Familial factors affecting prostatic cancer risk and plasma sex-steroid levels

Wayne Meikle, A.; Smith, Joseph A.; West, Dee W.

doi:10.1002/pros.2990060202

Cited by 110Prostate Cancer Treatment and ResearchProstate Cancer Diagnosis and TreatmentHormonal and reproductive studies

Familial factors affecting prostatic cancer risk and plasma sex-steroid levels

Wayne Meikle, A., Smith, Joseph A., West, Dee W.·1985·The Prostate

DOI 10.1002/pros.2990060202

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Abstract

Whether familial factors affect the frequency of prostatic cancer and the plasma content of sex‐steroids was investigated. Brothers (n = 257) of probands (n = 150) diagnosed with prostatic cancer before age 62 years had a fourfold higher risk for developing the disease than men in the general population in the State of Utah and their brothers‐in‐law (n = 202). Familial factors markedly affected the plasma content of sex steroids (testosterone, dihydro‐testosterone, the ratio of testosterone to DHT, sex‐hormone binding globulin, and the free fraction of testosterone) in nonendocrinologically treated probands and their brothers and sons and in normal men in the general populations. Index cases and their brothers and sons had a significantly lower mean plasma testosterone content than controls of comparable age. Preliminary data suggest that the metabolic clearance rate of testosterone and the conversion ratio of testosterone to estradiol are relatively high in probands. The observations indicate that familial factors are potent risk factors for the development of prostatic cancer. They also suggest that plasma androgen values in families with prostatic cancer cluster in the lower range of normal and that plasma sex‐steroid content is more similar in each brothers with or without prostatic cancer than among nonbrothers.

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In 25 young men with upper respiratory infections, serial testosterone assessments showed a transient mean 10% decline during the acute phase, with reductions up to 30% in a select cohort.
“Results demonstrated a transient mean 10% decline in T during the acute phase of the illness, with reductions of up to 30% in a select cohort of patients.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [81]
Both acute and chronic disease states are associated with decreasing testosterone levels.
“Both acute and chronic disease states are associated with decreasing T levels.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [81]

