The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Longitudinal Assessment of Pseudomonas aeruginosa in Young Children with Cystic Fibrosis
Abstract
Pseudomonas aeruginosa lung infection is an important cause of morbidity and mortality in cystic fibrosis (CF). Longitudinal assessment of the phenotypic changes in P. aeruginosa isolated from young children with CF is lacking. This study investigated genotypic and phenotypic changes in P. aeruginosa from oropharynx (OP) and bronchoalveolar lavage fluid (BALF) in a cohort of 40 CF patients during the first 3 years of life; antibody response was also examined. A high degree of genotypic variability was identified, and each patient had unique genotypes. Early isolates had a phenotype distinct from those of usual CF isolates: generally nonmucoid and antibiotic susceptible. Genotype and phenotype correlated between OP and BALF isolates. As determined by culture, 72.5% of patients demonstrated P. aeruginosa during their first 3 years. On the basis of combined culture and serologic results, 97.5% of patients had evidence of infection by age 3 years, which suggests that P. aeruginosa infection occurs early in CF and may be intermittent or undetectable by culture.
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Cites
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Cited by
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
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Bronchial microbiome of severe COPD patients colonised by Pseudomonas aeruginosa
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Metadata
- Authors
- Burns, J. L., Gibson, R. L., McNamara, S., Yim, D., Emerson, J., Rosenfeld, M., Hiatt, P., McCoy, K., Castile, R., Smith, A. L., & Ramsey, B. W.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-02
- Volume
- 183
- Issue
- 3
- Pages
- 444-452
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2166779461
- Cited by
- 555
- References
- 25
- FWCI
- 18.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burns, J. L., Gibson, R. L., McNamara, S., Yim, D., Emerson, J., Rosenfeld, M., Hiatt, P., McCoy, K., Castile, R., Smith, A. L., & Ramsey, B. W. (2001). Longitudinal Assessment of Pseudomonas aeruginosa in Young Children with Cystic Fibrosis. The Journal of Infectious Diseases. https://doi.org/10.1086/318075
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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