The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Silk fibroin: Structural implications of a remarkable amino acid sequence
Open accessAbstract
The amino acid sequence of the heavy chain of Bombyx mori silk fibroin was derived from the gene sequence. The 5,263‐residue (391‐kDa) polypeptide chain comprises 12 low‐complexity “crystalline” domains made up of Gly–X repeats and covering 94% of the sequence; X is Ala in 65%, Ser in 23%, and Tyr in 9% of the repeats. The remainder includes a nonrepetitive 151‐residue header sequence, 11 nearly identical copies of a 43‐residue spacer sequence, and a 58‐residue C‐terminal sequence. The header sequence is homologous to the N‐terminal sequence of other fibroins with a completely different crystalline region. In Bombyx mori, each crystalline domain is made up of subdomains of ∼70 residues, which in most cases begin with repeats of the GAGAGS hexapeptide and terminate with the GAAS tetrapeptide. Within the subdomains, the Gly–X alternance is strict, which strongly supports the classic Pauling–Corey model, in which β‐sheets pack on each other in alternating layers of Gly/Gly and X/X contacts. When fitting the actual sequence to that model, we propose that each subdomain forms a β‐strand and each crystalline domain a two‐layered β‐sandwich, and we suggest that the β‐sheets may be parallel, rather than antiparallel, as has been assumed up to now. Proteins 2001;44:119–122. © 2001 Wiley‐Liss, Inc.
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Cites
An investigation of the structure of silk fibroin
Marsh, R. E., Corey, R. B., & Pauling, L. (1955) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(55)90178-5 · Cited by 721
Fine organization of Bombyx mori fibroin heavy chain gene
Zhou, C.-Z. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.12.2413 · Cited by 711
Self-citationTanaka, K., Kajiyama, N., Ishikura, K., Waga, S., Kikuchi, A., Ohtomo, K., Takagi, T., & Mizuno, S. (1999) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(99)00088-6 · Cited by 259
Structure refinement and diffuse streak scattering of silk (Bombyx mori)
Takahashi, Y., Gehoh, M., & Yuzuriha, K. (1999) · International Journal of Biological Macromolecules · doi:10.1016/s0141-8130(98)00080-4 · Cited by 253
Primary structure of the silk fibroin light chain determined by cDNA sequencing and peptide analysis
Yamaguchi, K., Kikuchi, Y., Takagi, T., Kikuchi, A., Oyama, F., Shimura, K., & Mizuno, S. (1989) · Journal of Molecular Biology · doi:10.1016/0022-2836(89)90295-7 · Cited by 206
Specifie codon usage pattern and its implications on the secondary structure of silk fibroin mRNA
Mita, K., Ichimura, S., Zama, M., & James, T. C. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90117-9 · Cited by 102
Gage, L. P., & Manning, R. F. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70582-1 · Cited by 85
Cited by
Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
Silk fibroin biomaterials for tissue regenerations
Kundu, B., Rajkhowa, R., Kundu, S. C., & Wang, X. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.09.043 · Cited by 1,391
Structures, mechanical properties and applications of silk fibroin materials
Koh, L.-D., Cheng, Y., Teng, C.-P., Khin, Y.-W., Loh, X.-J., Tee, S.-Y., Low, M., Ye, E., Yu, H.-D., Zhang, Y.-W., et al. (2015) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.001 · Cited by 1,241
Design of nanostructured biological materials through self-assembly of peptides and proteins
Zhang, S., Marini, D. M., Hwang, W., & Santoso, S. (2002) · Current Opinion in Chemical Biology · doi:10.1016/s1367-5931(02)00391-5 · Cited by 572
Silk fibroin as a functional biomaterial for tissue engineering
Sun, W., Gregory, D. A., Tomeh, M. A., & Zhao, X. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031499 · Cited by 552
Metadata
- Authors
- Zhou, C., Confalonieri, F., Jacquet, M., Perasso, R., Li, Z., & Janin, J.
- Venue
- Proteins: Structure, Function, and Bioinformatics
- Publisher
- Wiley
- Published
- 2001-05-25
- Volume
- 44
- Issue
- 2
- Pages
- 119-122
- ISSN
- 0887-3585 (ISSN-L)
- 1097-0134
- OpenAlex
- W2112761739
- Cited by
- 784
- References
- 7
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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