Drug-induced prolongation of the QT interval
Abstract
The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or torsade de pointes, a condition that can be fatal. This review summarizes the current knowledge about molecular and clinical predictors of drug-induced QT-interval prolongation and torsade de pointes and discusses how new molecular predictors of drug action might be incorporated into drug-development programs and clinical practice. A general approach to drugs suspected of causing this problem is presented.
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Berberine belongs to the broader group of drugs and supplements with a risk of induced arrhythmia, monitorable through pharmacovigilance, in which the pharmacist's assessment has a preventive role.
“This places berberine within the broader group of drugs and supplements with a risk of induced arrhythmia, monitorable through pharmacovigilance, in which the pharmacist’s assessment has a preventive role [91,93,94].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [93]
Drugs that prolong QT and predispose patients to torsades de pointes and other tachyarrhythmias, such as antidepressive drugs, besides provoking dizziness or syncope, may also induce arrhythmia-related palpitations.
“Drugs that prolong QT and predispose patients to torsades de pointes and other tachyarrhythmias, such as antidepressive drugs, besides provoking dizziness or syncope, may also induce arrhythmia-related palpitations.43,44”
From Management of patients with palpitations: a position paper from the European Heart Rhythm Association (2011) · cites this paper as [44]
Cites
Sanguinetti, M. C., Jiang, C., Curran, M. E., & Keating, M. T. (1995) · Cell · doi:10.1016/0092-8674(95)90340-2 · Cited by 2,422 · see citing works
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
Curran, M. E., Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D., & Keating, M. T. (1995) · Cell · doi:10.1016/0092-8674(95)90358-5 · Cited by 2,253 · see citing works
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
Wang, Q., Curran, M. E., Splawski, I., Burn, T. C., Millholland, J. M., Raay, T. J. V., Shen, J., Timothy, K. W., Vincent, G. M., Jager, T. D., et al. (1996) · Nature Genetics · doi:10.1038/ng0196-17 · Cited by 1,756 · see citing works
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
Wang, Q. K., Shen, J., Splawski, I., Atkinson, D. L., Li, Z., Robinson, J. L., Moss, A. J., Towbin, J. A., & Keating, M. T. (1995) · Cell · doi:10.1016/0092-8674(95)90359-3 · Cited by 1,682 · see citing works
Jervell, A., & Lange-Nielsen, F. (1957) · American Heart Journal · doi:10.1016/0002-8703(57)90079-0 · Cited by 1,603 · see citing works
Lee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594 · see citing works
Risk Stratification in the Long-QT Syndrome
Priori, S. G., Schwartz, P. J., Napolitano, C., Bloise, R., Ronchetti, E., Grillo, M., Vicentini, A., Spazzolini, C., Nastoli, J., Bottelli, G., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022147 · Cited by 1,456 · see citing works
Dofetilide in Patients with Congestive Heart Failure and Left Ventricular Dysfunction
Torp-Pedersen, C. T., Møller, M., Bloch-Thomsen, P.-E., Køber, L., Sandøe, E., Egstrup, K., Agner, E., Carlsen, J. E., Videbæk, J., Marchant, B., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411201 · Cited by 1,012 · see citing works
Timing of new black box warnings and withdrawals for prescription medications
Lasser, K. E. (2002) · JAMA · doi:10.1001/jama.287.17.2215 · Cited by 1,005 · see citing works
Molecular and Cellular Mechanisms of Cardiac Arrhythmias
Keating, M. T., & Sanguinetti, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00243-4 · Cited by 1,003 · see citing works
Female Gender as a Risk Factor for Torsades de Pointes Associated With Cardiovascular Drugs
Makkar, R. (1993) · JAMA · doi:10.1001/jama.270.21.2590 · Cited by 972 · see citing works
Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death
Mohler, P. J., Schott, J.-J., Gramolini, A. O., Dilly, K. W., Guatimosim, S., duBell, W. H., Song, L.-S., Haurogné, K., Kyndt, F., Ali, M. E., et al. (2003) · Nature · doi:10.1038/nature01335 · Cited by 957 · see citing works
A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN.
