Incorporation of concentration data below the limit of quantification in population pharmacokinetic analyses

Ways to Fit a PK Model with Some Data Below the Quantification Limit

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Handling Data Below the Limit of Quantification in Mixed Effect Models

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Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non‐nucleoside reverse transcriptase inhibitors in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry

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Impact of censoring data below an arbitrary quantification limit on structural model misspecification

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AN APPLICATION OF BAYESIAN POPULATION PHARMACOKINETIC/PHARMACODYNAMIC MODELS TO DOSE RECOMMENDATION

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Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D

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A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry

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A rapid and sensitive LC–MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel

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Validated assay for the simultaneous determination of the anti‐cancer agent gemcitabine and its metabolite 2′,2′‐difluorodeoxyuridine in human plasma by high‐performance liquid chromatography with tandem mass spectrometry

Vainchtein, L. D., Rosing, H., Thijssen, B., Schellens, J. H. M., & Beijnen, J. H. (2007) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3096 · Cited by 37 · see citing works

Liquid chromatography atmospheric pressure chemical ionization tandem mass spectrometry method for the quantification of pregabalin in human plasma

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Simultaneous quantification of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP and TMP in cultured cell models by LC-MS/MS

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Simultaneous quantification of 2′,2′‐difluorodeoxycytidine and 2′,2′‐difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry

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Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

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Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820

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A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry

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A novel and sensitive method for ethinylestradiol quantification in human plasma by high-performance liquid chromatography coupled to atmospheric pressure photoionization (APPI) tandem mass spectrometry: Application to a comparative pharmacokinetics study

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Simultaneous quantification of psoralen and isopsoralen in rat plasma by ultra-performance liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study after oral administration of Haigou Pill

Gu, Y. J., Si, D., Gao, J., Zeng, Y., & Liu, C. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.07.035 · Cited by 20 · see citing works

The bioanalysis of vinorelbine and 4‐O‐deacetylvinorelbine in human and mouse plasma using high‐performance liquid chromatography coupled with heated electrospray ionization tandem mass–spectrometry

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Validation and application of a liquid chromatography–tandem mass spectrometric method for quantification of the drug transport probe fexofenadine in human plasma using 96-well filter plates

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Development and validation of a semi-automated assay for the highly sensitive quantification of Biolimus A9 in human whole blood using high-performance liquid chromatography–tandem mass spectrometry

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A Semi-Physiological Population Pharmacokinetic Model Describing the Non-linear Disposition of Indisulam

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Liquid chromatography–tandem mass spectrometry method for the quantification of dimebon in rat plasma and brain tissue

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Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high‐performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry

Vainchtein, L. D., Rosing, H., Mirejovsky, D., Huynh, V., Lenaz, L., Hillebrand, M. J. X., Schellens, J. H. M., & Beijnen, J. H. (2006) · Journal of Mass Spectrometry · doi:10.1002/jms.1086 · Cited by 11 · see citing works

Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study

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Liquid chromatography/positive ion electrospray tandem mass spectrometry method for the quantification of hydrochloride meptazinol in human plasma: Application to a pharmacokinetic study

Qiao, J., Tan, Z., Li, W., Huang, L., & Miaomiao, G. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.08.051 · Cited by 7 · see citing works

Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4‐benzenedisulphonamide) in human plasma, urine and faeces by high‐performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

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Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry

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A phase I study of E7070, a chloroindolyl-sulfonamide, in combination with irinotecan in gastrointestinal and thoracic carcinomas

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A simple method of sample size calculation for linear and logistic regression

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Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure

Basu, R., Poglitsch, M., Yogasundaram, H., Thomas, J., Rowe, B. H., & Oudit, G. Y. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.064 · Cited by 197 · see citing works

Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

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Antiepileptic Drug Exposure in Infants of Breastfeeding Mothers With Epilepsy

Birnbaum, A. K., Meador, K. J., KARANAM, A. B., Brown, C. A., May, R., Gerard, E. E., Gedzelman, E. R., Penovich, P. E., Kalayjian, L. A., Cavitt, J. L., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.4443 · Cited by 138 · see citing works

Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals

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Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: results from the BIOSIGNAL study

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Modeling the Kinetics of Serum Glial Fibrillary Acidic Protein, Ubiquitin Carboxyl-Terminal Hydrolase-L1, and S100B Concentrations in Patients with Traumatic Brain Injury

