromosomal Abnormalities
(2007) · Obstetrics & Gynecology · doi:10.1097/00006250-200701000-00054 · Cited by 581
Limits of body mass index to detect obesity and predict body composition
Frankenfield, D. C., Rowe, W. A., Cooney, R. N., Smith, J. S., & Becker, D. (2001) · Nutrition · doi:10.1016/s0899-9007(00)00471-8 · Cited by 554
Sparks, A. B., Struble, C. A., Wang, E. T., Song, K., & Oliphant, A. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.01.030 · Cited by 395
Self-citationScreening for Fetal Chromosomal Abnormalities: ACOG Practice Bulletin Summary, Number 226
(2020) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000004107 · Cited by 385
Zimmermann, B., Hill, M., Gemelos, G., Demko, Z., Banjevic, M., Baner, J., Ryan, A., Sigurjonsson, S., Chopra, N., Dodd, M., et al. (2012) · Prenatal Diagnosis · doi:10.1002/pd.3993 · Cited by 328
Cited by
Cell-free DNA Analysis for Noninvasive Examination of Trisomy
Norton, M. E., Jacobsson, B., Swamy, G. K., Laurent, L. C., Ranzini, A. C., Brar, H., Tomlinson, M. W., Pereira, L., Spitz, J. L., Hollemon, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1407349 · Cited by 817
Self-citationon behalf of the European Society of Human Genetics (ESHG) and the American Society of Human Genetics (ASHG), Dondorp, W., de Wert, G., Bombard, Y., Bianchi, D. W., Bergmann, C., Borry, P., Chitty, L. S., Fellmann, F., Forzano, F., et al. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.57 · Cited by 349
Benn, P., Borrell, A., Chiu, R. W. K., Cuckle, H., Dugoff, L., Faas, B., Gross, S., Huang, T., Johnson, J., Maymon, R., et al. (2015) · Prenatal Diagnosis · doi:10.1002/pd.4608 · Cited by 292
Dar, P., Curnow, K. J., Gross, S. J., Hall, M. P., Stosic, M., Demko, Z., Zimmermann, B., Hill, M., Sigurjonsson, S., Ryan, A., et al. (2014) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.08.006 · Cited by 277
Hui, L., Ellis, K., Mayen, D., Pertile, M. D., Reimers, R., Sun, L., Vermeesch, J., Vora, N. L., & Chitty, L. S. (2023) · Prenatal Diagnosis · doi:10.1002/pd.6357 · Cited by 109
Metadata
- Authors
- Wang, E., Batey, A., Struble, C., Musci, T., Song, K., & Oliphant, A.
- Venue
- Prenatal Diagnosis
- Publisher
- Wiley
- Published
- 2013-05-09
- Volume
- 33
- Issue
- 7
- Pages
- 662-666
- ISSN
- 0197-3851 (ISSN-L)
- 1097-0223
- OpenAlex
- W1576120545
- Cited by
- 440
- References
- 20
- FWCI
- 30.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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