Ward, O. C. (1964) · PubMed · Cited by 830 · see citing works
Low Penetrance in the Long-QT Syndrome
Priori, S. G., Napolitano, C., & Schwartz, P. J. (1999) · Circulation · doi:10.1161/01.cir.99.4.529 · Cited by 814 · see citing works
Mutations in the hminK gene cause long QT syndrome and suppress lKs function
Splawski, I., Tristani‐Firouzi, M., Lehmann, M. H., Sanguinetti, M. C., & Keating, M. T. (1997) · Nature Genetics · doi:10.1038/ng1197-338 · Cited by 767 · see citing works
Terfenadine-Ketoconazole Interaction: Pharmacokinetic and Electrocardiographic Consequences
Honig, P. K. (1993) · JAMA · doi:10.1001/jama.1993.03500120051025 · Cited by 664 · see citing works
Taking the “Idio” out of “Idiosyncratic”: Predicting Torsades de Pointes
Roden, D. M. (1998) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1998.tb00148.x · Cited by 662 · see citing works
Self-citationMechanism of the Cardiotoxic Actions of Terfenadine
Woosley, R. L. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1993.03500120070028 · Cited by 646 · see citing works
Aggravation and provocation of ventricular arrhythmias by antiarrhythmic drugs.
Velebit, V., Podrid, P. J., Lown, B., Cohen, B. H., & Graboys, T. B. (1982) · Circulation · doi:10.1161/01.cir.65.5.886 · Cited by 629 · see citing works
Selzer, A., & WRAY, H. W. (1964) · Circulation · doi:10.1161/01.cir.30.1.17 · Cited by 564 · see citing works
Torsades de pointes occurring in association with terfenadine use
Monahan, B. P. (1990) · JAMA · doi:10.1001/jama.264.21.2788 · Cited by 554 · see citing works
Allelic Variants in Long-QT Disease Genes in Patients With Drug-Associated Torsades de Pointes
Yang, P., Kanki, H., Drolet, B., Yang, T., Wei, J., Viswanathan, P. C., Hohnloser, S. H., Shimizu, W., Schwartz, P. J., Stanton, M. S., et al. (2002) · Circulation · doi:10.1161/01.cir.0000014448.19052.4c · Cited by 551 · see citing works
Self-citationVariant of SCN5A Sodium Channel Implicated in Risk of Cardiac Arrhythmia
Splawski, I., Timothy, K. W., Tateyama, M., Clancy, C. E., Malhotra, A., Beggs, A. H., Cappuccio, F. P., Sagnella, G. A., Kass, R. S., & Keating, M. T. (2002) · Science · doi:10.1126/science.1073569 · Cited by 523 · see citing works
Locati, E. H., Zaręba, W., Moss, A. J., Schwartz, P. J., Vincent, G. M., Lehmann, M. H., Towbin, J. A., Priori, S. G., Napolitano, C., Robinson, J. L., et al. (1998) · Circulation · doi:10.1161/01.cir.97.22.2237 · Cited by 490 · see citing works
Roden, D. M., Woosley, R. L., & Primm, R. K. (1986) · American Heart Journal · doi:10.1016/0002-8703(86)90010-4 · Cited by 489 · see citing works
Self-citationStambler, B. S., Wood, M. A., Ellenbogen, K. A., Perry, K. T., Wakefield, L. K., & VanderLugt, J. T. (1996) · Circulation · doi:10.1161/01.cir.94.7.1613 · Cited by 485 · see citing works
A common polymorphism associated with antibiotic-induced cardiac arrhythmia
Sesti, F., Abbott, G. W., Wei, J., Murray, K. T., Saksena, S. V., Schwartz, P. J., Priori, S. G., Roden, D. M., George, A. L., & Goldstein, S. A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180223197 · Cited by 479 · see citing works
Self-citationKay, G. N., Plumb, V. J., Arciniegas Joaquin, G., Henthorn, R. W., & L, W. (1983) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(83)80226-5 · Cited by 463 · see citing works
Yan, G., Shimizu, W., & Antzelevitch, C. (1998) · Circulation · doi:10.1161/01.cir.98.18.1921 · Cited by 451 · see citing works
Malík, M., Färbom, P., Batchvarov, V., Hnatkova, K., & Camm, A. J. (2002) · Heart · doi:10.1136/heart.87.3.220 · Cited by 437 · see citing works
Extracellular Potassium Modulation of Drug Block of IKr
Yang, T., & Roden, D. M. (1996) · Circulation · doi:10.1161/01.cir.93.3.407 · Cited by 428 · see citing works
Self-citationThe Electrophysiological Mechanism of Ventricular Arrhythmias in the Long QT Syndrome
El‐Sherif, N., Caref, E. B., Yin, H. S., & Restivo, M. (1996) · Circulation Research · doi:10.1161/01.res.79.3.474 · Cited by 425 · see citing works
[Ventricular tachycardia with 2 variable opposing foci].