Statistical Methods in Medical Research.
Wickham, C. A. C., Armitage, P., & Berry, G. (1988) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.2307/2982765 · Cited by 1,410 · see citing works
Testosterone Secretion and Metabolism in Male Senescence
Vermeulen, A., Rubens, R. D., & Verdonck, L. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-4-730 · Cited by 536 · see citing works
Increased Estrogen Production in Obese Men*
SCHNEIDER, G. T., Kirschner, M. A., Berkowitz, R. D., & Ertel, N. H. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-4-633 · Cited by 507 · see citing works
The Testis in Normal and Infertile Men.
(1977) · Annals of Internal Medicine · doi:10.7326/0003-4819-87-6-805_4 · Cited by 483 · see citing works
Low serum testosterone and sex-hormone-binding-globulin in massively obese men
GLASS, A. R., SWERDLOFF, R. S., BRAY, G. A., DAHMS, W. T., & ATKINSON, R. L. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-6-1211 · Cited by 430 · see citing works
Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone
Horton, R., & Tait, J. F. (1966) · Journal of Clinical Investigation · doi:10.1172/jci105344 · Cited by 401 · see citing works
Capacity of the Testosterone-Binding Globulin in Human Plasma and Influence of Specific Binding of Testosterone on Its Metabolic Clearance Rate
Vermeulen, A., Verdonck, L., Straeten, M. V. D., & ORIE, N. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-11-1470 · Cited by 385 · see citing works
Conversion of blood androgens to estrogens in normal adult men and women
Longcope, C., Kato, T., & Horton, R. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106185 · Cited by 368 · see citing works
Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men
Gordon, G. G., Altman, K. I., Southren, A. L., Rubin, E., & Lieber, C. S. (1976) · New England Journal of Medicine · doi:10.1056/nejm197610072951501 · Cited by 364 · see citing works
CHANGES IN THE PITUITARY‐TESTICULAR SYSTEM WITH AGE
Baker, H. W. G., Burger, H., KRETSER, D. M. D., Hudson, B., O'connor, S., Wang, C.-L., MIROVICS, A., Court, J. M., Dunlop, M., & RENNIE, G. C. (1976) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1976.tb01964.x · Cited by 305 · see citing works
The Estimation of Intraclass Correlation in the Analysis of Family Data
Donner, A. P., & Koval, J. J. (1980) · Biometrics · doi:10.2307/2530491 · Cited by 305 · see citing works
Further Studies on Leydig Cell Function in Old Age
Rubens, R. D., Dhont, M. A., & Vermeulen, A. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-39-1-40 · Cited by 271 · see citing works
Declining testicular function with age
Stearns, E. L., MacDonnell, J. A., Kaufman, B. J., Padua, R., Lucman, T. S., Winter, J. S. D., & Faiman, C. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90850-x · Cited by 266 · see citing works
An investigation of the familial aspects of carcinoma of the prostate
Woolf, C. M. (1960) · Cancer · doi:10.1002/1097-0142(196007/08)13:4 · Cited by 243 · see citing works
Reproductive Endocrinology.
(1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-6-1016_3 · Cited by 210 · see citing works
Genetic study of breast cancer: Identification of a high risk group
Anderson, D. E. (1974) · Cancer · doi:10.1002/1097-0142(197410)34:4 · Cited by 206 · see citing works
AGE RELATED CHANGES AND INTERRELATIONSHIPS BETWEEN PLASMA TESTOSTERONE, OESTRADIOL AND TESTOSTERONE-BINDING GLOBULIN IN NORMAL ADULT MALES
Pirke, K. M., & Doerr, P. (1973) · European Journal of Endocrinology · doi:10.1530/acta.0.0740792 · Cited by 181 · see citing works
Mild hypogonadotropic hypogonadism in obese men
Strain, G. W., Zumoff, B., Kream, J., Strain, J. J., Deucher, R., Rosenfeld, R. S., Levin, J., & Fukushima, D. K. (1982) · Metabolism · doi:10.1016/0026-0495(82)90175-5 · Cited by 174 · see citing works
Recent Studies on the Mechanism of Action of Testosterone
Deykin, D., Balko, C., & Wilson, J. D. (1972) · New England Journal of Medicine · doi:10.1056/nejm197212212872508 · Cited by 171 · see citing works
Effect of Hormonal Therapy on Plasma Testosterone Levels in Prostatic Carcinoma
Robinson, M. R. G., & Thomas, B. S. (1971) · BMJ · doi:10.1136/bmj.4.5784.391 · Cited by 162 · see citing works
Depressed Plasma Testosterone and Fractional Binding of Testosterone in Obese Males*
Amatruda, J. M., Harman, S. M., Pourmotabbed, G., & LOCKWOODF, D. H. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-47-2-268 · Cited by 132 · see citing works
AGE RELATED CHANGES IN FREE PLASMA TESTOSTERONE, DIHYDROTESTOSTERONE AND OESTRADIOL
Pirke, K. M., & Doerr, P. (1975) · European Journal of Endocrinology · doi:10.1530/acta.0.0800171 · Cited by 130 · see citing works
The metabolic clearance rate and origin of plasma dihydrotestosterone in man and its conversion to the 5α-androstanediols
MAHOUDEAU, J. A., Bardin, C. W., & Lipsett, M. B. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106613 · Cited by 123 · see citing works
The Conversion of Androgens to Estrogens in Hyperthyroidism*
Southren, A. L., Olivo, J., Gordon, G. G., Vittek, J., Brener, J. L., & Rafii, F. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-2-207 · Cited by 123 · see citing works
ANDROGEN LEVELS IN THE PLASMA AND PROSTATIC TISSUES OF PATIENTS WITH BENIGN HYPERTROPHY AND CARCINOMA OF THE PROSTATE
Habib, F. K., LEE, I. R., Stitch, S. R., & Smith, P. H. (1976) · Journal of Endocrinology · doi:10.1677/joe.0.0710099 · Cited by 117 · see citing works