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Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats

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Approaches to handling missing or “problematic” pharmacology data: Pharmacokinetics

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Pervasive exposure of wild small mammals to legacy and currently used pesticide mixtures in arable landscapes

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The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study

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Fixed dose rivaroxaban can be used in extremes of bodyweight: A population pharmacokinetic analysis

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Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease

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Carbonyl Compounds Produced by Vaporizing Cannabis Oil Thinning Agents

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Population pharmacokinetics of recombinant coagulation factor VIII‐SingleChain in patients with severe hemophilia A

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The Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A Report from the Children’s Oncology Group

Beechinor, R. J., Thompson, P. A., Hwang, M. F., Vargo, R. C., Bomgaars, L. R., Gerhart, J. G., Dreyer, Z. E., & González, D. (2019) · Clinical Pharmacokinetics · doi:10.1007/s40262-018-00734-0 · Cited by 38 · see citing works

Plasma and tissue angiotensin-converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease

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Semiphysiologically based pharmacokinetic model for midazolam and CYP3A mediated metabolite 1‐OH‐midazolam in morbidly obese and weight loss surgery patients

Brill, M. J. E., Välitalo, P. A. J., Darwich, A. S., van Ramshorst, B., van Dongen, H., Rostami‐Hodjegan, A., Danhof, M., & Knibbe, C. (2015) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12048 · Cited by 36 · see citing works

Topical delivery of climbazole to mammalian skin

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Increased cortisol metabolism in women with pregnancy-related hypertension

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Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis

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Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite

Kervezee, L., Hartman, R., van den Berg, D., Meijer, J. H., & de Lange, E. C. M. (2017) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2017.05.048 · Cited by 31 · see citing works

Altered microbiota-host metabolic cross talk preceding neutropenic fever in patients with acute leukemia

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Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children

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Relationship between in feed drugs, antibiotics and organic enrichment in marine sediments at Canadian Atlantic salmon aquaculture sites

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Robust and Comprehensive Targeted Metabolomics Method for Quantification of 50 Different Primary, Secondary, and Sulfated Bile Acids in Multiple Biological Species (Human, Monkey, Rabbit, Dog, and Rat) and Matrices (Plasma and Urine) Using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS) Analysis

Sangaraju, D., Shi, Y., Parys, M. V., Ray, A., Walker, A., Caminiti, R., Milanowski, D. J., Jaochico, A., Dean, B., & Liang, X. (2021) · Journal of the American Society for Mass Spectrometry · doi:10.1021/jasms.0c00435 · Cited by 29 · see citing works

Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism

Adin, D. B., Atkins, C. E., Domenig, O., DeFrancesco, T. C., Keene, B. W., Tou, S. P., Stern, J. A., & Meurs, K. M. (2020) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.15746 · Cited by 28 · see citing works

Utilization of Data Below the Analytical Limit of Quantitation in Pharmacokinetic Analysis and Modeling: Promoting Interdisciplinary Debate

Hecht, M., Veigure, R., Couchman, L., S Barker, C. I., Standing, J. F., Takkis, K., Evard, H., Johnston, A., Herodes, K., Leito, I., et al. (2018) · Bioanalysis · doi:10.4155/bio-2018-0078 · Cited by 34 · see citing works

Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers

Lee, M. R., Farokhnia, M., Cobbina, E., Saravanakumar, A., Li, X., Battista, J. T., Farinelli, L. A., Akhlaghi, F., & Leggio, L. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107788 · Cited by 27 · see citing works

Effect of supplementation with Saccharomyces Boulardii on academic examination performance and related stress in healthy medical students: a randomized, double-blind, placebo-controlled trial

Karbownik, M. S., Kręczyńska, J., Kwarta, P., Cybula, M., Wiktorowska-Owczarek, A., Kowalczyk, E., Pietras, T., & Szemraj, J. (2020) · Nutrients · doi:10.3390/nu12051469 · Cited by 26 · see citing works

A quantitative LC-MS/MS method for analysis of mitochondrial -specific oxysterol metabolism

Borah, K., Rickman, O. J., Voutsina, N., Ampong, I., Gao, D., Baple, E. L., Dias, I. H. K., Crosby, A. H., & Griffiths, H. R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101595 · Cited by 26 · see citing works

Precision dosing of intravenous busulfan in pediatric hematopoietic stem cell transplantation: Results from a multicenter population pharmacokinetic study