Dessertenne, F. (1966) · PubMed · Cited by 414 · see citing works
Haverkamp, W. (2000) · European Heart Journal · doi:10.1053/euhj.2000.2249 · Cited by 414 · see citing works
Shimizu, W., & Antzelevitch, C. N. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00582-3 · Cited by 379 · see citing works
Drici, M., Burklow, T. R., Haridasse, V., Glazer, R. I., & Woosley, R. L. (1996) · Circulation · doi:10.1161/01.cir.94.6.1471 · Cited by 371 · see citing works
Mechanism of Block and Identification of the Verapamil Binding Domain to HERG Potassium Channels
Zhang, S., Zhou, Z., Gong, Q., Makielski, J. C., & January, C. T. (1999) · Circulation Research · doi:10.1161/01.res.84.9.989 · Cited by 366 · see citing works
KVLQT1 C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome
Donger, C., Denjoy, I., Berthet, M., et al. (1997) · Circulation · doi:10.1161/01.cir.96.9.2778 · Cited by 349 · see citing works
Roden, D. M., & Hoffman, B. F. (1985) · Circulation Research · doi:10.1161/01.res.56.6.857 · Cited by 343 · see citing works
Self-citationBrachmann, J., Scherlag, B. J., Rosenshtraukh, L. V., & Lazzara, R. (1983) · Circulation · doi:10.1161/01.cir.68.4.846 · Cited by 312 · see citing works
Akar, F. G., Yan, G., Antzelevitch, C. N., & ROSENBAUM, D. S. (2002) · Circulation · doi:10.1161/hc1002.105231 · Cited by 301 · see citing works
Napolitano, C., Schwartz, P. J., Brown, A. M., Ronchetti, E., Bianchi, L. K., Pinnavaia, A., Aquaro, G. D., & Priori, S. G. (2000) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2000.tb00033.x · Cited by 300 · see citing works
Hennessy, S., Bilker, W. B., Knauss, J. S., Margolis, D. J., Kimmel, S. E., Reynolds, R. F., Glasser, D. B., Morrison, M. F., & Strom, B. L. (2002) · BMJ · doi:10.1136/bmj.325.7372.1070 · Cited by 261 · see citing works
Carlsson, L. M. S., Abrahamsson, C., Andersson, B., Duker, G., & Schiller-Linhardt, G. (1993) · Cardiovascular Research · doi:10.1093/cvr/27.12.2186 · Cited by 213 · see citing works
Ohnishi, K., Yoshida, H., Shigeno, K., et al. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-11-200012050-00012 · Cited by 212 · see citing works
Drug Block of I Kr : Model Systems and Relevance to Human Arrhythmias
Yang, T., Snyders, D. J., & Roden, D. M. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200111000-00010 · Cited by 172 · see citing works
Self-citationSafety of Newly Approved Drugs
Temple, R. J., & Himmel, M. H. (2002) · JAMA · doi:10.1001/jama.287.17.2273 · Cited by 172 · see citing works
Cardiotoxic effect with convulsions in terfenadine overdose.