PLASMA STEROID AND PROTEIN HORMONE CONCENTRATIONS IN PATIENTS WITH PROSTATIC CARCINOMA, BEFORE AND DURING OESTROGEN THERAPY
Harper, M. E., Peeling, W. B., Cowley, T., Brownsey, B. G., Phillips, M. E., Groom, G. V., Fahmy, D. R., & Griffiths, K. (1976) · European Journal of Endocrinology · doi:10.1530/acta.0.0810409 · Cited by 109 · see citing works
Influence of Major Surgical Stress on Plasma Levels of Testosterone, Luteinizing Hormone and Follicle-Stimulating Hormone in Male Patients
Aono, T., Kurachi, K., Mizutani, S., HAMANAKA, Y., UOZUMI, T., Nakasima, A., KOSHIYAMA, K., & Matsumoto, K. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-4-535 · Cited by 100 · see citing works
Familial Prostatic Cancer Risk and Low Testosterone*
Meikle, A. W., & Stanish, W. M. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-6-1104 · Cited by 100 · see citing works
SEX HORMONE BINDING GLOBULIN BINDING CAPACITY, TESTOSTERONE, 5α-DIHYDROTESTOSTERONE, OESTRADIOL AND PROLACTIN IN PLASMA OF PATIENTS WITH PROSTATIC CARCINOMA UNDER VARIOUS TYPES OF HORMONAL TREATMENT
BARTSCH, W., Horst, H.-J., Becker, H., & Nehse, G. (1977) · European Journal of Endocrinology · doi:10.1530/acta.0.0850650 · Cited by 98 · see citing works
Measures of Disease Incidence Used in Epidemiologic Research
Morgenstern, H., Kleinbaum, D. G., & Kupper, L. L. (1980) · International Journal of Epidemiology · doi:10.1093/ije/9.1.97 · Cited by 94 · see citing works
Plasma Testosterone Levels in Patients with Prostatic Carcinoma Before and after Treatment
YOUNG, H. H., & Kent, J. R. (1968) · The Journal of Urology · doi:10.1016/s0022-5347(17)62795-2 · Cited by 92 · see citing works
ALTERED BLOOD ANDROGENS IN ELDERLY MEN WITH PROSTATE HYPERPLASIA.
Horton, R., Hsieh, P., Barberia, J. M., Pages, L., & Cosgrove, M. D. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-4-793 · Cited by 88 · see citing works
Altered Metabolism of Androgens in Elderly Men with Benign Prostatic Hyperplasia
Ishimaru, T., Pages, L., & Horton, R. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-4-695 · Cited by 78 · see citing works
Abnormal levels of plasma hormones in men with prostate cancer: Evidence toward a “two‐disease” theory
Zumoff, B., Levin, J., Strain, G. W., Rosenfeld, R. S., O'Connor, J., Freed, S. Z., Kream, J., Whitmore, W. S., Fukushima, D. K., & HELLMAN, L. (1982) · The Prostate · doi:10.1002/pros.2990030607 · Cited by 75 · see citing works
RECHERCHES CLINICO-STATISTIQUES ET GÉNÉTIQUES SUR LES NÉOPLASIES DE LA PROSTATE
Morganti, G., Gianferrari, L., Cresseri, A., Arrigoni, G., & Lovati, G. (1956) · Human Heredity · doi:10.1159/000150844 · Cited by 71 · see citing works
Plasma 5α-Reduced Androgens in Men and Hirsute Women: Role of Adrenals and Gonads*
Meikle, A. W., Stringham, J. D., Wilson, D. E., & Dolman, L. I. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-6-969 · Cited by 71 · see citing works
Familial effects on plasma sex-steroid content in man: Testosterone, estradiol and sex-hormone-binding globulin
Meikle, A. W., Stanish, W. M., Taylor, N., Edwards, C. Q., & Bishop, C. T. (1982) · Metabolism · doi:10.1016/0026-0495(82)90019-1 · Cited by 61 · see citing works
Environmental factors, hormone status, and prostatic cancer
Hill, P., Wynder, E. L., Garnes, H. A., & Walker, A. R. (1980) · Preventive Medicine · doi:10.1016/0091-7435(80)90037-7 · Cited by 60 · see citing works
Epidemiology of prostatic cancer.
Hutchison, G. B. (1976) · PubMed · Cited by 54 · see citing works
The effects of hormones and prostaglandins on the calcium pools in cultured myocardial cells
Moura, A.-M., & Simpkins, H. (1976) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(76)90017-4 · Cited by 41 · see citing works
Evidence for an adrenal origin of plasma estrogens in alcoholic men
Thiel, D. H. V., & Loriaux, D. L. (1979) · Metabolism · doi:10.1016/0026-0495(79)90194-x · Cited by 32 · see citing works
THE EFFECT OF ACTH ON PLASMA TESTOSTERONE AND ANDROSTENEDIONE CONCENTRATIONS IN PATIENTS WITH PROSTATIC CARCINOMA
Cowley, T., Brownsey, B. G., Harper, M. E., Peeling, W. B., & Griffiths, K. (1976) · European Journal of Endocrinology · doi:10.1530/acta.0.0810310 · Cited by 29 · see citing works
HUMAN TESTOSTERONE-OESTRADIOL BINDING GLOBULIN IN HEALTH AND DISEASE
Wenn, R. V., KAMBERI, I. A., Vossough, P., Kariminejad, M. H., Torabee, E., Ayoughi, F., Keyvanjah, M., & Sarberi, N. (1977) · European Journal of Endocrinology · doi:10.1530/acta.0.0840850 · Cited by 27 · see citing works
Steroid Secretion by the Human Testis
Lipsett, M. B. (1970) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-9008-8_30 · Cited by 21 · see citing works
The epidemiology of cancer of the prostate
Higgins, I. T. T. (1975) · Journal of Chronic Diseases · doi:10.1016/0021-9681(75)90029-6 · Cited by 19 · see citing works
Blood hormone levels related to stages and grades of prostatic cancer
Høisaeter, P. A., Haukaas, S. A., Bakke, Å., Höiem, L., Segadal, E., & Thorsen, T. (1982) · The Prostate · doi:10.1002/pros.2990030407 · Cited by 13 · see citing works
The Testis in Normal and Infertile Men
Koninckx, P. (2009) · Andrologia · doi:10.1111/j.1439-0272.1978.tb03056.x · Cited by 7 · see citing works
HUMAN TESTOSTERONE-OESTRADIOL BINDING GLOBULIN IN HEALTH AND DISEASE
Wenn, R. V., KAMBERI, I. A., Vossough, P., Kariminejad, M. H., Torabee, E., Ayoughi, F., Keyvanjah, M., & Sarberi, N. (1977) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-197710000-00019 · Cited by 3 · see citing works

