Pharmacoepidemiology of QT‐interval prolonging drug administration in critically ill patients
Open accessAbstract
Purpose: Commonly prescribed medications produce QT‐prolongation and are associated with torsades de pointes in non‐acutely ill patients. We examined patterns of QT‐prolonging drug use in critically ill individuals. Methods: An administrative critical care database was utilized to identify patients receiving drugs associated with QT‐interval prolongation or torsades de pointes for ≥ 24 hours. Results: Data from 212 016 individuals collected over a 63‐month period was examined to identify 6125 patients (2.9%) receiving QT‐interval prolonging drugs. These individuals had a mean (±SE) age of 63.0 (±0.2) years, were predominately male (55.4%) and Caucasian (84.4%), and were exposed to QT‐interval prolonging agents for a mean (±SE) 53.1 (±0.4)% of their ICU length of stay. Respiratory and cardiovascular illnesses were the most common reasons for ICU admission (17.2, 12.0%, respectively). The most frequently administered agents were amiodarone (23.5%), haloperidol (19.8%), and levofloxacin (19.7%); no other single agent accounted for more than 10% of QT‐interval prolonging drugs prescribed. Coadministration of QT‐prolonging drugs occurred in 1139 patients (18.6%). These patients had higher ICU mortality rate and longer ICU lengths of stay, compared to patients not receiving coadministered drugs (p < 0.001 for both). For patients receiving coadministered drugs, overlap occurred for 71.4 (±0.8)% of the time that the drugs were given. Amiodarone coadministration with antibiotics, haloperidol coadministration with antibiotics, and haloperidol coadministration with amiodarone, comprised 15.2, 13.7, and 9.4%, of all coadministered agents, respectively. Conclusions: QT‐prolonging drugs were used in a minority of critically ill patients. Prospective evaluation in the ICU environment is necessary to determine whether administration of these agents is associated with adverse cardiac events comparable to those reported in ambulatory patients. Copyright © 2008 John Wiley & Sons, Ltd.
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Haloperidol has a number of side effects, the most problematic of which is prolongation of the corrected QT interval.
“Haloperidol has, however, a number of side effects, the most problematic of which is prolongation of the corrected QT interval [33].”
From Nicotine withdrawal and agitation in ventilated critically ill patients (2010) · cites this paper as [33]
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Cites
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,333 · see citing works
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379 · see citing works
APACHE II: a severity of disease classification system.
Knaus, W. A., Draper, E. S., Wagner, D. P., & Zimmerman, J. E. (1985) · PubMed · Cited by 6,034 · see citing works
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675 · see citing works
Drug-induced prolongation of the QT interval
Roden, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra032426 · Cited by 1,965 · see citing works
Timing of new black box warnings and withdrawals for prescription medications
Lasser, K. E. (2002) · JAMA · doi:10.1001/jama.287.17.2215 · Cited by 1,005 · see citing works
Antipsychotic Drugs: Prolonged QTc Interval, Torsade de Pointes, and Sudden Death
Glassman, A. H., & Bigger, J. T. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1774 · Cited by 821 · see citing works
What Clinicians Should Know About the QT Interval
Al‐Khatib, S. M., LaPointe, N. M. A., Kramer, J. M., & Califf, R. M. (2003) · JAMA · doi:10.1001/jama.289.16.2120 · Cited by 671 · see citing works
Variant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia
Splawski, I., Timothy, K. W., Tateyama, M., Clancy, C. E., Malhotra, A., Beggs, A. H., Cappuccio, F. P., Sagnella, G. A., Kass, R. S., & Keating, M. T. (2002) · Science · doi:10.1126/science.1073569 · Cited by 523 · see citing works
Oral Erythromycin and the Risk of Sudden Death from Cardiac Causes
Ray, W. A., Murray, K. T., Meredith, S., Narasimhulu, S. S., Hall, K., & Stein, C. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040582 · Cited by 493 · see citing works
A common polymorphism associated with antibiotic-induced cardiac arrhythmia
Sesti, F., Abbott, G. W., Wei, J., Murray, K. T., Saksena, S. V., Schwartz, P. J., Priori, S. G., Roden, D. M., George, A. L., & Goldstein, S. A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180223197 · Cited by 479 · see citing works
