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Cited by 12Electrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applicationsNanoparticle-Based Drug Delivery

Electrospun poly(l‐lactide‐co‐ε‐caprolactone)/gelatin core–shell nanofibers encapsulated with doxorubicin hydrochloride as a drug delivery system

Liu, Yi, Wang, Lei, Huang, Yifan, Hou, Chao, Xin, Binjie, Li, Tingxiao, Jiang, Qian·2023·Polymer International
DOI 10.1002/pi.6458
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Abstract

Advanced application of coaxial electrospinning nanofibers in controlled drug release systems has gathered much attention since they have had a tunable structure for tailored release of drugs, including various proteins, growth factors, antibacterial and anticancer agents. The composite polymer poly(l‐lactide‐co‐ε‐caprolactone) (PLCL) blended with gelatin (GE) was used as the shell material to electrospin core–shell nanofibers. Model drug doxorubicin hydrochloride (DOX) was encapsulated in the core layers. The morphology and core–shell structure were evaluated by SEM and TEM respectively. The existence of DOX in the inner part of DOX/PLCL/GE nanofibers could be proved by Fourier transform infrared spectroscopy results. The water contact angle test results indicated that DOX/PLCL/GE nanofibers all possess good hydrophilicity with water contact angles as low as 51.2°. The in vitro release results indicated that the DOX/PLCL/GE nanofibers showed a sustained release profile for 480 h. The fitting results showed that the release kinetics of DOX from nanofibers was consistent with a Ritger–Peppas model, presenting a typical Fickian diffusion mechanism. Overall, the DOX/PLCL/GE core–shell nanofibers showed regulable mechanical properties and could be used as a promising drug release system for drug sustained release and tissue engineering. © 2022 Society of Chemical Industry.

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  • Core-shell nanofibers of PLCL and gelatin achieve continuous and stable release of model drug adriamycin within 20 days and avoid in vivo toxicity caused by burst release of DOX in short term.

    “Liu et al. used PLCL and gelatin as matrix materials and mixed them to prepare core-shell nanofibers capable of loading multiple drugs and factors, which could achieve continuous and stable release of model drug adriamycin within 20 days and avoid in vivo toxicity caused by burst release of doxorubicin hydrochloride (DOX) in the short term [220].”

    From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [220]

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Authors
Liu, Y., Wang, L., Huang, Y., Hou, C., Xin, B., Li, T., & Jiang, Q.
Affiliations
  • Shanghai University of Engineering Science (CN)
  • Tiangong University (CN)
Corresponding author
  • Xin, Binjie
  • Li, Tingxiao
ORCID
Venue
Polymer International
Publisher
Wiley
Published
2022-10-14
Volume
72
Issue
2
Pages
166-175
ISSN
  • 0959-8103 (ISSN-L)
  • 1097-0126
DOI
10.1002/pi.6458
OpenAlex
W4296240304
Cited by
12
References
40
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 3
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
Polymer International (publishedVersion)
Funders
Ministry of Education
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
core-shell nanofibers, poly(L-lactide-co-ε-caprolactone), gelatin, doxorubicin hydrochloride, coaxial electrospinning, sustained drug release, Ritger-Peppas model, Fickian diffusion, hydrophilicity, tissue engineering scaffolds, anticancer drug delivery

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