Trace metal metabolism in plants
Open accessAbstract
Many trace metals are essential micronutrients, but also potent toxins. Due to natural and anthropogenic causes, vastly different trace metal concentrations occur in various habitats, ranging from deficient to toxic levels. Therefore, one focus of plant research is on the response to trace metals in terms of uptake, transport, sequestration, speciation, physiological use, deficiency, toxicity, and detoxification. In this review, we cover most of these aspects for the essential micronutrients copper, iron, manganese, molybdenum, nickel, and zinc to provide a broader overview than found in other recent reviews, to cross-link aspects of knowledge in this very active research field that are often seen in a separated way. For example, individual processes of metal usage, deficiency, or toxicity often were not mechanistically interconnected. Therefore, this review also aims to stimulate the communication of researchers following different approaches, such as gene expression analysis, biochemistry, or biophysics of metalloproteins. Furthermore, we highlight recent insights, emphasizing data obtained under physiologically and environmentally relevant conditions.
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Metal ion transport into vacuoles occurs through CDF (cation diffusion facilitator), MTP (metal tolerance protein), and P1B type ATPase HMA3.
“Moreover, metal ion transport into vacuoles occurs through CDF (cation diffusion facilitator), MTP (metal tolerance protein), and P1B type ATPase HMA3 (Krämer et al., 2007; Verbruggen et al., 2009b; Andresen et al., 2018).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Andresen et al., 2018
The Manganese section identifies MTP8 as a vacuolar CDF protein that mediates vacuolar Mn storage, and the Zinc section says MTP1 sequesters Zn into vacuoles. These passages support CDF/MTP-mediated transport, but the passages found for HMA proteins do not establish that HMA3 transports metals into vacuoles. (LLM, conf=0.86)
Experimental — accuracy not yet measuredA great deal of metal ion transport has been explored through studies on ZIP transporters, as they are involved mainly in the uptake of metal ions.
“A great deal of metal ion transport has been explored through studies on ZIP transporters, as they are involved mainly in the uptake of metal ions (Krämer et al., 2007; Andresen et al., 2018).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Andresen et al., 2018
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Awasthi, S., Chauhan, R., & Srivastava, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822916-3.00001-9 · Cited by 32 · see citing works
Samreen, S., Khan, A. A., Khan, M. R., Ansari, S. A., & Khan, A. (2021) · Water Air & Soil Pollution · doi:10.1007/s11270-021-05124-0 · Cited by 31 · see citing works
John, W. A., Lückel, B., Matschiavelli, N., Hübner, R., Matschi, S., Hoehenwarter, W., & Sachs, S. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153700 · Cited by 31 · see citing works
Zinc deficiency responses: bridging the gap between Arabidopsis and dicotyledonous crops
Thiébaut, N., & Hanikenne, M. (2021) · Journal of Experimental Botany · doi:10.1093/jxb/erab491 · Cited by 31 · see citing works
Gao, H., Huang, L., Gong, Z., Wang, X., Qiao, X., Xiao, F., Yang, Y., Yu, B., Guo, X., Yu, C., et al. (2022) · Plant Growth Regulation · doi:10.1007/s10725-022-00857-2 · Cited by 30 · see citing works
- Authors
- Andresen, E., Peiter, E., & Küpper, H.
- Affiliations
- Czech Academy of Sciences (CZ)
- Martin Luther University Halle-Wittenberg (DE)
- Corresponding author
- Küpper, Hendrik
- Venue
- Journal of Experimental Botany
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-02-13
- Volume
- 69
- Issue
- 5
- Pages
- 909-954
- ISSN
- 0022-0957 (ISSN-L)
- 1460-2431
- OpenAlex
- W2791034768
- Cited by
- 431
- References
- 611
- Citations by year
- 2026: 30 · 2025: 49 · 2024: 58 · 2023: 65 · 2022: 70 · 2021: 87 · 2020: 34 · 2019: 26 · 2018: 11
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Experimental Botany (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education of the Czech Republic (CZ.02.1.01/0.0/0.0/15_003/0000336)
- Czech Academy of Sciences (60077344)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Chemistry › Analytical Chemistry › Heavy Metals in Plants
- Keywords
- trace metal metabolism, micronutrients, metal uptake, metal transport, metal sequestration, metal speciation, metal deficiency, metal toxicity, detoxification, copper, iron, manganese, molybdenum, nickel, zinc, metalloproteins, plant metal homeostasis
- MeSH terms
- Metals, Plants, Trace Elements
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