Davies, A., Harindra, V., McEwan, A., & Ghose, R. R. (1989) · BMJ · doi:10.1136/bmj.298.6669.325 · Cited by 164 · see citing works
Gintant, G. A., Limberis, J. T., McDermott, J. S., Wegner, C. D., & Cox, B. F. (2001) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200105000-00012 · Cited by 157 · see citing works
Pham, T. V., Sosunov, E. A., Gainullin, R. Z., Danilo, P., & Rosen, M. R. (2001) · Circulation · doi:10.1161/01.cir.103.17.2207 · Cited by 143 · see citing works
Pratt, C. M., Ruberg, S. J., Morganroth, J., McNutt, B. E., Woodward, J. K., Harris, S. I., Ruskin, J. N., & Moyé, L. A. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90525-6 · Cited by 141 · see citing works
Anderson, M. E., Al‐Khatib, S. M., Roden, D. M., & Califf, R. M. (2002) · American Heart Journal · doi:10.1067/mhj.2002.125804 · Cited by 136 · see citing works
Self-citationNattel, S., & Quantz, M. (1988) · Cardiovascular Research · doi:10.1093/cvr/22.11.808 · Cited by 128 · see citing works
Anderson, M. E., Al‐Khatib, S. M., Roden, D. M., & Califf, R. M. (2002) · American Heart Journal · doi:10.1016/s0002-8703(02)80007-2 · Cited by 124 · see citing works
Self-citationHoultz, B., Darpö, B., Edvardsson, N. G., Blomström, P., Brachmann, J., Crijns, H. J. G. M., Jensen, S. M., Svernhage, E., Vallin, H., & Swedberg, K. B. (1998) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1998.tb00150.x · Cited by 117 · see citing works
Sicouri, S., & Antzelevitch, C. (1993) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.1993.tb01211.x · Cited by 108 · see citing works
Pharmacies and Prevention of Potentially Fatal Drug Interactions
Cavuto, N. J. (1996) · JAMA · doi:10.1001/jama.1996.03530380028022 · Cited by 107 · see citing works
Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences
Honig, P. K. (1993) · JAMA · doi:10.1001/jama.269.12.1513 · Cited by 102 · see citing works
Arrhythmias in the congenital long QT syndrome: how often is torsade de pointes pause dependent?
Viskin, S., Fish, R., Zeltser, D., Belhassen, B., Heller, K., Brosh, D., Laniado, S., & Barron, H. V. (2000) · Heart · doi:10.1136/heart.83.6.661 · Cited by 99 · see citing works
A new approach for TU complex characterization
Vila, X. A., Gang, Y., Presedo, J., et al. (2000) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.844227 · Cited by 98 · see citing works
Mechanism of the cardiotoxic actions of terfenadine
Woosley, R. L. (1993) · JAMA · doi:10.1001/jama.269.12.1532 · Cited by 94 · see citing works
Amiodarone and Torsade de Pointes
Lazzara, R. (1989) · Annals of Internal Medicine · doi:10.7326/0003-4819-111-7-549 · Cited by 90 · see citing works
Exaggerated QT prolongation after cardioversion of atrial fibrillation
Choy, A. M. J., Darbar, D., Dell’Orto, S., & Roden, D. M. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00226-0 · Cited by 89 · see citing works
Self-citationEffects of cisapride on QT interval in children
Khongphatthanayothin, A., Lane, J., Thomas, D., et al. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70177-5 · Cited by 85 · see citing works
Gbadebo, T. D., Trimble, R. W., Khoo, M. S. C., Temple, J., Roden, D. M., & Anderson, M. E. (2002) · Circulation · doi:10.1161/hc0602.103724 · Cited by 81 · see citing works
Self-citationEl‐Sherif, N., Caref, E. B., Chinushi, M., & Restivo, M. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00700-1 · Cited by 74 · see citing works
Testosterone Diminishes the Proarrhythmic Effects of Dofetilide in Normal Female Rabbits
Pham, T. V., Sosunov, E. A., Anyukhovsky, E. P., Danilo, P., & Rosen, M. R. (2002) · Circulation · doi:10.1161/01.cir.0000033596.21845.d8 · Cited by 69 · see citing works
BURASHNTKOV, A., & Antzelevitch, C. (2000) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2000.tb00342.x · Cited by 62 · see citing works
Molecular Basis of Cardiovascular Drug Metabolism
Abernethy, D. R., & Flockhart, D. A. (2000) · Circulation · doi:10.1161/01.cir.101.14.1749 · Cited by 54 · see citing works
Nowinski, K., Gadler, F., Jensen‐Urstad, M., & Bergfeldt, L. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01274-3 · Cited by 53 · see citing works
Reduced repolarization reserve in ventricular myocytes from female mice
Wu, Y. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00387-x · Cited by 53 · see citing works
Drug Labeling Revisions—Guaranteed to Fail?