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Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients

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A new population pharmacokinetic model for vancomycin in patients with variable renal function: Therapeutic drug monitoring based on extended covariate model using CKD‐EPI estimation

Kim, D., Lee, D. H., Ahn, S., Jung, J., Kiem, S., Kim, S. W., & Shin, J. (2019) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.12995 · Cited by 26 · see citing works

Effect of angiotensin receptor blockers and angiotensin-converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in cats with heart disease

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Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns: A Pooled Population Pharmacokinetic Study

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Pharmacokinetics of Ceftazidime-Avibactam in Combination with Aztreonam (COMBINE) in a Phase 1, Open-Label Study of Healthy Adults

Lodise, T. P., O’Donnell, J. N., Balevic, S. J., Liu, X., Gu, K., George, J. M., Raja, S. M., Guptill, J. T., Zaharoff, S., Schwager, N., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00936-22 · Cited by 24 · see citing works

Population pharmacokinetic and pharmacodynamic analysis of BIIB023, an anti‐TNF‐like weak inducer of apoptosis (anti‐TWEAK) monoclonal antibody

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Increased CNTF levels in adults with autism spectrum disorders

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Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children

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A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents

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Dexmedetomidine Pharmacokinetics and a New Dosing Paradigm in Infants Supported With Cardiopulmonary Bypass

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Prognostic value of neurofilament light chain in chronic inflammatory demyelinating polyneuropathy

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Quantification Below the Lloq in Regulated Lc–Ms/Ms Assays: A Review of Bioanalytical Considerations and Cautions

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Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study

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Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis

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Topical delivery of hexamidine

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Population pharmacokinetics and pulmonary modeling of eravacycline and the determination of microbiological breakpoint and cutoff of PK/PD

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Ultra-sensitive LC–MS/MS method for the quantification of gemcitabine and its metabolite 2′,2′-difluorodeoxyuridine in human plasma for a microdose clinical trial

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Cancer risk assessment from exposure to trihalomethanes in showers by inhalation.

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Neuroendocrine Response to Exogenous Ghrelin Administration, Combined With Alcohol, in Heavy-Drinking Individuals: Findings From a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study

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Therapeutic monitoring of serum concentrations of acyclovir and its metabolite 9-(carboxymethoxymethyl) guanine in routine clinical practice

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Circulating metabolite signatures indicate differential gut-liver crosstalk in lean and obese MASLD

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Population Pharmacokinetics of Paritaprevir, Ombitasvir, and Ritonavir in Japanese Patients with Hepatitis C Virus Genotype 1b Infection

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A meta-analysis of protein binding of flucloxacillin in healthy volunteers and hospitalized patients

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Elevated acute phase proteins affect pharmacokinetics in COVID‐19 trials: Lessons from the CounterCOVID ‐ imatinib study

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Pharmacokinetic analysis across studies to drive knowledge‐integration: A tutorial on individual patient data meta‐analysis (IPDMA)

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A Pragmatic Approach to Handling Censored Data Below the Lower Limit of Quantification in Pharmacokinetic Modeling

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A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium

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Predictive PBPK modeling as a tool in the formulation of the drug candidate TMP-001

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The lower limit of quantification in pharmacokinetic analyses

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Urinary Elimination of Ecdysterone and its Metabolites following a Single-Dose Administration in Humans

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Population pharmacokinetics of lenalidomide in multiple myeloma patients

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A Population Pharmacokinetic Model of Intravenous Dexmedetomidine for Mechanically Ventilated Children after Neurosurgery

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Comprehensive Pharmacokinetic Evaluation of High Melanin Binder Levofloxacin in Rabbits Shows Potential of Topical Eye Drops for Posterior Segment Treatment

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Population pharmacokinetics of paritaprevir, ombitasvir, dasabuvir, ritonavir and ribavirin in hepatitis C virus genotype 1 infection: analysis of six phase III trials

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Optimising the dose of clonidine to achieve sedation in intensive care unit patients with population pharmacokinetics

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Hepatic Expression of the Na+-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation

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Body weight, gender and pregnancy affect enantiomer‐specific ketorolac pharmacokinetics

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Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing

Yin, A., Ettaieb, M. H. T., Swen, J. J., van Deun, L., Kerkhofs, T. M. A., van der Straaten, R. J. H. M., Corssmit, E. P. M., Gelderblom, H. A. J., Kerstens, M. N., Feelders, R. A., et al. (2020) · Clinical Pharmacokinetics · doi:10.1007/s40262-020-00913-y · Cited by 13 · see citing works