Flagged first, then by citations

1 of the 49 references couldn’t be matched to a known paper.

Sorted by citations

Mendelian inheritance of familial prostate cancer.
Carter, B. S., Beaty, T. H., Steinberg, G. D., Childs, B., & Walsh, P. C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3367 · Cited by 780 · see citing works
Family history and the risk of prostate cancer
Steinberg, G. D., Carter, B. S., Beaty, T. H., Childs, B., & Walsh, P. C. (1990) · The Prostate · doi:10.1002/pros.2990170409 · Cited by 718 · see citing works
Human prostate cancer risk factors
Bostwick, D. G., BURKE, H. B., Djakiew, D., Euling, S. Y., Ho, S., Landolph, J. R., MORRISON, H. I., Sonawane, B. R., Shifflett, T., Waters, D. J., et al. (2004) · Cancer · doi:10.1002/cncr.20408 · Cited by 644 · see citing works
Hereditary Prostate Cancer: Epidemiologic and Clinical Features
Carter, B. S., Bova, G. S., Beaty, T. H., Steinberg, G. D., Childs, B., Isaacs, W. B., & Walsh, P. C. (1993) · The Journal of Urology · doi:10.1016/s0022-5347(17)35617-3 · Cited by 612 · see citing works
Predisposing Gene for Early-Onset Prostate Cancer, Localized on Chromosome 1q42.2-43
Berthon, P., Valéri, A., Cohen-Akenine, A., Drelon, E., Paiss, T., Wöhr, G., Latil, A., Millasseau, P., Mellah, I., Cohen, N., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301879 · Cited by 361 · see citing works
A systematic review and meta‐analysis of familial prostate cancer risk
Johns, L. E., & Houlston, R. S. (2003) · British Journal of Urology · doi:10.1046/j.1464-410x.2003.04232.x · Cited by 312 · see citing works
Chapter 2: The Role of Steroid Hormones in Prostate Carcinogenesis
Bosland, M. C. (2000) · JNCI Monographs · doi:10.1093/oxfordjournals.jncimonographs.a024244 · Cited by 307 · see citing works
Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma
Zeegers, M. P., Jellema, A., & D, H. O. M. (2003) · Cancer · doi:10.1002/cncr.11262 · Cited by 224 · see citing works
Molecular Genetics and Epidemiology of Prostate Carcinoma
Ruijter, E., van de Kaa, C., Miller, G. J., Ruiter, D. J., Debruyne, F. M. J., & Schalken, J. A. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.1.0356 · Cited by 183 · see citing works
INFLUENCE OF RADICAL PROSTATECTOMY ON SERUM HORMONE LEVELS
MILLER, L. R., Partin, A. W., Chan, D. W., Bruzek, D. J., Dobs, A. S., Epstein, J. I., & Walsh, P. C. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62922-7 · Cited by 178 · see citing works
A Genome Screen of Multiplex Sibships with Prostate Cancer
Suarez, B. K., Lin, J., Burmester, J. K., Broman, K. W., Weber, J. L., Banerjee, T. K., Goddard, K. A. B., Witte, J. S., Elston, R. C., & Catàlona, W. J. (2000) · The American Journal of Human Genetics · doi:10.1086/302818 · Cited by 156 · see citing works
Infiltrating lobular carcinoma of the breast: Clinicopathologic analysis of 975 cases with reference to data on conservative therapy and metastatic patterns
Sastre‐Garau, X., Jouve, M., Asselain, B. J. R., Vincent‐Salomon, A., Beuzeboc, P., Dorval, T., Durand, J. C., Fourquet, A., & Pouillart, P. (1996) · Cancer · doi:10.1002/(sici)1097-0142(19960101)77:1 · Cited by 422 · see citing works
Family History and Prostate Cancer Risk
Lesko, S. M., Rosenberg, L. A., & Shapiro, S. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008876 · Cited by 147 · see citing works
Role of Androgens in Prostatic Cancer
Isaacs, J. T. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61152-8 · Cited by 146 · see citing works
Epidemiologic evidence regarding predisposing factors to prostate cancer
Carter, B. S., Carter, H. B., & Isaacs, J. T. (1990) · The Prostate · doi:10.1002/pros.2990160302 · Cited by 145 · see citing works
Family history and prostate cancer risk in a population-based cohort of Iowa men.
Cerhan, J. R., Parker, A. S., Putnam, S. D., Chiu, B. C. ‐., Lynch, C. F., Cohen, M. B., Torner, J. C., & Cantor, K. P. (1999) · PubMed · Cited by 124 · see citing works
Sex hormone-induced prostatic carcinogenesis in the Noble rat: The role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the development of prostate cancer
Wang, Y. Z., & Wong, Y. C. (1998) · The Prostate · doi:10.1002/(sici)1097-0045(19980515)35:3 · Cited by 123 · see citing works
Genetics and the common cancers.
Peto, J., & Houlston, R. (2001) · European Journal of Cancer · doi:10.1016/s0959-8049(01)00255-6 · Cited by 127 · see citing works
Original Articles
Bastacky, S., Wojno, K. J., Walsh, P. C., Carmichael, M. J., & Epstein, J. I. (1995) · The Journal of Urology · doi:10.1097/00005392-199503001-00023 · Cited by 119 · see citing works
Original Articles: Prostate Cancer: Pathological Features of Hereditary Prostate Cancer
Bastacky, S., Wojno, K. J., Walsh, P. C., Carmichael, M. J., & Epstein, J. I. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67619-5 · Cited by 117 · see citing works
Vitamin D and Prostate Cancer
Feldman, D., Skowroński, R., & Peehl, D. M. (1995) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-0949-7_5 · Cited by 110 · see citing works
Utilizing effective group models for prostate cancer patients and their families
Kules, A. R., & Axelrod, A. (1995) · Cancer · doi:10.1002/1097-0142(19950401)75:7+ · Cited by 6 · see citing works
Epidemiology of Prostate Cancer
Meikle, A. W., & Smith, J. A. J. (1990) · Urologic Clinics of North America · doi:10.1016/s0094-0143(21)01366-5 · Cited by 108 · see citing works
Self-citation
Serum Androgens: Associations With Prostate Cancer Risk and Hair Patterning
Demark‐Wahnefried, W., Lesko, S. M., Conaway, M. R., Robertson, C. N., Clark, R. V., Lobaugh, B., Mathias, B. J., Strigo, T. S., & Paulson, D. F. (1997) · Journal of Andrology · doi:10.1002/j.1939-4640.1997.tb01964.x · Cited by 107 · see citing works