Antipsychotics and the Risk of Sudden Cardiac Death
Ray, W. A., Meredith, S. K., Thapa, P. B., Meador, K. G., Hall, K., & Murray, K. T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.12.1161 · Cited by 430 · see citing works
Regulating Off-Label Drug Use — Rethinking the Role of the FDA
Stafford, R. S. (2008) · New England Journal of Medicine · doi:10.1056/nejmp0802107 · Cited by 350 · see citing works
Torsade de Pointes Due to Noncardiac Drugs
Zeltser, D., Justo, D., Halkin, A., Prokhorov, V., Heller, K., & Viskin, S. (2003) · Medicine · doi:10.1097/01.md.0000085057.63483.9b · Cited by 273 · see citing works
Antipsychotics and the Risk of Sudden Cardiac Death
Straus, S. M. J. M., Bleumink, G. S., Dieleman, J. P., van der Lei, J., Jong, G. W. ‘., Kingma, J. H., Sturkenboom, M., & Stricker, B. H. C. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.12.1293 · Cited by 262 · see citing works
Hennessy, S., Bilker, W. B., Knauss, J. S., Margolis, D. J., Kimmel, S. E., Reynolds, R. F., Glasser, D. B., Morrison, M. F., & Strom, B. L. (2002) · BMJ · doi:10.1136/bmj.325.7372.1070 · Cited by 261 · see citing works
Contraindicated Use of Cisapride
Smalley, W. E., Shatin, D., Wysowski, D. K., Gurwitz, J. H., Andrade, S. E., Goodman, M. J., Chan, K. A., Platt, R. G., Schech, S. D., & Ray, W. A. (2000) · JAMA · doi:10.1001/jama.284.23.3036 · Cited by 253 · see citing works
Higgins, T. L., McGee, W. T., Steingrub, J. S., Rapoport, J., Lemeshow, S. A., & Teres, D. (2003) · Critical Care Medicine · doi:10.1097/00003246-200301000-00007 · Cited by 218 · see citing works
Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients
Curtis, L. H., Østbye, T., Sendersky, V., Hutchison, S., LaPointe, N. M. A., Al‐Khatib, S. M., Yasuda, S. U., Dans, P. E., Wright, A., Califf, R. M., et al. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01455-9 · Cited by 175 · see citing works
Ponti, F. D., Poluzzi, E., & Montanaro, N. (2001) · European Journal of Clinical Pharmacology · doi:10.1007/s002280100290 · Cited by 171 · see citing works
The Pharmacological Basis of Therapeutics
David, N. A. (1966) · JAMA · doi:10.1001/jama.1966.03100010106040 · Cited by 162 · see citing works
Freeman, B. D., Borecki, I. B., Coopersmith, C. M., & Buchman, T. G. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000186369.91799.44 · Cited by 162 · see citing works
Self-citationIn Defense of Pharmacoepidemiology — Embracing the Yin and Yang of Drug Research
Avorn, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmp0706892 · Cited by 162 · see citing works
Thioridazine and sudden unexplained death in psychiatric in-patients
Reilly, J. G., Ayis, S. A., Ferrier, I. N., Jones, S., & Thomas, S. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.180.6.515 · Cited by 157 · see citing works
Prescription of QT-prolonging drugs in a cohort of about 5 million outpatients
Curtis, L. H., Østbye, T., & Sendersky, V. (2003) · ACC Current Journal Review · doi:10.1016/s1062-1458(03)00200-9 · Cited by 149 · see citing works
Rapoport, J. (2000) · JAMA · doi:10.1001/jama.283.19.2559 · Cited by 120 · see citing works
Project IMPACT: Results from a Pilot Validity Study of a New Observational Database
Cook, S. F., Visscher, W. A., Hobbs, C. L., & Williams, R. L. (2002) · Critical Care Medicine · doi:10.1097/00003246-200212000-00024 · Cited by 90 · see citing works
Protecting the Health of the Public — Institute of Medicine Recommendations on Drug Safety
Psaty, B. M., & Burke, S. P. (2006) · New England Journal of Medicine · doi:10.1056/nejmp068228 · Cited by 84 · see citing works
Safeguarding Patients in Clinical Trials with High Mortality Rates
Freeman, B. D., Danner, R. L., BANKS, S. M., & Natanson, C. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.2.2011028 · Cited by 68 · see citing works
Self-citationGlance, L. G., Osler, T. M., & Dick, A. W. (2002) · Critical Care Medicine · doi:10.1097/00003246-200209000-00008 · Cited by 56 · see citing works
An Underrecognized Challenge in Evaluating Postmarketing Drug Safety
Roden, D. M. (2005) · Circulation · doi:10.1161/01.cir.0000154578.45378.8c · Cited by 20 · see citing works
Challenges of implementing pharmacogenetics in the critical care environment
Freeman, B. D., & McLeod, H. L. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1285 · Cited by 18 · see citing works
Self-citationCritical-care studies: redefining the rules.
