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Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3‐kinases: Binding partners of SH3 domains?
Abstract
Two SH3 domain‐containing cytosolic components of the NADPH oxidase, p47 phox and p40 phox, are shown by analyses of their sequences to contain single copies of a novel class of domain, the PX (phox) domain. Homologous domains are demonstrated to be present in the Cpk class of phosphatidylinositol 3‐kinase, S. cerevisiae Bem1p, and S. pombe Scd2, and a large family of human sorting nexin 1 (SNX1) homologues. The majority of these domains contains a polyproline motif, typical of SH3 domain‐binding proteins. Two further findings are reported. A third NADPH oxidase subunit, p67 phox, is shown to contain four tetratricopeptide repeats (TPRs) within its N‐terminal Racl GTP‐binding region, and a 28 residue motif in p40 phox is demonstrated to be present in protein kinase C isoforms τ/λ and ζ, and in three ZZ domain‐containing proteins.
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SNX17 contains a putative PX domain in its N-terminus.
“contains a putative PXdomain in the N-terminus”
From The PX‐domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor (2002) · cites this paper as Ponting, 1996
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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899
The PX domains of p47phox and p40phox bind to lipid products of PI(3)K
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Metadata
- Authors
- Ponting, C. P.
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 1996-11
- Volume
- 5
- Issue
- 11
- Pages
- 2353-2357
- ISSN
- 0961-8368
- 1469-896X
- Cited by
- 253
- References
- 4
- Language
- en
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