Clustering with missing and left‐censored data: A simulation study comparing multiple‐imputation‐based procedures

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Monitoring topiramate concentrations at delivery and during lactation

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Umbilical Cord, Maternal Milk, and Breastfed Infant Levetiracetam Concentrations Monitoring at Delivery and during Early Postpartum Period

Kacířová, I., Grundmann, M., & Brozmanová, H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030398 · Cited by 13 · see citing works

Effect of angiotensin receptor blockers and angiotensin converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in dogs with heart disease

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Disability-Adjusted Life Year Frameworks for Comparing Health Impacts Associated with Mycobacterium avium, Trihalomethanes, and Haloacetic Acids in a Building Plumbing System

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Therapeutic monitoring of carbamazepine and its active metabolite during the 1st postnatal month: Influence of drug interactions

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Visually guided preprocessing of bioanalytical laboratory data using an interactive R notebook (pguIMP)

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Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report

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Simvastatin, but Not Atorvastatin, Is Associated with Higher Peak Rivaroxaban Serum Levels and Bleeding: an Asian Cohort Study from Singapore

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Exploring Serum Biomarkers for Neuropathic Pain in Rat Models of Chemotherapy-Induced Peripheral Neuropathy: A Comparative Pilot Study with Oxaliplatin, Paclitaxel, Bortezomib, and Vincristine

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Comparison of area under the curve for vancomycin from one- and two-compartment models using sparse data

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Monitoring of lamotrigine concentrations in mothers, colostrum, and breastfed newborns during the early postpartum period

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Pharmacokinetic analysis of linezolid for multidrug resistant tuberculosis at a tertiary care centre in Mumbai, India

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A Data Science-Based Analysis Points at Distinct Patterns of Lipid Mediator Plasma Concentrations in Patients With Dementia

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Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life

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Population pharmacokinetics of gabapentin in patients with neuropathic pain: Lack of effect of diabetes or glycaemic control

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Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment

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Between-day reliability of cytokines and adipokines for application in research and practice

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Meropenem pharmacokinetics in cerebrospinal fluid: comparing intermittent and continuous infusion strategies in critically ill patients—a prospective cohort study

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Population Pharmacokinetic and Toxicity Analysis of High-Dose Methotrexate in Patients with Central Nervous System Lymphoma

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A study of the dosage and duration for levobupivacaine infusion by the caudal‐epidural route in infants aged 3‐6 months

Vashisht, R., Bendon, A. A., Okonkwo, I., Patel, D., Fullwood, C., Ogungbenro, K., Aarons, L. J., & Darwich, A. S. (2018) · Pediatric Anesthesia · doi:10.1111/pan.13548 · Cited by 10 · see citing works

Population pharmacokinetics of ethambutol in African children: a pooled analysis

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Circulating Immune and Endocrine Markers in Currently Drinking and Abstinent Individuals With Alcohol Use Disorder and Controls

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Development, validation, and clinical application of a high-performance liquid chromatography-tandem mass spectrometry assay for the quantification of total intracellular β-decitabine nucleotides and genomic DNA incorporated β-decitabine and 5-methyl-2′-deoxycytidine

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Social withdrawal and testosterone levels in early adolescent boys

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Impact of enantiomer‐specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis

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Cardiorenal and endocrine effects of synthetic canine BNP1-32 in dogs with compensated congestive heart failure caused by myxomatous mitral valve disease

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The complementarity of phosphatidylethanol in whole blood and ethyl glucuronide in hair as biomarkers for the monitoring of alcohol use

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Total Dealcoholisation of Wines by Very Low Temperature Vacuum Distillation Technology Called GoLo

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Longitudinal effects of maternal depressive and anxious symptomatology on child hair cortisol and cortisone from pregnancy to 5-years: The EDEN mother-child cohort

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Determination of milk concentrations and pharmacokinetics of salicylic acid following acetylsalicylic acid (aspirin) administration in postpartum dairy cows

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Methods for Non-Compartmental Pharmacokinetic Analysis With Observations Below the Limit of Quantification

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Utilization of Data Below the Analytical Limit of Quantitation in Pharmacokinetic Analysis and Modeling: Promoting Interdisciplinary Debate

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