Cited by 1,391Silk-based biomaterials and applicationsElectrospun Nanofibers in Biomedical ApplicationsBone Tissue Engineering Materials

Silk fibroin biomaterials for tissue regenerations

Kundu, Banani, Rajkhowa, Rangam, Kundu, Subhas C., Wang, Xungai·2013·Advanced Drug Delivery Reviews

Abstract

Regeneration of tissues using cells, scaffolds and appropriate growth factors is a key approach in the treatments of tissue or organ failure. Silk protein fibroin can be effectively used as a scaffolding material in these treatments. Silk fibers are obtained from diverse sources such as spiders, silkworms, scorpions, mites and flies. Among them, silk of silkworms is a good source for the development of biomedical device. It possesses good biocompatibility, suitable mechanical properties and is produced in bulk in the textile sector. The unique combination of elasticity and strength along with mammalian cell compatibility makes silk fibroin an attractive material for tissue engineering. The present article discusses the processing of silk fibroin into different forms of biomaterials followed by their uses in regeneration of different tissues. Applications of silk for engineering of bone, vascular, neural, skin, cartilage, ligaments, tendons, cardiac, ocular, and bladder tissues are discussed. The advantages and limitations of silk systems as scaffolding materials in the context of biocompatibility, biodegradability and tissue specific requirements are also critically reviewed.

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Registry

Crossref · 10.1016/j.addr.2012.09.043

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223 of 223 references verified0 citation errors · 0 not checkable

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  • Sericin membranes made from aqueous solutions of regenerated silk fibroin have a tensile strength of about 0.02 GPa and elongation at break of about 2%.

    “The tensile strength and elongation at the break of sericin membranes made from aqueous solutions of regenerated silk fibroin are about 0.02 GPa and 2% [23].”

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Authors
Kundu, B., Rajkhowa, R., Kundu, S. C., & Wang, X.
Affiliations
  • Indian Institute of Technology Kharagpur (IN)
  • Deakin University (AU)
Corresponding author
  • Kundu, Subhas C.
  • Wang, Xungai
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2013-04
Volume
65
Issue
4
Pages
457-470
ISSN
0169-409X (ISSN-L)
OpenAlex
W2052116137
Cited by
1,391
References
223
Citations by year
2026: 79 · 2025: 117 · 2024: 147 · 2023: 122 · 2022: 135 · 2021: 136 · 2020: 129 · 2019: 111 · 2018: 87 · 2017: 92 · 2016: 87 · 2015: 77 · 2014: 56 · 2013: 15
FWCI
2.44
Type
journal article
Language
en
Open access
closed
Locations
  • Advanced Drug Delivery Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
Australian Research Council
Topics
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
silk fibroin, tissue engineering scaffolds, tissue regeneration, biocompatibility, biodegradability, bone tissue engineering, vascular tissue engineering, neural tissue engineering, skin tissue engineering, cartilage tissue engineering, cardiac tissue engineering, ocular tissue engineering, bladder tissue engineering, silkworm silk, spider silk, biodegradable biomaterials
MeSH terms
Animals, Biocompatible Materials, Fibroins, Humans, Regeneration, Bombyx, Tissue Engineering, Tissue Scaffolds

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