Vertebral compression fracture as a presenting feature of acute lymphoblastic leukemia in children
Ribeiro, R. C., Pui, C., & Schell, M. J. (1988) · Cancer · doi:10.1002/1097-0142(19880201)61:3 · Cited by 44 · see citing works
Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials
Trost, L. W., & Mulhall, J. P. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.04.068 · Cited by 98 · see citing works
Family History and Risk of Fatal Prostate Cancer
Rodríguez, C., Calle, E. E., Miracle-McMahill, H. L., Tatham, L. M., Wingo, P. A., Thun, M. J., & Heath, C. W. (1997) · Epidemiology · doi:10.1097/00001648-199710000-00007 · Cited by 97 · see citing works
Review of the role of androgenic hormones in the epidemiology of benign prostatc hyperplasia and prostate cancer
Montie, J. E., & Pienta, K. J. (1994) · Urology · doi:10.1016/0090-4295(94)90163-5 · Cited by 94 · see citing works
Serum androgens and prostate cancer.
Nomura, A. M. Y., Stemmermann, G. N., Chyou, P.-H., Henderson, B. E., & Stanczyk, F. Z. (1996) · PubMed · Cited by 91 · see citing works
BIOLOGICAL AGGRESSIVENESS OF HEREDITARY PROSTATE CANCER: LONG-TERM EVALUATION FOLLOWING RADICAL PROSTATECTOMY
Bova, G. S., Partin, A. W., Isaacs, S. D., Carter, B. S., BEATY, T. L., Isaacs, W. B., & Walsh, P. C. (1998) · The Journal of Urology · doi:10.1016/s0022-5347(01)62748-4 · Cited by 86 · see citing works
Hypermethylation of the APC (adenomatous Polyposis Coli) gene promoter region in human colorectal carcinoma
Hiltunen, M., Alhonen, L. I., Koıstınaho, J., Myöhänen, S., Pääkkönen, M. E., Marin, S., Kosma, V.-M., & Jänne, J. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970317)70:6 · Cited by 192 · see citing works
Familial Aspects of Prostate Cancer: A Case Control Study
Keetch, D. W., Rice, J. P., Suarez, B. K., & Catàlona, W. J. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)66705-3 · Cited by 81 · see citing works
Genetic and Environmental Factors in Prostate Cancer Genesis:Identifying High-Risk Cohorts
Ekman, P. (1999) · European Urology · doi:10.1159/000019910 · Cited by 78 · see citing works
The Etiopathogenesis of Prostatic Cancer with Special Reference to Environmental Factors
Bosland, M. C. (1988) · Advances in cancer research · doi:10.1016/s0065-230x(08)60220-1 · Cited by 74 · see citing works
Cellular and Molecular Pathology of Prostate Cancer Precursors
Foster, C. S., Bostwick, D. G., Bonkhoff, H., Damber, J., van der Kwast, T., Montironi, R., & Sakr, W. A. (2000) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/003655900750169284 · Cited by 74 · see citing works
Prostate Cancer Susceptibility Locus HPC1 in Utah High-Risk Pedigrees
Neuhausen, S. L., Farnham, J. M., Kort, E. N., Tavtigian, S. V., Skolnick, M. H., & Cannon‐Albright, L. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.13.2437 · Cited by 72 · see citing works
Association of codon 72 polymorphism of p53 with lower prostate cancer risk
Henner, W. D., Evans, A. J., Hough, K. M., Harris, E. L., Lowe, B. A., & Beer, T. M. (2001) · The Prostate · doi:10.1002/pros.10021 · Cited by 71 · see citing works
Hereditary prostate cancer
Bratt, O. (2000) · BJU International · doi:10.1046/j.1464-410x.2000.00457.x · Cited by 65 · see citing works
A Screening Study of Prostate Cancer in High Risk Families
McWhorter, W. P., Hernandez, A. D., Meikle, A. W., Terreros, D. A., Smith, J. A. J., Skolnick, M. H., Cannon‐Albright, L., & Eyre, H. J. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)36733-2 · Cited by 69 · see citing works
Self-citation
Significance of Familial History of Prostate Cancer to Traditional Prognostic Variables, Genetic Biomarkers, and Recurrence after Radical Prostatectomy
Bauer, J. J., Srivastava, S. K., Connelly, R. R., Sesterhenn, I. A., Preston, D., McLeod, D. G., & Moul, J. W. (1998) · Urology · doi:10.1016/s0090-4295(98)00103-4 · Cited by 66 · see citing works
TNM classification of malignant tumors, fifth edition (1997)
Sobin, L. H., & Fleming, I. D. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971101)80:9 · Cited by 996 · see citing works
Family aggregation of cancer of the prostate in quebec: The tip of the iceberg
Ghadirian, P., Cadotte, M., Lacroix, A., & Perret, C. (1991) · The Prostate · doi:10.1002/pros.2990190105 · Cited by 62 · see citing works
Family History and the Risk of Prostatic Carcinoma in a High Risk Group of Urological Patients
Aprikian, A. G., Bazinet, M., PLANTE, M. K., Meshref, A. W., Trudel, C., Aronson, S., Nachabé, M., Péloquin, F., Dessureault, J., Narod, S. A., et al. (1995) · The Journal of Urology · doi:10.1097/00005392-199508000-00022 · Cited by 60 · see citing works
Sex hormone-induced nuclear DNA damage and lipid peroxidation in the dorsolaterel prostates of Noble rats
Ho, S., & Roy, D. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90370-0 · Cited by 55 · see citing works
Evaluation of cancer information on the Internet
Biermann, J. S., Golladay, G. J., Greenfield, M. L. V. H., & Baker, L. H. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990801)86:3 · Cited by 240 · see citing works
Angiostatin generation by human tumor cell lines: Involvement of plasminogen activators
Westphal, J. R., Hullenaar, R. V., Geurts-Moespot, A. J., Sweep, F. C. G. J., Verheijen, J. H., Bussemakers, M. J. G., Askaa, J., Clemmensen, I. H., Eggermont, A. M. M., Ruiter, D. J., et al. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000615)86:6 · Cited by 52 · see citing works
Familial study of prostate cancer in Jamaica
Glover, F. E., Coffey, D. S., Douglas, L. L., Russell, H. E., Cadigan, M., Tulloch, T., Wedderburn, K., Wan, R. L., Baker, T. D., & Walsh, P. C. (1998) · Urology · doi:10.1016/s0090-4295(98)00200-3 · Cited by 48 · see citing works