Woosley, R. L. (2000) · JAMA · doi:10.1001/jama.284.23.3047 · Cited by 45 · see citing works
Arsenic Trioxide Therapy for Relapsed Acute Promyelocytic Leukemia: an Useful Salvage Therapy
Huang, S., Yang, C.-H., & Chen, Y. (2000) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190009087019 · Cited by 36 · see citing works
Burkhart, G. A., Sevka, M. J., Temple, R., & Honig, P. K. (1997) · Clinical Pharmacology & Therapeutics · doi:10.1016/s0009-9236(97)90185-5 · Cited by 35 · see citing works
Kamisako, T., Adachi, Y., Nakagawa, H., et al. (1995) · Internal Medicine · doi:10.2169/internalmedicine.34.92 · Cited by 30 · see citing works
Singh, B. N. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90824-5 · Cited by 30 · see citing works
Amiodarone and torsades de pointes
Jorens, P. G., van den Heuvel, P. A., & Parizel, G. A. (1990) · American Heart Journal · doi:10.1016/0002-8703(90)90276-4 · Cited by 16 · see citing works
Pharmacies and prevention of potentially fatal drug interactions
Cavuto, N. J. (1996) · JAMA · doi:10.1001/jama.275.14.1086 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Priori, S. G., Blomström-Lundqvist, C., Mazzanti, A., Blom, N., Borggrefe, M., Camm, J., Elliott, P. M., Fitzsimons, D., Hatala, R., Hindricks, G., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv316 · Cited by 3,893 · see citing works
Atypical antipsychotic drugs and the risk of sudden cardiac death
Ray, W. A., Chung, C. P., Murray, K. T., Hall, K., & Stein, C. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806994 · Cited by 1,194 · see citing works
Curigliano, G., Lenihan, D., Fradley, M., Ganatra, S., Barac, A., Blaes, A., Herrmann, J., Porter, C., Lyon, A. R., Lancellotti, P., et al. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2019.10.023 · Cited by 1,031 · see citing works
Drew, B. J., Ackerman, M. J., Funk, M., Gibler, W. B., Kligfield, P., Menon, V., Philippides, G. J., Roden, D. M., & Zareba, W. (2010) · Circulation · doi:10.1161/circulationaha.109.192704 · Cited by 821 · see citing works
Self-citationDrew, B. J., Califf, R. M., Funk, M., Kaufman, E. S., Krucoff, M. W., Laks, M. M., Macfarlane, P. W., Sommargren, C., Swiryn, S., & Van Hare, G. F. (2004) · Circulation · doi:10.1161/01.cir.0000145144.56673.59 · Cited by 609 · see citing works
Al-Khatib, S. M., Stevenson, W. G., Ackerman, M. J., Bryant, W. J., Callans, D. J., Curtis, A. B., Deal, B. J., Dickfeld, T., Field, M. E., Fonarow, G. C., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000548 · Cited by 412 · see citing works
Targeted Cancer Therapy: Giving Histone Deacetylase Inhibitors All They Need To Succeed
Gryder, B. E., Sodji, Q. H., & Oyelere, A. K. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.3 · Cited by 404 · see citing works
Matsa, E., Rajamohan, D., Dick, E., Young, L., Mellor, I., Staniforth, A., & Denning, C. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr073 · Cited by 389 · see citing works
Antipsychotic-Induced Dopamine Supersensitivity Psychosis: Pharmacology, Criteria, and Therapy
Chouinard, G., Samaha, A.-N., Chouinard, V.-A., Peretti, C.-S., Kanahara, N., Takase, M., & Iyo, M. (2017) · Psychotherapy and Psychosomatics · doi:10.1159/000477313 · Cited by 270 · see citing works
Wu, C., Tsai, Y., & Tsai, H. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.114.001568 · Cited by 191 · see citing works
Raviele, A., Giada, F., Bergfeldt, L., Blanc, J. J., Blomstrom-Lundqvist, C., Mont, L., Morgan, J. M., Raatikainen, M. J. P., Steinbeck, G., Viskin, S., et al. (2011) · Europace · doi:10.1093/europace/eur130 · Cited by 149 · see citing works
Hinterseer, M., Thomsen, M. B., Beckmann, B.-M., Pfeufer, A., Schimpf, R., Wichmann, H.-E., Steinbeck, G., Vos, M. A., & Kaab, S. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm586 · Cited by 126 · see citing works
Patel, D., Mc Conkey, N. D., Sohaney, R., Mc Neil, A., Jedrzejczyk, A., & Armaganijan, L. (2013) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2013/159850 · Cited by 124 · see citing works
QT Interval Screening in Methadone Maintenance Treatment: Report of a SAMHSA Expert Panel
Martin, J. A., Campbell, A., Killip, T., Kotz, M., Krantz, M. J., Kreek, M. J., McCarroll, B. A., Mehta, D., Payte, J. T., Stimmel, B., et al. (2011) · Journal of Addictive Diseases · doi:10.1080/10550887.2011.610710 · Cited by 87 · see citing works
Does this patient with palpitations have a cardiac arrhythmia?