Palazzo, M., & Soni, N. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02342-3 · Cited by 10 · see citing works
Flagged first, then by citations
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Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4683-6 · Cited by 6,621 · see citing works
Self-citationSurviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016.
Rhodes, A., Evans, L. E., Alhazzani, W., Levy, M. M., Antonelli, M., Ferrer, R., Kumar, A., Sevransky, J. E., Sprung, C. L., Nunnally, M. E., et al. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002255 · Cited by 3,652 · see citing works
Self-citationWeiss, S. L., Peters, M. J., Alhazzani, W. A., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., et al. (2020) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000002198 · Cited by 1,268 · see citing works
Weiss, S. L., Peters, M. J., Alhazzani, W. A., Agus, M. S. D., Flori, H. R., Inwald, D. P., Nadel, S., Schlapbach, L. J., Tasker, R. C., Argent, A. C., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-019-05878-6 · Cited by 638 · see citing works
Reade, M. C., O’Sullivan, K., Bates, S., Goldsmith, D., Ainslie, W. R., & Bellomo, R. (2009) · Critical Care · doi:10.1186/cc7890 · Cited by 265 · see citing works
Pickham, D. M., Helfenbein, E. D., Shinn, J. A., Chan, G. K., Funk, M., Weinacker, A. B., Liu, J., & Drew, B. J. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e318232db4a · Cited by 145 · see citing works
Macrolides and viral infections: focus on azithromycin in COVID-19 pathology
Pani, A., Lauriola, M., Romandini, A., & Scaglione, F. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.106053 · Cited by 136 · see citing works
S3-Leitlinie Sepsis – Prävention, Diagnose, Therapie und Nachsorge
Deutsche Sepsis Gesellschaft e., V., Brunkhorst, F. M., Weigand, M. A., Pletz, M. W., Gastmeier, P., Lemmen, S., Meier‐Hellmann, A., Ragaller, M., Weyland, A., Marx, G., et al. (2020) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-020-00685-0 · Cited by 119 · see citing works
Smithburger, P. L., Kane‐Gill, S. L., & Seybert, A. L. (2012) · International Journal of Pharmacy Practice · doi:10.1111/j.2042-7174.2012.00221.x · Cited by 90 · see citing works
Antibiotic‐induced Cardiac Arrhythmias
Abo‐Salem, E., Fowler, J. C., Attari, M., Cox, C. D., Perez‐Verdia, A., Panikkath, R., & NUGENT, K. M. (2013) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12054 · Cited by 90 · see citing works
Nicotine withdrawal and agitation in ventilated critically ill patients
Lucidarme, O., Seguin, A., Daubin, C., Ramakers, M., Terzi, N., Beck, P., Charbonneau, P., & du Cheyron, D. (2010) · Critical Care · doi:10.1186/cc8954 · Cited by 85 · see citing works
Drug-drug interactions contributing to QT prolongation in cardiac intensive care units
Armahizer, M. J., Seybert, A. L., Smithburger, P. L., & Kane‐Gill, S. L. (2013) · Journal of Critical Care · doi:10.1016/j.jcrc.2012.10.014 · Cited by 83 · see citing works
Barnes, B. J., & Hollands, J. M. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181de112a · Cited by 73 · see citing works
Tleyjeh, I. M., Kashour, Z., AlDosary, O., Riaz, M. A., Tlayjeh, H., Garbati, M. A., Tleyjeh, R., Al-Mallah, M. H., Sohail, M. R., Gerberi, D., et al. (2020) · Mayo Clinic Proceedings Innovations Quality & Outcomes · doi:10.1016/j.mayocpiqo.2020.10.005 · Cited by 64 · see citing works
Co-Prescription of QT-Interval Prolonging Drugs: An Analysis in a Large Cohort of Geriatric Patients
Schächtele, S., Tümena, T., Gaßmann, K., Fromm, M. F., & Maas, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155649 · Cited by 55 · see citing works
Bakker, T., Abu–Hanna, A., Dongelmans, D. A., Vermeijden, W., Bosman, R. J., de Lange, D. W., Klopotowska, J. E., de Keizer, N. F., Hendriks, S. A., Cate, J. T. M. H. T., et al. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.11.020 · Cited by 46 · see citing works
Drug‐induced long QT syndrome and fatal arrhythmias in the intensive care unit