Molecular Genetics and Epidemiology of Prostate Carcinoma
Ruijter, E. T. G. (1999) · Endocrine Reviews · doi:10.1210/er.20.1.22 · Cited by 44 · see citing works
Epidemiology of prostate cancer: molecular and environmental clues
Pienta, K. J., Goodson, J. A., & Esper, P. S. (1996) · Urology · doi:10.1016/s0090-4295(96)00219-1 · Cited by 41 · see citing works
Estrogens and aspects of prostate disease
Prezioso, D., Denis, L., Klocker, H., Sciarra, A., Reis, M., Naber, K. G., Lobel, B., Pacík, D., & Griffiths, K. (2006) · International Journal of Urology · doi:10.1111/j.1442-2042.2006.01476.x · Cited by 35 · see citing works
Detection of subclinical cancers by prostate-specific antigen screening in asymptomatic men from high-risk prostate cancer families.
Matikainen, M. P., Schleutker, J., Mörsky, P. J., Kallioniemi, O., & Tammela, T. L. J. (1999) · PubMed · Cited by 34 · see citing works
A randomized double-blind study evaluating anandron® associated with orchiectomy in stage D prostate cancer
Namer, M., Toubol, J., Caty, A., Couette, J. E., Douchez, J., Kerbrat, P., & Droz, J. (1990) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(90)90442-n · Cited by 34 · see citing works
Genetic epidemiology of prostate cancer.
Narod, S. (1999) · Biochimica et Biophysica Acta · doi:10.1016/s0304-419x(98)00030-4 · Cited by 22 · see citing works
Familial prostate cancer: the evidence and the Cancer Research Campaign/British Prostate Group (CRC/BPG) UK Familial Prostate Cancer Study.
Eeles, R., Dearnaley, D., Ardern-jones, A., Shearer, R., Easton, D., Ford, D., Edwards, S., & Dowe, A. (1997) · British Journal of Urology · doi:10.1111/j.1464-410x.1997.tb00795.x · Cited by 38 · see citing works
Familial and Hereditary Prostate Cancer by Definition in an Italian Surgical Series: Clinical Features and Outcome
Sacco, E., Prayer‐Galetti, T., Pinto, F., Ciaccia, M., Fracalanza, S., Betto, G., & Pagano, F. C. (2005) · European Urology · doi:10.1016/j.eururo.2005.01.016 · Cited by 30 · see citing works
Meta-analytic insights into factors influencing the repeatability of hormone levels in agricultural, ecological, and medical fields
Fanson, K. V., & Biro, P. A. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00006.2018 · Cited by 29 · see citing works
Progress in prostate cancer
Cannon-Albright, L., & Eeles, R. (1995) · Nature Genetics · doi:10.1038/ng0495-336 · Cited by 26 · see citing works
Environmental and genetic factors: a possible link with prostate cancer
Ekman, P., Pan, Y., Li, C., & Dich, J. (1997) · British Journal of Urology · doi:10.1111/j.1464-410x.1997.tb16919.x · Cited by 23 · see citing works
Hereditary aspects of prostate cancer.
McLellan, D. L., & Norman, R. W. (1995) · Europe PMC (PubMed Central) · Cited by 23 · see citing works
Familial prostate cancer studies in Utah.
Neuhausen, S., Skolnick, M., & Cannon-Albright, L. (1997) · British Journal of Urology · doi:10.1111/j.1464-410x.1997.tb00796.x · Cited by 25 · see citing works
Genetics and the common cancers
Houlston, R. S., & Peto, J. (1996) · Springer eBooks · doi:10.1007/978-1-4899-4501-3_13 · Cited by 20 · see citing works
The Prevention of Prostate Cancer
Griffiths, K., Prezioso, D., Turkes, A. O., & Denis, L. (2007) · Springer eBooks · doi:10.1007/978-3-540-40901-4_4 · Cited by 18 · see citing works
Androgens and the prostate
Frick, J., Jungwirth, A., & Rovan, E. (1998) · Springer eBooks · doi:10.1007/978-3-642-72185-4_9 · Cited by 18 · see citing works
Familial Prostate Cancer in Japan
Ohtake, N., Hatori, M., Yamanaka, H., Nakata, S., Sada, M., & Tsuji, T. (1998) · International Journal of Urology · doi:10.1111/j.1442-2042.1998.tb00262.x · Cited by 17 · see citing works
Associations between coronary heart disease, obesity and histological prostate cancer
Stamatiou, K. N., Alevizos, A., Mihas, K., Mariolis, A. D., Michalodimitrakis, E. N., & Sofras, F. (2006) · International Urology and Nephrology · doi:10.1007/s11255-006-9010-z · Cited by 16 · see citing works
Effect of combined testosterone and estradiol-17β treatment on the metabolism of E2 in the prostate and liver of noble rats
Lane, K. E., Ricci, M. J., & Ho, S. (1997) · The Prostate · doi:10.1002/(sici)1097-0045(19970301)30:4 · Cited by 14 · see citing works
[The PROGENE study, the French project of genetic analysis of familial prostatic cancer: recruitment and analysis].
Valéri, A., Berthon, P., Fournier, G., Buzzi, J.-C., Briollais, L., MERIA, P., Blanché, H., Bellanné‐Chantelot, C., Teillac, P., Démenais, F., et al. (1996) · PubMed · Cited by 13 · see citing works
Strategies for the management of recurrent and advanced urologic cancers. Quality of life
Herr, H. W. (1987) · Cancer · doi:10.1002/1097-0142(19870801)60:3+ · Cited by 15 · see citing works
Benign and Malignant Prostatic Neoplasms: Human Studies
Partin, A. W., & Coffey, D. S. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-571149-4.50020-9 · Cited by 12 · see citing works
Prostate cancer
Badalament, R. A., & Drago, J. R. (1991) · Disease-a-Month · doi:10.1016/0011-5029(91)90004-u · Cited by 12 · see citing works
Update in the management of prostate cancer
Raghavan, D., & Rogers, J. H. (1990) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1990.tb125270.x · Cited by 11 · see citing works
Hereditary Prostate Cancer
Isaacs, W. B., Xu, J., & Walsh, P. C. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-009-4_2 · Cited by 10 · see citing works
Hereditary Prostate Cancer
Damber, J. (1999) · Scandinavian Journal of Urology and Nephrology · doi:10.1080/00365599950510012-1 · Cited by 9 · see citing works
