PharmML in Action: an Interoperable Language for Modeling and Simulation
Open accessAbstract
PharmML is an XML-based exchange format created with a focus on nonlinear mixed-effect (NLME) models used in pharmacometrics, but providing a very general framework that also allows describing mathematical and statistical models such as single-subject or nonlinear and multivariate regression models. This tutorial provides an overview of the structure of this language, brief suggestions on how to work with it, and use cases demonstrating its power and flexibility.
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No single standard currently exists for open-source standardized QSP model formats, but there are a number of options, such as SBML, PharmML, and PK‐Sim/MoBi.
“Although no single standard currently exists, there are a number of options, such as SBML,28 PharmML,29 and PK‐Sim/MoBi.30”
From Reproducibility of Quantitative Systems Pharmacology Models: Current Challenges and Future Opportunities (2019) · cites this paper as [29]
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- Authors
- Bizzotto, R., Comets, E., Smith, G., Yvon, F., Kristensen, N., & Swat, M.
- Affiliations
- National Research Council (IT)
- Inserm (FR)
- Scientific Computing Group, Cyprotex Discovery Ltd Cheshire United Kingdom
- European Bioinformatics Institute (GB)
- Novo Nordisk Denmark
- EMBL‐EBI, Wellcome Genome Campus Hinxton United Kingdom
- Corresponding author
- Comets, E
- Venue
- CPT: Pharmacometrics & Systems Pharmacology
- Publisher
- Wiley
- Published
- 2017-09-15
- Volume
- 6
- Issue
- 10
- Pages
- 651-665
- ISSN
- 2163-8306 (ISSN-L)
- PMC
- PMC5658288
- OpenAlex
- W2620915022
- Cited by
- 9
- References
- 37
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- CPT Pharmacometrics & Systems Pharmacology (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- European Federation of Pharmaceutical Industries and Associations (FP7/20072013)
- European Commission (115156, 2007–2013, FP7 2007-2013, FP7/2007)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Modeling and Simulation Systems
- Keywords
- interoperability, nonlinear mixed-effects models, pharmacometrics, nonlinear regression, multivariate regression, model exchange
- MeSH terms
- Computer Simulation, Humans, User-Computer Interface, Models, Statistical, Nonlinear Dynamics, Computational Biology
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