Silk fibroin biomaterials for tissue regenerations
Abstract
Regeneration of tissues using cells, scaffolds and appropriate growth factors is a key approach in the treatments of tissue or organ failure. Silk protein fibroin can be effectively used as a scaffolding material in these treatments. Silk fibers are obtained from diverse sources such as spiders, silkworms, scorpions, mites and flies. Among them, silk of silkworms is a good source for the development of biomedical device. It possesses good biocompatibility, suitable mechanical properties and is produced in bulk in the textile sector. The unique combination of elasticity and strength along with mammalian cell compatibility makes silk fibroin an attractive material for tissue engineering. The present article discusses the processing of silk fibroin into different forms of biomaterials followed by their uses in regeneration of different tissues. Applications of silk for engineering of bone, vascular, neural, skin, cartilage, ligaments, tendons, cardiac, ocular, and bladder tissues are discussed. The advantages and limitations of silk systems as scaffolding materials in the context of biocompatibility, biodegradability and tissue specific requirements are also critically reviewed.
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Sericin membranes made from aqueous solutions of regenerated silk fibroin have a tensile strength of about 0.02 GPa and elongation at break of about 2%.
“The tensile strength and elongation at the break of sericin membranes made from aqueous solutions of regenerated silk fibroin are about 0.02 GPa and 2% [23].”
From Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review (2025) · cites this paper as [23]
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Porous silk scaffolds can be used for tissue engineering annulus fibrosus
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Structures, mechanical properties and applications of silk fibroin materials
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Plasticizing Silk Protein for On‐Skin Stretchable Electrodes
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Silk scaffolds in bone tissue engineering: An overview
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Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review
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“The tensile strength and elongation at the break of sericin membranes made from aqueous solutions of regenerated silk fibroin are about 0.02 GPa and 2% [23].”
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
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- Authors
- Kundu, B., Rajkhowa, R., Kundu, S. C., & Wang, X.
- Affiliations
- Indian Institute of Technology Kharagpur (IN)
- Deakin University (AU)
- Corresponding author
- Kundu, Subhas C.
- Wang, Xungai
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 65
- Issue
- 4
- Pages
- 457-470
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2052116137
- Cited by
- 1,391
- References
- 223
- Citations by year
- 2026: 79 · 2025: 117 · 2024: 147 · 2023: 122 · 2022: 135 · 2021: 136 · 2020: 129 · 2019: 111 · 2018: 87 · 2017: 92 · 2016: 87 · 2015: 77 · 2014: 56 · 2013: 15
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Research Council
- Topics
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- silk fibroin, tissue engineering scaffolds, tissue regeneration, biocompatibility, biodegradability, bone tissue engineering, vascular tissue engineering, neural tissue engineering, skin tissue engineering, cartilage tissue engineering, cardiac tissue engineering, ocular tissue engineering, bladder tissue engineering, silkworm silk, spider silk, biodegradable biomaterials
- MeSH terms
- Animals, Biocompatible Materials, Fibroins, Humans, Regeneration, Bombyx, Tissue Engineering, Tissue Scaffolds
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