T he D iagnostic A pplications of S aliva — A R eview

Kaufman, Eliaz; Lamster, Ira B.

doi:10.1177/154411130201300209

Cited by 892Salivary Gland Disorders and FunctionsClinical Laboratory Practices and Quality ControlHIV/AIDS oral health manifestations

T he D iagnostic A pplications of S aliva — A R eview

Kaufman, Eliaz, Lamster, Ira B.·2002·Critical Reviews in Oral Biology & Medicine

DOI 10.1177/154411130201300209

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Abstract

This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

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Saliva analysis can provide a cost-effective approach for screening large populations.
“Saliva analysis can also provide a cost-effective approach for screening large populations 153.”
From Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices (2022) · cites this paper as [153]
Saliva is a complex oral fluid, produced mainly by the parotid gland and composed of numerous constituents, such as metabolites, enzymes, hormones, proteins, microorganisms and ions.
“Saliva is a complex oral fluid, which is produced mainly by the parotid gland and is composed of numerous constituents, such as metabolites, enzymes, hormones, proteins, microorganisms and ions125,135-140.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [136]

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Salivary and serum IgA antigliadin antibodies in dermatitis herpetiformis
Patinen, P., Björkstén, F., Malmström, M., Savilahrtl, E., & Reunala, T. L. (1995) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.1995.tb00027.x · Cited by 13 · see citing works
Salivary antiepileptic drug levels in Thai children.
Kankirawatana, P. (1999) · PubMed · Cited by 12 · see citing works