Thavendiranathan, P. (2009) · JAMA · doi:10.1001/jama.2009.1673 · Cited by 75 · see citing works
Ventricular repolarization measures for arrhythmic risk stratification
Monitillo, F. (2016) · World Journal of Cardiology · doi:10.4330/wjc.v8.i1.57 · Cited by 66 · see citing works
Cardiovascular Disease in Women
Stock, E. O., & Redberg, R. (2012) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2012.07.001 · Cited by 65 · see citing works
Castelletti, S., Dagradi, F., Goulene, K., Danza, A. I., Baldi, E., Stramba-Badiale, M., & Schwartz, P. J. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.03.097 · Cited by 63 · see citing works
Pharmacoepidemiology of QT‐interval prolonging drug administration in critically ill patients
Freeman, B. D., Dixon, D. J., Coopersmith, C. M., Zehnbauer, B. A., & Buchman, T. G. (2008) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1637 · Cited by 48 · see citing works
Blazeski, A., Lowenthal, J., Zhu, R., Ewoldt, J., Boheler, K. R., & Tung, L. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.04.002 · Cited by 40 · see citing works
Prolonged QT interval corrected for heart rate during diabetic ketoacidosis in children
Kuppermann, N., Park, J., Glatter, K., Marcin, J. P., & Glaser, N. S. (2008) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpedi.162.6.544 · Cited by 41 · see citing works
Drug-induced long-QT syndrome and torsade de pointes: an underrated problem?
Rao, P., & Kowey, P. R. (2014) · Europace · doi:10.1093/europace/eut331 · Cited by 4 · see citing works
Dumitru, C. N., Marcu, T., Dumitru, A. O., Tudor, S. S., Ferțu, I. D., Elisei, A.-M., & Goroftei, L. (2026) · Pharmaceuticals · doi:10.3390/ph19081313 · Cited by 2 · see citing works
“This places berberine within the broader group of drugs and supplements with a risk of induced arrhythmia, moni-torable through pharmacovigilance, in which the pharmacist’s assessment has a preventive role [91,93,94].”
Influential
- Authors
- Roden, D. M.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Roden, Dan M.
- ORCID
- Roden, Dan M.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2004-03-04
- Volume
- 350
- Issue
- 10
- Pages
- 1013-1022
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2131308754
- Cited by
- 1,965
- References
- 78
- Citations by year
- 2026: 57 · 2025: 40 · 2024: 43 · 2023: 48 · 2022: 69 · 2021: 96 · 2020: 85 · 2019: 65 · 2018: 70 · 2017: 101 · 2016: 91 · 2015: 95 · 2014: 98 · 2013: 104 · 2012: 105
- FWCI
- 20.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-65962, R01HL049989, HL49989, HL46681, P01HL046681)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- drug-induced QT prolongation, torsades de pointes, polymorphic ventricular tachycardia, molecular predictors, clinical predictors, drug safety, drug development, antiarrhythmic drugs
- MeSH terms
- Action Potentials, Electrocardiography, Humans, Long QT Syndrome, Risk Factors, Syncope, Torsades de Pointes, Drug-Related Side Effects and Adverse Reactions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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