Familial prostate cancer and its management
Eeles, R. A., & Cannon‐Albright, L. (1996) · Springer eBooks · doi:10.1007/978-1-4899-4501-3_22 · Cited by 8 · see citing works
Clinical and pathologic characteristics of familial prostate cancer in Asian population
Kim, M., Kim, J. K., Ye, C., Lee, H., Oh, J. J., Lee, S., Jeong, S. J., Lee, S.-C., Hong, S. K., & Byun, S. (2019) · The Prostate · doi:10.1002/pros.23917 · Cited by 7 · see citing works
The Clinical Genetics of Prostate Cancer
Kommu, S. S., Edwards, S. M., & Eeles, R. A. (2004) · Hereditary Cancer in Clinical Practice · doi:10.1186/1897-4287-2-3-111 · Cited by 7 · see citing works
Relationship between HLA-DR Antigen and HLA-DRB1 Alleles and Prostate Cancer in Japanese Men
Azuma, H., Sada, M., Tsuji, T., Ueda, H., & Katsuoka, Y. (1999) · International Urology and Nephrology · doi:10.1023/a:1007126219791 · Cited by 6 · see citing works
AN ANALYSIS OF FAMILIAL PROSTATE CANCER
Nakata, S., Masuda, H., Satō, J., Shimizu, N., Suzuki, K., Imai, K., Yamanaka, H., Saito, K., Nakamura, T., Kato, N., et al. (1995) · The Japanese Journal of Urology · doi:10.5980/jpnjurol1989.86.1483 · Cited by 6 · see citing works
Human leukocyte antigen subtype analysis in patients with advanced adenocarcinoma of the prostate
Akdaş, A., Türkeri, L., Alican, Y., Şimşěk, F., & Akoğlu, T. (1994) · The Prostate · doi:10.1002/pros.2990240302 · Cited by 6 · see citing works
Genetic heterogeneity in Finnish hereditary prostate cancer using ordered subset analysis
Simpson, C. L., Cropp, C. D., Wahlfors, T., George, A., Jones, M. S., Harper, U. L., Ponciano‐Jackson, D., Tammela, T. L. J., Schleutker, J., & Wilson, J. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.185 · Cited by 5 · see citing works
BIOLOGICAL AGGRESSIVENESS OF HEREDITARY PROSTATE CANCER
Bova, G. S., Partin, A. W., Isaacs, S. D., Carter, B. S., BEATY, T. L., Isaacs, W. B., & Walsh, P. C. (1998) · The Journal of Urology · doi:10.1097/00005392-199809010-00004 · Cited by 5 · see citing works
[Cancer of the prostate. 1. Epidemiology].
Auselo, N. M., Costa, P., Pellec, L. L., Louis, J., & Navratil, H. (1995) · PubMed · Cited by 5 · see citing works
Prostate cancer old problems and new approaches
Honn, K. V., Aref, A., Chen, Y. Q., Cher, M. L., rissman, J. D., Forman, J. D., Gao, X., Grignon, D. J., Hussain, M., Porter, A. T., et al. (1996) · Pathology & Oncology Research · doi:10.1007/bf02904824 · Cited by 5 · see citing works
Role of Genetic Polymorphisms in the Development and Prognosis of Sporadic and Familial Prostate Cancer
Reis, S. T., Viana, N. I., Leite, K. R. M., Erico, D., Antunes, A. A., Iscaife, A., Nesrallah, A., PASSEROTTI, C. C., Srougi, V., Pontes‐Júnior, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166380 · Cited by 4 · see citing works
Prostate cancer occurring in identical twins: A case report
Spaas, P., & Bagshaw, M. A. (1990) · The Prostate · doi:10.1002/pros.2990160305 · Cited by 4 · see citing works
Verletzungen und Erkrankungen der Prostata
Flüchter, S. H., Bichler, K.-H., Weigl, A., & Kalchthaler, M. (2004) · Springer eBooks · doi:10.1007/978-3-642-18568-7_12 · Cited by 3 · see citing works
Familial Aggregation of Prostate Cancer Management while Waiting for the Identification of Hereditary Prostate Cancer Genes
Damber, J. (2001) · European Urology · doi:10.1159/000052576 · Cited by 3 · see citing works
Familial Prostate Cancer
Kommu, S. S., & Eeles, R. A. (2005) · Springer eBooks · doi:10.1007/1-84628-015-x_2 · Cited by 2 · see citing works
Possible enhancement of prostate carcinogenesis by some chemoprevention agents
Bosland, M. C. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240501230 · Cited by 2 · see citing works
Prostate cancer old problems and new approaches
Honn, K. V., Aref, A., Chen, Y. Q., Cher, M. L., Crissman, J. D., Forman, J. D., Gao, X., Grignon, D. J., Hussain, M., Porter, A. T., et al. (1996) · Pathology & Oncology Research · doi:10.1007/bf02893960 · Cited by 2 · see citing works
Prostatakarzinom
Altwein, J. E., & Wirth, M. (1994) · Springer eBooks · doi:10.1007/978-3-662-22585-1_6 · Cited by 2 · see citing works
Familial Aspects of Prostate Cancer
Keetch, D. W., Rice, J. P., Suarez, B. K., & Catàlona, W. J. (1995) · The Journal of Urology · doi:10.1097/00005392-199512000-00038 · Cited by 2 · see citing works
Prostate Cancer Genetics
Kommu, S. S., Bishara, S., & Edwards, S. M. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2864-9_11 · Cited by 1 · see citing works
Genetic Epidemiology of Hereditary Prostate Cancer in Finland
Matikainen, M. P. (2001) · Tampere University Institutional Repository (Tampere University) · Cited by 1 · see citing works
Hereditary Predisposition and Prostate Cancer
Sacco, E., Prayer-Galetti, T., Pinto, F., Ciaccia, M., Fracalanza, S., Betto, G., & Pagano, F. C. (2005) · Urologia Journal · doi:10.1177/039156030507200201 · Cited by 1 · see citing works
Hereditary Aspects of Urologic Cancer
Naitoh, J., & Walzak, M. P. (1994) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(18)30505-2 · Cited by 1 · see citing works
The genetics of prostate cancer
Eeles, R. A. (1995) · Cancer biology and medicine · doi:10.1007/978-94-011-0677-1_4
GENETIC EPIDEMIOLOGY OF HEREDITARY PROSTATE CANCER IN FINLAND
Matikainen, M. P., Schleutker, J., Koivisto, P. A., Tammela, T. L. J., Xu, J., Isaacs, W. B., Smith, J. R., Carpten, J. D., Stephan, D. A., Wilson, J., et al. (1999) · The Journal of Urology · doi:10.1097/00005392-199904010-00220
Self-citation
Heterogeneity in Genetic Susceptibility to Prostate Cancer
Seppälä, E. H. (2006) · Tampere University Institutional Repository (Tampere University)
4 The genetics of prostate cancer
Eeles, R. A. (1995)