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Wearable biosensors for healthcare monitoring
Kim, J., Campbell, A. S., de Ávila, B. E.-F., & Wang, J. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0045-y · Cited by 3,373 · see citing works
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Hiemke, C., Bergemann, N., Clement, H. ‐., Conca, A., Deckert, J., Domschke, K., Eckermann, G., Egberts, K. M., Gerlach, M., Greiner, C., et al. (2017) · Pharmacopsychiatry · doi:10.1055/s-0043-116492 · Cited by 1,466 · see citing works
Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research
Nater, U. M., & Rohleder, N. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.014 · Cited by 1,370 · see citing works
The human volatilome: volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva
Amann, A., Costello, B. D. L., Miekisch, W., Schubert, J., Buszewski, B., Pleil, J., Ratcliffe, N., & Risby, T. (2014) · Journal of Breath Research · doi:10.1088/1752-7155/8/3/034001 · Cited by 804 · see citing works
Diagnostic Potential of Saliva: Current State and Future Applications
Pfaffe, T., Cooper-White, J. J., Beyerlein, P., Kostner, K., & Punyadeera, C. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2010.153767 · Cited by 803 · see citing works
Non-invasive matrices in human biomonitoring: A review
Esteban, M., & Castaño, A. (2008) · Environment International · doi:10.1016/j.envint.2008.09.003 · Cited by 564 · see citing works
The role of natural salivary defences in maintaining a healthy oral microbiota
Pedersen, A. M. L., & Belstrøm, D. (2019) · Journal of Dentistry · doi:10.1016/j.jdent.2018.08.010 · Cited by 496 · see citing works
Microfluidic Chips for Point‐of‐Care Immunodiagnostics
Gervais, L., de Rooij, N., & Delamarche, E. (2011) · Advanced Materials · doi:10.1002/adma.201100464 · Cited by 490 · see citing works
Saliva diagnostics – Current views and directions
Kaczor‐Urbanowicz, K. E., Carreras‐Presas, C. M., Aro, K. L. S., Tu, M. K., Garcı́a-Godoy, F., & Wong, D. T. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216681550 · Cited by 482 · see citing works
Testosterone-mediated immune functions and male life histories
Muehlenbein, M. P., & Bribiescas, R. G. (2005) · American Journal of Human Biology · doi:10.1002/ajhb.20419 · Cited by 449 · see citing works
Comparative Human Salivary and Plasma Proteomes
Loo, J. A., Yan, W., Ramachandran, P., & Wong, D. T. (2010) · Journal of Dental Research · doi:10.1177/0022034510380414 · Cited by 446 · see citing works
Advances and challenges in biosensor-based diagnosis of infectious diseases
Sin, M. L. Y., Mach, K. E., Wong, P. K., & Liao, J. C. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.888313 · Cited by 437 · see citing works
Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted?
McCullough, M. E., Churchland, P. S., & Mendez, A. J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.018 · Cited by 416 · see citing works
Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
Wang, B., Zhao, C., Wang, Z., Yang, K.-A., Cheng, X., Liu, W., Yu, W., Lin, S., Zhao, Y., Cheung, K. M., et al. (2022) · Science Advances · doi:10.1126/sciadv.abk0967 · Cited by 411 · see citing works
Current Developments in Salivary Diagnostics
Miller, C. S., Foley, J. D., Bailey, A. L., Campell, C. L., Humphries, R. L., Christodoulides, N. J., Floriano, P. N., Simmons, G. W., Bhagwandin, B., Jacobson, J. W., et al. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.68 · Cited by 395 · see citing works
Saliva: potential diagnostic value and transmission of 2019-nCoV
Xu, R., Cui, B., Duan, X., Zhang, P., Zhou, X., & Yuan, Q. (2020) · International Journal of Oral Science · doi:10.1038/s41368-020-0080-z · Cited by 393 · see citing works
Salivary biomarkers of existing periodontal disease
Miller, C. S., King, C. P., Langub, M. C., Kryscio, R. J., & Thomas, M. V. (2006) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2006.0181 · Cited by 362 · see citing works
Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid: a systematic review
Soares Nunes, L. A., Mussavira, S., & Sukumaran Bindhu, O. (2015) · Biochemia Medica · doi:10.11613/bm.2015.018 · Cited by 333 · see citing works
Analysis of matrix metalloproteinases, especially MMP‐8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases
Sorsa, T. A., Gürsoy, U. K., Nwhator, S. O., Hernández, M., Tervahartiala, T. I., Leppilahti, J. M., Gürsoy, M., Könönen, E., Emingil, G., Pussinen, P. J., et al. (2015) · Periodontology 2000 · doi:10.1111/prd.12101 · Cited by 319 · see citing works