Beitland, S., Platou, E. S., & Sunde, K. (2014) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12257 · Cited by 39 · see citing works
Pickham, D. M., Helfenbein, E. D., Shinn, J. A., Chan, G. K., Funk, M., & Drew, B. J. (2010) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2010.05.016 · Cited by 38 · see citing works
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Tay, K., Ewald, M. B., & Bourgeois, F. T. (2013) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.3455 · Cited by 26 · see citing works
Life-threatening cardiac arrhythmias due to drug-induced QT prolongation
Michels, G., Kochanek, M., & Pfister, R. (2015) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-015-0071-6 · Cited by 19 · see citing works
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Drug-induced QT interval prolongation in cancer patients
Becker, T. K., & Yeung, S. J. (2010) · Oncology Reviews · doi:10.1007/s12156-010-0058-8 · Cited by 16 · see citing works
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Padilla, S., Telenti, G., Guillén, L., García, J. A., García‐Abellán, J., Ding, C., Mora, A., García-Pachón, E., Gutiérrez, F., & Masiá, M. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.106142 · Cited by 7 · see citing works
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Su, K., McGloin, R., & Gellatly, R. M. (2020) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2400 · Cited by 7 · see citing works
Chen, L., Liu, M.-J., Wang, S., Yang, D., Ding, N.-N., & Zhang, J. (2025) · Cardiovascular Toxicology · doi:10.1007/s12012-025-10051-1 · Cited by 3 · see citing works
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Shah, R., & Gussak, I. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4978-1_6 · Cited by 2 · see citing works
Genetic QT Score and Sleep Apnea as Predictors of Sudden Cardiac Death in the UK BiobankPreprint
Arora, A., Zaręba, W., Woosley, R. L., Klimentidis, Y. C., Patel, I., Quan, S. F., Wendel, C. S., Shamoun, F. E., Guerra, S., Parthasarathy, S., et al. (2023) · medRxiv · doi:10.1101/2023.11.07.23298237 · Cited by 1 · see citing works
Kozik, T. M. (2010) · UA Campus Repository (The University of Arizona)
Researchwithdrawal and agitation in ventilated critically ill patients
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Current awareness: Pharmacoepidemiology and drug safety
(2008) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1644
Hajimirzaei, N., Khalili, N. P., Boroumand, B., Safari, F., Pourhosseini, A., & Tavakoli, F. (2020) · doi:10.21203/rs.2.20889/v1
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Bezerra, S. R. A., Trevisan, D. D., & Secoli, S. R. (2022) · Revista Colombiana de Ciencias Químico Farmacéuticas · doi:10.15446/rcciquifa.v51n2.98897
Mandal, M., Bhakta, P., Sheehan, J. R., O’Brien, B., & Bhattacharya, D. (2023) · Noninvasive ventilation. The essentials · doi:10.1007/978-3-031-44626-9_37
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- Authors
- Freeman, B. D., Dixon, D. J., Coopersmith, C. M., Zehnbauer, B. A., & Buchman, T. G.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Freeman, Bradley D.
- Venue
- Pharmacoepidemiology and Drug Safety
- Publisher
- Wiley
- Published
- 2008-08-11
- Volume
- 17
- Issue
- 10
- Pages
- 971-981
- ISSN
- 1053-8569 (ISSN-L)
- 1099-1557
- PMC
- PMC2587152
- OpenAlex
- W2014113885
- Cited by
- 48
- References
- 33
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 12 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 2
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacoepidemiology and Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (K08GM000691, GM00601)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- QT prolongation, torsades de pointes, critically ill patients, amiodarone, haloperidol, levofloxacin, drug-drug interactions, co-administration, ICU mortality, ICU length of stay, adverse cardiac events
- MeSH terms
- Cardiovascular Agents, Female, Humans, Long QT Syndrome, Male, Middle Aged, Torsades de Pointes, Databases, Factual, Critical Illness, Pharmacoepidemiology
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