Familial Prostatic Cancer Risk and Low Testosterone*
Meikle, A. W., & Stanish, W. M. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-6-1104 · Cited by 100 · see citing works
Production, clearance, and metabolism of testosterone in men with prostatic cancer
Meikle, A. W., Smith, J. A., & Stringham, J. D. (1987) · The Prostate · doi:10.1002/pros.2990100106 · Cited by 36 · see citing works
Self-citation
Serum pituitary and sex steroid hormone levels in the etiology of prostatic cancer – a population-based case-control study
Andersson, S.-O., Adami, H., Bergström, R., & WIDE, L. E. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.293 · Cited by 63 · see citing works
Familial Aspects of Prostate Cancer: A Case Control Study
Keetch, D. W., Rice, J. P., Suarez, B. K., & Catàlona, W. J. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)66705-3 · Cited by 81 · see citing works
Prostate cancer characteristics in fathers and risk of early onset high‐risk prostate cancer in sons
Lin, E., Garmo, H., Beckmann, K., Ola Bratt, A., Akre, O., Stattin, P., & Gedeborg, R. (2025) · International Journal of Cancer · doi:10.1002/ijc.70133 · Cited by 2 · see citing works

Authors: Wayne Meikle, A., Smith, J. A., & West, D. W.
Affiliations: University of Utah (US)
Venue: The Prostate
Publisher: Wiley
Published: 1985-01
Volume: 6
Issue: 2
Pages: 121-128
ISSN: 0270-4137 (ISSN-L)
1097-0045
DOI: 10.1002/pros.2990060202
OpenAlex: W1976692247
Cited by: 110
References: 49
Citations by year: 2019: 1 · 2018: 2 · 2016: 2 · 2015: 1 · 2012: 2
FWCI: 2.44
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7870 d)
Locations: The Prostate (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA-25031)
National Center for Research Resources (RR-64)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: prostate cancer, familial risk, plasma sex steroids, testosterone, dihydrotestosterone, sex hormone-binding globulin, free testosterone, androgen metabolism, Utah
MeSH terms: Adult, Aged, Humans, Male, Metabolic Clearance Rate, Middle Aged, Prostatic Neoplasms, Risk, Gonadal Steroid Hormones, Dihydrotestosterone, Testosterone

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Familial factors affecting prostatic cancer risk and plasma sex-steroid levels

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