The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Identification of human whole saliva protein components using proteomics
Abstract
The determination of salivary biomarkers as a means of monitoring general health and for the early diagnosis of disease is of increasing interest in clinical research. Based on the linkage between salivary proteins and systemic diseases, the aim of this work was the identification of saliva proteins using proteomics. Salivary proteins were separated using two‐dimensional (2‐D) gel electrophoresis over a pH range between 3–10, digested, and then analyzed by matrix assisted laser desorption/ionization‐time of flight (MALDI‐TOF)‐TOF mass spectrometry (MS) and tandem mass spectrometry (MS/MS). Proteins were identified using automated MS and MS/MS data acquisition. The resulting data were searched against a protein database using an internal Mascot search routine. Ninety spots give identifications with high statistical reliability. Of the identified proteins, 11 were separated and identified in saliva for the first time using proteomics tools. Moreover, three proteins that have not been previously identified in saliva, PLUNC, cystatin A, and cystatin B were identified.
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Cites
T he D iagnostic A pplications of S aliva — A R eview
Kaufman, E., & Lamster, I. B. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300209 · Cited by 887
Streckfus, C., & Bigler, L. (2002) · Oral Diseases · doi:10.1034/j.1601-0825.2002.1o834.x · Cited by 374
Cited by
Mass Spectrometric Analyses of Peptides and Proteins in Human Gingival Crevicular Fluid
Ngo, L. H., Veith, P. D., Chen, Y.-Y., Chen, D., Darby, I. B., & Reynolds, E. C. (2010) · Journal of Proteome Research · doi:10.1021/pr900775s · Cited by 82
Jang, S. W., Cho, M. K., Park, M. K., Kang, S. A., Na, B.-K., Ahn, S. C., Kim, D.-H., & Yu, H. S. (2011) · The Korean Journal of Parasitology · doi:10.3347/kjp.2011.49.3.245 · Cited by 59
Metadata
- Authors
- Vitorino, R., Lobo, M. J. C., Ferrer‐Correira, A. J., Dubin, J. R., Tomer, K. B., Domingues, P. M., & Amado, F. M. L.
- Venue
- PROTEOMICS
- Publisher
- Wiley
- Published
- 2004-03-23
- Volume
- 4
- Issue
- 4
- Pages
- 1109-1115
- ISSN
- 1615-9853 (ISSN-L)
- 1615-9861
- OpenAlex
- W2006290622
- Cited by
- 295
- References
- 2
- FWCI
- 11.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vitorino, R., Lobo, M. J. C., Ferrer‐Correira, A. J., Dubin, J. R., Tomer, K. B., Domingues, P. M., & Amado, F. M. L. (2004). Identification of human whole saliva protein components using proteomics. PROTEOMICS. https://doi.org/10.1002/pmic.200300638
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