Identification of human whole saliva protein components using proteomics
Vitorino, R. M. P., Calheiros‐Lobo, M. J., Ferrer‐Correira, A. J., Dubin, J. R., Tomer, K. B., Domingues, P. M., & Amado, F. M. L. (2004) · PROTEOMICS · doi:10.1002/pmic.200300638 · Cited by 295 · see citing works
Medication effects on salivary cortisol: Tactics and strategy to minimize impact in behavioral and developmental science
Granger, D. A., Hibel, L. C., Fortunato, C., & Kapelewski, C. H. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.017 · Cited by 295 · see citing works
Hybrid Volatolomics and Disease Detection
Broza, Y. Y., Mochalski, P., Ruzsányi, V., Amann, A., & Haick, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500153 · Cited by 291 · see citing works
Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans
Walsh, M. C., Brennan, L., Malthouse, J. P. G., Roche, H. M., & Gibney, M. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.3.531 · Cited by 291 · see citing works
The rôle of saliva in maintaining oral health and as an aid to diagnosis.
Llena, C. (2006) · PubMed · Cited by 285 · see citing works
The human saliva metabolome
Dame, Z. T., Aziat, F., Mandal, R., Krishnamurthy, R., Bouatra, S., Borzouie, S., Guo, A. C., Sajed, T., Deng, L., Lin, H., et al. (2015) · Metabolomics · doi:10.1007/s11306-015-0840-5 · Cited by 275 · see citing works
Discovery and Preclinical Validation of Salivary Transcriptomic and Proteomic Biomarkers for the Non-Invasive Detection of Breast Cancer
Zhang, L., Xiao, H., Karlan, S. R., Zhou, H., Gross, J., Elashoff, D. A., Akin, D., Yan, X., Chia, D., Karlan, B. Y., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015573 · Cited by 272 · see citing works
Salivary markers of inflammation in response to acute stress
Slavish, D. C., Graham‐Engeland, J. E., Smyth, J. M., & Engeland, C. G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.008 · Cited by 263 · see citing works
Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics
Malon, R. S. P., Sadir, S., Balakrishnan, M., & Córcoles, E. P. (2014) · BioMed Research International · doi:10.1155/2014/962903 · Cited by 260 · see citing works
Salivary Biomarkers of Stress, Anxiety and Depression
Chojnowska, S., Ptaszyńska-Sarosiek, I., Kępka, A., Knaś, M., & Waszkiewicz, N. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030517 · Cited by 251 · see citing works
Exploiting salivary miR‐31 as a clinical biomarker of oral squamous cell carcinoma
Liu, C., Lin, S., Yang, C., Cheng, H., & Chang, K. (2011) · Head & Neck · doi:10.1002/hed.21713 · Cited by 236 · see citing works
Salivary biomarkers of periodontal disease in response to treatment
Sexton, W. M., Lin, Y., Kryscio, R. J., Dawson, D. R., Ebersole, J. L., & Miller, C. S. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01706.x · Cited by 235 · see citing works
Evaluation and comparison of in vitro degradation kinetics of DNA in serum, urine and saliva: A qualitative study
Wang, Y., Chen, M. Y., Nan, X., & Liu, H. (2016) · Gene · doi:10.1016/j.gene.2016.06.033 · Cited by 232 · see citing works
Salivary markers of oxidative stress in oral diseases
Tóthová, Ľ., Kamodyová, N., Červenka, T., & Celec, P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00073 · Cited by 222 · see citing works
An update: salivary hormones and physical exercise
Gatti, R., & De Palo, E. F. (2011) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2010.01252.x · Cited by 213 · see citing works
Identification of N-Linked Glycoproteins in Human Saliva by Glycoprotein Capture and Mass Spectrometry
Ramachandran, P., Boontheung, P., Xie, Y., Sondej, M. A., Wong, D. T., & Loo, J. A. (2006) · Journal of Proteome Research · doi:10.1021/pr050492k · Cited by 213 · see citing works
Characterization of RNA in Saliva
Park, N. J., Li, Y., Yu, T., Brinkman, B. M. N., & Wong, D. T. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.063206 · Cited by 213 · see citing works
Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices
Pullano, S. A., Greco, M., Bianco, M. G., Foti, D., Brunetti, A., & Fiorillo, A. S. (2022) · Theranostics · doi:10.7150/thno.64035 · Cited by 210 · see citing works
Salivary gland function, development, and regeneration
Chibly, A. M., Aure, M. H., Patel, V. N., & Hoffman, M. P. (2022) · Physiological Reviews · doi:10.1152/physrev.00015.2021 · Cited by 207 · see citing works
Trends in Nanomaterial-Based Non-Invasive Diabetes Sensing Technologies
Makaram, P., Owens, D., & Aceros, J. C. (2014) · Diagnostics · doi:10.3390/diagnostics4020027 · Cited by 202 · see citing works
Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment
Hemadi, A. S., Huang, R., Zhou, Y., & Zou, J. (2017) · International Journal of Oral Science · doi:10.1038/ijos.2017.35 · Cited by 202 · see citing works
Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives
Cristaldi, M., Mauceri, R., Fede, O. D., Giuliana, G., Campisi, G., & Panzarella, V. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01476 · Cited by 199 · see citing works
Nanoscale Sensor Technologies for Disease Detection via Volatolomics
Vishinkin, R., & Haick, H. (2015) · Small · doi:10.1002/smll.201501904 · Cited by 198 · see citing works
Salivary Exosomes: Emerging Roles in Systemic Disease
Han, Y., Jia, L., Zheng, Y., & Li, W. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.25018 · Cited by 193 · see citing works
Proteomic Analysis of Human Saliva From Lung Cancer Patients Using Two-Dimensional Difference Gel Electrophoresis and Mass Spectrometry
Xiao, H., Zhang, L., Zhou, H., Lee, J. M., Garon, E. B., & Wong, D. T. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.012112 · Cited by 192 · see citing works
Salivary Biomarkers for Detection of Systemic Diseases
Rathnayake, N., Åkerman, S., Klinge, B., Lundegren, N., Jansson, H., Tryselius, Y., Sorsa, T. A., & Gustafsson, A. K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061356 · Cited by 191 · see citing works
Use of Saliva-Based Nano-Biochip Tests for Acute Myocardial Infarction at the Point of Care: A Feasibility Study
Floriano, P. N., Christodoulides, N. J., Miller, C. S., Ebersole, J. L., Spertus, J. A., Rose, B. G., Kinane, D. F., Novak, M. J., Steinhubl, S. R., Acosta, S., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.117713 · Cited by 188 · see citing works
Host-to-Host Airborne Transmission As a Multiphase Flow Problem For Science-Based Social Distance Guidelines
Balachandar, S., Zaleski, S., Soldati, A., Ahmadi, G., & Bourouiba, L. (2020) · International Journal of Multiphase Flow · doi:10.1016/j.ijmultiphaseflow.2020.103439 · Cited by 187 · see citing works
Lipid Peroxidation Levels and Total Oxidant/Antioxidant Status in Serum and Saliva From Patients With Chronic and Aggressive Periodontitis. Oxidative Stress Index: A New Biomarker for Periodontal Disease?
Baltacıoğlu, E., Yuva, P., Aydın, G., Alver, A., Kahraman, C., Karabulut, E., & Akalın, F. A. (2014) · Journal of Periodontology · doi:10.1902/jop.2014.130654 · Cited by 182 · see citing works
Salivary biomarkers of oral health – a cross‐sectional study
Rathnayake, N., Åkerman, S., Klinge, B., Lundegren, N., Jansson, H., Tryselius, Y., Sorsa, T. A., & Gustafsson, A. K. (2012) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12038 · Cited by 180 · see citing works
Association Between Obesity, Flow Rate of Whole Saliva, and Dental Caries in Adolescents
Modéer, T., Blomberg, C., Wondimu, B., Julihn, A., & Marcus, C. (2010) · Obesity · doi:10.1038/oby.2010.63 · Cited by 180 · see citing works
Effects of diabetes mellitus on salivary secretion and its composition in the human
Mata, A., Marques, D. N. D. S., Rocha, S., Francisco, H., Santos, C., de Mesquita, M. F., & Singh, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000028748.40917.6f · Cited by 179 · see citing works
Validation of a high-sensitivity assay for C-reactive protein in human saliva
Ouellet‐Morin, I., Danese, A., Williams, B. S., & Arseneault, L. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.020 · Cited by 176 · see citing works
Salivary steroid assays – research or routine?
Wood, P. J. (2009) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2008.008208 · Cited by 175 · see citing works
A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients
Rhodus, N. L., Cheng, B., Myers, S. L., Bowles, W. R., Ho, V., & Ondrey, F. G. (2005) · Clinical Immunology · doi:10.1016/j.clim.2004.12.003 · Cited by 171 · see citing works
Human saliva as a diagnostic material
Chojnowska, S., Baran, T., Wilińska, I., Sienicka, P., Cabaj-Wiater, I., & Knaś, M. (2017) · Advances in Medical Sciences · doi:10.1016/j.advms.2017.11.002 · Cited by 170 · see citing works
Toward Defining the Human Parotid Gland Salivary Proteome and Peptidome: Identification and Characterization Using 2D SDS−PAGE, Ultrafiltration, HPLC, and Mass Spectrometry
Hardt, M., Thomas, L. R., Dixon, S. E., Newport, G., Agabian, N. M., Prakobphol, A., Hall, S. C., Witkowska, H. E., & Fisher, S. J. (2005) · Biochemistry · doi:10.1021/bi048176r · Cited by 167 · see citing works
Saliva--a diagnostic window to the body, both in health and in disease.
