Cited by 1,965Cardiac electrophysiology and arrhythmiasPharmacogenetics and Drug MetabolismPharmaceutical Practices and Patient Outcomes

Drug-induced prolongation of the QT interval

Roden, Dan M.·2004·New England Journal of Medicine

Abstract

The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or torsade de pointes, a condition that can be fatal. This review summarizes the current knowledge about molecular and clinical predictors of drug-induced QT-interval prolongation and torsade de pointes and discusses how new molecular predictors of drug action might be incorporated into drug-development programs and clinical practice. A general approach to drugs suspected of causing this problem is presented.

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Registry

Crossref · 10.1056/nejmra032426

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78 of 78 references verified0 citation errors · 0 not checkable

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  • Berberine belongs to the broader group of drugs and supplements with a risk of induced arrhythmia, monitorable through pharmacovigilance, in which the pharmacist's assessment has a preventive role.

    “This places berberine within the broader group of drugs and supplements with a risk of induced arrhythmia, monitorable through pharmacovigilance, in which the pharmacist’s assessment has a preventive role [91,93,94].”
  • Drugs that prolong QT and predispose patients to torsades de pointes and other tachyarrhythmias, such as antidepressive drugs, besides provoking dizziness or syncope, may also induce arrhythmia-related palpitations.

    “Drugs that prolong QT and predispose patients to torsades de pointes and other tachyarrhythmias, such as antidepressive drugs, besides provoking dizziness or syncope, may also induce arrhythmia-related palpitations.43,44”

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Authors
Roden, D. M.
Affiliations
Vanderbilt University (US)
Corresponding author
Roden, Dan M.
Venue
New England Journal of Medicine
Published
2004-03-04
Volume
350
Issue
10
Pages
1013-1022
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W2131308754
Cited by
1,965
References
78
Citations by year
2026: 57 · 2025: 40 · 2024: 43 · 2023: 48 · 2022: 69 · 2021: 96 · 2020: 85 · 2019: 65 · 2018: 70 · 2017: 101 · 2016: 91 · 2015: 95 · 2014: 98 · 2013: 104 · 2012: 105
FWCI
20.56
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL-65962, R01HL049989, HL49989, HL46681, P01HL046681)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
drug-induced QT prolongation, torsades de pointes, polymorphic ventricular tachycardia, molecular predictors, clinical predictors, drug safety, drug development, antiarrhythmic drugs
MeSH terms
Action Potentials, Electrocardiography, Humans, Long QT Syndrome, Risk Factors, Syncope, Torsades de Pointes, Drug-Related Side Effects and Adverse Reactions

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