The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Structure and function of enzymes in heme biosynthesis
Open accessAbstract
Tetrapyrroles like hemes, chlorophylls, and cobalamin are complex macrocycles which play essential roles in almost all living organisms. Heme serves as prosthetic group of many proteins involved in fundamental biological processes like respiration, photosynthesis, and the metabolism and transport of oxygen. Further, enzymes such as catalases, peroxidases, or cytochromes P450 rely on heme as essential cofactors. Heme is synthesized in most organisms via a highly conserved biosynthetic route. In humans, defects in heme biosynthesis lead to severe metabolic disorders called porphyrias. The elucidation of the 3D structures for all heme biosynthetic enzymes over the last decade provided new insights into their function and elucidated the structural basis of many known diseases. In terms of structure and function several rather unique proteins were revealed such as the V‐shaped glutamyl‐tRNA reductase, the dipyrromethane cofactor containing porphobilinogen deaminase, or the “Radical SAM enzyme” coproporphyrinogen III dehydrogenase. This review summarizes the current understanding of the structure–function relationship for all heme biosynthetic enzymes and their potential interactions in the cell.
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tRNAGlu as a cofactor in δ-aminolevulinate biosynthesis: steps that regulate chlorophyll synthesis
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The enzymic conversion of coproporphyrinogen III into protoporphyrin IX
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Trace metal metabolism in plants
Andresen, E., Peiter, E., & Küpper, H. (2018) · Journal of Experimental Botany · doi:10.1093/jxb/erx465 · Cited by 431
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product
Dailey, H. A., Dailey, T. A., Gerdes, S., Jahn, D., Jahn, M., O'Brian, M. R., & Warren, M. J. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00048-16 · Cited by 340
Self-citationTetrapyrrole Metabolism in Arabidopsis thaliana
Tanaka, R., Kobayashi, K., & Masuda, T. (2011) · The Arabidopsis Book · doi:10.1199/tab.0145 · Cited by 281
5‐ALA in the management of malignant glioma
Stepp, H., & Stummer, W. (2018) · Lasers in Surgery and Medicine · doi:10.1002/lsm.22933 · Cited by 234
Metadata
- Authors
- Layer, G., Reichelt, J., Jahn, D., & Heinz, D. W.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 2010-05-24
- Volume
- 19
- Issue
- 6
- Pages
- 1137-1161
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- OpenAlex
- W2023070199
- Cited by
- 357
- References
- 9
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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