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Cited by 2Protein Structure and DynamicsSARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

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Coronaviruses spike glycoprotein endodomains: The sequence and structure‐based comprehensive study

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Kumar, Prateek, Bhardwaj, Aparna, Mukherjee, Bodhidipra, Joshi, Richa, Giri, Rajanish·2023·Protein Science
DOI 10.1002/pro.4804PMC PMC10599102

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Abstract

Any protein's flexibility or region makes it available to interact with many biomolecules in the cell. Specifically, such interactions in viruses help them to perform more functions despite having a smaller genome. Therefore, these flexible regions can be exciting and essential targets to be explored for their role in pathogenicity and therapeutic developments as they achieve essential interactions. In the continuation with our previous study on disordered analysis of SARS‐CoV‐2 spike protein's cytoplasmic tail (CTR), or endodomain, here we have explored the endodomain's disordered potential of six other coronaviruses using multiple bioinformatics approaches and molecular dynamics simulations. Based on the comprehensive analysis of its sequence and structural composition, we report the varying disorder propensity in endodomains of spike proteins of coronaviruses. The observations of this study may help to understand the importance of spike glycoprotein endodomain and creating therapeutic interventions against them.

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Research works printed but not linked: 60

  1. 10.1016/j.softx.2015.06.001 · DOI · Paper page
  2. 10.1038/s41467-020-19883-7 · DOI · Paper page
  3. 10.3892/ijmm.2017.3036 · DOI
  4. 10.1016/j.heliyon.2020.e04743 · DOI
  5. 10.1128/JVI.80.3.1302-1310.2006 · DOI
  6. 10.1128/JVI.80.7.3225-3237.2006 · DOI
  7. 10.1523/JNEUROSCI.1635-10.2010 · DOI
  8. 10.1038/ncb0502-e127 · DOI
  9. 10.1093/nar/gkr1064 · DOI
  10. 10.1093/nar/gkt1047 · DOI
  11. 10.3389/fimmu.2018.01581 · DOI
  12. 10.1038/nbt0901-805 · DOI · Paper page
  13. 10.1016/S0959-440X(02)00289-0 · DOI · Paper page
  14. Dyson HJ, 2018, How do intrinsically disordered viral proteins hijack the cell?, Biochem Int, 57, 4045
  15. 10.1007/s00018-020-03603-x · DOI
  16. 10.3201/eid1002.030913 · DOI
  17. 10.1021/acs.biochem.6b00790 · DOI
  18. 10.1093/nar/gkm363 · DOI
  19. 10.1002/jcc.20945 · DOI · Paper page
  20. 10.1093/bioinformatics/btu744 · DOI
  21. 10.1038/s41467-020-20321-x · DOI
  22. 10.1093/bioinformatics/btq480 · DOI
  23. 10.1128/JVI.06147-11 · DOI
  24. 10.1016/B978-0-323-90264-9.00030-1 · DOI
  25. 10.1016/j.virol.2021.11.005 · DOI
  26. 10.1021/acs.jctc.5b00935 · DOI
  27. 10.1146/annurev-virology-110615-042301 · DOI · Paper page
  28. 10.1016/j.str.2003.10.002 · DOI
  29. 10.1002/pro.2443 · DOI
  30. 10.1016/j.jmb.2019.03.008 · DOI
  31. 10.1371/journal.pone.0141603 · DOI
  32. 10.1128/JVI.02146-06 · DOI
  33. 10.1016/j.virol.2010.05.031 · DOI
  34. 10.1093/nar/gky384 · DOI
  35. 10.1128/JVI.76.14.7174-7186.2002 · DOI
  36. 10.1002/prot.10532 · DOI
  37. 10.1186/1471-2105-7-208 · DOI
  38. 10.1016/j.virol.2006.10.034 · DOI
  39. 10.1016/B978-0-323-40181-4.00222-X · DOI
  40. 10.1371/journal.pone.0029210 · DOI
  41. 10.1016/j.virol.2009.12.020 · DOI
  42. 10.1093/nar/gku316 · DOI · Paper page
  43. 10.1002/1097-0134(20010101)42:1<38::AID-PROT50>3.0.CO;2-3 · DOI
  44. 10.1016/j.phrs.2012.04.005 · DOI
  45. 10.1007/s12038-017-9676-7 · DOI
  46. 10.1038/msb.2011.75 · DOI
  47. 10.1016/j.celrep.2018.07.080 · DOI
  48. 10.1038/s41557-021-00758-3 · DOI
  49. 10.1021/cr4005082 · DOI
  50. 10.1016/j.sbi.2015.08.009 · DOI
  51. 10.1021/cr400525m · DOI
  52. 10.1016/j.cell.2009.04.029 · DOI
  53. 10.1093/nar/gkaa275 · DOI
  54. 10.3390/w12061598 · DOI
  55. World Health Organization, 2021, WHO coronavirus disease (COVID‐19) dashboard with vaccination data. WHO coronavirus (COVID‐19) dashboard with vaccination data, 1
  56. 10.1038/s41392-021-00651-y · DOI
  57. 10.3390/v13010109 · DOI · Paper page
  58. 10.1016/j.bbapap.2010.01.011 · DOI
  59. 10.1038/srep31988 · DOI
  60. 10.3389/fmolb.2021.629873 · DOI

Metadata

Authors
Kumar, P., Bhardwaj, A., Mukherjee, B., Joshi, R., & Giri, R.
Affiliations
Indian Institute of Technology Mandi (IN)
Corresponding author
Giri, Rajanish
ORCID
Venue
Protein Science
Publisher
Wiley
Published
2023-10-25
Volume
32
Issue
11
Pages
e4804-e4804
ISSN
  • 0961-8368 (ISSN-L)
  • 1469-896X
DOI
10.1002/pro.4804
PMC
PMC10599102
OpenAlex
W4387607370
Cited by
2
References
2
Citations by year
2025: 1 · 2023: 1
FWCI
0.18
Type
journal article
Language
en
Open access
Licence
Locations
  • Protein Science (publishedVersion)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Science and Engineering Research Board (CRG/2019/005603)
  • Indian Council of Medical Research (52/04/2020/BIO/BMS, 58/6/2020/PHA/BMS)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords
cytoplasmic tail, intrinsically disordered regions, molecular dynamics simulation, SARS-CoV-2, therapeutic target
MeSH terms
SARS-CoV-2, Glycoproteins, Humans, Molecular Dynamics Simulation, Spike Glycoprotein, Coronavirus

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