Structure and distribution of pentapeptide repeats in bacteria
Open accessAbstract
We report the discovery of a novel family of proteins, each member contains tandem pentapeptide (five residue) repeats, described by the motif A(D/N)LXX. Members of this family are both membrane bound and cytoplasmic. The function of these repeats is uncertain, but they may have a targeting or structural function rather than enzymatic activity. This family is most common in cyanobacteria, suggesting a function related to cyanobacterial‐specific metabolism. Although no experimental information is available for the structure of this family, it is predicted that the tandem pentapeptide repeats will form a right‐handed β‐helical structure. A structural model of the pentapeptide repeats is presented.
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Analyzing AF2 results, a novel beta-solenoid structure was predicted for a large family of pentapeptide repeats found in mycobacterial PPE proteins (Pfam: PF01469).
“Analyzing the AF2 results, we found a novel beta-solenoid structure predicted for a large family of pentapeptide repeats26, found in the mycobacterial PPE proteins (Pfam: PF01469) (Fig. 2e and Supplementary Fig. 6).”
From A structural biology community assessment of AlphaFold2 applications (2022) · cites this paper as [26]
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A structural biology community assessment of AlphaFold2 applications
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Self-citationβ‐Rolls, β‐Helices, and Other β‐Solenoid Proteins
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- Authors
- Bateman, A., Murzin, A. G., & Teichmann, S. A.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Bateman, Alex
- Venue
- Protein Science
- Publisher
- Wiley
- Published
- 1998-06
- Volume
- 7
- Issue
- 6
- Pages
- 1477-1480
- ISSN
- 0961-8368 (ISSN-L)
- 1469-896X
- PMC
- PMC2144021
- OpenAlex
- W2168757976
- Cited by
- 99
- References
- 24
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 8 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 4
- FWCI
- 0.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Protein Science (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Boehringer Ingelheim Fonds
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Physical Sciences › Materials Science › Materials Chemistry › Enzyme Structure and Function
- Keywords
- tandem repeats, bacterial proteins, cyanobacteria, membrane proteins, protein targeting, structural model, protein families
- MeSH terms
- Cyanobacteria, Amino Acid Sequence, Bacterial Proteins, Models, Molecular, Molecular Sequence Data, Oligopeptides, Protein Kinases, Repetitive Sequences, Nucleic Acid, Protein Structure, Secondary, HSP70 Heat-Shock Proteins
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