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Cited by 395

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosis*

Rosenfeld, Margaret, Gibson, Ronald L., McNamara, Sharon, Emerson, Julia, Burns, Jane L., Castile, Robert, Hiatt, Peter, McCoy, Karen, Wilson, Christopher B., Inglis, Andrew, Smith, Arnold, Martin, Thomas R., Ramsey, Bonnie W.·2001·Pediatric Pulmonology
DOI 10.1002/ppul.1144
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Abstract

A thorough understanding of the early natural history of cystic fibrosis (CF) lung disease is critical for the development of effective interventions in the youngest patients. We assessed the evolution of pulmonary infection, inflammation, and clinical course among 40 infants over a 2‐year period through annual bronchoalveolar lavage (BAL) for culture and measurements of pro‐ and anti‐inflammatory cytokines, semiannual infant pulmonary function testing, and quarterly clinical evaluations. Both the prevalence of CF pathogens and their density in BAL fluid increased with age. Infants had neutrophilic lower airway inflammation and elevated IL‐8 concentrations independent of whether CF pathogens were recovered. Total leukocyte and neutrophil densities and IL‐8 concentrations increased with density of CF pathogens in BAL fluid, whether the isolated organism was P. aeruginosa or another pathogen. IL‐10 concentrations were similar in CF subjects and non‐CF historical controls. Infants generally had suboptimal growth (low weight and height percentiles) and obstructive lung disease (decreased expiratory flows and air trapping). Subjects from whom CF pathogens were isolated at > 10 5 cfu/mL had the worst air trapping and lowest Brasfield chest X‐ray scores. Our findings provide a foundation for future studies of early intervention in CF lung disease, including antimicrobial and anti‐inflammatory therapy. Pediatr Pulmonol. 2001; 32:356–366. © 2001 Wiley‐Liss, Inc.

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Metadata

Authors
Rosenfeld, M., Gibson, R. L., McNamara, S., Emerson, J., Burns, J. L., Castile, R., Hiatt, P., McCoy, K., Wilson, C. B., Inglis, A., Smith, A., Martin, T. R., & Ramsey, B. W.
Venue
Pediatric Pulmonology
Publisher
Wiley
Published
2001-10-09
Volume
32
Issue
5
Pages
356-366
ISSN
  • 1099-0496 (ISSN-L)
  • 8755-6863
DOI
10.1002/ppul.1144
OpenAlex
W2057496127
Cited by
395
References
24
FWCI
8.82
Type
journal article
Language
en
Open access
closed

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