Greabu, M., Battino, M. A., Mohora, M., Totan, A., Didilescu, A. C., Spînu, T. C., Totan, C., Miricescu, D., & Rădulescu, R. (2009) · PubMed Central · Cited by 163 · see citing works
Salivary infectious agents and periodontal disease status
Saygun, I., Nizam, N., Keskiner, İ., Bal, M. V., Kubar, A., Açıkel, C., Serdar, M. A., & Slots, J. (2011) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2010.01335.x · Cited by 162 · see citing works
Saliva as a non-invasive diagnostic tool for inflammation and insulin-resistance
Desai, G. S. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i6.730 · Cited by 158 · see citing works
Oral-fluid samples for surveillance of commercial growing pigs for porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 infections
Prickett, J., Kim, W., Simer, R., Yoon, K. J., & Zimmerman, J. J. (2008) · Journal of Swine Health and Production · doi:10.54846/jshap/565 · Cited by 156 · see citing works
Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer
Sun, Y., Liu, S., Qiao, Z., Shang, Z., Xia, Z., Niu, X., Qian, L., Zhang, Y., Fan, L.-Y., Cao, C., et al. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.06.005 · Cited by 153 · see citing works
A Review of Selected Studies That Determine the Physical and Chemical Properties of Saliva in the Field of Dental Treatment
Kubala, E., Strzelecka, P. M., Grzegocka, M., Lietz–Kijak, D., Gronwald, H., Skomro, P., & Kijak, E. (2018) · BioMed Research International · doi:10.1155/2018/6572381 · Cited by 152 · see citing works
Serum, plasma and saliva biomarkers for head and neck cancer
Arantes, L. M. R. B., de Carvalho, A. C., Melendez, M. E., & Carvalho, A. L. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1404906 · Cited by 151 · see citing works
Characterization of the Human Salivary Proteome by Capillary Isoelectric Focusing/Nanoreversed-Phase Liquid Chromatography Coupled with ESI-Tandem MS
Guo, T., Rudnick, P. A., Wang, W., Lee, C. S., DeVoe, D. L., & Balgley, B. M. (2006) · Journal of Proteome Research · doi:10.1021/pr060065m · Cited by 150 · see citing works
Salivary Biomarkers for Caries Risk Assessment
Guo, L., & Wenyuan, S. (2013) · Journal of the California Dental Association · doi:10.1080/19424396.2013.12222284 · Cited by 149 · see citing works
Proteome analysis of glandular parotid and submandibular‐sublingual saliva in comparison to whole human saliva by two‐dimensional gel electrophoresis
Walz, A., Stühler, K., Wattenberg, A., Hawranke, E., Meyer, H. E., Schmalz, G., Blüggel, M., & Rühl, S. (2006) · PROTEOMICS · doi:10.1002/pmic.200500125 · Cited by 146 · see citing works
Saliva-based microfluidic point-of-care diagnostic
Pittman, T. W., Decsi, D. B., Punyadeera, C., & Henry, C. S. (2023) · Theranostics · doi:10.7150/thno.78872 · Cited by 146 · see citing works
Two-Dimensional Liquid Chromatography Study of the Human Whole Saliva Proteome
Wilmarth, P. A., Riviere, M. A., Rustvold, D. L., Lauten, J. D., Madden, T., & David, L. L. (2004) · Journal of Proteome Research · doi:10.1021/pr049911o · Cited by 144 · see citing works
Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone
Rhodus, N., Cheng, B., Bowles, W. R., Myers, S. L., Miller, L., & Ondrey, F. G. (2005) · Oral Diseases · doi:10.1111/j.1601-0825.2005.01165.x · Cited by 139 · see citing works
Non-invasive wearable chemical sensors in real-life applications
Promphet, N., Ummartyotin, S., Ngeontae, W., Puthongkham, P., & Rodthongkum, N. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.338643 · Cited by 138 · see citing works
Salivary biomarkers detection: Analytical and immunological methods overview
Gug, I., Tertiş, M., Hosu, O., & Cristea, C. (2019) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.02.020 · Cited by 136 · see citing works
Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer
Kumar, P., Gupta, S., & Das, B. C. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101827 · Cited by 136 · see citing works
Bone Remodeling Biomarkers of Periodontal Disease in Saliva
Frodge, B. D., Ebersole, J. L., Kryscio, R. J., Thomas, M. V., & Miller, C. S. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.080070 · Cited by 134 · see citing works
Comparison of Salivary and Serum Glucose Levels in Diabetic Patients
Gupta, S., Sandhu, S. V., Bansal, H., & Sharma, D. (2014) · Journal of Diabetes Science and Technology · doi:10.1177/1932296814552673 · Cited by 131 · see citing works
Rheumatoid arthritis and salivary biomarkers of periodontal disease
Mirrielees, J., Crofford, L. J., Lin, Y., Kryscio, R. J., Dawson, D. R., Ebersole, J. L., & Miller, C. S. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01625.x · Cited by 131 · see citing works
Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases
Fábián, T., Fejérdy, P., & Csermely, P. (2008) · Current Genomics · doi:10.2174/138920208783884900 · Cited by 129 · see citing works
Analysis of the saliva proteome from patients with head and neck squamous cell carcinoma reveals differences in abundance levels of proteins associated with tumour progression and metastasis
Dowling, P., Wormald, R. N., Meleady, P., Henry, M. A., Curran, A. J., & CLYNES, M. M. (2008) · Journal of Proteomics · doi:10.1016/j.jprot.2008.04.004 · Cited by 127 · see citing works
Modern creatinine (Bio)sensing: Challenges of point-of-care platforms
Cánovas, R., Cuartero, M., & Crespo, G. A. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.01.048 · Cited by 127 · see citing works
Quantitative analysis of estradiol and six other steroid hormones in human saliva using a high throughput liquid chromatography–tandem mass spectrometry assay
Gao, W., Tobias Stalder, A., & Kirschbaum, C. (2015) · Talanta · doi:10.1016/j.talanta.2015.05.004 · Cited by 127 · see citing works
Emerging 0D, 1D, 2D, and 3D nanostructures for efficient point-of-care biosensing
Byakodi, M., Shrikrishna, N. S., Sharma, R., Bhansali, S., Mishra, Y. K., Kaushik, A. K., & Gandhi, S. (2022) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2022.100284 · Cited by 123 · see citing works
Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples
Kumari, A., Pasini, P., & Daunert, S. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2002-3 · Cited by 122 · see citing works
Analysis of the human saliva proteome
Amado, F. M. L., Vitorino, R. M. P., Domingues, P. M., Calheiros‐Lobo, M. J., & Duarte, J. A. (2005) · Expert Review of Proteomics · doi:10.1586/14789450.2.4.521 · Cited by 122 · see citing works
Saliva as a matrix for human biomonitoring in occupational and environmental medicine
Michalke, B., Roßbach, B., Göen, T., Schäferhenrich, A., & Scherer, G. (2014) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-014-0938-5 · Cited by 121 · see citing works
The physics of respiratory particle generation, fate in the air, and inhalation
Morawska, L., Buonanno, G., Mikszewski, A., & Stabile, L. (2022) · Nature Reviews Physics · doi:10.1038/s42254-022-00506-7 · Cited by 121 · see citing works
Vibration spectroscopy and body biofluids: Literature review for clinical applications
Leal, L. B., Nogueira, M. S., Canevari, R. D. A., & Carvalho, L. F. C. S. (2018) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2018.09.008 · Cited by 119 · see citing works
Lung Cancer Biomarkers
Hoseok, I., & Cho, J. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2015.07.003 · Cited by 119 · see citing works
Bacterial and viral pathogens in saliva: disease relationship and infectious risk
Slots, J., & Slots, H. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00361.x · Cited by 119 · see citing works
Saliva: A Fluid of Study for OMICS
Cuevas-Córdoba, B., & Santiago-Garcı́a, J. (2014) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2013.0064 · Cited by 118 · see citing works
Electrochemical sensors for cortisol detections: Almost there
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Non-blood circulating tumor DNA detection in cancer
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Authors: Kaufman, E., & Lamster, I. B.
Affiliations: Columbia University (US)
ORCID: Lamster, Ira B.
Venue: Critical Reviews in Oral Biology & Medicine
Publisher: SAGE Publications
Published: 2002-03
Volume: 13
Issue: 2
Pages: 197-212
ISSN: 1045-4411 (ISSN-L)
1544-1113
DOI: 10.1177/154411130201300209
OpenAlex: W2084107384
Cited by: 887
References: 212
Citations by year: 2026: 39 · 2025: 32 · 2024: 52 · 2023: 61 · 2022: 39 · 2021: 40 · 2020: 47 · 2019: 43 · 2018: 34 · 2017: 36 · 2016: 38 · 2015: 56 · 2014: 57 · 2013: 52 · 2012: 55
FWCI: 0.98
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Critical Reviews in Oral Biology & Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › HIV/AIDS oral health manifestations
Keywords: saliva diagnostics, whole saliva, non-invasive biomarkers, systemic disease diagnosis, salivary gland pathology, autoimmune disease, genetic disorders, cancer, infectious diseases, endocrine disorders, therapeutic drug monitoring, mass screening
MeSH terms: Animals, Autoimmune Diseases, Communicable Diseases, Hormones, Humans, Mouth Diseases, Saliva, Biomarkers, Drug Monitoring, Clinical Chemistry Tests, Genetic Diseases, Inborn

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